Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
2 recherche sur le mot-clé 'Genetic overlap'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development / E. STERGIAKOULI in Molecular Autism, 8 (2017)
[article]
Titre : Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development Type de document : Texte imprimé et/ou numérique Auteurs : E. STERGIAKOULI, Auteur ; George DAVEY SMITH, Auteur ; J. MARTIN, Auteur ; D. H. SKUSE, Auteur ; W. VIECHTBAUER, Auteur ; S. M. RING, Auteur ; A. RONALD, Auteur ; D. E. EVANS, Auteur ; S. E. FISHER, Auteur ; A. THAPAR, Auteur ; B. ST POURCAIN, Auteur Article en page(s) : 18p. Langues : Anglais (eng) Mots-clés : ADHD symptoms Alspac Clinical ADHD Genetic overlap Social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however, subject to dynamic changes during development. We investigated the continuity of genetic overlap between ASD and ADHD symptoms in a general population sample during childhood and adolescence. We also studied uni- and cross-dimensional trait-disorder links with respect to genetic ADHD and ASD risk. METHODS: Social-communication difficulties (N = 5551, Social and Communication Disorders Checklist, SCDC) and combined hyperactive-impulsive/inattentive ADHD symptoms (N = 5678, Strengths and Difficulties Questionnaire, SDQ-ADHD) were repeatedly measured in a UK birth cohort (ALSPAC, age 7 to 17 years). Genome-wide summary statistics on clinical ASD (5305 cases; 5305 pseudo-controls) and ADHD (4163 cases; 12,040 controls/pseudo-controls) were available from the Psychiatric Genomics Consortium. Genetic trait variances and genetic overlap between phenotypes were estimated using genome-wide data. RESULTS: In the general population, genetic influences for SCDC and SDQ-ADHD scores were shared throughout development. Genetic correlations across traits reached a similar strength and magnitude (cross-trait rg = 1, pmin = 3 x 10(-4)) as those between repeated measures of the same trait (within-trait rg = 0.94, pmin = 7 x 10(-4)). Shared genetic influences between traits, especially during later adolescence, may implicate variants in K-RAS signalling upregulated genes (p-meta = 6.4 x 10(-4)). Uni-dimensionally, each population-based trait mapped to the expected behavioural continuum: risk-increasing alleles for clinical ADHD were persistently associated with SDQ-ADHD scores throughout development (marginal regression R(2) = 0.084%). An age-specific genetic overlap between clinical ASD and social-communication difficulties during childhood was also shown, as per previous reports. Cross-dimensionally, however, neither SCDC nor SDQ-ADHD scores were linked to genetic risk for disorder. CONCLUSIONS: In the general population, genetic aetiologies between social-communication difficulties and ADHD symptoms are shared throughout child and adolescent development and may implicate similar biological pathways that co-vary during development. Within both the ASD and the ADHD dimension, population-based traits are also linked to clinical disorder, although much larger clinical discovery samples are required to reliably detect cross-dimensional trait-disorder relationships. En ligne : http://dx.doi.org/10.1186/s13229-017-0131-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331
in Molecular Autism > 8 (2017) . - 18p.[article] Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development [Texte imprimé et/ou numérique] / E. STERGIAKOULI, Auteur ; George DAVEY SMITH, Auteur ; J. MARTIN, Auteur ; D. H. SKUSE, Auteur ; W. VIECHTBAUER, Auteur ; S. M. RING, Auteur ; A. RONALD, Auteur ; D. E. EVANS, Auteur ; S. E. FISHER, Auteur ; A. THAPAR, Auteur ; B. ST POURCAIN, Auteur . - 18p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 18p.
Mots-clés : ADHD symptoms Alspac Clinical ADHD Genetic overlap Social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however, subject to dynamic changes during development. We investigated the continuity of genetic overlap between ASD and ADHD symptoms in a general population sample during childhood and adolescence. We also studied uni- and cross-dimensional trait-disorder links with respect to genetic ADHD and ASD risk. METHODS: Social-communication difficulties (N = 5551, Social and Communication Disorders Checklist, SCDC) and combined hyperactive-impulsive/inattentive ADHD symptoms (N = 5678, Strengths and Difficulties Questionnaire, SDQ-ADHD) were repeatedly measured in a UK birth cohort (ALSPAC, age 7 to 17 years). Genome-wide summary statistics on clinical ASD (5305 cases; 5305 pseudo-controls) and ADHD (4163 cases; 12,040 controls/pseudo-controls) were available from the Psychiatric Genomics Consortium. Genetic trait variances and genetic overlap between phenotypes were estimated using genome-wide data. RESULTS: In the general population, genetic influences for SCDC and SDQ-ADHD scores were shared throughout development. Genetic correlations across traits reached a similar strength and magnitude (cross-trait rg = 1, pmin = 3 x 10(-4)) as those between repeated measures of the same trait (within-trait rg = 0.94, pmin = 7 x 10(-4)). Shared genetic influences between traits, especially during later adolescence, may implicate variants in K-RAS signalling upregulated genes (p-meta = 6.4 x 10(-4)). Uni-dimensionally, each population-based trait mapped to the expected behavioural continuum: risk-increasing alleles for clinical ADHD were persistently associated with SDQ-ADHD scores throughout development (marginal regression R(2) = 0.084%). An age-specific genetic overlap between clinical ASD and social-communication difficulties during childhood was also shown, as per previous reports. Cross-dimensionally, however, neither SCDC nor SDQ-ADHD scores were linked to genetic risk for disorder. CONCLUSIONS: In the general population, genetic aetiologies between social-communication difficulties and ADHD symptoms are shared throughout child and adolescent development and may implicate similar biological pathways that co-vary during development. Within both the ASD and the ADHD dimension, population-based traits are also linked to clinical disorder, although much larger clinical discovery samples are required to reliably detect cross-dimensional trait-disorder relationships. En ligne : http://dx.doi.org/10.1186/s13229-017-0131-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 Changing Concepts and Findings on Autism / Michael RUTTER in Journal of Autism and Developmental Disorders, 43-8 (August 2013)
[article]
Titre : Changing Concepts and Findings on Autism Type de document : Texte imprimé et/ou numérique Auteurs : Michael RUTTER, Auteur Article en page(s) : p.1749-1757 Langues : Anglais (eng) Mots-clés : Phenotypic overlap among disorders Genetic overlap Fractionable autism triad Broader autism phenotype Rett syndrome Epilepsy Index. décimale : PER Périodiques Résumé : New research findings provide major challenges regarding our understanding of the concept of autism. These are critically discussed in relation to research relevant to classification, genetics, environmental risk factors, gene-environment interplay, animal models, biomarkers, clinical features, neuropathology, pharmacotherapy, behavioral treatments, and functioning in adult life. It is concluded that, although there have been major research advances; there is a need for a reconceptualization and an avoidance of claims that go beyond the evidence. En ligne : http://dx.doi.org/10.1007/s10803-012-1713-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205
in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1749-1757[article] Changing Concepts and Findings on Autism [Texte imprimé et/ou numérique] / Michael RUTTER, Auteur . - p.1749-1757.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1749-1757
Mots-clés : Phenotypic overlap among disorders Genetic overlap Fractionable autism triad Broader autism phenotype Rett syndrome Epilepsy Index. décimale : PER Périodiques Résumé : New research findings provide major challenges regarding our understanding of the concept of autism. These are critically discussed in relation to research relevant to classification, genetics, environmental risk factors, gene-environment interplay, animal models, biomarkers, clinical features, neuropathology, pharmacotherapy, behavioral treatments, and functioning in adult life. It is concluded that, although there have been major research advances; there is a need for a reconceptualization and an avoidance of claims that go beyond the evidence. En ligne : http://dx.doi.org/10.1007/s10803-012-1713-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205