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Auteur Kate LAWRENCE |
Documents disponibles écrits par cet auteur (2)
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Can autistic children read the mind of an animated triangle? / Gemma SALTER in Autism, 12-4 (July 2008)
[article]
Titre : Can autistic children read the mind of an animated triangle? Type de document : Texte imprimé et/ou numérique Auteurs : Gemma SALTER, Auteur ; David H. SKUSE, Auteur ; Anna SEIGAL, Auteur ; Melanie CLAXTON, Auteur ; Kate LAWRENCE, Auteur Année de publication : 2008 Article en page(s) : p.349-371 Langues : Anglais (eng) Mots-clés : animations Asperger-syndrome autism mentalizing theory-of-mind Index. décimale : PER Périodiques Résumé : Are children with an autism spectrum disorder (ASD), but normal-range intelligence, impaired on theory of mind skills measured by responses to abstract animations in the form of a computerized cartoon? Fifty-six cases and closely matched comparisons were tested. We rated verbal responses according to the length of their descriptions, their appropriateness and the children's use of `mentalizing' terms. Children with ASD used `mentalizing' language to describe the animations as well as comparisons, although the content of their descriptions was significantly less appropriate. Performance on this task was not well correlated with standardized measures of parent-reported behaviour or the child's interactions with an observer. The implications of our results are discussed in relation to previous studies that have used this methodology. En ligne : http://dx.doi.org/10.1177/1362361308091654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535
in Autism > 12-4 (July 2008) . - p.349-371[article] Can autistic children read the mind of an animated triangle? [Texte imprimé et/ou numérique] / Gemma SALTER, Auteur ; David H. SKUSE, Auteur ; Anna SEIGAL, Auteur ; Melanie CLAXTON, Auteur ; Kate LAWRENCE, Auteur . - 2008 . - p.349-371.
Langues : Anglais (eng)
in Autism > 12-4 (July 2008) . - p.349-371
Mots-clés : animations Asperger-syndrome autism mentalizing theory-of-mind Index. décimale : PER Périodiques Résumé : Are children with an autism spectrum disorder (ASD), but normal-range intelligence, impaired on theory of mind skills measured by responses to abstract animations in the form of a computerized cartoon? Fifty-six cases and closely matched comparisons were tested. We rated verbal responses according to the length of their descriptions, their appropriateness and the children's use of `mentalizing' terms. Children with ASD used `mentalizing' language to describe the animations as well as comparisons, although the content of their descriptions was significantly less appropriate. Performance on this task was not well correlated with standardized measures of parent-reported behaviour or the child's interactions with an observer. The implications of our results are discussed in relation to previous studies that have used this methodology. En ligne : http://dx.doi.org/10.1177/1362361308091654 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 The role of inflammation in the prospective associations between early childhood sleep problems and ADHD at 10?years: findings from a UK birth cohort study / Isabel MORALES-MUÑOZ in Journal of Child Psychology and Psychiatry, 64-6 (June 2023)
[article]
Titre : The role of inflammation in the prospective associations between early childhood sleep problems and ADHD at 10?years: findings from a UK birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Isabel MORALES-MUÑOZ, Auteur ; Rachel UPTHEGROVE, Auteur ; Kate LAWRENCE, Auteur ; Rasiah THAYAKARAN, Auteur ; Sandra KOOIJ, Auteur ; Alice M GREGORY, Auteur ; Steven MARWAHA, Auteur Article en page(s) : p.930-940 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Several underlying mechanisms potentially account for the link between sleep and attention deficit and hyperactivity disorder (ADHD), including inflammation. However, studies so far have been cross sectional. We investigate (a) the association between early childhood sleep and probable ADHD diagnosis in childhood and (b) whether childhood circulating inflammatory markers mediate these prospective associations. Methods Data from the Avon Longitudinal Study of Parents and Children were available for 7,658 10-year-old children. Parent-reported sleep duration, night awakening frequency and regular sleep routines were collected at 3.5?years. The Development and Wellbeing Assessment was administered to capture children with clinically relevant ADHD symptoms, or probable ADHD diagnosis. Blood samples were collected at 9?years, from which two inflammatory markers were obtained [interleukin-6 (IL-6) and C-reactive protein (CRP)]. Logistic regression analyses were applied to investigate the associations between sleep variables at 3.5?years and probable ADHD diagnosis at 10?years. Further, path analysis was applied to examine the potential mediating role of inflammation at 9?years (as measured by CRP and IL-6) in the associations between early sleep and ADHD at 10?years. Results Less regular sleep routines (OR = 0.51, 95% CI = 0.28-0.93, p = .029), shorter nighttime sleep (OR = 0.70, 95% CI = 0.56-0.89, p = .004) and higher night awakening frequency (OR = 1.27, 95% CI = 1.06-1.52, p = .009) at 3.5?years were associated with higher odds of ADHD at 10?years. Further, IL-6 at 9?years, but not CRP, mediated the association between irregular sleep routines and ADHD (bias-corrected estimate, ?0.002; p = .005) and between night awakening and ADHD (bias-corrected estimate, 0.002; p = .003). Conclusions Several sleep problems in early childhood constitute a risk factor for probable ADHD diagnosis at 10?years. Further, these associations are partially mediated by IL-6 at 9?years. These results open a new research vista to the pathophysiology of ADHD and highlight sleep and inflammation as potential preventative targets for ADHD. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13755 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504
in Journal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.930-940[article] The role of inflammation in the prospective associations between early childhood sleep problems and ADHD at 10?years: findings from a UK birth cohort study [Texte imprimé et/ou numérique] / Isabel MORALES-MUÑOZ, Auteur ; Rachel UPTHEGROVE, Auteur ; Kate LAWRENCE, Auteur ; Rasiah THAYAKARAN, Auteur ; Sandra KOOIJ, Auteur ; Alice M GREGORY, Auteur ; Steven MARWAHA, Auteur . - p.930-940.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.930-940
Index. décimale : PER Périodiques Résumé : Background Several underlying mechanisms potentially account for the link between sleep and attention deficit and hyperactivity disorder (ADHD), including inflammation. However, studies so far have been cross sectional. We investigate (a) the association between early childhood sleep and probable ADHD diagnosis in childhood and (b) whether childhood circulating inflammatory markers mediate these prospective associations. Methods Data from the Avon Longitudinal Study of Parents and Children were available for 7,658 10-year-old children. Parent-reported sleep duration, night awakening frequency and regular sleep routines were collected at 3.5?years. The Development and Wellbeing Assessment was administered to capture children with clinically relevant ADHD symptoms, or probable ADHD diagnosis. Blood samples were collected at 9?years, from which two inflammatory markers were obtained [interleukin-6 (IL-6) and C-reactive protein (CRP)]. Logistic regression analyses were applied to investigate the associations between sleep variables at 3.5?years and probable ADHD diagnosis at 10?years. Further, path analysis was applied to examine the potential mediating role of inflammation at 9?years (as measured by CRP and IL-6) in the associations between early sleep and ADHD at 10?years. Results Less regular sleep routines (OR = 0.51, 95% CI = 0.28-0.93, p = .029), shorter nighttime sleep (OR = 0.70, 95% CI = 0.56-0.89, p = .004) and higher night awakening frequency (OR = 1.27, 95% CI = 1.06-1.52, p = .009) at 3.5?years were associated with higher odds of ADHD at 10?years. Further, IL-6 at 9?years, but not CRP, mediated the association between irregular sleep routines and ADHD (bias-corrected estimate, ?0.002; p = .005) and between night awakening and ADHD (bias-corrected estimate, 0.002; p = .003). Conclusions Several sleep problems in early childhood constitute a risk factor for probable ADHD diagnosis at 10?years. Further, these associations are partially mediated by IL-6 at 9?years. These results open a new research vista to the pathophysiology of ADHD and highlight sleep and inflammation as potential preventative targets for ADHD. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13755 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504