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Brief Report: Platelet-Poor Plasma Serotonin in Autism / George M. ANDERSON in Journal of Autism and Developmental Disorders, 42-7 (July 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1510-1514 Titre : Brief Report: Platelet-Poor Plasma Serotonin in Autism Type de document : Texte imprimé et/ou numérique Auteurs : George M. ANDERSON, Auteur ; Margaret E. HERTZIG, Auteur ; P.A. MCBRIDE, Auteur Année de publication : 2012 Article en page(s) : p.1510-1514 Langues : Anglais (eng) Mots-clés : Autism  Serotonin  Hyperserotonemia  Platelet  Platelet-poor plasma (PPP) Index. décimale : PER Périodiques Résumé : Possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet’s handling of serotonin (5-hydroxyserotonin, 5-HT) or an increased exposure of the platelet to 5-HT. Measurement of platelet-poor plasma (PPP) levels of 5-HT appears to provide the best available index of in vivo exposure of the platelet to 5-HT. Mean (±SD) concentrations of PPP 5-HT observed in the autism (N = 18), hyperserotonemic subgroup (N = 5) and control (N = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nM, respectively. The results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-HT and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet’s handling of 5-HT. En ligne : http://dx.doi.org/10.1007/s10803-011-1371-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] Brief Report: Platelet-Poor Plasma Serotonin in Autism [Texte imprimé et/ou numérique] / George M. ANDERSON, Auteur ; Margaret E. HERTZIG, Auteur ; P.A. MCBRIDE, Auteur . - 2012 . - p.1510-1514. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1510-1514 Mots-clés : Autism  Serotonin  Hyperserotonemia  Platelet  Platelet-poor plasma (PPP) Index. décimale : PER Périodiques Résumé : Possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet’s handling of serotonin (5-hydroxyserotonin, 5-HT) or an increased exposure of the platelet to 5-HT. Measurement of platelet-poor plasma (PPP) levels of 5-HT appears to provide the best available index of in vivo exposure of the platelet to 5-HT. Mean (±SD) concentrations of PPP 5-HT observed in the autism (N = 18), hyperserotonemic subgroup (N = 5) and control (N = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nM, respectively. The results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-HT and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet’s handling of 5-HT. En ligne : http://dx.doi.org/10.1007/s10803-011-1371-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166