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Genetic variation in serotonin transporter modulates tactile hyperresponsiveness in ASD / Kimberly B. SCHAUDER in Research in Autism Spectrum Disorders, 10 (February 2015)
[article]
Titre : Genetic variation in serotonin transporter modulates tactile hyperresponsiveness in ASD Type de document : Texte imprimé et/ou numérique Auteurs : Kimberly B. SCHAUDER, Auteur ; Christopher L. MULLER, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Carissa J. CASCIO, Auteur Article en page(s) : p.93-100 Langues : Anglais (eng) Mots-clés : SERT Tactile hyperresponsiveness Sensory processing Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Several lines of evidence implicate dysfunction of the serotonin (5-HT) system in autism spectrum disorder (ASD). Specifically, the serotonin transporter (5-HTT, SERT) has been scrutinized as an ASD candidate risk gene. SERT plays key roles in the development of circuits that underlie sensory function, particularly in the somatosensory system. One previous study in ASD found association of a rare, hyperfunctional SERT variant with sensory aversion, but studies of common SERT variants have never examined sensory symptoms in ASD. Using standardized caregiver assessments of sensory function in children, we evaluated patterns of sensory responsiveness in 47 children with ASD and 38 typically developing (TD) children. Study participants were genotyped for the functional SERT promoter polymorphisms, 5-HTTLPR and rs25531, to test the hypothesis that the higher expressing genotypes would be associated with hyperresponsiveness to touch, a common sensory aversion in ASD. All measures of sensory hypo- and hyperresponsiveness were increased in children with ASD, with hyporesponsive sensory patterns negatively correlated to age and hyperresponsive sensory patterns positively correlated to repetitive behavior. Strikingly, high-expressing SERT genotypes were associated with increased tactile hyperresponsiveness in the ASD group. Our findings indicate genetic variation that increases SERT function may specifically impact somatosensory processing in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.11.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Research in Autism Spectrum Disorders > 10 (February 2015) . - p.93-100[article] Genetic variation in serotonin transporter modulates tactile hyperresponsiveness in ASD [Texte imprimé et/ou numérique] / Kimberly B. SCHAUDER, Auteur ; Christopher L. MULLER, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Carissa J. CASCIO, Auteur . - p.93-100.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 10 (February 2015) . - p.93-100
Mots-clés : SERT Tactile hyperresponsiveness Sensory processing Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Several lines of evidence implicate dysfunction of the serotonin (5-HT) system in autism spectrum disorder (ASD). Specifically, the serotonin transporter (5-HTT, SERT) has been scrutinized as an ASD candidate risk gene. SERT plays key roles in the development of circuits that underlie sensory function, particularly in the somatosensory system. One previous study in ASD found association of a rare, hyperfunctional SERT variant with sensory aversion, but studies of common SERT variants have never examined sensory symptoms in ASD. Using standardized caregiver assessments of sensory function in children, we evaluated patterns of sensory responsiveness in 47 children with ASD and 38 typically developing (TD) children. Study participants were genotyped for the functional SERT promoter polymorphisms, 5-HTTLPR and rs25531, to test the hypothesis that the higher expressing genotypes would be associated with hyperresponsiveness to touch, a common sensory aversion in ASD. All measures of sensory hypo- and hyperresponsiveness were increased in children with ASD, with hyporesponsive sensory patterns negatively correlated to age and hyperresponsive sensory patterns positively correlated to repetitive behavior. Strikingly, high-expressing SERT genotypes were associated with increased tactile hyperresponsiveness in the ASD group. Our findings indicate genetic variation that increases SERT function may specifically impact somatosensory processing in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.11.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260