7 recherche sur le mot-clé 'Hyperserotonemia'

Is there sexual dimorphism of hyperserotonemia in autism spectrum disorder? / Lauren C. SHUFFREY in Autism Research, 10-8 (August 2017)  

Public ISBD [article]  inAutism Research > 10-8 (August 2017) . - p.1417-1423 Titre : Is there sexual dimorphism of hyperserotonemia in autism spectrum disorder? Type de document : Texte imprimé et/ou numérique Auteurs : Lauren C. SHUFFREY, Auteur ; Stephen J. GUTER, Auteur ; Shannon DELANEY, Auteur ; Suma JACOB, Auteur ; George M. ANDERSON, Auteur ; James S. SUTCLIFFE, Auteur ; Edwin H. Jr COOK, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.1417-1423 Langues : Anglais (eng) Mots-clés : serotonin  5-HT  autism spectrum disorder  hyperserotonemia Index. décimale : PER Périodiques Résumé : Approximately 30% of individuals with autism spectrum disorder (ASD) have elevated whole blood serotonin (5-HT) levels. Genetic linkage and association studies of ASD and of whole blood 5-HT levels as a quantitative trait have revealed sexual dimorphism. Few studies have examined the presence of a sex difference on hyperserotonemia within ASD. To assess whether the rate of hyperserotonemia is different in males than in females with ASD, we measured whole blood 5-HT levels in 292 children and adolescents with ASD, the largest sample in which this biomarker has been assessed. Based upon previous work suggesting that hyperserotonemia is more common prior to puberty, we focused our analysis on the 182 pre-pubertal children with ASD. 42% of pre-pubertal participants were within the hyperserotonemia range. In this population, we found that males were significantly more likely to manifest hyperserotonemia than females (P?=?0.03). As expected, no significant difference was found in the post-pubertal population. Additional work will be needed to replicate this intriguing finding and to understand whether it could potentially explain differences in patterns of ASD risk between males and females. En ligne : http://dx.doi.org/10.1002/aur.1791 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310 [article] Is there sexual dimorphism of hyperserotonemia in autism spectrum disorder? [Texte imprimé et/ou numérique] / Lauren C. SHUFFREY, Auteur ; Stephen J. GUTER, Auteur ; Shannon DELANEY, Auteur ; Suma JACOB, Auteur ; George M. ANDERSON, Auteur ; James S. SUTCLIFFE, Auteur ; Edwin H. Jr COOK, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.1417-1423. Langues : Anglais (eng) in Autism Research > 10-8 (August 2017) . - p.1417-1423 Mots-clés : serotonin  5-HT  autism spectrum disorder  hyperserotonemia Index. décimale : PER Périodiques Résumé : Approximately 30% of individuals with autism spectrum disorder (ASD) have elevated whole blood serotonin (5-HT) levels. Genetic linkage and association studies of ASD and of whole blood 5-HT levels as a quantitative trait have revealed sexual dimorphism. Few studies have examined the presence of a sex difference on hyperserotonemia within ASD. To assess whether the rate of hyperserotonemia is different in males than in females with ASD, we measured whole blood 5-HT levels in 292 children and adolescents with ASD, the largest sample in which this biomarker has been assessed. Based upon previous work suggesting that hyperserotonemia is more common prior to puberty, we focused our analysis on the 182 pre-pubertal children with ASD. 42% of pre-pubertal participants were within the hyperserotonemia range. In this population, we found that males were significantly more likely to manifest hyperserotonemia than females (P?=?0.03). As expected, no significant difference was found in the post-pubertal population. Additional work will be needed to replicate this intriguing finding and to understand whether it could potentially explain differences in patterns of ASD risk between males and females. En ligne : http://dx.doi.org/10.1002/aur.1791 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=310

Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism / Miranda ZUNIGA-KENNEDY in Journal of Autism and Developmental Disorders, 52-9 (September 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3780-3789 Titre : Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism Type de document : Texte imprimé et/ou numérique Auteurs : Miranda ZUNIGA-KENNEDY, Auteur ; Micah DAVOREN, Auteur ; Lauren C. SHUFFREY, Auteur ; Ruth Ann LUNA, Auteur ; Tor SAVIDGE, Auteur ; Vinay PRASAD, Auteur ; George M. ANDERSON, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Kent C. WILLIAMS, Auteur Article en page(s) : p.3780-3789 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Biomarkers  Child  Humans  Male  Serotonin  Autism  Hyperserotonemia  Immunity  Whole blood serotonin Index. décimale : PER Périodiques Résumé : Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study investigated whether intestinal 5-HT levels, 5-HT gene expression, or intestinal cell types predict WB5-HT. Participants included thirty-one males aged 3-18 who were classified into one of three groups: ASD and functional GI issues, typically developing with GI issues, and typically developing without GI issues. Samples from a lower endoscopy were analyzed to examine the pathways in predicting WB-5HT. Results demonstrated an association between T-Lymphocytes and WB5-HT. En ligne : http://dx.doi.org/10.1007/s10803-022-05597-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism [Texte imprimé et/ou numérique] / Miranda ZUNIGA-KENNEDY, Auteur ; Micah DAVOREN, Auteur ; Lauren C. SHUFFREY, Auteur ; Ruth Ann LUNA, Auteur ; Tor SAVIDGE, Auteur ; Vinay PRASAD, Auteur ; George M. ANDERSON, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Kent C. WILLIAMS, Auteur . - p.3780-3789. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3780-3789 Mots-clés : Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Biomarkers  Child  Humans  Male  Serotonin  Autism  Hyperserotonemia  Immunity  Whole blood serotonin Index. décimale : PER Périodiques Résumé : Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study investigated whether intestinal 5-HT levels, 5-HT gene expression, or intestinal cell types predict WB5-HT. Participants included thirty-one males aged 3-18 who were classified into one of three groups: ASD and functional GI issues, typically developing with GI issues, and typically developing without GI issues. Samples from a lower endoscopy were analyzed to examine the pathways in predicting WB-5HT. Results demonstrated an association between T-Lymphocytes and WB5-HT. En ligne : http://dx.doi.org/10.1007/s10803-022-05597-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Brief Report: Platelet-Poor Plasma Serotonin in Autism / George M. ANDERSON in Journal of Autism and Developmental Disorders, 42-7 (July 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1510-1514 Titre : Brief Report: Platelet-Poor Plasma Serotonin in Autism Type de document : Texte imprimé et/ou numérique Auteurs : George M. ANDERSON, Auteur ; Margaret E. HERTZIG, Auteur ; P.A. MCBRIDE, Auteur Année de publication : 2012 Article en page(s) : p.1510-1514 Langues : Anglais (eng) Mots-clés : Autism  Serotonin  Hyperserotonemia  Platelet  Platelet-poor plasma (PPP) Index. décimale : PER Périodiques Résumé : Possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet’s handling of serotonin (5-hydroxyserotonin, 5-HT) or an increased exposure of the platelet to 5-HT. Measurement of platelet-poor plasma (PPP) levels of 5-HT appears to provide the best available index of in vivo exposure of the platelet to 5-HT. Mean (±SD) concentrations of PPP 5-HT observed in the autism (N = 18), hyperserotonemic subgroup (N = 5) and control (N = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nM, respectively. The results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-HT and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet’s handling of 5-HT. En ligne : http://dx.doi.org/10.1007/s10803-011-1371-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] Brief Report: Platelet-Poor Plasma Serotonin in Autism [Texte imprimé et/ou numérique] / George M. ANDERSON, Auteur ; Margaret E. HERTZIG, Auteur ; P.A. MCBRIDE, Auteur . - 2012 . - p.1510-1514. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1510-1514 Mots-clés : Autism  Serotonin  Hyperserotonemia  Platelet  Platelet-poor plasma (PPP) Index. décimale : PER Périodiques Résumé : Possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet’s handling of serotonin (5-hydroxyserotonin, 5-HT) or an increased exposure of the platelet to 5-HT. Measurement of platelet-poor plasma (PPP) levels of 5-HT appears to provide the best available index of in vivo exposure of the platelet to 5-HT. Mean (±SD) concentrations of PPP 5-HT observed in the autism (N = 18), hyperserotonemic subgroup (N = 5) and control (N = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nM, respectively. The results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-HT and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet’s handling of 5-HT. En ligne : http://dx.doi.org/10.1007/s10803-011-1371-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

Commentary on "Platelet Studies in Autism Spectrum Disorder Patients and First-Degree Relatives" / George M. ANDERSON in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 20p. Titre : Commentary on "Platelet Studies in Autism Spectrum Disorder Patients and First-Degree Relatives" Type de document : Texte imprimé et/ou numérique Auteurs : George M. ANDERSON, Auteur ; Edwin H. Jr COOK, Auteur Article en page(s) : 20p. Langues : Anglais (eng) Mots-clés : 5-ht  Autism  Hyperserotonemia  Platelet aggregation  Platelet count  Platelet functioning  Platelet release  Serotonin Index. décimale : PER Périodiques Résumé : We comment on the recent report entitled "Platelet Studies in Autism Spectrum Disorder Patients and First-Degree Relatives" [Molecular Autism 2015;6:57]. We find it commendable that the authors have investigated platelet factors potentially involved in the well-replicated observation of platelet hyperserotonemia in autism. However, we believe the results need a fuller discussion in the context of prior studies, think that certain aspects of the interpretation need to be reassessed, and attempt to provide a framework for further research in this area. En ligne : http://dx.doi.org/10.1186/s13229-016-0086-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Commentary on "Platelet Studies in Autism Spectrum Disorder Patients and First-Degree Relatives" [Texte imprimé et/ou numérique] / George M. ANDERSON, Auteur ; Edwin H. Jr COOK, Auteur . - 20p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 20p. Mots-clés : 5-ht  Autism  Hyperserotonemia  Platelet aggregation  Platelet count  Platelet functioning  Platelet release  Serotonin Index. décimale : PER Périodiques Résumé : We comment on the recent report entitled "Platelet Studies in Autism Spectrum Disorder Patients and First-Degree Relatives" [Molecular Autism 2015;6:57]. We find it commendable that the authors have investigated platelet factors potentially involved in the well-replicated observation of platelet hyperserotonemia in autism. However, we believe the results need a fuller discussion in the context of prior studies, think that certain aspects of the interpretation need to be reassessed, and attempt to provide a framework for further research in this area. En ligne : http://dx.doi.org/10.1186/s13229-016-0086-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Biological determinants of the origin and development of the opposite psychological and behavioral traits associated with autism spectrum disorders and Williams syndrome / Klara VERNEROVA in Research in Autism Spectrum Disorders, 118 (October 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 118 (October 2024) . - 102479 Titre : Biological determinants of the origin and development of the opposite psychological and behavioral traits associated with autism spectrum disorders and Williams syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Klara VERNEROVA, Auteur ; Roman SOLC, Auteur Article en page(s) : 102479 Langues : Anglais (eng) Mots-clés : Williams syndrome  Autism spectrum disorders  Duplication 7q11.23 syndrome  TFII-I genetic family  Hyperserotonemia  Timothy syndrome Index. décimale : PER Périodiques Résumé : Williams syndrome is a genetical disorder caused by microdeletion on chromosome 7, specifically of 7q11.23 region. Its phenotype is characterized by typical facial features, mild mental retardation, cardiovascular problems (patients often suffer from supravalvular aortic stenosis), gastrointestinal problems and endocrine abnormalities. However, Williams syndrome is best known for its unique behavioural-cognitive profile which leads to friendly, hypersocial and talkative personality. This specific neuropsychological profile is repeatedly considered to be the right opposite of the psychological profile, which is characteristic for people with autism spectrum disorder. Individuals with autism spectrum disorder often have severe impairments in social interaction, communication and they suffer from social anxieties. This contrasting cognitive-behavioural phenotype inspired many studies to examine possible biological causes, which might determine given personality features. Several results from these studies suggest that small genetical TFII-I family, which lies in the critical Williams syndrome region, could have a significant impact on the extent of personality qualities such as sociality and communication. En ligne : https://doi.org/10.1016/j.rasd.2024.102479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540 [article] Biological determinants of the origin and development of the opposite psychological and behavioral traits associated with autism spectrum disorders and Williams syndrome [Texte imprimé et/ou numérique] / Klara VERNEROVA, Auteur ; Roman SOLC, Auteur . - 102479. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 118 (October 2024) . - 102479 Mots-clés : Williams syndrome  Autism spectrum disorders  Duplication 7q11.23 syndrome  TFII-I genetic family  Hyperserotonemia  Timothy syndrome Index. décimale : PER Périodiques Résumé : Williams syndrome is a genetical disorder caused by microdeletion on chromosome 7, specifically of 7q11.23 region. Its phenotype is characterized by typical facial features, mild mental retardation, cardiovascular problems (patients often suffer from supravalvular aortic stenosis), gastrointestinal problems and endocrine abnormalities. However, Williams syndrome is best known for its unique behavioural-cognitive profile which leads to friendly, hypersocial and talkative personality. This specific neuropsychological profile is repeatedly considered to be the right opposite of the psychological profile, which is characteristic for people with autism spectrum disorder. Individuals with autism spectrum disorder often have severe impairments in social interaction, communication and they suffer from social anxieties. This contrasting cognitive-behavioural phenotype inspired many studies to examine possible biological causes, which might determine given personality features. Several results from these studies suggest that small genetical TFII-I family, which lies in the critical Williams syndrome region, could have a significant impact on the extent of personality qualities such as sociality and communication. En ligne : https://doi.org/10.1016/j.rasd.2024.102479 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=540

Serotonin Disturbance in Mouse Models of Autism Spectrum Disorders / Kota TAMADA

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Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder / E. AARON in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

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