Altered immune function associated with disordered neural connectivity and executive dysfunctions: A neurophysiological study on children with autism spectrum disorders / Yvonne M.Y. HAN in Research in Autism Spectrum Disorders, 7-6 (June 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-6 (June 2013) . - p.662-674 Titre : Altered immune function associated with disordered neural connectivity and executive dysfunctions: A neurophysiological study on children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M. K. LAM, Auteur ; Priscilla M. K. POON, Auteur Article en page(s) : p.662-674 Langues : Anglais (eng) Mots-clés : EEG coherence  Immunologic function  Executive dysfunction  Autism  Children Index. décimale : PER Périodiques Résumé : Previous studies have shown that children with autism spectrum disorders (ASDs) have impaired executive function, disordered neural connectivity, and abnormal immunologic function. The present study examined whether these abnormalities were associated. Seventeen high-functioning (HFA) and 17 low-functioning (LFA) children with ASD, aged 8–17 years, participated voluntarily in the study. The two groups of children were compared on their general intelligence in terms of IQ; executive function as measured by the Hong Kong List Learning Test, D2 Test of Concentration, Five Point Test, Children's Color Trail Test, Tower of California Test, and Go/No-Go task; a non-executive task as measured by the Picture Completion Task; neural connectivity as measured by theta coherence in the anterior and posterior regions; and immunologic function as measured by the level of circulating CD3+ CD8+ suppressor/cytotoxic T lymphocytes in a blood sample. Results on executive function showed that LFA children performed significantly poorer than HFA children as shown on their lower Executive Composite as well as individual executive function scores. However, there was no group difference on the Picture Completion Task. Results on neural connectivity showed that LFA children demonstrated a different pattern of electroencephalography (EEG) coherence from HFA children as shown in the significantly elevated theta coherence in the anterior network, as well as at the left intra-hemispheric (LA-LP) and right-to-left inter-hemisphere (RA-LP) connections of LFA children. In immunologic function, results showed that LFA children had significantly elevated level of suppressor/cytotoxic T lymphocytes (CD3+ CD8+) (p lt; 0.05). In addition, the executive dysfunction, disordered neural connectivity, and abnormal immunologic function were found to be associated. These results provided some initial evidence to support the notion that immunologic factors are associated with neuronal damage, measureable by EEG coherence and manifested as executive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.02.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199 [article] Altered immune function associated with disordered neural connectivity and executive dysfunctions: A neurophysiological study on children with autism spectrum disorders [Texte imprimé et/ou numérique] / Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M. K. LAM, Auteur ; Priscilla M. K. POON, Auteur . - p.662-674. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 7-6 (June 2013) . - p.662-674 Mots-clés : EEG coherence  Immunologic function  Executive dysfunction  Autism  Children Index. décimale : PER Périodiques Résumé : Previous studies have shown that children with autism spectrum disorders (ASDs) have impaired executive function, disordered neural connectivity, and abnormal immunologic function. The present study examined whether these abnormalities were associated. Seventeen high-functioning (HFA) and 17 low-functioning (LFA) children with ASD, aged 8–17 years, participated voluntarily in the study. The two groups of children were compared on their general intelligence in terms of IQ; executive function as measured by the Hong Kong List Learning Test, D2 Test of Concentration, Five Point Test, Children's Color Trail Test, Tower of California Test, and Go/No-Go task; a non-executive task as measured by the Picture Completion Task; neural connectivity as measured by theta coherence in the anterior and posterior regions; and immunologic function as measured by the level of circulating CD3+ CD8+ suppressor/cytotoxic T lymphocytes in a blood sample. Results on executive function showed that LFA children performed significantly poorer than HFA children as shown on their lower Executive Composite as well as individual executive function scores. However, there was no group difference on the Picture Completion Task. Results on neural connectivity showed that LFA children demonstrated a different pattern of electroencephalography (EEG) coherence from HFA children as shown in the significantly elevated theta coherence in the anterior network, as well as at the left intra-hemispheric (LA-LP) and right-to-left inter-hemisphere (RA-LP) connections of LFA children. In immunologic function, results showed that LFA children had significantly elevated level of suppressor/cytotoxic T lymphocytes (CD3+ CD8+) (p lt; 0.05). In addition, the executive dysfunction, disordered neural connectivity, and abnormal immunologic function were found to be associated. These results provided some initial evidence to support the notion that immunologic factors are associated with neuronal damage, measureable by EEG coherence and manifested as executive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.02.011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199

Altered right frontal cortical connectivity during facial emotion recognition in children with autism spectrum disorders / Michael K. YEUNG in Research in Autism Spectrum Disorders, 8-11 (November 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1567-1577 Titre : Altered right frontal cortical connectivity during facial emotion recognition in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Michael K. YEUNG, Auteur ; Yvonne M. Y. HAN, Auteur ; Sophia L. SZE, Auteur ; Agnes S. CHAN, Auteur Article en page(s) : p.1567-1577 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Facial emotion  Social  Connectivity  Theta  Coherence Index. décimale : PER Périodiques Résumé : A growing body of evidence suggests that autism spectrum disorders (ASD) is associated with altered functional connectivity of the brain and with impairment in recognizing others’ emotions. To better understand the relationships among these neural and behavioral abnormalities, we examined cortical connectivity which was indicated by theta coherence during tasks of facial emotion recognition in 18 children with ASD and 18 typically developing (TD) children who were between 6 and 18 years of age. We found that the children with ASD had general impairment in recognizing facial emotions, after controlling for response bias. Additionally, we found that the TD children demonstrated significant modulation of right frontal theta coherence in response to emotional faces compared to neutral faces, whereas children with ASD did not exhibit any modulation of theta coherence. The extent of modulation of theta coherence to emotions was further found to be related to the severity of social impairments in ASD. Our findings of a general impairment in facial emotion recognition and the involvement of disordered cortical connectivity in social deficits in children with ASD have shed light for future exploration of interventions regarding emotional processing and social functioning in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.08.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Altered right frontal cortical connectivity during facial emotion recognition in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Michael K. YEUNG, Auteur ; Yvonne M. Y. HAN, Auteur ; Sophia L. SZE, Auteur ; Agnes S. CHAN, Auteur . - p.1567-1577. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-11 (November 2014) . - p.1567-1577 Mots-clés : Autism spectrum disorders  Facial emotion  Social  Connectivity  Theta  Coherence Index. décimale : PER Périodiques Résumé : A growing body of evidence suggests that autism spectrum disorders (ASD) is associated with altered functional connectivity of the brain and with impairment in recognizing others’ emotions. To better understand the relationships among these neural and behavioral abnormalities, we examined cortical connectivity which was indicated by theta coherence during tasks of facial emotion recognition in 18 children with ASD and 18 typically developing (TD) children who were between 6 and 18 years of age. We found that the children with ASD had general impairment in recognizing facial emotions, after controlling for response bias. Additionally, we found that the TD children demonstrated significant modulation of right frontal theta coherence in response to emotional faces compared to neutral faces, whereas children with ASD did not exhibit any modulation of theta coherence. The extent of modulation of theta coherence to emotions was further found to be related to the severity of social impairments in ASD. Our findings of a general impairment in facial emotion recognition and the involvement of disordered cortical connectivity in social deficits in children with ASD have shed light for future exploration of interventions regarding emotional processing and social functioning in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.08.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

An intranasal herbal medicine improves executive functions and activates the underlying neural network in children with autism / Agnes S. CHAN in Research in Autism Spectrum Disorders, 8-6 (June 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-6 (June 2014) . - p.681-691 Titre : An intranasal herbal medicine improves executive functions and activates the underlying neural network in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Yvonne M.Y. HAN, Auteur Article en page(s) : p.681-691 Langues : Anglais (eng) Mots-clés : Autism  Herbal medicine  Executive functions  EEG  Prefrontal  Anterior cingulate Index. décimale : PER Périodiques Résumé : Our animal and human studies have provided empirical evidence that a patented intranasal herbal medicine alters brain functions and neurophysiology. In particular, it reduces clinical symptoms and immunological anomalies in children with autism spectrum disorders (ASD). The present study explored whether the herbal formula can improve executive functions and the associated neuroelectrophysiological activity in ASD. Thirty children with ASD were evenly assigned to receive a daily intranasal administration of the herbal formula or no treatment. Their executive functions, behavioral problems, and electroencephalographic activity during an executive control task were measured before and after six months of treatment with the herbal formula. After treatment, the experimental group showed significantly improved inhibitory control, mental flexibility, and planning, which coincided with an event-related elevation in the activity of their prefrontal and anterior cingulate cortices (regions that are critical for executive control of behaviors) as well as reduced daily dysexecutive behaviors. In contrast, the control group showed no significant changes in executive functions or neural system activity. These findings support the administration of the intranasal herbal medicine as a possible intervention for improving executive functions in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232 [article] An intranasal herbal medicine improves executive functions and activates the underlying neural network in children with autism [Texte imprimé et/ou numérique] / Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Yvonne M.Y. HAN, Auteur . - p.681-691. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-6 (June 2014) . - p.681-691 Mots-clés : Autism  Herbal medicine  Executive functions  EEG  Prefrontal  Anterior cingulate Index. décimale : PER Périodiques Résumé : Our animal and human studies have provided empirical evidence that a patented intranasal herbal medicine alters brain functions and neurophysiology. In particular, it reduces clinical symptoms and immunological anomalies in children with autism spectrum disorders (ASD). The present study explored whether the herbal formula can improve executive functions and the associated neuroelectrophysiological activity in ASD. Thirty children with ASD were evenly assigned to receive a daily intranasal administration of the herbal formula or no treatment. Their executive functions, behavioral problems, and electroencephalographic activity during an executive control task were measured before and after six months of treatment with the herbal formula. After treatment, the experimental group showed significantly improved inhibitory control, mental flexibility, and planning, which coincided with an event-related elevation in the activity of their prefrontal and anterior cingulate cortices (regions that are critical for executive control of behaviors) as well as reduced daily dysexecutive behaviors. In contrast, the control group showed no significant changes in executive functions or neural system activity. These findings support the administration of the intranasal herbal medicine as a possible intervention for improving executive functions in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=232

Disordered connectivity associated with memory deficits in children with autism spectrum disorders / Agnes S. CHAN in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.237-245 Titre : Disordered connectivity associated with memory deficits in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Agnes S. CHAN, Auteur ; Yvonne M.Y. HAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Cho Yee TO, Auteur ; Raymond C. K. CHAN, Auteur Année de publication : 2011 Article en page(s) : p.237-245 Langues : Anglais (eng) Mots-clés : Autism EEG Coherence Memory Theta Children Index. décimale : PER Périodiques Résumé : The present study examined the memory performance and cortical connectivity of children with ASD, and investigated whether the memory deficits exhibited by these children were associated with the cortical connectivity. Twenty-one children with ASD and 21 children with normal development (NC), aged 5–14 years, participated in the study. Each child was administered a neuropsychological battery that included the Test of Non-verbal Intelligence (TONI-III), Digit Span test (DS), Rey-Osterrieth Complex Figure Test (Rey-O), and Hong Kong List Learning Test (HKLLT); and an EEG recording session when performing the visual encoding Object Recognition (OR) task. Six neuropsychological measures from the test battery and six EEG coherence measures in the theta band were compared between the children with ASD and normal children. Results indicated that children with ASD performed at comparable levels with normal children in the DS and Rey-O, but were significantly poorer in HKLLT and OR. They also exhibited significantly elevated long-range coherences in the fronto-posterior connections involving the left hemisphere (left anterior–left posterior; left anterior–right posterior). Pearson correlation showed significant negative associations between the anterior–posterior EEG coherences and memory performance. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.04.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 [article] Disordered connectivity associated with memory deficits in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Agnes S. CHAN, Auteur ; Yvonne M.Y. HAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Cho Yee TO, Auteur ; Raymond C. K. CHAN, Auteur . - 2011 . - p.237-245. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.237-245 Mots-clés : Autism EEG Coherence Memory Theta Children Index. décimale : PER Périodiques Résumé : The present study examined the memory performance and cortical connectivity of children with ASD, and investigated whether the memory deficits exhibited by these children were associated with the cortical connectivity. Twenty-one children with ASD and 21 children with normal development (NC), aged 5–14 years, participated in the study. Each child was administered a neuropsychological battery that included the Test of Non-verbal Intelligence (TONI-III), Digit Span test (DS), Rey-Osterrieth Complex Figure Test (Rey-O), and Hong Kong List Learning Test (HKLLT); and an EEG recording session when performing the visual encoding Object Recognition (OR) task. Six neuropsychological measures from the test battery and six EEG coherence measures in the theta band were compared between the children with ASD and normal children. Results indicated that children with ASD performed at comparable levels with normal children in the DS and Rey-O, but were significantly poorer in HKLLT and OR. They also exhibited significantly elevated long-range coherences in the fronto-posterior connections involving the left hemisphere (left anterior–left posterior; left anterior–right posterior). Pearson correlation showed significant negative associations between the anterior–posterior EEG coherences and memory performance. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.04.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111

Verbal memory deficits in relation to organization strategy in high- and low-functioning autistic children / Mei-chun CHEUNG in Research in Autism Spectrum Disorders, 4-4 (October-December 2010)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 4-4 (October-December 2010) . - p.764-771 Titre : Verbal memory deficits in relation to organization strategy in high- and low-functioning autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Mei-chun CHEUNG, Auteur ; Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Winnie Wing-man LEUNG, Auteur ; Cho Yee TO, Auteur Année de publication : 2010 Article en page(s) : p.764-771 Langues : Anglais (eng) Mots-clés : Memory  Encoding  Retrieval  Organization  Autism  Children Index. décimale : PER Périodiques Résumé : The present study examined the verbal memory profile and its relation to organizational strategies in high-functioning (Hi-AUT) and low-functioning (Lo-AUT) children with autism. Twenty-two Hi-AUT and 16 Lo-AUT, and 22 age-, gender- and handedness-matched normal children (NC) were required to remember a list of semantically related words for immediate and delayed recall and recognition. All autistic children showed impaired free recall, a reduced discrimination score and an elevated false alarm rate at recognition. While Hi-AUT children showed encoding and retrieval deficit, Lo-AUT children demonstrated more severe encoding problem and an additional retention difficulty. Lo-AUT, but not the Hi-AUT, children showed impaired semantic clustering. The recall performance in autistic children was not as strongly correlated with semantic clustering as in NC. The dual deficits of encoding and retrieval in autistic children, regardless of functioning level, implicate a frontal-lobe problem commonly observed in autism. The additional retention difficulty shown by low-functioning autistic children may be suggestive of pathological temporal-lobe involvement. The present findings may provide insights into future exploration of memory intervention for autistic children. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.02.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=167 [article] Verbal memory deficits in relation to organization strategy in high- and low-functioning autistic children [Texte imprimé et/ou numérique] / Mei-chun CHEUNG, Auteur ; Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Winnie Wing-man LEUNG, Auteur ; Cho Yee TO, Auteur . - 2010 . - p.764-771. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 4-4 (October-December 2010) . - p.764-771 Mots-clés : Memory  Encoding  Retrieval  Organization  Autism  Children Index. décimale : PER Périodiques Résumé : The present study examined the verbal memory profile and its relation to organizational strategies in high-functioning (Hi-AUT) and low-functioning (Lo-AUT) children with autism. Twenty-two Hi-AUT and 16 Lo-AUT, and 22 age-, gender- and handedness-matched normal children (NC) were required to remember a list of semantically related words for immediate and delayed recall and recognition. All autistic children showed impaired free recall, a reduced discrimination score and an elevated false alarm rate at recognition. While Hi-AUT children showed encoding and retrieval deficit, Lo-AUT children demonstrated more severe encoding problem and an additional retention difficulty. Lo-AUT, but not the Hi-AUT, children showed impaired semantic clustering. The recall performance in autistic children was not as strongly correlated with semantic clustering as in NC. The dual deficits of encoding and retrieval in autistic children, regardless of functioning level, implicate a frontal-lobe problem commonly observed in autism. The additional retention difficulty shown by low-functioning autistic children may be suggestive of pathological temporal-lobe involvement. The present findings may provide insights into future exploration of memory intervention for autistic children. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.02.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=167

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