[article]
| Titre : |
Classification of Behaviorally Defined Disorders: Biology Versus the DSM |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Isabelle RAPIN, Auteur |
| Article en page(s) : |
p.2661-2666 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Nosology DSM RDoC Behavioral classification Biologic classification Pathogenesis |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Three levels of investigation underlie all biologically based attempts at classification of behaviorally defined developmental and psychiatric disorders: Level A, pseudo-categorical classification of mostly dimensional descriptions of behaviors and their disorders included in the 2013 American Psychiatric Association’s Fifth Edition of the Diagnostic and Statistical Manual (DSM-5); Level C, mostly categorical classification of genetic and environmental causes (etiologies) of Level A disorders; and Level B, the pathophysiologic—both categorical and dimensional—biologic mechanisms underlying Level A “diagnoses” which comprise hierarchically interacting molecular, cellular, and neural networks and major brain pathways orchestrated by Level C etiologies. Besides modest numbers of effective psychotropic medications and their derivatives, major advances in treatment have addressed the behavioral symptoms of Level A-defined developmental and psychiatric disorders. The National Institute of Mental Health proposes support for a new biologically based Research Domain Criteria (RDoC) classification; its goal is to apply to behaviorally defined Level A developmental and psychiatric disorders the biologically based Level C and Level B research strategies that have greatly accelerated treatment and prevention of medical disorders. It plans to supplement effective educational and behavioral symptom-based interventions with faster, more potent and specific biologic therapies and, hopefully, to discover how effective behavioral interventions alter brain function. This commentary raises the question of whether a hybrid nosology that maps biology onto behavior is attainable. At a minimum, such a nosologic effort requires greater in-depth and better informed dialog between investigators of behavior and biology than occurs typically, and more realistic communication of the implications of research results to the public. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-014-2127-5 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 |
in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2661-2666
[article] Classification of Behaviorally Defined Disorders: Biology Versus the DSM [Texte imprimé et/ou numérique] / Isabelle RAPIN, Auteur . - p.2661-2666. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2661-2666
| Mots-clés : |
Nosology DSM RDoC Behavioral classification Biologic classification Pathogenesis |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Three levels of investigation underlie all biologically based attempts at classification of behaviorally defined developmental and psychiatric disorders: Level A, pseudo-categorical classification of mostly dimensional descriptions of behaviors and their disorders included in the 2013 American Psychiatric Association’s Fifth Edition of the Diagnostic and Statistical Manual (DSM-5); Level C, mostly categorical classification of genetic and environmental causes (etiologies) of Level A disorders; and Level B, the pathophysiologic—both categorical and dimensional—biologic mechanisms underlying Level A “diagnoses” which comprise hierarchically interacting molecular, cellular, and neural networks and major brain pathways orchestrated by Level C etiologies. Besides modest numbers of effective psychotropic medications and their derivatives, major advances in treatment have addressed the behavioral symptoms of Level A-defined developmental and psychiatric disorders. The National Institute of Mental Health proposes support for a new biologically based Research Domain Criteria (RDoC) classification; its goal is to apply to behaviorally defined Level A developmental and psychiatric disorders the biologically based Level C and Level B research strategies that have greatly accelerated treatment and prevention of medical disorders. It plans to supplement effective educational and behavioral symptom-based interventions with faster, more potent and specific biologic therapies and, hopefully, to discover how effective behavioral interventions alter brain function. This commentary raises the question of whether a hybrid nosology that maps biology onto behavior is attainable. At a minimum, such a nosologic effort requires greater in-depth and better informed dialog between investigators of behavior and biology than occurs typically, and more realistic communication of the implications of research results to the public. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-014-2127-5 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 |
|
Classification of Behaviorally Defined Disorders: Biology Versus the DSM in Journal of Autism and Developmental Disorders, 44-10 (October 2014)
