Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Andrea LANFRANCHI |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Methylation of the glucocorticoid receptor promoter in children: Links with parents as teachers, early life stress, and behavior problems / Elena Silvia GARDINI in Development and Psychopathology, 34-3 (August 2022)
[article]
Titre : Methylation of the glucocorticoid receptor promoter in children: Links with parents as teachers, early life stress, and behavior problems Type de document : Texte imprimé et/ou numérique Auteurs : Elena Silvia GARDINI, Auteur ; Simone SCHAUB, Auteur ; Alex NEUHAUSER, Auteur ; Erich RAMSEIER, Auteur ; Arna VILLIGER, Auteur ; Ulrike EHLERT, Auteur ; Andrea LANFRANCHI, Auteur ; Gustavo TURECKI, Auteur Article en page(s) : p.810-822 Langues : Anglais (eng) Mots-clés : child behavior problems early life stress NR3C1 methylation Parents as Teachers social interventions Index. décimale : PER Périodiques Résumé : The present study examined the effect of early life stress (ELS) on the glucocorticoid receptor gene (NR3C1) methylation, the associations between NR3C1 methylation and behavior problems, and the effect of the program Parents as Teachers (PAT) on NR3C1 methylation. Participants included 132 children, 72 assigned to the PAT intervention group and 60 to the PAT control group. Children were aged 3 years, and were living in psychosocially at-risk families. We assessed NR3C1 methylation of the NGFI-A binding regions of exon 1F via sodium bisulfite sequencing from saliva DNA. Results indicated that (a) children living in families receiving PAT had decreased methylation at one single cytosine “guanine dinucleotides (CpG) site; (b) current maternal depressive symptoms and parental disagreement were predictive of increased methylation of mean NGFI-A and three single CpG sites; and (c) increased methylation of mean NGFI-A and one single CpG site was significantly associated with increased internalizing and externalizing symptoms. In addition, mean NGFI-A was a mediator of the association between parental disagreement and a child's affective problems. These results suggest that PAT may contribute to preventing NR3C1 methylation in preschool children living in psychosocially at-risk situations, and confirm previous findings on the associations between ELS, NR3C1 methylation, and behavior problems. En ligne : http://dx.doi.org/10.1017/S0954579420001984 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484
in Development and Psychopathology > 34-3 (August 2022) . - p.810-822[article] Methylation of the glucocorticoid receptor promoter in children: Links with parents as teachers, early life stress, and behavior problems [Texte imprimé et/ou numérique] / Elena Silvia GARDINI, Auteur ; Simone SCHAUB, Auteur ; Alex NEUHAUSER, Auteur ; Erich RAMSEIER, Auteur ; Arna VILLIGER, Auteur ; Ulrike EHLERT, Auteur ; Andrea LANFRANCHI, Auteur ; Gustavo TURECKI, Auteur . - p.810-822.
Langues : Anglais (eng)
in Development and Psychopathology > 34-3 (August 2022) . - p.810-822
Mots-clés : child behavior problems early life stress NR3C1 methylation Parents as Teachers social interventions Index. décimale : PER Périodiques Résumé : The present study examined the effect of early life stress (ELS) on the glucocorticoid receptor gene (NR3C1) methylation, the associations between NR3C1 methylation and behavior problems, and the effect of the program Parents as Teachers (PAT) on NR3C1 methylation. Participants included 132 children, 72 assigned to the PAT intervention group and 60 to the PAT control group. Children were aged 3 years, and were living in psychosocially at-risk families. We assessed NR3C1 methylation of the NGFI-A binding regions of exon 1F via sodium bisulfite sequencing from saliva DNA. Results indicated that (a) children living in families receiving PAT had decreased methylation at one single cytosine “guanine dinucleotides (CpG) site; (b) current maternal depressive symptoms and parental disagreement were predictive of increased methylation of mean NGFI-A and three single CpG sites; and (c) increased methylation of mean NGFI-A and one single CpG site was significantly associated with increased internalizing and externalizing symptoms. In addition, mean NGFI-A was a mediator of the association between parental disagreement and a child's affective problems. These results suggest that PAT may contribute to preventing NR3C1 methylation in preschool children living in psychosocially at-risk situations, and confirm previous findings on the associations between ELS, NR3C1 methylation, and behavior problems. En ligne : http://dx.doi.org/10.1017/S0954579420001984 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484