Autism Biomarkers: Challenges, Pitfalls and Possibilities / George M. ANDERSON in Journal of Autism and Developmental Disorders, 45-4 (April 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-4 (April 2015) . - p.1103-1113 Titre : Autism Biomarkers: Challenges, Pitfalls and Possibilities Type de document : Texte imprimé et/ou numérique Auteurs : George M. ANDERSON, Auteur Article en page(s) : p.1103-1113 Langues : Anglais (eng) Mots-clés : Autism  Conceptualization of autism  Biomarker  Mutualism  Emergenesis  Network Index. décimale : PER Périodiques Résumé : Network perspectives, in their emphasis on components and their interactions, might afford the best approach to the complexities of the ASD realm. Categorical approaches are unlikely to be fruitful as one should not expect to find a single or even predominant underlying cause of autism behavior across individuals. It is possible that the complex, highly interactive, heterogeneous and individualistic nature of the autism realm is intractable in terms of identifying clinically useful biomarker tests. It is hopeful from an emergenic perspective that small corrective changes in a single component of a deleterious network/configuration might have large beneficial consequences on developmental trajectories and in later treatment. It is suggested that the relationship between ASD and intellectual disability might be fundamentally different in single-gene versus nonsyndromic ASD. It is strongly stated that available biomarker “tests” for autism/ASD will do more harm than good. Finally, the serotonin–melatonin-oxidative stress-placental intersection might be an especially fruitful area of biological investigation. En ligne : http://dx.doi.org/10.1007/s10803-014-2225-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 [article] Autism Biomarkers: Challenges, Pitfalls and Possibilities [Texte imprimé et/ou numérique] / George M. ANDERSON, Auteur . - p.1103-1113. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-4 (April 2015) . - p.1103-1113 Mots-clés : Autism  Conceptualization of autism  Biomarker  Mutualism  Emergenesis  Network Index. décimale : PER Périodiques Résumé : Network perspectives, in their emphasis on components and their interactions, might afford the best approach to the complexities of the ASD realm. Categorical approaches are unlikely to be fruitful as one should not expect to find a single or even predominant underlying cause of autism behavior across individuals. It is possible that the complex, highly interactive, heterogeneous and individualistic nature of the autism realm is intractable in terms of identifying clinically useful biomarker tests. It is hopeful from an emergenic perspective that small corrective changes in a single component of a deleterious network/configuration might have large beneficial consequences on developmental trajectories and in later treatment. It is suggested that the relationship between ASD and intellectual disability might be fundamentally different in single-gene versus nonsyndromic ASD. It is strongly stated that available biomarker “tests” for autism/ASD will do more harm than good. Finally, the serotonin–melatonin-oxidative stress-placental intersection might be an especially fruitful area of biological investigation. En ligne : http://dx.doi.org/10.1007/s10803-014-2225-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259

Brief Report: Platelet-Poor Plasma Serotonin in Autism / George M. ANDERSON in Journal of Autism and Developmental Disorders, 42-7 (July 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1510-1514 Titre : Brief Report: Platelet-Poor Plasma Serotonin in Autism Type de document : Texte imprimé et/ou numérique Auteurs : George M. ANDERSON, Auteur ; Margaret E. HERTZIG, Auteur ; P.A. MCBRIDE, Auteur Année de publication : 2012 Article en page(s) : p.1510-1514 Langues : Anglais (eng) Mots-clés : Autism  Serotonin  Hyperserotonemia  Platelet  Platelet-poor plasma (PPP) Index. décimale : PER Périodiques Résumé : Possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet’s handling of serotonin (5-hydroxyserotonin, 5-HT) or an increased exposure of the platelet to 5-HT. Measurement of platelet-poor plasma (PPP) levels of 5-HT appears to provide the best available index of in vivo exposure of the platelet to 5-HT. Mean (±SD) concentrations of PPP 5-HT observed in the autism (N = 18), hyperserotonemic subgroup (N = 5) and control (N = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nM, respectively. The results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-HT and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet’s handling of 5-HT. En ligne : http://dx.doi.org/10.1007/s10803-011-1371-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] Brief Report: Platelet-Poor Plasma Serotonin in Autism [Texte imprimé et/ou numérique] / George M. ANDERSON, Auteur ; Margaret E. HERTZIG, Auteur ; P.A. MCBRIDE, Auteur . - 2012 . - p.1510-1514. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1510-1514 Mots-clés : Autism  Serotonin  Hyperserotonemia  Platelet  Platelet-poor plasma (PPP) Index. décimale : PER Périodiques Résumé : Possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet’s handling of serotonin (5-hydroxyserotonin, 5-HT) or an increased exposure of the platelet to 5-HT. Measurement of platelet-poor plasma (PPP) levels of 5-HT appears to provide the best available index of in vivo exposure of the platelet to 5-HT. Mean (±SD) concentrations of PPP 5-HT observed in the autism (N = 18), hyperserotonemic subgroup (N = 5) and control (N = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nM, respectively. The results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-HT and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet’s handling of 5-HT. En ligne : http://dx.doi.org/10.1007/s10803-011-1371-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder / Sarah MARLER in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1124-1130 Titre : Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sarah MARLER, Auteur ; Bradley J. FERGUSON, Auteur ; Evon BATEY LEE, Auteur ; Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Erin MCDONNELL, Auteur ; Eric A. MACKLIN, Auteur ; Pat LEVITT, Auteur ; Catherine HAGAN GILLESPIE, Auteur ; George M. ANDERSON, Auteur ; Kara Gross MARGOLIS, Auteur ; David Q. BEVERSDORF, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.1124-1130 Langues : Anglais (eng) Mots-clés : Serotonin  5-HT  Gastrointestinal (GI)  IL-6  Medical comorbidities  Autism Treatment Network Index. décimale : PER Périodiques Résumé : Elevated whole blood serotonin levels are observed in more than 25 % of children with autism spectrum disorder (ASD). Co-occurring gastrointestinal (GI) symptoms are also common in ASD but have not previously been examined in relationship with hyperserotonemia, despite the synthesis of serotonin in the gut. In 82 children and adolescents with ASD, we observed a correlation between a quantitative measure of lower GI symptoms and whole blood serotonin levels. No significant association was seen between functional constipation diagnosis and serotonin levels in the hyperserotonemia range, suggesting that this correlation is not driven by a single subgroup. More specific assessment of gut function, including the microbiome, will be necessary to evaluate the contribution of gut physiology to serotonin levels in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2646-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Sarah MARLER, Auteur ; Bradley J. FERGUSON, Auteur ; Evon BATEY LEE, Auteur ; Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Erin MCDONNELL, Auteur ; Eric A. MACKLIN, Auteur ; Pat LEVITT, Auteur ; Catherine HAGAN GILLESPIE, Auteur ; George M. ANDERSON, Auteur ; Kara Gross MARGOLIS, Auteur ; David Q. BEVERSDORF, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.1124-1130. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1124-1130 Mots-clés : Serotonin  5-HT  Gastrointestinal (GI)  IL-6  Medical comorbidities  Autism Treatment Network Index. décimale : PER Périodiques Résumé : Elevated whole blood serotonin levels are observed in more than 25 % of children with autism spectrum disorder (ASD). Co-occurring gastrointestinal (GI) symptoms are also common in ASD but have not previously been examined in relationship with hyperserotonemia, despite the synthesis of serotonin in the gut. In 82 children and adolescents with ASD, we observed a correlation between a quantitative measure of lower GI symptoms and whole blood serotonin levels. No significant association was seen between functional constipation diagnosis and serotonin levels in the hyperserotonemia range, suggesting that this correlation is not driven by a single subgroup. More specific assessment of gut function, including the microbiome, will be necessary to evaluate the contribution of gut physiology to serotonin levels in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2646-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Commentary on "Platelet Studies in Autism Spectrum Disorder Patients and First-Degree Relatives" / George M. ANDERSON in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 20p. Titre : Commentary on "Platelet Studies in Autism Spectrum Disorder Patients and First-Degree Relatives" Type de document : Texte imprimé et/ou numérique Auteurs : George M. ANDERSON, Auteur ; Edwin H. Jr COOK, Auteur Article en page(s) : 20p. Langues : Anglais (eng) Mots-clés : 5-ht  Autism  Hyperserotonemia  Platelet aggregation  Platelet count  Platelet functioning  Platelet release  Serotonin Index. décimale : PER Périodiques Résumé : We comment on the recent report entitled "Platelet Studies in Autism Spectrum Disorder Patients and First-Degree Relatives" [Molecular Autism 2015;6:57]. We find it commendable that the authors have investigated platelet factors potentially involved in the well-replicated observation of platelet hyperserotonemia in autism. However, we believe the results need a fuller discussion in the context of prior studies, think that certain aspects of the interpretation need to be reassessed, and attempt to provide a framework for further research in this area. En ligne : http://dx.doi.org/10.1186/s13229-016-0086-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Commentary on "Platelet Studies in Autism Spectrum Disorder Patients and First-Degree Relatives" [Texte imprimé et/ou numérique] / George M. ANDERSON, Auteur ; Edwin H. Jr COOK, Auteur . - 20p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 20p. Mots-clés : 5-ht  Autism  Hyperserotonemia  Platelet aggregation  Platelet count  Platelet functioning  Platelet release  Serotonin Index. décimale : PER Périodiques Résumé : We comment on the recent report entitled "Platelet Studies in Autism Spectrum Disorder Patients and First-Degree Relatives" [Molecular Autism 2015;6:57]. We find it commendable that the authors have investigated platelet factors potentially involved in the well-replicated observation of platelet hyperserotonemia in autism. However, we believe the results need a fuller discussion in the context of prior studies, think that certain aspects of the interpretation need to be reassessed, and attempt to provide a framework for further research in this area. En ligne : http://dx.doi.org/10.1186/s13229-016-0086-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders / Jeremy GOLDBERG in Journal of Autism and Developmental Disorders, 39-1 (January 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.97-104 Titre : Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jeremy GOLDBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; George M. ANDERSON, Auteur ; Claude NAHMIAS, Auteur ; Geoffrey B. C. HALL, Auteur ; Ann THOMPSON, Auteur Année de publication : 2009 Article en page(s) : p.97-104 Langues : Anglais (eng) Mots-clés : Autism Positron-emission-tomography Setoperone [18Fluoro]setoperone Serotonin Endophenotype Index. décimale : PER Périodiques Résumé : Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [18F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [18F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior. En ligne : http://dx.doi.org/10.1007/s10803-008-0604-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660 [article] Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Jeremy GOLDBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; George M. ANDERSON, Auteur ; Claude NAHMIAS, Auteur ; Geoffrey B. C. HALL, Auteur ; Ann THOMPSON, Auteur . - 2009 . - p.97-104. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.97-104 Mots-clés : Autism Positron-emission-tomography Setoperone [18Fluoro]setoperone Serotonin Endophenotype Index. décimale : PER Périodiques Résumé : Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [18F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [18F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior. En ligne : http://dx.doi.org/10.1007/s10803-008-0604-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660

Face scanning and spontaneous emotion preference in Cornelia de Lange syndrome and Rubinstein-Taybi syndrome / Hayley CRAWFORD in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

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Gaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors / David G. AMARAL in Autism Research, 12-5 (May 2019)  

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Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice / Travis KERR in Molecular Autism, (October 2013)  

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Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism / Miranda ZUNIGA-KENNEDY in Journal of Autism and Developmental Disorders, 52-9 (September 2022)  

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Is there sexual dimorphism of hyperserotonemia in autism spectrum disorder? / Lauren C. SHUFFREY in Autism Research, 10-8 (August 2017)  

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Network Analysis of Anxiety in the Autism Realm / F. MONTAZERI in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

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Network Analysis of Behaviors in the Depression and Autism Realms: Inter-Relationships and Clinical Implications / Farhad MONTAZERI in Journal of Autism and Developmental Disorders, 50-5 (May 2020)  

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Network Approach to Autistic Traits: Group and Subgroup Analyses of ADOS Item Scores / George M. ANDERSON in Journal of Autism and Developmental Disorders, 45-10 (October 2015)  

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Network Structure of Autism Spectrum Disorder Behaviors and Its Evolution in Preschool Children: Insights from a New Longitudinal Network Analysis Method / Farhad MONTAZERI in Journal of Autism and Developmental Disorders, 53-11 (November 2023)  

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Neurochemical Studies of Autism / George M. ANDERSON

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