1 recherche sur le mot-clé 'Bipolar-disorder children face-perception neural-connectivity amygdala'

Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit / Brendan A. RICH in Journal of Child Psychology and Psychiatry, 49-1 (January 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-1 (January 2008) . - p.88–96 Titre : Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit Type de document : texte imprimé Auteurs : Brendan A. RICH, Auteur ; Daniel S. PINE, Auteur ; Melissa A. BROTMAN, Auteur ; Ellen LEIBENLUFT, Auteur ; Stephen J. FROMM, Auteur ; Lisa H. BERGHORST, Auteur ; Daniel P. DICKSTEIN, Auteur Année de publication : 2007 Article en page(s) : p.88–96 Langues : Anglais (eng) Mots-clés : Bipolar-disorder children face-perception neural-connectivity amygdala Index. décimale : PER Périodiques Résumé : Background: Pediatric bipolar disorder (BD), a highly debilitating illness, is characterized by amygdala abnormalities, i.e., volume reduction and hyperactivation during face processing. Evidence of perturbed amygdala functional connectivity with other brain regions would implicate a distributed neural circuit in the pathophysiology of BD, and would further elucidate the neural mechanisms associated with BD face emotion misinterpretation. Methods: Thirty-three BD and 24 healthy age, gender, and IQ-matched subjects completed a functional magnetic resonance imaging (fMRI) task of face emotion identification in which attention was directed to emotional (hostility, fearfulness) and nonemotional (nose width) aspects of faces. Voxel-wise analyses examined whole brain functional connectivity with the left amygdala. Results: Compared to healthy subjects, BD subjects had significantly reduced connectivity between the left amygdala and two regions: right posterior cingulate/precuneus and right fusiform gyrus/parahippocampal gyrus. Deficits were evident regardless of mood state and comorbid diagnoses. Conclusions: BD youth exhibit deficient connectivity between the amygdala and temporal association cortical regions previously implicated in processing facial expressions and social stimuli. In conjunction with previously documented volumetric and functional perturbations in these brain regions, dysfunction in this distributed neural circuit may begin to clarify the pathophysiology of the face emotion misperceptions and social deficits seen in BD youth. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01819.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311 [article] Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit [texte imprimé] / Brendan A. RICH, Auteur ; Daniel S. PINE, Auteur ; Melissa A. BROTMAN, Auteur ; Ellen LEIBENLUFT, Auteur ; Stephen J. FROMM, Auteur ; Lisa H. BERGHORST, Auteur ; Daniel P. DICKSTEIN, Auteur . - 2007 . - p.88–96. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-1 (January 2008) . - p.88–96 Mots-clés : Bipolar-disorder children face-perception neural-connectivity amygdala Index. décimale : PER Périodiques Résumé : Background: Pediatric bipolar disorder (BD), a highly debilitating illness, is characterized by amygdala abnormalities, i.e., volume reduction and hyperactivation during face processing. Evidence of perturbed amygdala functional connectivity with other brain regions would implicate a distributed neural circuit in the pathophysiology of BD, and would further elucidate the neural mechanisms associated with BD face emotion misinterpretation. Methods: Thirty-three BD and 24 healthy age, gender, and IQ-matched subjects completed a functional magnetic resonance imaging (fMRI) task of face emotion identification in which attention was directed to emotional (hostility, fearfulness) and nonemotional (nose width) aspects of faces. Voxel-wise analyses examined whole brain functional connectivity with the left amygdala. Results: Compared to healthy subjects, BD subjects had significantly reduced connectivity between the left amygdala and two regions: right posterior cingulate/precuneus and right fusiform gyrus/parahippocampal gyrus. Deficits were evident regardless of mood state and comorbid diagnoses. Conclusions: BD youth exhibit deficient connectivity between the amygdala and temporal association cortical regions previously implicated in processing facial expressions and social stimuli. In conjunction with previously documented volumetric and functional perturbations in these brain regions, dysfunction in this distributed neural circuit may begin to clarify the pathophysiology of the face emotion misperceptions and social deficits seen in BD youth. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01819.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311