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Maternal warmth and directiveness jointly moderate the etiology of childhood conduct problems / S. Alexandra BURT in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)
[article]
Titre : Maternal warmth and directiveness jointly moderate the etiology of childhood conduct problems Type de document : Texte imprimé et/ou numérique Auteurs : S. Alexandra BURT, Auteur ; Ashlea M. KLAHR, Auteur ; Michael C. NEALE, Auteur ; Kelly L. KLUMP, Auteur Article en page(s) : p.1030-1037 Langues : Anglais (eng) Mots-clés : Child conduct problems GxE maternal directiveness or control maternal warmth Index. décimale : PER Périodiques Résumé : Background Prior studies exploring gene–environment interactions (GxE) in the development of youth conduct problems (CP) have focused almost exclusively on single-risk experiences, despite research indicating that the presence of other risk factors and or the absence of protective factors can accentuate the influence of a given risk factor on CP. The goal of the current study was to fill this gap in the literature, evaluating whether risky and protective aspects of parenting might combine to jointly moderate the etiology of CP. Methods The sample consisted of 500 child twin pairs from the Michigan State University Twin Registry (MSUTR). Child CP was assessed using multiple informant reports. Maternal warmth and directiveness were assessed via videotaped dyadic interactions between mothers and each of their twins. Results Biometric GxE analyses revealed that directiveness and warmth did appear to jointly moderate the etiology of CP. In particular, shared environmental influences were accentuated by colder, less directive or ‘less engaged’ mothering, whereas genetic influences were strongest when the child was experiencing warmer, more directive or ‘more authoritative’ mothering. Conclusions Such findings serve to highlight the synergistic effects of risky and protective experiences on child outcomes. They also provide additional empirical support for the bioecological form of GxE, which postulates that, in some cases, genetic influences may be most strongly expressed in the presence of low-risk environments. En ligne : http://dx.doi.org/10.1111/jcpp.12095 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212
in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1030-1037[article] Maternal warmth and directiveness jointly moderate the etiology of childhood conduct problems [Texte imprimé et/ou numérique] / S. Alexandra BURT, Auteur ; Ashlea M. KLAHR, Auteur ; Michael C. NEALE, Auteur ; Kelly L. KLUMP, Auteur . - p.1030-1037.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1030-1037
Mots-clés : Child conduct problems GxE maternal directiveness or control maternal warmth Index. décimale : PER Périodiques Résumé : Background Prior studies exploring gene–environment interactions (GxE) in the development of youth conduct problems (CP) have focused almost exclusively on single-risk experiences, despite research indicating that the presence of other risk factors and or the absence of protective factors can accentuate the influence of a given risk factor on CP. The goal of the current study was to fill this gap in the literature, evaluating whether risky and protective aspects of parenting might combine to jointly moderate the etiology of CP. Methods The sample consisted of 500 child twin pairs from the Michigan State University Twin Registry (MSUTR). Child CP was assessed using multiple informant reports. Maternal warmth and directiveness were assessed via videotaped dyadic interactions between mothers and each of their twins. Results Biometric GxE analyses revealed that directiveness and warmth did appear to jointly moderate the etiology of CP. In particular, shared environmental influences were accentuated by colder, less directive or ‘less engaged’ mothering, whereas genetic influences were strongest when the child was experiencing warmer, more directive or ‘more authoritative’ mothering. Conclusions Such findings serve to highlight the synergistic effects of risky and protective experiences on child outcomes. They also provide additional empirical support for the bioecological form of GxE, which postulates that, in some cases, genetic influences may be most strongly expressed in the presence of low-risk environments. En ligne : http://dx.doi.org/10.1111/jcpp.12095 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 LPHN3 and attention-deficit/hyperactivity disorder: interaction with maternal stress during pregnancy / Zia CHOUDHRY in Journal of Child Psychology and Psychiatry, 53-8 (August 2012)
[article]
Titre : LPHN3 and attention-deficit/hyperactivity disorder: interaction with maternal stress during pregnancy Type de document : Texte imprimé et/ou numérique Auteurs : Zia CHOUDHRY, Auteur ; Sarojini M. SENGUPTA, Auteur ; Natalie GRIZENKO, Auteur ; Marie-Eve FORTIER, Auteur ; Geeta A. THAKUR, Auteur ; Johanne BELLINGHAM, Auteur ; Ridha JOOBER, Auteur Année de publication : 2012 Article en page(s) : p.892-902 Langues : Anglais (eng) Mots-clés : ADHD LPHN3 maternal stress environmental factors GXE genetic association Index. décimale : PER Périodiques Résumé : Background: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous behavioral disorder, complex both in etiology and clinical expression. Both genetic and environmental factors have been implicated, and it has been suggested that gene-environment interactions may play a pivotal role in the disorder. Recently, a significant association was reported between ADHD and LPHN3 (which codes for latrophilin 3), and replicated in independent samples. Methods: We have examined the association between tag single nucleotide polymorphisms (SNPs) in LPHN3 within the region previously implicated in ADHD. Family based association tests (FBAT) were conducted (n = 380 families) with the categorical diagnosis of ADHD, behavioral and cognitive phenotypes related to ADHD, and response to treatment (given a fixed dose of methylphenidate, 0.5 mg/day). Stratified FBAT analyses, based on maternal smoking and stress during pregnancy, was conducted. Results: Whereas limited association was observed in the total sample, highly significant interaction between four LPHN3 tag SNPs (rs6551665, rs1947274, rs6858066, rs2345039) and maternal stress during pregnancy was noted. Analysis conducted in the sub-group of mothers exposed to minimal stress during pregnancy showed significant associations with ADHD, behavioral and cognitive dimensions related to ADHD, as well as treatment response. Although extensive association was observed with the candidate SNPs, the findings are partially inconsistent with previously published results with the opposite alleles over-transmitted in these studies. Conclusions: These results provide evidence for the interaction between a genetic and environmental factor independently shown to be associated with ADHD. If confirmed in independent large studies, they may present a step forward in unraveling the complex etiology of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02551.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177
in Journal of Child Psychology and Psychiatry > 53-8 (August 2012) . - p.892-902[article] LPHN3 and attention-deficit/hyperactivity disorder: interaction with maternal stress during pregnancy [Texte imprimé et/ou numérique] / Zia CHOUDHRY, Auteur ; Sarojini M. SENGUPTA, Auteur ; Natalie GRIZENKO, Auteur ; Marie-Eve FORTIER, Auteur ; Geeta A. THAKUR, Auteur ; Johanne BELLINGHAM, Auteur ; Ridha JOOBER, Auteur . - 2012 . - p.892-902.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-8 (August 2012) . - p.892-902
Mots-clés : ADHD LPHN3 maternal stress environmental factors GXE genetic association Index. décimale : PER Périodiques Résumé : Background: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous behavioral disorder, complex both in etiology and clinical expression. Both genetic and environmental factors have been implicated, and it has been suggested that gene-environment interactions may play a pivotal role in the disorder. Recently, a significant association was reported between ADHD and LPHN3 (which codes for latrophilin 3), and replicated in independent samples. Methods: We have examined the association between tag single nucleotide polymorphisms (SNPs) in LPHN3 within the region previously implicated in ADHD. Family based association tests (FBAT) were conducted (n = 380 families) with the categorical diagnosis of ADHD, behavioral and cognitive phenotypes related to ADHD, and response to treatment (given a fixed dose of methylphenidate, 0.5 mg/day). Stratified FBAT analyses, based on maternal smoking and stress during pregnancy, was conducted. Results: Whereas limited association was observed in the total sample, highly significant interaction between four LPHN3 tag SNPs (rs6551665, rs1947274, rs6858066, rs2345039) and maternal stress during pregnancy was noted. Analysis conducted in the sub-group of mothers exposed to minimal stress during pregnancy showed significant associations with ADHD, behavioral and cognitive dimensions related to ADHD, as well as treatment response. Although extensive association was observed with the candidate SNPs, the findings are partially inconsistent with previously published results with the opposite alleles over-transmitted in these studies. Conclusions: These results provide evidence for the interaction between a genetic and environmental factor independently shown to be associated with ADHD. If confirmed in independent large studies, they may present a step forward in unraveling the complex etiology of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02551.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177 The influence of harshness and unpredictability on female sexual development: Addressing gene?environment interplay using a polygenic score / Gabriel L. SCHLOMER in Development and Psychopathology, 34-2 (May 2022)
[article]
Titre : The influence of harshness and unpredictability on female sexual development: Addressing gene?environment interplay using a polygenic score Type de document : Texte imprimé et/ou numérique Auteurs : Gabriel L. SCHLOMER, Auteur ; Qi SUN, Auteur Article en page(s) : 731-741 Langues : Anglais (eng) Mots-clés : ALSPAC GxE life history theory menarche PGS sexual behavior Index. décimale : PER Périodiques Résumé : Recent developments in the application life history theory to human development indicate two fundamental dimension of the early environment ? harshness and unpredictability ? are key regulators life history strategies. Few studies have examined the manner with which these dimensions influence development, though age at menarche (AAM) and age at first sexual intercourse have been proposed as possible mechanisms among women. Data from the Avon Longitudinal Study of Parents and Children (N = 3,645) were used to examine direct and indirect effects of harshness (financial difficulties) and unpredictability (paternal transitions) on lifetime and past year sexual partners during adolescence and young adulthood. Genetic confounding was addressed using an AAM polygenic score (PGS) and potential gene-by-environment interactions were also evaluated using the PGS. Path model results showed only harshness was directly related to AAM. Harshness, unpredictability, and AAM were indirectly related to lifetime and past year sexual partner number via age at first sexual intercourse. The PGS did not account for any of the associations and no significant interactions were detected. Implications of these results for developmental models derived from life history theory are discussed as well as the role of PGSs in gene?environment interplay research. En ligne : http://dx.doi.org/10.1017/s0954579421001589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474
in Development and Psychopathology > 34-2 (May 2022) . - 731-741[article] The influence of harshness and unpredictability on female sexual development: Addressing gene?environment interplay using a polygenic score [Texte imprimé et/ou numérique] / Gabriel L. SCHLOMER, Auteur ; Qi SUN, Auteur . - 731-741.
Langues : Anglais (eng)
in Development and Psychopathology > 34-2 (May 2022) . - 731-741
Mots-clés : ALSPAC GxE life history theory menarche PGS sexual behavior Index. décimale : PER Périodiques Résumé : Recent developments in the application life history theory to human development indicate two fundamental dimension of the early environment ? harshness and unpredictability ? are key regulators life history strategies. Few studies have examined the manner with which these dimensions influence development, though age at menarche (AAM) and age at first sexual intercourse have been proposed as possible mechanisms among women. Data from the Avon Longitudinal Study of Parents and Children (N = 3,645) were used to examine direct and indirect effects of harshness (financial difficulties) and unpredictability (paternal transitions) on lifetime and past year sexual partners during adolescence and young adulthood. Genetic confounding was addressed using an AAM polygenic score (PGS) and potential gene-by-environment interactions were also evaluated using the PGS. Path model results showed only harshness was directly related to AAM. Harshness, unpredictability, and AAM were indirectly related to lifetime and past year sexual partner number via age at first sexual intercourse. The PGS did not account for any of the associations and no significant interactions were detected. Implications of these results for developmental models derived from life history theory are discussed as well as the role of PGSs in gene?environment interplay research. En ligne : http://dx.doi.org/10.1017/s0954579421001589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474