Autism Spectrum Disorder and Mental Health Problems: Patterns of Difficulties and Longitudinal Trajectories in a Population-Based Twin Sample / E. COLVERT in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1077-1091 Titre : Autism Spectrum Disorder and Mental Health Problems: Patterns of Difficulties and Longitudinal Trajectories in a Population-Based Twin Sample Type de document : Texte imprimé et/ou numérique Auteurs : E. COLVERT, Auteur ; E. SIMONOFF, Auteur ; Simone J CAPP, Auteur ; A. RONALD, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.1077-1091 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/complications/diagnosis/epidemiology  Child  Child, Preschool  Diseases in Twins/diagnosis/epidemiology  Humans  Mental Health  Phenotype  Twins  Adolescents  Autism spectrum disorders  Longitudinal research Index. décimale : PER Périodiques Résumé : There is increasing concern regarding additional psychiatric problems that co-occur with Autism Spectrum Disorder (ASD), as reflected in recent changes to diagnostic schemes. However, there remains little research with population-based samples across childhood. We report on additional problems, as measured by the Strengths and Difficulties Questionnaire, in a population-based sample of 135 twins with ASD, 55 non-ASD co-twins, and 144 comparison twins low in ASD traits. Frequencies, associated demographic factors, and changes in mental health difficulties from age 4 to 13 years are presented. Our data confirm the high rates of additional difficulties reported in previous studies, and suggest that the profile, associated risk factors and longitudinal course of additional difficulties in ASD may differ from those in typically-developing populations. En ligne : http://dx.doi.org/10.1007/s10803-021-05006-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Autism Spectrum Disorder and Mental Health Problems: Patterns of Difficulties and Longitudinal Trajectories in a Population-Based Twin Sample [Texte imprimé et/ou numérique] / E. COLVERT, Auteur ; E. SIMONOFF, Auteur ; Simone J CAPP, Auteur ; A. RONALD, Auteur ; Patrick BOLTON, Auteur ; Francesca HAPPE, Auteur . - p.1077-1091. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1077-1091 Mots-clés : Adolescent  Autism Spectrum Disorder/complications/diagnosis/epidemiology  Child  Child, Preschool  Diseases in Twins/diagnosis/epidemiology  Humans  Mental Health  Phenotype  Twins  Adolescents  Autism spectrum disorders  Longitudinal research Index. décimale : PER Périodiques Résumé : There is increasing concern regarding additional psychiatric problems that co-occur with Autism Spectrum Disorder (ASD), as reflected in recent changes to diagnostic schemes. However, there remains little research with population-based samples across childhood. We report on additional problems, as measured by the Strengths and Difficulties Questionnaire, in a population-based sample of 135 twins with ASD, 55 non-ASD co-twins, and 144 comparison twins low in ASD traits. Frequencies, associated demographic factors, and changes in mental health difficulties from age 4 to 13 years are presented. Our data confirm the high rates of additional difficulties reported in previous studies, and suggest that the profile, associated risk factors and longitudinal course of additional difficulties in ASD may differ from those in typically-developing populations. En ligne : http://dx.doi.org/10.1007/s10803-021-05006-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Autism spectrum disorder and obstetric optimality: a twin study and meta-analysis of sibling studies / S. GÓMEZ-VALLEJO in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1353-1362 Titre : Autism spectrum disorder and obstetric optimality: a twin study and meta-analysis of sibling studies Type de document : Texte imprimé et/ou numérique Auteurs : S. GÓMEZ-VALLEJO, Auteur ; M. LEONI, Auteur ; A. RONALD, Auteur ; E. COLVERT, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur Article en page(s) : p.1353-1362 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/etiology/genetics  Autistic Disorder  Child  Diseases in Twins  Female  Humans  Infant, Newborn  Pregnancy  Siblings  Twins  Autism spectrum disorder  genetics  obstetric complications Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with a strong genetic basis. Recent studies have suggested that its aetiology is also influenced by environmental factors. Some of the most examined environmental factors are obstetric complications. However, the results are inconsistent. METHODS: We aimed to explore the association between obstetric complications and autism in a population-based twin sample using the Obstetric Enquiry Scale (OES), a scale that measures the presence or absence of pre-, peri- and neonatal factors. Additionally, we report the meta-analytic results for obstetrical factors reported in previously published sibling studies. RESULTS: Our study included 115 cases pairs and 62 controls pairs and showed that children with autism and their unaffected co-twins present significantly more obstetric complications than controls (ASD vs. controls ? 1.26, CI 95% 1.11-1.40 p < .001; unaffected co-twin vs. controls ? 1.20, 95% CI 1.07-1.36 p < .003). However, we did not find statistically significant differences between children with ASD and their unaffected co-twins (? .96, 95% CI 0.85-1.09, p 0.55). Meta-analysis demonstrated that maternal hypertension (RR 1.35, CI 95% 1.23-1.48), uterine bleeding (RR 1.20 CI 95% 1.01-1.42) and exposure to antibiotic during pregnancy (1.11 CI 95% 1.00-1.22) increase risk of ASD. CONCLUSIONS: This study confirms that children with ASD and their unaffected twins show more obstetric complications than controls. However, these complications do not distinguish between ASD twins and their unaffected co-twins. In addition, the meta-analysis showed little influence of birth factors on ASD which suggests a shared familial liability for both obstetric complications and autism, rather than a causal association. En ligne : http://dx.doi.org/10.1111/jcpp.13526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Autism spectrum disorder and obstetric optimality: a twin study and meta-analysis of sibling studies [Texte imprimé et/ou numérique] / S. GÓMEZ-VALLEJO, Auteur ; M. LEONI, Auteur ; A. RONALD, Auteur ; E. COLVERT, Auteur ; Francesca HAPPE, Auteur ; Patrick BOLTON, Auteur . - p.1353-1362. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1353-1362 Mots-clés : Autism Spectrum Disorder/etiology/genetics  Autistic Disorder  Child  Diseases in Twins  Female  Humans  Infant, Newborn  Pregnancy  Siblings  Twins  Autism spectrum disorder  genetics  obstetric complications Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with a strong genetic basis. Recent studies have suggested that its aetiology is also influenced by environmental factors. Some of the most examined environmental factors are obstetric complications. However, the results are inconsistent. METHODS: We aimed to explore the association between obstetric complications and autism in a population-based twin sample using the Obstetric Enquiry Scale (OES), a scale that measures the presence or absence of pre-, peri- and neonatal factors. Additionally, we report the meta-analytic results for obstetrical factors reported in previously published sibling studies. RESULTS: Our study included 115 cases pairs and 62 controls pairs and showed that children with autism and their unaffected co-twins present significantly more obstetric complications than controls (ASD vs. controls ? 1.26, CI 95% 1.11-1.40 p < .001; unaffected co-twin vs. controls ? 1.20, 95% CI 1.07-1.36 p < .003). However, we did not find statistically significant differences between children with ASD and their unaffected co-twins (? .96, 95% CI 0.85-1.09, p 0.55). Meta-analysis demonstrated that maternal hypertension (RR 1.35, CI 95% 1.23-1.48), uterine bleeding (RR 1.20 CI 95% 1.01-1.42) and exposure to antibiotic during pregnancy (1.11 CI 95% 1.00-1.22) increase risk of ASD. CONCLUSIONS: This study confirms that children with ASD and their unaffected twins show more obstetric complications than controls. However, these complications do not distinguish between ASD twins and their unaffected co-twins. In addition, the meta-analysis showed little influence of birth factors on ASD which suggests a shared familial liability for both obstetric complications and autism, rather than a causal association. En ligne : http://dx.doi.org/10.1111/jcpp.13526 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 / D. MASON in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1684-1694 Titre : Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 Type de document : Texte imprimé et/ou numérique Auteurs : D. MASON, Auteur ; A. RONALD, Auteur ; A. AMBLER, Auteur ; Avshalom CASPI, Auteur ; R. HOUTS, Auteur ; R. POULTON, Auteur ; S. RAMRAKHA, Auteur ; J. WERTZ, Auteur ; T. E. MOFFITT, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.1684-1694 Langues : Anglais (eng) Mots-clés : Adult  Aging  Autism Spectrum Disorder  Autistic Disorder  Humans  Middle Aged  Surveys and Questionnaires  aging  autistic traits  intelligence  physical health  socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45?years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (? = 0.09), facial age (? = 0.08), self- (? = -0.15), informant (? = -0.12), and interviewer-rated (? = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 [Texte imprimé et/ou numérique] / D. MASON, Auteur ; A. RONALD, Auteur ; A. AMBLER, Auteur ; Avshalom CASPI, Auteur ; R. HOUTS, Auteur ; R. POULTON, Auteur ; S. RAMRAKHA, Auteur ; J. WERTZ, Auteur ; T. E. MOFFITT, Auteur ; Francesca HAPPE, Auteur . - p.1684-1694. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1684-1694 Mots-clés : Adult  Aging  Autism Spectrum Disorder  Autistic Disorder  Humans  Middle Aged  Surveys and Questionnaires  aging  autistic traits  intelligence  physical health  socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45?years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (? = 0.09), facial age (? = 0.08), self- (? = -0.15), informant (? = -0.12), and interviewer-rated (? = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Editorial: The new genetics of autism / B. FRANKE in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1271-1273 Titre : Editorial: The new genetics of autism Type de document : Texte imprimé et/ou numérique Auteurs : B. FRANKE, Auteur ; E. FOMBONNE, Auteur ; A. RONALD, Auteur Article en page(s) : p.1271-1273 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.13527 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Editorial: The new genetics of autism [Texte imprimé et/ou numérique] / B. FRANKE, Auteur ; E. FOMBONNE, Auteur ; A. RONALD, Auteur . - p.1271-1273. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1271-1273 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.13527 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Editorial: The psychopathology p factor: will it revolutionise the science and practice of child and adolescent psychiatry? / A. RONALD in Journal of Child Psychology and Psychiatry, 60-5 (May 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-5 (May 2019) . - p.497-499 Titre : Editorial: The psychopathology p factor: will it revolutionise the science and practice of child and adolescent psychiatry? Type de document : Texte imprimé et/ou numérique Auteurs : A. RONALD, Auteur Article en page(s) : p.497-499 Langues : Anglais (eng) Mots-clés : Psychopathology  autism  child and adolescent psychiatry  genetics  neurodevelopment  p factor Index. décimale : PER Périodiques Résumé : The psychopathology p factor has emerged from a series of strong empirical studies, largely in the adult psychiatry literature. Here, some of the recent findings relating to the p factor in children and adolescents are considered and the implications for child and adolescent psychiatry are discussed. Is it essential to covary for 'p' when we study specific domains of psychopathology? Do neurodevelopmental conditions make up part of the psychopathology p factor? How do we treat the 'p factor' in clinics? This editorial considers some of the contributions from this issue of Journal of Child Psychology and Psychiatry together with the wider literature that speak to these issues. En ligne : http://dx.doi.org/10.1111/jcpp.13063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392 [article] Editorial: The psychopathology p factor: will it revolutionise the science and practice of child and adolescent psychiatry? [Texte imprimé et/ou numérique] / A. RONALD, Auteur . - p.497-499. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-5 (May 2019) . - p.497-499 Mots-clés : Psychopathology  autism  child and adolescent psychiatry  genetics  neurodevelopment  p factor Index. décimale : PER Périodiques Résumé : The psychopathology p factor has emerged from a series of strong empirical studies, largely in the adult psychiatry literature. Here, some of the recent findings relating to the p factor in children and adolescents are considered and the implications for child and adolescent psychiatry are discussed. Is it essential to covary for 'p' when we study specific domains of psychopathology? Do neurodevelopmental conditions make up part of the psychopathology p factor? How do we treat the 'p factor' in clinics? This editorial considers some of the contributions from this issue of Journal of Child Psychology and Psychiatry together with the wider literature that speak to these issues. En ligne : http://dx.doi.org/10.1111/jcpp.13063 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392

Genetic and environmental influences on the stability of psychotic experiences and negative symptoms in adolescence / L. HAVERS in Journal of Child Psychology and Psychiatry, 60-7 (July 2019)  

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RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation / A. SAFFARI in Molecular Autism, 10 (2019)  

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Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development / E. STERGIAKOULI in Molecular Autism, 8 (2017)  

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A twin study exploring the association between childhood emotional and behaviour problems and specific psychotic experiences in a community sample of adolescents / S. SHAKOOR in Journal of Child Psychology and Psychiatry, 59-5 (May 2018)  

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