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Integrative analysis of genomic and exposomic influences on youth mental health / Karmel W. CHOI in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)
[article]
Titre : Integrative analysis of genomic and exposomic influences on youth mental health Type de document : Texte imprimé et/ou numérique Auteurs : Karmel W. CHOI, Auteur ; Marina WILSON, Auteur ; Tian GE, Auteur ; Aaron KANDOLA, Auteur ; Chirag J. PATEL, Auteur ; S. Hong LEE, Auteur ; Jordan W. SMOLLER, Auteur Année de publication : 2022 Article en page(s) : p.1196-1205 Langues : Anglais (eng) Mots-clés : Adolescent Genomics Humans Mental Health Psychopathology Schools Exposome G×e depression gene-environment interaction genetics heritability youth mental health Index. décimale : PER Périodiques Résumé : BACKGROUND: Understanding complex influences on mental health problems in young people is needed to inform early prevention strategies. Both genetic and environmental factors are known to influence youth mental health, but a more comprehensive picture of their interplay, including wide-ranging environmental exposures - that is, the exposome - is needed. We perform an integrative analysis of genomic and exposomic data in relation to internalizing and externalizing symptoms in a cohort of 4,314 unrelated youth from the Adolescent Brain and Cognitive Development (ABCD) Study. METHODS: Using novel GREML-based approaches, we model the variance in internalizing and externalizing symptoms explained by additive and interactive influences from the genome (G) and modeled exposome (E) consisting of up to 133 variables at the family, peer, school, neighborhood, life event, and broader environmental levels, including genome-by-exposome (G×E) and exposome-by-exposome (E×E) effects. RESULTS: A best-fitting integrative model with G, E, and G×E components explained 35% and 63% of variance in youth internalizing and externalizing symptoms, respectively. Youth in the top quintile of model-predicted risk accounted for the majority of individuals with clinically elevated symptoms at follow-up (60% for internalizing; 72% for externalizing). Of note, different domains of environmental exposures were most impactful for internalizing (life events) and externalizing (contextual including family, school, and peer-level factors) symptoms. In addition, variance explained by G×E contributions was substantially larger for externalizing (33%) than internalizing (13%) symptoms. CONCLUSIONS: Advanced statistical genetic methods in a longitudinal cohort of youth can be leveraged to address fundamental questions about the role of 'nature and nurture' in developmental psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13664 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486
in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1196-1205[article] Integrative analysis of genomic and exposomic influences on youth mental health [Texte imprimé et/ou numérique] / Karmel W. CHOI, Auteur ; Marina WILSON, Auteur ; Tian GE, Auteur ; Aaron KANDOLA, Auteur ; Chirag J. PATEL, Auteur ; S. Hong LEE, Auteur ; Jordan W. SMOLLER, Auteur . - 2022 . - p.1196-1205.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1196-1205
Mots-clés : Adolescent Genomics Humans Mental Health Psychopathology Schools Exposome G×e depression gene-environment interaction genetics heritability youth mental health Index. décimale : PER Périodiques Résumé : BACKGROUND: Understanding complex influences on mental health problems in young people is needed to inform early prevention strategies. Both genetic and environmental factors are known to influence youth mental health, but a more comprehensive picture of their interplay, including wide-ranging environmental exposures - that is, the exposome - is needed. We perform an integrative analysis of genomic and exposomic data in relation to internalizing and externalizing symptoms in a cohort of 4,314 unrelated youth from the Adolescent Brain and Cognitive Development (ABCD) Study. METHODS: Using novel GREML-based approaches, we model the variance in internalizing and externalizing symptoms explained by additive and interactive influences from the genome (G) and modeled exposome (E) consisting of up to 133 variables at the family, peer, school, neighborhood, life event, and broader environmental levels, including genome-by-exposome (G×E) and exposome-by-exposome (E×E) effects. RESULTS: A best-fitting integrative model with G, E, and G×E components explained 35% and 63% of variance in youth internalizing and externalizing symptoms, respectively. Youth in the top quintile of model-predicted risk accounted for the majority of individuals with clinically elevated symptoms at follow-up (60% for internalizing; 72% for externalizing). Of note, different domains of environmental exposures were most impactful for internalizing (life events) and externalizing (contextual including family, school, and peer-level factors) symptoms. In addition, variance explained by G×E contributions was substantially larger for externalizing (33%) than internalizing (13%) symptoms. CONCLUSIONS: Advanced statistical genetic methods in a longitudinal cohort of youth can be leveraged to address fundamental questions about the role of 'nature and nurture' in developmental psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13664 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486