Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
2 recherche sur le mot-clé 'PGS'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Father absence, age at menarche, and genetic confounding: A replication and extension using a polygenic score / Gabriel L. SCHLOMER in Development and Psychopathology, 34-1 (February 2022)
[article]
Titre : Father absence, age at menarche, and genetic confounding: A replication and extension using a polygenic score Type de document : Texte imprimé et/ou numérique Auteurs : Gabriel L. SCHLOMER, Auteur ; Kristine MARCEAU, Auteur Article en page(s) : p.355-366 Langues : Anglais (eng) Mots-clés : ALSPAC father absence LIN28B menarche PGS Index. décimale : PER Périodiques Résumé : Father absence has a small but robust association with earlier age at menarche (AAM), likely reflecting both genetic confounding and an environmental influence on life history strategy development. Studies that have attempted to disambiguate genetic versus environmental contributions to this association have shown conflicting findings, though genomic-based studies have begun to establish the role of gene?environment interplay in the father absence/AAM literature. The purpose of this study was to replicate and extend prior genomic work using the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective longitudinal cohort study (N = 2,685), by (a) testing if an AAM polygenic score (PGS) could account for the father absence/AAM association, (b) replicating G*E research on lin-28 homolog B (LIN28B) variation and father absence, and (c) testing the G*E hypothesis using the PGS. Results showed that the PGS could not explain the father absence/AAM association and there was no interaction between father absence and the PGS. Findings using LIN28B largely replicated prior work that showed LIN28B variants predicted later AAM in father-present girls, but this AAM-delaying effect was absent or reversed in father-absent girls. Findings are discussed in terms genetic confounding, the unique biological role of LIN28B, and using PGSs for G*E tests. En ligne : http://dx.doi.org/10.1017/s0954579420000929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474
in Development and Psychopathology > 34-1 (February 2022) . - p.355-366[article] Father absence, age at menarche, and genetic confounding: A replication and extension using a polygenic score [Texte imprimé et/ou numérique] / Gabriel L. SCHLOMER, Auteur ; Kristine MARCEAU, Auteur . - p.355-366.
Langues : Anglais (eng)
in Development and Psychopathology > 34-1 (February 2022) . - p.355-366
Mots-clés : ALSPAC father absence LIN28B menarche PGS Index. décimale : PER Périodiques Résumé : Father absence has a small but robust association with earlier age at menarche (AAM), likely reflecting both genetic confounding and an environmental influence on life history strategy development. Studies that have attempted to disambiguate genetic versus environmental contributions to this association have shown conflicting findings, though genomic-based studies have begun to establish the role of gene?environment interplay in the father absence/AAM literature. The purpose of this study was to replicate and extend prior genomic work using the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective longitudinal cohort study (N = 2,685), by (a) testing if an AAM polygenic score (PGS) could account for the father absence/AAM association, (b) replicating G*E research on lin-28 homolog B (LIN28B) variation and father absence, and (c) testing the G*E hypothesis using the PGS. Results showed that the PGS could not explain the father absence/AAM association and there was no interaction between father absence and the PGS. Findings using LIN28B largely replicated prior work that showed LIN28B variants predicted later AAM in father-present girls, but this AAM-delaying effect was absent or reversed in father-absent girls. Findings are discussed in terms genetic confounding, the unique biological role of LIN28B, and using PGSs for G*E tests. En ligne : http://dx.doi.org/10.1017/s0954579420000929 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 The influence of harshness and unpredictability on female sexual development: Addressing gene?environment interplay using a polygenic score / Gabriel L. SCHLOMER in Development and Psychopathology, 34-2 (May 2022)
[article]
Titre : The influence of harshness and unpredictability on female sexual development: Addressing gene?environment interplay using a polygenic score Type de document : Texte imprimé et/ou numérique Auteurs : Gabriel L. SCHLOMER, Auteur ; Qi SUN, Auteur Article en page(s) : 731-741 Langues : Anglais (eng) Mots-clés : ALSPAC GxE life history theory menarche PGS sexual behavior Index. décimale : PER Périodiques Résumé : Recent developments in the application life history theory to human development indicate two fundamental dimension of the early environment ? harshness and unpredictability ? are key regulators life history strategies. Few studies have examined the manner with which these dimensions influence development, though age at menarche (AAM) and age at first sexual intercourse have been proposed as possible mechanisms among women. Data from the Avon Longitudinal Study of Parents and Children (N = 3,645) were used to examine direct and indirect effects of harshness (financial difficulties) and unpredictability (paternal transitions) on lifetime and past year sexual partners during adolescence and young adulthood. Genetic confounding was addressed using an AAM polygenic score (PGS) and potential gene-by-environment interactions were also evaluated using the PGS. Path model results showed only harshness was directly related to AAM. Harshness, unpredictability, and AAM were indirectly related to lifetime and past year sexual partner number via age at first sexual intercourse. The PGS did not account for any of the associations and no significant interactions were detected. Implications of these results for developmental models derived from life history theory are discussed as well as the role of PGSs in gene?environment interplay research. En ligne : http://dx.doi.org/10.1017/s0954579421001589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474
in Development and Psychopathology > 34-2 (May 2022) . - 731-741[article] The influence of harshness and unpredictability on female sexual development: Addressing gene?environment interplay using a polygenic score [Texte imprimé et/ou numérique] / Gabriel L. SCHLOMER, Auteur ; Qi SUN, Auteur . - 731-741.
Langues : Anglais (eng)
in Development and Psychopathology > 34-2 (May 2022) . - 731-741
Mots-clés : ALSPAC GxE life history theory menarche PGS sexual behavior Index. décimale : PER Périodiques Résumé : Recent developments in the application life history theory to human development indicate two fundamental dimension of the early environment ? harshness and unpredictability ? are key regulators life history strategies. Few studies have examined the manner with which these dimensions influence development, though age at menarche (AAM) and age at first sexual intercourse have been proposed as possible mechanisms among women. Data from the Avon Longitudinal Study of Parents and Children (N = 3,645) were used to examine direct and indirect effects of harshness (financial difficulties) and unpredictability (paternal transitions) on lifetime and past year sexual partners during adolescence and young adulthood. Genetic confounding was addressed using an AAM polygenic score (PGS) and potential gene-by-environment interactions were also evaluated using the PGS. Path model results showed only harshness was directly related to AAM. Harshness, unpredictability, and AAM were indirectly related to lifetime and past year sexual partner number via age at first sexual intercourse. The PGS did not account for any of the associations and no significant interactions were detected. Implications of these results for developmental models derived from life history theory are discussed as well as the role of PGSs in gene?environment interplay research. En ligne : http://dx.doi.org/10.1017/s0954579421001589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474