4 recherche sur le mot-clé 'Excitation/inhibition balance'

Exploring the mechanisms underlying excitation/inhibition imbalance in human iPSC-derived models of ASD / Lorenza CULOTTA in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 32 p. Titre : Exploring the mechanisms underlying excitation/inhibition imbalance in human iPSC-derived models of ASD Type de document : texte imprimé Auteurs : Lorenza CULOTTA, Auteur ; Peter PENZES, Auteur Article en page(s) : 32 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Excitation/inhibition balance  Induced pluripotent stem cell Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a range of neurodevelopmental disorders characterized by impaired social interaction and communication, and repetitive or restricted behaviors. ASD subjects exhibit complex genetic and clinical heterogeneity, thus hindering the discovery of pathophysiological mechanisms. Considering that several ASD-risk genes encode proteins involved in the regulation of synaptic plasticity, neuronal excitability, and neuronal connectivity, one hypothesis that has emerged is that ASD arises from a disruption of the neuronal network activity due to perturbation of the synaptic excitation and inhibition (E/I) balance. The development of induced pluripotent stem cell (iPSC) technology and recent advances in neuronal differentiation techniques provide a unique opportunity to model complex neuronal connectivity and to test the E/I hypothesis of ASD in human-based models. Here, we aim to review the latest advances in studying the different cellular and molecular mechanisms contributing to E/I balance using iPSC-based in vitro models of ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00339-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Exploring the mechanisms underlying excitation/inhibition imbalance in human iPSC-derived models of ASD [texte imprimé] / Lorenza CULOTTA, Auteur ; Peter PENZES, Auteur . - 32 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 32 p. Mots-clés : Autism spectrum disorder  Excitation/inhibition balance  Induced pluripotent stem cell Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a range of neurodevelopmental disorders characterized by impaired social interaction and communication, and repetitive or restricted behaviors. ASD subjects exhibit complex genetic and clinical heterogeneity, thus hindering the discovery of pathophysiological mechanisms. Considering that several ASD-risk genes encode proteins involved in the regulation of synaptic plasticity, neuronal excitability, and neuronal connectivity, one hypothesis that has emerged is that ASD arises from a disruption of the neuronal network activity due to perturbation of the synaptic excitation and inhibition (E/I) balance. The development of induced pluripotent stem cell (iPSC) technology and recent advances in neuronal differentiation techniques provide a unique opportunity to model complex neuronal connectivity and to test the E/I hypothesis of ASD in human-based models. Here, we aim to review the latest advances in studying the different cellular and molecular mechanisms contributing to E/I balance using iPSC-based in vitro models of ASD. En ligne : http://dx.doi.org/10.1186/s13229-020-00339-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Task-Related Aperiodic EEG (1/f) Activity in Autism / Magdalena MATYJEK in Autism Research, 19-8 (August 2026)  

Public ISBD [article]  inAutism Research > 19-8 (August 2026) . - p.e70314 Titre : Task-Related Aperiodic EEG (1/f) Activity in Autism Type de document : texte imprimé Auteurs : Magdalena MATYJEK, Auteur ; Salvador Soto FARACO, Auteur ; Claudia Alvarez MARTIN, Auteur ; Mireia Torralba CUELLO, Auteur Article en page(s) : p.e70314 Langues : Anglais (eng) Mots-clés : 1/f slope  aperiodic activity  autism  E/I  EEG  excitation/inhibition balance Index. décimale : PER Périodiques Résumé : ABSTRACT Autism has been hypothesized to involve atypicalities in the balance between neural excitation and inhibition (E/I). Aperiodic EEG activity, characterized by the 1/f exponent of the power spectrum, provides a proxy of cortical E/I dynamics. However, prior studies in autism report mixed findings regarding the slope of aperiodic activity. One potentially important modulator of EEG slope is task engagement. Here, we examined variations in aperiodic slopes in autistic (n?=?35) and neurotypical (n?=?39) adults during passive viewing and an active, goal-directed task. The data revealed that autistic participants exhibited steeper slopes (indicative of increased inhibition vs. excitation) during the active task relative to passive viewing, whereas neurotypical participants showed no significant task-related changes. These findings suggest that aperiodic activity reflects dynamic, task-dependent neural adaptation rather than baseline group differences. Task engagement may reveal compensatory inhibitory processes in autistic adults, underscoring the importance of considering task demands and individual variability when investigating E/I balance in autism. En ligne : https://doi.org/10.1002/aur.70314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Task-Related Aperiodic EEG (1/f) Activity in Autism [texte imprimé] / Magdalena MATYJEK, Auteur ; Salvador Soto FARACO, Auteur ; Claudia Alvarez MARTIN, Auteur ; Mireia Torralba CUELLO, Auteur . - p.e70314. Langues : Anglais (eng) in Autism Research > 19-8 (August 2026) . - p.e70314 Mots-clés : 1/f slope  aperiodic activity  autism  E/I  EEG  excitation/inhibition balance Index. décimale : PER Périodiques Résumé : ABSTRACT Autism has been hypothesized to involve atypicalities in the balance between neural excitation and inhibition (E/I). Aperiodic EEG activity, characterized by the 1/f exponent of the power spectrum, provides a proxy of cortical E/I dynamics. However, prior studies in autism report mixed findings regarding the slope of aperiodic activity. One potentially important modulator of EEG slope is task engagement. Here, we examined variations in aperiodic slopes in autistic (n?=?35) and neurotypical (n?=?39) adults during passive viewing and an active, goal-directed task. The data revealed that autistic participants exhibited steeper slopes (indicative of increased inhibition vs. excitation) during the active task relative to passive viewing, whereas neurotypical participants showed no significant task-related changes. These findings suggest that aperiodic activity reflects dynamic, task-dependent neural adaptation rather than baseline group differences. Task engagement may reveal compensatory inhibitory processes in autistic adults, underscoring the importance of considering task demands and individual variability when investigating E/I balance in autism. En ligne : https://doi.org/10.1002/aur.70314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives / Vardan ARUTIUNIAN in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 19p. Titre : The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives Type de document : texte imprimé Auteurs : Vardan ARUTIUNIAN, Auteur ; Megha SANTHOSH, Auteur ; Emily NEUHAUS, Auteur ; Heather BORLAND, Auteur ; Chris TOMPKINS, Auteur ; Raphael A. BERNIER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Abha R. GUPTA, Auteur ; Allison JACK, Auteur ; Shafali S. JESTE, Auteur ; James C. MCPARTLAND, Auteur ; Adam J. NAPLES, Auteur ; John D. VAN HORN, Auteur ; Kevin A. PELPHREY, Auteur ; Sara Jane WEBB, Auteur Article en page(s) : 19p. Langues : Anglais (eng) Mots-clés : Humans  Autism Spectrum Disorder/physiopathology/psychology  Male  Female  Adolescent  Gamma Rhythm  Child  Electroencephalography  Language  Family  Siblings  Autism Spectrum Disorder (ASD)  Excitation/inhibition balance  Gamma power  Language skills  Unaffected siblings  Health, and BlackThorn Therapeutics, has received research funding from Janssen  Research and Development, serves on the Scientific Advisory Boards of Pastorus  and Modern Clinics, and receives royalties from Guilford Press, Lambert, Oxford,  and Springer. The remaining authors have no conflict of interest to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Most children with Autism Spectrum Disorder (ASD) have co-occurring language impairments and some of these autism-specific language difficulties are also present in their non-autistic first-degree relatives. One of the possible neural mechanisms associated with variability in language functioning is alterations in cortical gamma-band oscillations, hypothesized to be related to neural excitation and inhibition balance. METHODS: We used a high-density 128-channel electroencephalography (EEG) to register brain response to speech stimuli in a large sex-balanced sample of participants: 125 youth with ASD, 121 typically developing (TD) youth, and 40 unaffected siblings (US) of youth with ASD. Language skills were assessed with Clinical Evaluation of Language Fundamentals. RESULTS: First, during speech processing, we identified significantly elevated gamma power in ASD participants compared to TD controls. Second, across all youth, higher gamma power was associated with lower language skills. Finally, the US group demonstrated an intermediate profile in both language and gamma power, with nonverbal IQ mediating the relationship between gamma power and language skills. LIMITATIONS: We only focused on one of the possible neural contributors to variability in language functioning. Also, the US group consisted of a smaller number of participants in comparison to the ASD or TD groups. Finally, due to the timing issue in EEG system we have provided only non-phase-locked analysis. CONCLUSIONS: Autistic youth showed elevated gamma power, suggesting higher excitation in the brain in response to speech stimuli and elevated gamma power was related to lower language skills. The US group showed an intermediate pattern of gamma activity, suggesting that the broader autism phenotype extends to neural profiles. En ligne : https://dx.doi.org/10.1186/s13229-024-00598-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives [texte imprimé] / Vardan ARUTIUNIAN, Auteur ; Megha SANTHOSH, Auteur ; Emily NEUHAUS, Auteur ; Heather BORLAND, Auteur ; Chris TOMPKINS, Auteur ; Raphael A. BERNIER, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Abha R. GUPTA, Auteur ; Allison JACK, Auteur ; Shafali S. JESTE, Auteur ; James C. MCPARTLAND, Auteur ; Adam J. NAPLES, Auteur ; John D. VAN HORN, Auteur ; Kevin A. PELPHREY, Auteur ; Sara Jane WEBB, Auteur . - 19p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 19p. Mots-clés : Humans  Autism Spectrum Disorder/physiopathology/psychology  Male  Female  Adolescent  Gamma Rhythm  Child  Electroencephalography  Language  Family  Siblings  Autism Spectrum Disorder (ASD)  Excitation/inhibition balance  Gamma power  Language skills  Unaffected siblings  Health, and BlackThorn Therapeutics, has received research funding from Janssen  Research and Development, serves on the Scientific Advisory Boards of Pastorus  and Modern Clinics, and receives royalties from Guilford Press, Lambert, Oxford,  and Springer. The remaining authors have no conflict of interest to declare. Index. décimale : PER Périodiques Résumé : BACKGROUND: Most children with Autism Spectrum Disorder (ASD) have co-occurring language impairments and some of these autism-specific language difficulties are also present in their non-autistic first-degree relatives. One of the possible neural mechanisms associated with variability in language functioning is alterations in cortical gamma-band oscillations, hypothesized to be related to neural excitation and inhibition balance. METHODS: We used a high-density 128-channel electroencephalography (EEG) to register brain response to speech stimuli in a large sex-balanced sample of participants: 125 youth with ASD, 121 typically developing (TD) youth, and 40 unaffected siblings (US) of youth with ASD. Language skills were assessed with Clinical Evaluation of Language Fundamentals. RESULTS: First, during speech processing, we identified significantly elevated gamma power in ASD participants compared to TD controls. Second, across all youth, higher gamma power was associated with lower language skills. Finally, the US group demonstrated an intermediate profile in both language and gamma power, with nonverbal IQ mediating the relationship between gamma power and language skills. LIMITATIONS: We only focused on one of the possible neural contributors to variability in language functioning. Also, the US group consisted of a smaller number of participants in comparison to the ASD or TD groups. Finally, due to the timing issue in EEG system we have provided only non-phase-locked analysis. CONCLUSIONS: Autistic youth showed elevated gamma power, suggesting higher excitation in the brain in response to speech stimuli and elevated gamma power was related to lower language skills. The US group showed an intermediate pattern of gamma activity, suggesting that the broader autism phenotype extends to neural profiles. En ligne : https://dx.doi.org/10.1186/s13229-024-00598-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

17-beta estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms / Federica FILICE in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 15p. Titre : 17-beta estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms Type de document : texte imprimé Auteurs : Federica FILICE, Auteur ; Emanuel LAUBER, Auteur ; K.J. VORCKEL, Auteur ; M. WOHR, Auteur ; Beat SCHWALLER, Auteur Article en page(s) : 15p. Langues : Anglais (eng) Mots-clés : 17-beta estradiol  Asd  Estradiol treatment  Excitation/inhibition balance  Parvalbumin  Social behavior  Ultrasonic vocalizations Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by two core symptoms: impaired social interaction and communication, and restricted, repetitive behaviors and interests. The pathophysiology of ASD is not yet fully understood, due to a plethora of genetic and environmental risk factors that might be associated with or causal for ASD. Recent findings suggest that one putative convergent pathway for some forms of ASD might be the downregulation of the calcium-binding protein parvalbumin (PV). PV-deficient mice (PV-/-, PV+/-), as well as Shank1-/-, Shank3-/-, and VPA mice, which show behavioral deficits relevant to all human ASD core symptoms, are all characterized by lower PV expression levels. Methods: Based on the hypothesis that PV expression might be increased by 17-beta estradiol (E2), PV+/- mice were treated with E2 from postnatal days 5-15 and ASD-related behavior was tested between postnatal days 25 and 31. Results: PV expression levels were significantly increased after E2 treatment and, concomitantly, sociability deficits in PV+/- mice in the direct reciprocal social interaction and the 3-chamber social approach assay, as well as repetitive behaviors, were attenuated. E2 treatment of PV+/+ mice did not increase PV levels and had detrimental effects on sociability and repetitive behavior. In PV-/- mice, E2 obviously did not affect PV levels; tested behaviors were not different from the ones in vehicle-treated PV-/- mice. Conclusion: Our results suggest that the E2-linked amelioration of ASD-like behaviors is specifically occurring in PV+/- mice, indicating that PV upregulation is required for the E2-mediated rescue of ASD-relevant behavioral impairments. En ligne : http://dx.doi.org/10.1186/s13229-018-0199-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] 17-beta estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms [texte imprimé] / Federica FILICE, Auteur ; Emanuel LAUBER, Auteur ; K.J. VORCKEL, Auteur ; M. WOHR, Auteur ; Beat SCHWALLER, Auteur . - 15p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 15p. Mots-clés : 17-beta estradiol  Asd  Estradiol treatment  Excitation/inhibition balance  Parvalbumin  Social behavior  Ultrasonic vocalizations Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by two core symptoms: impaired social interaction and communication, and restricted, repetitive behaviors and interests. The pathophysiology of ASD is not yet fully understood, due to a plethora of genetic and environmental risk factors that might be associated with or causal for ASD. Recent findings suggest that one putative convergent pathway for some forms of ASD might be the downregulation of the calcium-binding protein parvalbumin (PV). PV-deficient mice (PV-/-, PV+/-), as well as Shank1-/-, Shank3-/-, and VPA mice, which show behavioral deficits relevant to all human ASD core symptoms, are all characterized by lower PV expression levels. Methods: Based on the hypothesis that PV expression might be increased by 17-beta estradiol (E2), PV+/- mice were treated with E2 from postnatal days 5-15 and ASD-related behavior was tested between postnatal days 25 and 31. Results: PV expression levels were significantly increased after E2 treatment and, concomitantly, sociability deficits in PV+/- mice in the direct reciprocal social interaction and the 3-chamber social approach assay, as well as repetitive behaviors, were attenuated. E2 treatment of PV+/+ mice did not increase PV levels and had detrimental effects on sociability and repetitive behavior. In PV-/- mice, E2 obviously did not affect PV levels; tested behaviors were not different from the ones in vehicle-treated PV-/- mice. Conclusion: Our results suggest that the E2-linked amelioration of ASD-like behaviors is specifically occurring in PV+/- mice, indicating that PV upregulation is required for the E2-mediated rescue of ASD-relevant behavioral impairments. En ligne : http://dx.doi.org/10.1186/s13229-018-0199-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354