3 recherche sur le mot-clé 'autoantibodies'

Dysregulated plasma autoantibodies are associated with B cell dysfunction in young Arab children with autism spectrum disorder in Qatar / Samia M. LTAIEF in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.1974-1993 Titre : Dysregulated plasma autoantibodies are associated with B cell dysfunction in young Arab children with autism spectrum disorder in Qatar Type de document : texte imprimé Auteurs : Samia M. LTAIEF, Auteur ; Wared NOUR-ELDINE, Auteur ; Nimshitha Pavathuparambil Abdul MANAPH, Auteur ; Ti-Myen TAN, Auteur ; Nur Diana ANUAR, Auteur ; Ilham BENSMAIL, Auteur ; Jilbin GEORGE, Auteur ; Houari B. ABDESSELEM, Auteur ; Abeer R. AL-SHAMMARI, Auteur Article en page(s) : p.1974-1993 Langues : Anglais (eng) Mots-clés : ASD  autism  autoantibodies  B cells  biomarkers  demographics  flow cytometry  logistic regression Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction and communication, as well as the occurrence of stereotyped and repetitive behaviors. Previous studies have provided solid evidence of dysregulated immune system in ASD; however, limited studies have investigated autoantibody profiles in individuals with ASD. This study aims to screen plasma autoantibodies in a well-defined cohort of young children with ASD (n 100) and their matched controls (n 60) utilizing a high-throughput KoRectly Expressed (KREX) i-Ome protein-array technology. We identified differential protein expression of 16 autoantibodies in ASD, which were correlated with differential gene expression of these markers in independent ASD cohorts. Meanwhile, we identified a distinct list of 33 autoantibodies associated with ASD severity; several of which were correlated with maternal age and birth weight in ASD. In addition, we found dysregulated numbers of circulating B cells and activated HLADR+ B cells in ASD, which were correlated with altered levels of several autoantibodies. Further in-depth analysis of B cell subpopulations revealed an increased frequency of activated naïve B cells in ASD, as well as an association of resting naïve B cells and transitional B cells with ASD severity. Pathway enrichment analysis revealed disrupted MAPK signaling in ASD, suggesting a potential relevance of this pathway to altered autoantibodies and B cell dysfunction in ASD. Finally, we found that a combination of eight autoantibodies associated with ASD severity showed an area under the curve (ROC-AUC) of 0.937 (95% CI 0.890, 0.983; p?< 0.001), which demonstrated the diagnostic accuracy of the eight-marker signature in the severity classification of ASD cases. Overall, this study determined dysregulated autoantibody profiles and B cell dysfunction in children with ASD and identified an eight-autoantibody panel for ASD severity classification. En ligne : https://doi.org/10.1002/aur.3235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Dysregulated plasma autoantibodies are associated with B cell dysfunction in young Arab children with autism spectrum disorder in Qatar [texte imprimé] / Samia M. LTAIEF, Auteur ; Wared NOUR-ELDINE, Auteur ; Nimshitha Pavathuparambil Abdul MANAPH, Auteur ; Ti-Myen TAN, Auteur ; Nur Diana ANUAR, Auteur ; Ilham BENSMAIL, Auteur ; Jilbin GEORGE, Auteur ; Houari B. ABDESSELEM, Auteur ; Abeer R. AL-SHAMMARI, Auteur . - p.1974-1993. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.1974-1993 Mots-clés : ASD  autism  autoantibodies  B cells  biomarkers  demographics  flow cytometry  logistic regression Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction and communication, as well as the occurrence of stereotyped and repetitive behaviors. Previous studies have provided solid evidence of dysregulated immune system in ASD; however, limited studies have investigated autoantibody profiles in individuals with ASD. This study aims to screen plasma autoantibodies in a well-defined cohort of young children with ASD (n 100) and their matched controls (n 60) utilizing a high-throughput KoRectly Expressed (KREX) i-Ome protein-array technology. We identified differential protein expression of 16 autoantibodies in ASD, which were correlated with differential gene expression of these markers in independent ASD cohorts. Meanwhile, we identified a distinct list of 33 autoantibodies associated with ASD severity; several of which were correlated with maternal age and birth weight in ASD. In addition, we found dysregulated numbers of circulating B cells and activated HLADR+ B cells in ASD, which were correlated with altered levels of several autoantibodies. Further in-depth analysis of B cell subpopulations revealed an increased frequency of activated naïve B cells in ASD, as well as an association of resting naïve B cells and transitional B cells with ASD severity. Pathway enrichment analysis revealed disrupted MAPK signaling in ASD, suggesting a potential relevance of this pathway to altered autoantibodies and B cell dysfunction in ASD. Finally, we found that a combination of eight autoantibodies associated with ASD severity showed an area under the curve (ROC-AUC) of 0.937 (95% CI 0.890, 0.983; p?< 0.001), which demonstrated the diagnostic accuracy of the eight-marker signature in the severity classification of ASD cases. Overall, this study determined dysregulated autoantibody profiles and B cell dysfunction in children with ASD and identified an eight-autoantibody panel for ASD severity classification. En ligne : https://doi.org/10.1002/aur.3235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Folate receptor autoantibodies are prevalent in children diagnosed with autism spectrum disorder, their normal siblings and parents / V. QUADROS EDWARD in Autism Research, 11-5 (May 2018)  

Public ISBD [article]  inAutism Research > 11-5 (May 2018) . - p.707-712 Titre : Folate receptor autoantibodies are prevalent in children diagnosed with autism spectrum disorder, their normal siblings and parents Type de document : texte imprimé Auteurs : V. QUADROS EDWARD, Auteur ; Jeffrey M. SEQUEIRA, Auteur ; W. Ted BROWN, Auteur ; Clifford MEVS, Auteur ; Elaine MARCHI, Auteur ; Michael J. FLORY, Auteur ; Edmund C. JENKINS, Auteur ; Milen T. VELINOV, Auteur ; Ira L. COHEN, Auteur Article en page(s) : p.707-712 Langues : Anglais (eng) Mots-clés : autism  folate receptor  autoantibodies Index. décimale : PER Périodiques Résumé : Folate deficiency can affect fetal and neonatal brain development Considering the reported association of Folate receptor alpha (FRα) autoantibodies (Abs) with autism and developmental disorders, we sought to confirm this in families of 82 children with ASD, 53 unaffected siblings, 65 fathers, and 70 mothers, along with 52 unrelated normal controls. Overall, 76% of the affected children, 75% of the unaffected siblings, 69% of fathers and 59% of mothers were positive for either blocking or binding Ab, whereas the prevalence of this Ab in the normal controls was 29%. The Ab was highly prevalent in affected families including unaffected siblings. The appearance of these antibodies may have a familial origin but the risk of developing ASD is likely influenced by other mitigating factors since some siblings who had the antibodies were not affected. The antibody response appears heritable with the blocking autoantibody in the parents and affected child increasing the risk of ASD. Autism Res 2018, 11: 707 712. ? 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Folate is an essential nutrient during fetal and infant development. Autoantibodies against the folate receptor alpha can block folate transport from the mother to the fetus and to the brain in infants. Children diagnosed with autism and their immediate family members were evaluated for the prevalence of folate receptor autoantibodies. The autoantibody was highly prevalent in affected families with similar distribution in parents, normal siblings and affected children. The presence of these antibodies appears to have a familial origin and may contribute to developmental deficits when combined with other factors. En ligne : https://doi.org/10.1002/aur.1934 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Folate receptor autoantibodies are prevalent in children diagnosed with autism spectrum disorder, their normal siblings and parents [texte imprimé] / V. QUADROS EDWARD, Auteur ; Jeffrey M. SEQUEIRA, Auteur ; W. Ted BROWN, Auteur ; Clifford MEVS, Auteur ; Elaine MARCHI, Auteur ; Michael J. FLORY, Auteur ; Edmund C. JENKINS, Auteur ; Milen T. VELINOV, Auteur ; Ira L. COHEN, Auteur . - p.707-712. Langues : Anglais (eng) in Autism Research > 11-5 (May 2018) . - p.707-712 Mots-clés : autism  folate receptor  autoantibodies Index. décimale : PER Périodiques Résumé : Folate deficiency can affect fetal and neonatal brain development Considering the reported association of Folate receptor alpha (FRα) autoantibodies (Abs) with autism and developmental disorders, we sought to confirm this in families of 82 children with ASD, 53 unaffected siblings, 65 fathers, and 70 mothers, along with 52 unrelated normal controls. Overall, 76% of the affected children, 75% of the unaffected siblings, 69% of fathers and 59% of mothers were positive for either blocking or binding Ab, whereas the prevalence of this Ab in the normal controls was 29%. The Ab was highly prevalent in affected families including unaffected siblings. The appearance of these antibodies may have a familial origin but the risk of developing ASD is likely influenced by other mitigating factors since some siblings who had the antibodies were not affected. The antibody response appears heritable with the blocking autoantibody in the parents and affected child increasing the risk of ASD. Autism Res 2018, 11: 707 712. ? 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Folate is an essential nutrient during fetal and infant development. Autoantibodies against the folate receptor alpha can block folate transport from the mother to the fetus and to the brain in infants. Children diagnosed with autism and their immediate family members were evaluated for the prevalence of folate receptor autoantibodies. The autoantibody was highly prevalent in affected families with similar distribution in parents, normal siblings and affected children. The presence of these antibodies appears to have a familial origin and may contribute to developmental deficits when combined with other factors. En ligne : https://doi.org/10.1002/aur.1934 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

Behavioral Correlates of Maternal Antibody Status Among Children with Autism / Daniel BRAUNSCHWEIG in Journal of Autism and Developmental Disorders, 42-7 (July 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1435-1445 Titre : Behavioral Correlates of Maternal Antibody Status Among Children with Autism Type de document : texte imprimé Auteurs : Daniel BRAUNSCHWEIG, Auteur ; Paul DUNCANSON, Auteur ; Robert BOYCE, Auteur ; David J. HANSEN, Auteur ; Paul ASHWOOD, Auteur ; Isaac N. PESSAH, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Judy VAN DE WATER, Auteur Année de publication : 2012 Article en page(s) : p.1435-1445 Langues : Anglais (eng) Mots-clés : Autism  Maternal antibodies  Autoantibodies  Fetal brain  Immunologie Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes. En ligne : http://dx.doi.org/10.1007/s10803-011-1378-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 [article] Behavioral Correlates of Maternal Antibody Status Among Children with Autism [texte imprimé] / Daniel BRAUNSCHWEIG, Auteur ; Paul DUNCANSON, Auteur ; Robert BOYCE, Auteur ; David J. HANSEN, Auteur ; Paul ASHWOOD, Auteur ; Isaac N. PESSAH, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Judy VAN DE WATER, Auteur . - 2012 . - p.1435-1445. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1435-1445 Mots-clés : Autism  Maternal antibodies  Autoantibodies  Fetal brain  Immunologie Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes. En ligne : http://dx.doi.org/10.1007/s10803-011-1378-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166