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Auteur Laura RAMO-FERNANDEZ |
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Characterization of the effects of age and childhood maltreatment on ELOVL2 DNA methylation / Laura RAMO-FERNANDEZ in Development and Psychopathology, 34-3 (August 2022)
[article]
Titre : Characterization of the effects of age and childhood maltreatment on ELOVL2 DNA methylation Type de document : Texte imprimé et/ou numérique Auteurs : Laura RAMO-FERNANDEZ, Auteur ; Alexander KARABATSIAKIS, Auteur ; Christina BOECK, Auteur ; Alexandra M. BACH, Auteur ; Anja M. GUMPP, Auteur ; R. Nehir MAVIOGLU, Auteur ; Ole AMMERPOHL, Auteur ; Iris-Tatjana KOLASSA, Auteur Article en page(s) : p.864-874 Langues : Anglais (eng) Mots-clés : childhood maltreatment epigenetics psychoneuroendocrinology accelerated aging DNA methylation Index. décimale : PER Périodiques Résumé : DNA methylation of the elongation of very long chain fatty acids protein 2 (ELOVL2) was suggested as a biomarker of biological aging, while childhood maltreatment (CM) has been associated with accelerated biological aging. We investigated the association of age and CM experiences with ELOVL2 methylation in peripheral blood mononuclear cells (PBMC). Furthermore, we investigated ELOVL2 methylation in the umbilical cord blood mononuclear cells (UBMC) of newborns of mothers with and without CM. PBMC and UBMC were isolated from 113 mother “newborn dyads and genomic DNA was extracted. Mothers with and without CM experiences were recruited directly postpartum. Mass array spectrometry and pyrosequencing were used for methylation analyses of ELOVL2 intron 1, and exon 1 and 5 2 end, respectively. ELOVL2 5 2 end and intron 1 methylation increased with higher age but were not associated with CM experiences. On the contrary, overall ELOVL2 exon 1 methylation increased with higher CM, but these changes were minimal and did not increase with age. Maternal CM experiences and neonatal methylation of ELOVL2 intron 1 or exon 1 were not significantly correlated. Our study suggests region-specific effects of chronological age and experienced CM on ELOVL2 methylation and shows that the epigenetic biomarker for age within the ELOVL2 gene does not show accelerated biological aging years after CM exposure. En ligne : http://dx.doi.org/10.1017/S0954579420001972 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484
in Development and Psychopathology > 34-3 (August 2022) . - p.864-874[article] Characterization of the effects of age and childhood maltreatment on ELOVL2 DNA methylation [Texte imprimé et/ou numérique] / Laura RAMO-FERNANDEZ, Auteur ; Alexander KARABATSIAKIS, Auteur ; Christina BOECK, Auteur ; Alexandra M. BACH, Auteur ; Anja M. GUMPP, Auteur ; R. Nehir MAVIOGLU, Auteur ; Ole AMMERPOHL, Auteur ; Iris-Tatjana KOLASSA, Auteur . - p.864-874.
Langues : Anglais (eng)
in Development and Psychopathology > 34-3 (August 2022) . - p.864-874
Mots-clés : childhood maltreatment epigenetics psychoneuroendocrinology accelerated aging DNA methylation Index. décimale : PER Périodiques Résumé : DNA methylation of the elongation of very long chain fatty acids protein 2 (ELOVL2) was suggested as a biomarker of biological aging, while childhood maltreatment (CM) has been associated with accelerated biological aging. We investigated the association of age and CM experiences with ELOVL2 methylation in peripheral blood mononuclear cells (PBMC). Furthermore, we investigated ELOVL2 methylation in the umbilical cord blood mononuclear cells (UBMC) of newborns of mothers with and without CM. PBMC and UBMC were isolated from 113 mother “newborn dyads and genomic DNA was extracted. Mothers with and without CM experiences were recruited directly postpartum. Mass array spectrometry and pyrosequencing were used for methylation analyses of ELOVL2 intron 1, and exon 1 and 5 2 end, respectively. ELOVL2 5 2 end and intron 1 methylation increased with higher age but were not associated with CM experiences. On the contrary, overall ELOVL2 exon 1 methylation increased with higher CM, but these changes were minimal and did not increase with age. Maternal CM experiences and neonatal methylation of ELOVL2 intron 1 or exon 1 were not significantly correlated. Our study suggests region-specific effects of chronological age and experienced CM on ELOVL2 methylation and shows that the epigenetic biomarker for age within the ELOVL2 gene does not show accelerated biological aging years after CM exposure. En ligne : http://dx.doi.org/10.1017/S0954579420001972 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484