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[article]
Titre : Postmortem studies of autism Type de document : Texte imprimé et/ou numérique Auteurs : Anthony J. BAILEY, Auteur Année de publication : 2008 Article en page(s) : p.265 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.51 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933
in Autism Research > 1-5 (October 2008) . - p.265[article] Postmortem studies of autism [Texte imprimé et/ou numérique] / Anthony J. BAILEY, Auteur . - 2008 . - p.265.
Langues : Anglais (eng)
in Autism Research > 1-5 (October 2008) . - p.265
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.51 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933 Relationships between multiple births and autism spectrum disorders, cerebral palsy, and intellectual disabilities: autism and developmental disabilities monitoring (ADDM) network - 2002 surveillance year / Kim VAN NAARDEN BRAUN in Autism Research, 1-5 (October 2008)
[article]
Titre : Relationships between multiple births and autism spectrum disorders, cerebral palsy, and intellectual disabilities: autism and developmental disabilities monitoring (ADDM) network - 2002 surveillance year Type de document : Texte imprimé et/ou numérique Auteurs : Kim VAN NAARDEN BRAUN, Auteur ; Li-Ching LEE, Auteur ; Joyce S. NICHOLAS, Auteur ; Russell S. KIRBY, Auteur ; Ellen GIARELLI, Auteur ; Maureen DURKIN, Auteur ; Laura A. SCHIEVE, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Julie L. DANIELS, Auteur Année de publication : 2008 Article en page(s) : p.266-274 Langues : Anglais (eng) Mots-clés : developmental-disabilities multiple-births autism-spectrum-disorders intellectual-disabilities cerebral-palsy Index. décimale : PER Périodiques Résumé : Since the 1970s, the prevalence of multiple births (MBs) in the United States has increased significantly. This has been attributed, in large part, to iatrogenic MBs resulting from infertility treatments that include ovulation stimulation. A past study has indicated that children from MBs have an increased prevalence of cerebral palsy (CP). Other studies also have suggested an association between MBs and intellectual disabilities (ID) and autism spectrum disorders (ASDs); however, results have been inconsistent. From the Autism and Developmental Disabilities Monitoring (ADDM) Network, a surveillance project among several US populations, we obtained MB estimates among children born in 1994 and classified by 8 years of age as having: an ASD (n=1,626 total children from 11 sites; 50 born as part of an MB); CP (n=302 total children from 3 sites; 25 born as part of an MB); or ID (n=1,195 total children from 3 sites; 45 born as part of an MB). All three MB estimates were notably higher than age-adjusted expected estimates of naturally conceived MBs derived from 1971 US natality data. However, when MB estimates from the ADDM Network were compared with expected MB estimates derived from 1994 natality data for the states corresponding to the relevant ADDM Network sites, we observed no association with ASDs (observed/expected=1.08 [0.78-1.38]), a moderate, but not statistically significant association with ID (observed/expected=1.34 [0.95-1.73]), and a strong association with CP (observed/expected=2.96 [1.80-4.12]). Further investigation of specific types of MBs (natural vs. iatrogenic) is warranted. En ligne : http://dx.doi.org/10.1002/aur.41 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933
in Autism Research > 1-5 (October 2008) . - p.266-274[article] Relationships between multiple births and autism spectrum disorders, cerebral palsy, and intellectual disabilities: autism and developmental disabilities monitoring (ADDM) network - 2002 surveillance year [Texte imprimé et/ou numérique] / Kim VAN NAARDEN BRAUN, Auteur ; Li-Ching LEE, Auteur ; Joyce S. NICHOLAS, Auteur ; Russell S. KIRBY, Auteur ; Ellen GIARELLI, Auteur ; Maureen DURKIN, Auteur ; Laura A. SCHIEVE, Auteur ; Jennifer A. PINTO-MARTIN, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Julie L. DANIELS, Auteur . - 2008 . - p.266-274.
Langues : Anglais (eng)
in Autism Research > 1-5 (October 2008) . - p.266-274
Mots-clés : developmental-disabilities multiple-births autism-spectrum-disorders intellectual-disabilities cerebral-palsy Index. décimale : PER Périodiques Résumé : Since the 1970s, the prevalence of multiple births (MBs) in the United States has increased significantly. This has been attributed, in large part, to iatrogenic MBs resulting from infertility treatments that include ovulation stimulation. A past study has indicated that children from MBs have an increased prevalence of cerebral palsy (CP). Other studies also have suggested an association between MBs and intellectual disabilities (ID) and autism spectrum disorders (ASDs); however, results have been inconsistent. From the Autism and Developmental Disabilities Monitoring (ADDM) Network, a surveillance project among several US populations, we obtained MB estimates among children born in 1994 and classified by 8 years of age as having: an ASD (n=1,626 total children from 11 sites; 50 born as part of an MB); CP (n=302 total children from 3 sites; 25 born as part of an MB); or ID (n=1,195 total children from 3 sites; 45 born as part of an MB). All three MB estimates were notably higher than age-adjusted expected estimates of naturally conceived MBs derived from 1971 US natality data. However, when MB estimates from the ADDM Network were compared with expected MB estimates derived from 1994 natality data for the states corresponding to the relevant ADDM Network sites, we observed no association with ASDs (observed/expected=1.08 [0.78-1.38]), a moderate, but not statistically significant association with ID (observed/expected=1.34 [0.95-1.73]), and a strong association with CP (observed/expected=2.96 [1.80-4.12]). Further investigation of specific types of MBs (natural vs. iatrogenic) is warranted. En ligne : http://dx.doi.org/10.1002/aur.41 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933 Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms / Luke HEUER in Autism Research, 1-5 (October 2008)
[article]
Titre : Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Luke HEUER, Auteur ; David J. HANSEN, Auteur ; Joseph SCHAUER, Auteur ; Paula GOINES, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur ; Isaac N. PESSAH, Auteur ; Paula KRAKOWIAK, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2008 Article en page(s) : p.275-283 Langues : Anglais (eng) Mots-clés : Autism immunoglobulin behavior IgG Index. décimale : PER Périodiques Résumé : Objectives: To assay if plasma antibody levels in children with autism or developmental delays (DD) differ from those with typical development as an indicator of immune function and to correlate antibody levels with severity of behavioral symptoms.
Methods: Plasma was collected from children with autistic disorder (AU; n=116), DD but not autism (n=32), autism spectrum disorder but not full autism (n=27), and age-matched typically developing (TD) controls (n=96). Samples were assayed for systemic levels of immunoglobulin (IgG, IgM, IgA, and IgE) by enzyme-linked immunosorbent assay. Subjects with autism were evaluated using the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview - Revised, and all subjects were scored on the Aberrant Behavior Checklist (ABC) by the parents. Numerical scores for each of the ABC subscales as well as the total scores were then correlated with Ig levels.
Results: Children with AU have a significantly reduced level of plasma IgG (5.39±0.29 mg/mL) compared to the TD (7.72±0.28 mg/mL; P<0.001) and DD children (8.23±0.49 mg/mL; P<0.001). Children with autism also had a reduced level of plasma IgM (0.670.06mg/mL) compared to TD (0.79±0.05 mg/mL; P<0.05). Ig levels were negatively correlated with ABC scores for all children (IgG: r=-0.334, P<0.0001; IgM: r=-0.167, P=0.0285).
Conclusion: Children with AU have significantly reduced levels of plasma IgG and IgM compared to both DD and TD controls, suggesting an underlying defect in immune function. This reduction in specific Ig levels correlates with behavioral severity, where those patients with the highest scores in the behavioral battery have the most reduced levels of IgG and IgM.En ligne : http://dx.doi.org/10.1002/aur.42 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933
in Autism Research > 1-5 (October 2008) . - p.275-283[article] Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms [Texte imprimé et/ou numérique] / Luke HEUER, Auteur ; David J. HANSEN, Auteur ; Joseph SCHAUER, Auteur ; Paula GOINES, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur ; Isaac N. PESSAH, Auteur ; Paula KRAKOWIAK, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Lisa A. CROEN, Auteur . - 2008 . - p.275-283.
Langues : Anglais (eng)
in Autism Research > 1-5 (October 2008) . - p.275-283
Mots-clés : Autism immunoglobulin behavior IgG Index. décimale : PER Périodiques Résumé : Objectives: To assay if plasma antibody levels in children with autism or developmental delays (DD) differ from those with typical development as an indicator of immune function and to correlate antibody levels with severity of behavioral symptoms.
Methods: Plasma was collected from children with autistic disorder (AU; n=116), DD but not autism (n=32), autism spectrum disorder but not full autism (n=27), and age-matched typically developing (TD) controls (n=96). Samples were assayed for systemic levels of immunoglobulin (IgG, IgM, IgA, and IgE) by enzyme-linked immunosorbent assay. Subjects with autism were evaluated using the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview - Revised, and all subjects were scored on the Aberrant Behavior Checklist (ABC) by the parents. Numerical scores for each of the ABC subscales as well as the total scores were then correlated with Ig levels.
Results: Children with AU have a significantly reduced level of plasma IgG (5.39±0.29 mg/mL) compared to the TD (7.72±0.28 mg/mL; P<0.001) and DD children (8.23±0.49 mg/mL; P<0.001). Children with autism also had a reduced level of plasma IgM (0.670.06mg/mL) compared to TD (0.79±0.05 mg/mL; P<0.05). Ig levels were negatively correlated with ABC scores for all children (IgG: r=-0.334, P<0.0001; IgM: r=-0.167, P=0.0285).
Conclusion: Children with AU have significantly reduced levels of plasma IgG and IgM compared to both DD and TD controls, suggesting an underlying defect in immune function. This reduction in specific Ig levels correlates with behavioral severity, where those patients with the highest scores in the behavioral battery have the most reduced levels of IgG and IgM.En ligne : http://dx.doi.org/10.1002/aur.42 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933 Overlap between autism and specific language impairment: comparison of Autism Diagnostic Interview and Autism Diagnostic Observation Schedule scores / Ovsanna T. LEYFER in Autism Research, 1-5 (October 2008)
[article]
Titre : Overlap between autism and specific language impairment: comparison of Autism Diagnostic Interview and Autism Diagnostic Observation Schedule scores Type de document : Texte imprimé et/ou numérique Auteurs : Ovsanna T. LEYFER, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Michael DOWD, Auteur ; J. Bruce TOMBLIN, Auteur ; S. E. FOLSTEIN, Auteur Année de publication : 2008 Article en page(s) : p.284-296 Langues : Anglais (eng) Mots-clés : autism specific-language-impairment developmental-disorders etiology Autism-Diagnostic-Interview-Revised Autism-Diagnostic-Observation-Schedule Index. décimale : PER Périodiques Résumé : Autism and specific language impairment (SLI) are developmental disorders that, although distinct by definition, have in common some features of both language and social behavior. The goal of this study was to further explore the extent to which specific clinical features of autism are seen in SLI. The children with the two disorders, matched for non-verbal IQ, were compared on the Autism Diagnostic Interview - Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). In the SLI group, 41% met autism or autism spectrum cut-offs for social or communication domains either on the ADI or ADOS or both. No relationship was found between the language deficits exhibited by the children with SLI and their scores on the ADI and ADOS. These findings contribute to evidence that there is some overlap in social and communicative deficits between autism and SLI, supporting the view that autism and SLI share etiologic factors. This continuum of pathology between SLI and autism appears to range from structural language abnormalities as seen in individuals with SLI to individuals with SLI with both structural and social abnormalities to individuals with autism with pragmatic impairment and language abnormalities. En ligne : http://dx.doi.org/10.1002/aur.43 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933
in Autism Research > 1-5 (October 2008) . - p.284-296[article] Overlap between autism and specific language impairment: comparison of Autism Diagnostic Interview and Autism Diagnostic Observation Schedule scores [Texte imprimé et/ou numérique] / Ovsanna T. LEYFER, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Michael DOWD, Auteur ; J. Bruce TOMBLIN, Auteur ; S. E. FOLSTEIN, Auteur . - 2008 . - p.284-296.
Langues : Anglais (eng)
in Autism Research > 1-5 (October 2008) . - p.284-296
Mots-clés : autism specific-language-impairment developmental-disorders etiology Autism-Diagnostic-Interview-Revised Autism-Diagnostic-Observation-Schedule Index. décimale : PER Périodiques Résumé : Autism and specific language impairment (SLI) are developmental disorders that, although distinct by definition, have in common some features of both language and social behavior. The goal of this study was to further explore the extent to which specific clinical features of autism are seen in SLI. The children with the two disorders, matched for non-verbal IQ, were compared on the Autism Diagnostic Interview - Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). In the SLI group, 41% met autism or autism spectrum cut-offs for social or communication domains either on the ADI or ADOS or both. No relationship was found between the language deficits exhibited by the children with SLI and their scores on the ADI and ADOS. These findings contribute to evidence that there is some overlap in social and communicative deficits between autism and SLI, supporting the view that autism and SLI share etiologic factors. This continuum of pathology between SLI and autism appears to range from structural language abnormalities as seen in individuals with SLI to individuals with SLI with both structural and social abnormalities to individuals with autism with pragmatic impairment and language abnormalities. En ligne : http://dx.doi.org/10.1002/aur.43 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933 Face inversion effects in autism: a combined looking time and pupillometric study / Terje FALCK-YTTER in Autism Research, 1-5 (October 2008)
[article]
Titre : Face inversion effects in autism: a combined looking time and pupillometric study Type de document : Texte imprimé et/ou numérique Auteurs : Terje FALCK-YTTER, Auteur Année de publication : 2008 Article en page(s) : p.297-306 Langues : Anglais (eng) Mots-clés : Autism-Spectrum-Disorder eye-movements face-perception Index. décimale : PER Périodiques Résumé : Previous research has found that in typically developing individuals, behavioral performance declines and electrophysiological brain responses are altered when the face is inverted. Such effects are generally attributed to disruption of configural information. Individuals with autism spectrum disorder (ASD) have been found to show less pronounced inversion effects, a result in line with the view that featural processing of faces is enhanced in ASD. No study has determined if, or how, such local bias is reflected in the eye movements used in face observation. In this eye tracking study, looking time and pupil dilation were investigated during the presentation of upright and inverted faces in preschool children with ASD and typically developing preschoolers. On average, both children with ASD and typically developing children looked less at the face and the eye areas during inverted presentations than during upright presentations. Nevertheless, individuals with ASD had a stronger tendency than typically developing children to look at the same face features during upright and inverted presentations, which is suggestive of a local bias. Pupil dilation, reflecting increased processing load, was larger for inverted than upright faces in the ASD group only, and pupillary inversion effects were stronger in ASD than in typically developing children. En ligne : http://dx.doi.org/10.1002/aur.45 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933
in Autism Research > 1-5 (October 2008) . - p.297-306[article] Face inversion effects in autism: a combined looking time and pupillometric study [Texte imprimé et/ou numérique] / Terje FALCK-YTTER, Auteur . - 2008 . - p.297-306.
Langues : Anglais (eng)
in Autism Research > 1-5 (October 2008) . - p.297-306
Mots-clés : Autism-Spectrum-Disorder eye-movements face-perception Index. décimale : PER Périodiques Résumé : Previous research has found that in typically developing individuals, behavioral performance declines and electrophysiological brain responses are altered when the face is inverted. Such effects are generally attributed to disruption of configural information. Individuals with autism spectrum disorder (ASD) have been found to show less pronounced inversion effects, a result in line with the view that featural processing of faces is enhanced in ASD. No study has determined if, or how, such local bias is reflected in the eye movements used in face observation. In this eye tracking study, looking time and pupil dilation were investigated during the presentation of upright and inverted faces in preschool children with ASD and typically developing preschoolers. On average, both children with ASD and typically developing children looked less at the face and the eye areas during inverted presentations than during upright presentations. Nevertheless, individuals with ASD had a stronger tendency than typically developing children to look at the same face features during upright and inverted presentations, which is suggestive of a local bias. Pupil dilation, reflecting increased processing load, was larger for inverted than upright faces in the ASD group only, and pupillary inversion effects were stronger in ASD than in typically developing children. En ligne : http://dx.doi.org/10.1002/aur.45 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933 Addendum : Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism / Zohreh TALEBIZADEH in Autism Research, 1-5 (October 2008)
[article]
Titre : Addendum : Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism Type de document : Texte imprimé et/ou numérique Auteurs : Zohreh TALEBIZADEH, Auteur ; Merlin G. BUTLER, Auteur ; Mariana F. THEODORO, Auteur Année de publication : 2008 Article en page(s) : p.307 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.46 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933
in Autism Research > 1-5 (October 2008) . - p.307[article] Addendum : Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism [Texte imprimé et/ou numérique] / Zohreh TALEBIZADEH, Auteur ; Merlin G. BUTLER, Auteur ; Mariana F. THEODORO, Auteur . - 2008 . - p.307.
Langues : Anglais (eng)
in Autism Research > 1-5 (October 2008) . - p.307
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.46 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933 Literature review: adult structural MRI, postmortem GABA-A protein, 1q21.1 microdeletion/microduplication / Edwin H. Jr COOK in Autism Research, 1-5 (October 2008)
[article]
Titre : Literature review: adult structural MRI, postmortem GABA-A protein, 1q21.1 microdeletion/microduplication Type de document : Texte imprimé et/ou numérique Auteurs : Edwin H. Jr COOK, Auteur Année de publication : 2008 Article en page(s) : p.308-310 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.44 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933
in Autism Research > 1-5 (October 2008) . - p.308-310[article] Literature review: adult structural MRI, postmortem GABA-A protein, 1q21.1 microdeletion/microduplication [Texte imprimé et/ou numérique] / Edwin H. Jr COOK, Auteur . - 2008 . - p.308-310.
Langues : Anglais (eng)
in Autism Research > 1-5 (October 2008) . - p.308-310
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.44 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=933
[article]
Titre : Lay abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2008 Article en page(s) : p.311-312 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.50 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934
in Autism Research > 1-5 (October 2008) . - p.311-312[article] Lay abstracts [Texte imprimé et/ou numérique] . - 2008 . - p.311-312.
Langues : Anglais (eng)
in Autism Research > 1-5 (October 2008) . - p.311-312
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.50 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934
[article]
Titre : The International Meeting for Autism Research Type de document : Texte imprimé et/ou numérique Année de publication : 2008 Article en page(s) : p.313-315 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.48 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934
in Autism Research > 1-5 (October 2008) . - p.313-315[article] The International Meeting for Autism Research [Texte imprimé et/ou numérique] . - 2008 . - p.313-315.
Langues : Anglais (eng)
in Autism Research > 1-5 (October 2008) . - p.313-315
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.48 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934
[article]
Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Année de publication : 2008 Article en page(s) : p.316 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.47 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934
in Autism Research > 1-5 (October 2008) . - p.316[article] International Society for Autism Research News [Texte imprimé et/ou numérique] . - 2008 . - p.316.
Langues : Anglais (eng)
in Autism Research > 1-5 (October 2008) . - p.316
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.47 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934