Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
2 recherche sur le mot-clé 'Metals'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Na(+) , K(+) -ATPase activity in children with autism spectrum disorder: Searching for the reason(s) of its decrease in blood cells / A. BOLOTTA in Autism Research, 11-10 (October 2018)
[article]
Titre : Na(+) , K(+) -ATPase activity in children with autism spectrum disorder: Searching for the reason(s) of its decrease in blood cells Type de document : Texte imprimé et/ou numérique Auteurs : A. BOLOTTA, Auteur ; Paola VISCONTI, Auteur ; G. FEDRIZZI, Auteur ; A. GHEZZO, Auteur ; M. MARINI, Auteur ; P. MANUNTA, Auteur ; E. MESSAGGIO, Auteur ; A. POSAR, Auteur ; A. VIGNINI, Auteur ; P. M. ABRUZZO, Auteur Article en page(s) : p.1388-1403 Langues : Anglais (eng) Mots-clés : Nrf2 Na+, K+-ATPase autism spectrum disorders beta-actin endogenous ouabain erythrocyte membrane membrane lipids metals oxidative stress Index. décimale : PER Périodiques Résumé : Na(+) , K(+) -ATPase (NKA) activity, which establishes the sodium and potassium gradient across the cell membrane and is instrumental in the propagation of the nerve impulses, is altered in a number of neurological and neuropsychiatric disorders, including autism spectrum disorders (ASD). In the present work, we examined a wide range of biochemical and cellular parameters in the attempt to understand the reason(s) for the severe decrease in NKA activity in erythrocytes of ASD children that we reported previously. NKA activity in leukocytes was found to be decreased independently from alteration in plasma membrane fluidity. The different subunits were evaluated for gene expression in leukocytes and for protein expression in erythrocytes: small differences in gene expression between ASD and typically developing children were not apparently paralleled by differences in protein expression. Moreover, no gross difference in erythrocyte plasma membrane oxidative modifications was detectable, although oxidative stress in blood samples from ASD children was confirmed by increased expression of NRF2 mRNA. Interestingly, gene expression of some NKA subunits correlated with clinical features. Excess inhibitory metals or ouabain-like activities, which might account for NKA activity decrease, were ruled out. Plasma membrane cholesterol, but not phosphatidylcholine and phosphatidlserine, was slighty decreased in erythrocytes from ASD children. Although no compelling results were obtained, our data suggest that alteration in the erytrocyte lipid moiety or subtle oxidative modifications in NKA structure are likely candidates for the observed decrease in NKA activity. These findings are discussed in the light of the relevance of NKA in ASD. Autism Res 2018, 11: 1388-1403. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The activity of the cell membrane enzyme NKA, which is instrumental in the propagation of the nerve impulses, is severely decreased in erythrocytes from ASD children and in other brain disorders, yet no explanation has been provided for this observation. We strived to find a biological/biochemical cause of such alteration, but most queries went unsolved because of the complexity of NKA regulation. As NKA activity is altered in many brain disorders, we stress the relevance of studies aimed at understanding its regulation in ASD. En ligne : http://dx.doi.org/10.1002/aur.2002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369
in Autism Research > 11-10 (October 2018) . - p.1388-1403[article] Na(+) , K(+) -ATPase activity in children with autism spectrum disorder: Searching for the reason(s) of its decrease in blood cells [Texte imprimé et/ou numérique] / A. BOLOTTA, Auteur ; Paola VISCONTI, Auteur ; G. FEDRIZZI, Auteur ; A. GHEZZO, Auteur ; M. MARINI, Auteur ; P. MANUNTA, Auteur ; E. MESSAGGIO, Auteur ; A. POSAR, Auteur ; A. VIGNINI, Auteur ; P. M. ABRUZZO, Auteur . - p.1388-1403.
Langues : Anglais (eng)
in Autism Research > 11-10 (October 2018) . - p.1388-1403
Mots-clés : Nrf2 Na+, K+-ATPase autism spectrum disorders beta-actin endogenous ouabain erythrocyte membrane membrane lipids metals oxidative stress Index. décimale : PER Périodiques Résumé : Na(+) , K(+) -ATPase (NKA) activity, which establishes the sodium and potassium gradient across the cell membrane and is instrumental in the propagation of the nerve impulses, is altered in a number of neurological and neuropsychiatric disorders, including autism spectrum disorders (ASD). In the present work, we examined a wide range of biochemical and cellular parameters in the attempt to understand the reason(s) for the severe decrease in NKA activity in erythrocytes of ASD children that we reported previously. NKA activity in leukocytes was found to be decreased independently from alteration in plasma membrane fluidity. The different subunits were evaluated for gene expression in leukocytes and for protein expression in erythrocytes: small differences in gene expression between ASD and typically developing children were not apparently paralleled by differences in protein expression. Moreover, no gross difference in erythrocyte plasma membrane oxidative modifications was detectable, although oxidative stress in blood samples from ASD children was confirmed by increased expression of NRF2 mRNA. Interestingly, gene expression of some NKA subunits correlated with clinical features. Excess inhibitory metals or ouabain-like activities, which might account for NKA activity decrease, were ruled out. Plasma membrane cholesterol, but not phosphatidylcholine and phosphatidlserine, was slighty decreased in erythrocytes from ASD children. Although no compelling results were obtained, our data suggest that alteration in the erytrocyte lipid moiety or subtle oxidative modifications in NKA structure are likely candidates for the observed decrease in NKA activity. These findings are discussed in the light of the relevance of NKA in ASD. Autism Res 2018, 11: 1388-1403. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The activity of the cell membrane enzyme NKA, which is instrumental in the propagation of the nerve impulses, is severely decreased in erythrocytes from ASD children and in other brain disorders, yet no explanation has been provided for this observation. We strived to find a biological/biochemical cause of such alteration, but most queries went unsolved because of the complexity of NKA regulation. As NKA activity is altered in many brain disorders, we stress the relevance of studies aimed at understanding its regulation in ASD. En ligne : http://dx.doi.org/10.1002/aur.2002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 Trace element levels and autism spectrum disorder in a sample of Algerian children: A case-control study investigation / Belkis STAMBOULI ; Imene KADDOUR-BENKADA ; Ahmed AMZIANE ; Akli Islam CHEBLI ; Mohammed Yacine ACHOURI ; Reda DJIDJIK ; Barkahoum ALAMIR in Research in Autism Spectrum Disorders, 110 (February 2024)
[article]
Titre : Trace element levels and autism spectrum disorder in a sample of Algerian children: A case-control study investigation Type de document : Texte imprimé et/ou numérique Auteurs : Belkis STAMBOULI, Auteur ; Imene KADDOUR-BENKADA, Auteur ; Ahmed AMZIANE, Auteur ; Akli Islam CHEBLI, Auteur ; Mohammed Yacine ACHOURI, Auteur ; Reda DJIDJIK, Auteur ; Barkahoum ALAMIR, Auteur Article en page(s) : p.102287 Mots-clés : ASD Autism Metals Trace elements ICP-MS Index. décimale : PER Périodiques Résumé : The prevalence of autism has been increasing in recent years due to better screening. diagnosis. and awareness campaigns. Toxic metals are considered to be one of the environmental factors that may contribute to autism spectrum disorders (ASD). This study aimed to investigate the levels of toxic and essential trace elements in autistic children and their connection to autism. The study included 40 autistic children and 41 controls. both aged 4?9 years. The levels of toxic metals and metalloids (Arsenic. Cadmium. Chromium. Mercury. Lead) and trace elements (Copper. Iron. Selenium. Zinc) were measured in whole blood. plasma. and urine using ICP-MS multi-elemental techniques. The results showed that the concentrations of toxic and essential metals were significantly higher in autistic children compared to controls. This was demonstrated by higher levels of Cadmium. Chromium. Copper. Zinc. and Lead in blood. plasma. and urine. while plasma Iron levels were lower in autistic children. The results suggest a possible association between autism and metal exposure. but causality cannot be established. En ligne : https://doi.org/10.1016/j.rasd.2023.102287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520
in Research in Autism Spectrum Disorders > 110 (February 2024) . - p.102287[article] Trace element levels and autism spectrum disorder in a sample of Algerian children: A case-control study investigation [Texte imprimé et/ou numérique] / Belkis STAMBOULI, Auteur ; Imene KADDOUR-BENKADA, Auteur ; Ahmed AMZIANE, Auteur ; Akli Islam CHEBLI, Auteur ; Mohammed Yacine ACHOURI, Auteur ; Reda DJIDJIK, Auteur ; Barkahoum ALAMIR, Auteur . - p.102287.
in Research in Autism Spectrum Disorders > 110 (February 2024) . - p.102287
Mots-clés : ASD Autism Metals Trace elements ICP-MS Index. décimale : PER Périodiques Résumé : The prevalence of autism has been increasing in recent years due to better screening. diagnosis. and awareness campaigns. Toxic metals are considered to be one of the environmental factors that may contribute to autism spectrum disorders (ASD). This study aimed to investigate the levels of toxic and essential trace elements in autistic children and their connection to autism. The study included 40 autistic children and 41 controls. both aged 4?9 years. The levels of toxic metals and metalloids (Arsenic. Cadmium. Chromium. Mercury. Lead) and trace elements (Copper. Iron. Selenium. Zinc) were measured in whole blood. plasma. and urine using ICP-MS multi-elemental techniques. The results showed that the concentrations of toxic and essential metals were significantly higher in autistic children compared to controls. This was demonstrated by higher levels of Cadmium. Chromium. Copper. Zinc. and Lead in blood. plasma. and urine. while plasma Iron levels were lower in autistic children. The results suggest a possible association between autism and metal exposure. but causality cannot be established. En ligne : https://doi.org/10.1016/j.rasd.2023.102287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520