2 recherche sur le mot-clé 'Herbal medicine'

An intranasal herbal medicine improves executive functions and activates the underlying neural network in children with autism / Agnes S. CHAN in Research in Autism Spectrum Disorders, 8-6 (June 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-6 (June 2014) . - p.681-691 Titre : An intranasal herbal medicine improves executive functions and activates the underlying neural network in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Yvonne M.Y. HAN, Auteur Article en page(s) : p.681-691 Langues : Anglais (eng) Mots-clés : Autism  Herbal medicine  Executive functions  EEG  Prefrontal  Anterior cingulate Index. décimale : PER Périodiques Résumé : Our animal and human studies have provided empirical evidence that a patented intranasal herbal medicine alters brain functions and neurophysiology. In particular, it reduces clinical symptoms and immunological anomalies in children with autism spectrum disorders (ASD). The present study explored whether the herbal formula can improve executive functions and the associated neuroelectrophysiological activity in ASD. Thirty children with ASD were evenly assigned to receive a daily intranasal administration of the herbal formula or no treatment. Their executive functions, behavioral problems, and electroencephalographic activity during an executive control task were measured before and after six months of treatment with the herbal formula. After treatment, the experimental group showed significantly improved inhibitory control, mental flexibility, and planning, which coincided with an event-related elevation in the activity of their prefrontal and anterior cingulate cortices (regions that are critical for executive control of behaviors) as well as reduced daily dysexecutive behaviors. In contrast, the control group showed no significant changes in executive functions or neural system activity. These findings support the administration of the intranasal herbal medicine as a possible intervention for improving executive functions in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 [article] An intranasal herbal medicine improves executive functions and activates the underlying neural network in children with autism [Texte imprimé et/ou numérique] / Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Yvonne M.Y. HAN, Auteur . - p.681-691. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-6 (June 2014) . - p.681-691 Mots-clés : Autism  Herbal medicine  Executive functions  EEG  Prefrontal  Anterior cingulate Index. décimale : PER Périodiques Résumé : Our animal and human studies have provided empirical evidence that a patented intranasal herbal medicine alters brain functions and neurophysiology. In particular, it reduces clinical symptoms and immunological anomalies in children with autism spectrum disorders (ASD). The present study explored whether the herbal formula can improve executive functions and the associated neuroelectrophysiological activity in ASD. Thirty children with ASD were evenly assigned to receive a daily intranasal administration of the herbal formula or no treatment. Their executive functions, behavioral problems, and electroencephalographic activity during an executive control task were measured before and after six months of treatment with the herbal formula. After treatment, the experimental group showed significantly improved inhibitory control, mental flexibility, and planning, which coincided with an event-related elevation in the activity of their prefrontal and anterior cingulate cortices (regions that are critical for executive control of behaviors) as well as reduced daily dysexecutive behaviors. In contrast, the control group showed no significant changes in executive functions or neural system activity. These findings support the administration of the intranasal herbal medicine as a possible intervention for improving executive functions in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232

A proprietary herbal medicine (5-Ling Granule) for Tourette syndrome: a randomized controlled trial / Yi ZHENG in Journal of Child Psychology and Psychiatry, 57-1 (January 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.74-83 Titre : A proprietary herbal medicine (5-Ling Granule) for Tourette syndrome: a randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Yi ZHENG, Auteur ; Zhang-Jin ZHANG, Auteur ; Xin-Min HAN, Auteur ; Ying DING, Auteur ; Yu-Yan CHEN, Auteur ; Xue-Feng WANG, Auteur ; Xiao-Wei WEI, Auteur ; Min-Jie WANG, Auteur ; Yan CHENG, Auteur ; Zhao-Hong NIE, Auteur ; Min ZHAO, Auteur ; Xi-Xi ZHENG, Auteur Article en page(s) : p.74-83 Langues : Anglais (eng) Mots-clés : Tourette syndrome  tics  herbal medicine  tiapride  5-Ling Granule Index. décimale : PER Périodiques Résumé : Background Tourette syndrome (TS) is a common tic disorder in children and adolescents. There is preliminary evidence that herbal medicine may possess the potential to treat tics. The purpose of this study was to formally evaluate the efficacy and safety of 5-Ling Granule (5-LGr), a proprietary polyherbal product, for the treatment of patients with TS in comparison with tiapride and placebo. Methods In this multisite, double-blind, double-dummy, randomized, placebo-controlled trial, 603 patients with TS aged 5–18 years were randomly assigned to treatment with placebo (n = 117), tiapride (n = 123, 200–400 mg/day) or 5-LGr (n = 363, 15–22.5 g/day) for 8 weeks. The primary outcome was measured using the Yale Global Tic Severity Scale (YGTSS) and its subscales, total tic Score (TTS) and tic-related impairment. Incidence of adverse events was compared among the three groups. Results While tics of all patients were reduced over time, 5-LGr and tiapride treatment produced significantly greater improvement on the YGTSS overall scale and subscale for TTS and impairment at endpoint than the placebo. Seventy-four percentage of patients in the 5-LGr arm and 68.3% in the tiapride arm had clinical response and these rates of response were significantly higher than those on placebo (44.0%, p < .001). The incidence of overall adverse events was significantly fewer for patients on placebo and 5-LGr compared to tiapride (11.2% and 13.8% vs. 26.0%, p = .002); in particular physical tiredness, dizziness and sleep disturbance. Conclusions The clinical efficacy of 5-LGr is comparable to tiapride in reducing tics. Its safety profile is better than tiapride. 5-LGr can be considered a safe and effective therapy for TS (Trial registration: www.clinicaltrials.gov: NCT01501695). En ligne : http://dx.doi.org/10.1111/jcpp.12432 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 [article] A proprietary herbal medicine (5-Ling Granule) for Tourette syndrome: a randomized controlled trial [Texte imprimé et/ou numérique] / Yi ZHENG, Auteur ; Zhang-Jin ZHANG, Auteur ; Xin-Min HAN, Auteur ; Ying DING, Auteur ; Yu-Yan CHEN, Auteur ; Xue-Feng WANG, Auteur ; Xiao-Wei WEI, Auteur ; Min-Jie WANG, Auteur ; Yan CHENG, Auteur ; Zhao-Hong NIE, Auteur ; Min ZHAO, Auteur ; Xi-Xi ZHENG, Auteur . - p.74-83. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-1 (January 2016) . - p.74-83 Mots-clés : Tourette syndrome  tics  herbal medicine  tiapride  5-Ling Granule Index. décimale : PER Périodiques Résumé : Background Tourette syndrome (TS) is a common tic disorder in children and adolescents. There is preliminary evidence that herbal medicine may possess the potential to treat tics. The purpose of this study was to formally evaluate the efficacy and safety of 5-Ling Granule (5-LGr), a proprietary polyherbal product, for the treatment of patients with TS in comparison with tiapride and placebo. Methods In this multisite, double-blind, double-dummy, randomized, placebo-controlled trial, 603 patients with TS aged 5–18 years were randomly assigned to treatment with placebo (n = 117), tiapride (n = 123, 200–400 mg/day) or 5-LGr (n = 363, 15–22.5 g/day) for 8 weeks. The primary outcome was measured using the Yale Global Tic Severity Scale (YGTSS) and its subscales, total tic Score (TTS) and tic-related impairment. Incidence of adverse events was compared among the three groups. Results While tics of all patients were reduced over time, 5-LGr and tiapride treatment produced significantly greater improvement on the YGTSS overall scale and subscale for TTS and impairment at endpoint than the placebo. Seventy-four percentage of patients in the 5-LGr arm and 68.3% in the tiapride arm had clinical response and these rates of response were significantly higher than those on placebo (44.0%, p < .001). The incidence of overall adverse events was significantly fewer for patients on placebo and 5-LGr compared to tiapride (11.2% and 13.8% vs. 26.0%, p = .002); in particular physical tiredness, dizziness and sleep disturbance. Conclusions The clinical efficacy of 5-LGr is comparable to tiapride in reducing tics. Its safety profile is better than tiapride. 5-LGr can be considered a safe and effective therapy for TS (Trial registration: www.clinicaltrials.gov: NCT01501695). En ligne : http://dx.doi.org/10.1111/jcpp.12432 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273