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Auteur Paul DE BOECK |
Documents disponibles écrits par cet auteur (1)
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Characterizing Sleep Problems in 16p11.2 Deletion and Duplication / Dana KAMARA in Journal of Autism and Developmental Disorders, 53-4 (April 2023)
[article]
Titre : Characterizing Sleep Problems in 16p11.2 Deletion and Duplication Type de document : Texte imprimé et/ou numérique Auteurs : Dana KAMARA, Auteur ; Paul DE BOECK, Auteur ; Luc LECAVALIER, Auteur ; Emily NEUHAUS, Auteur ; Theodore P. BEAUCHAINE, Auteur Article en page(s) : p.1462-1475 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Studies of 16p11.2 copy number variants (CNVs) provide an avenue to identify mechanisms of impairment and develop targeted treatments for individuals with neurodevelopmental disorders. 16p11.2 deletion and duplication phenotypes are currently being ascertained; however, sleep disturbances are minimally described. In this study, we examine sleep disturbance in a well-characterized national sample of 16p11.2 CNVs, the Simons Foundation Autism Research Initiative (SFARI) database of youth and adults (n=692). Factor analyses and multilevel models of derived sleep questionnaires for youth (n=345) and adults (n=347) indicate that 16p11.2 carriers show elevated sleep disturbance relative to community controls. Non-carrier family members also show elevated sleep disturbance. However, sleep duration does not differ between carriers and controls. Further studies of sleep in 16p11.2 are needed. En ligne : https://doi.org/10.1007/s10803-021-05311-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500
in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1462-1475[article] Characterizing Sleep Problems in 16p11.2 Deletion and Duplication [Texte imprimé et/ou numérique] / Dana KAMARA, Auteur ; Paul DE BOECK, Auteur ; Luc LECAVALIER, Auteur ; Emily NEUHAUS, Auteur ; Theodore P. BEAUCHAINE, Auteur . - p.1462-1475.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1462-1475
Index. décimale : PER Périodiques Résumé : Studies of 16p11.2 copy number variants (CNVs) provide an avenue to identify mechanisms of impairment and develop targeted treatments for individuals with neurodevelopmental disorders. 16p11.2 deletion and duplication phenotypes are currently being ascertained; however, sleep disturbances are minimally described. In this study, we examine sleep disturbance in a well-characterized national sample of 16p11.2 CNVs, the Simons Foundation Autism Research Initiative (SFARI) database of youth and adults (n=692). Factor analyses and multilevel models of derived sleep questionnaires for youth (n=345) and adults (n=347) indicate that 16p11.2 carriers show elevated sleep disturbance relative to community controls. Non-carrier family members also show elevated sleep disturbance. However, sleep duration does not differ between carriers and controls. Further studies of sleep in 16p11.2 are needed. En ligne : https://doi.org/10.1007/s10803-021-05311-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500