[article] 
inMolecular Autism > 10 (2019) . - 27 p.

Titre :	Generalizability and reproducibility of functional connectivity in autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	J. B. KING, Auteur ; M. B. D. PRIGGE, Auteur ; C. K. KING, Auteur ; J. MORGAN, Auteur ; F. WEATHERSBY, Auteur ; J. C. FOX, Auteur ; D. C. DEAN, Auteur ; A. FREEMAN, Auteur ; J. A. M. VILLARUZ, Auteur ; Karen L. KANE, Auteur ; Erin D. BIGLER, Auteur ; A. L. ALEXANDER, Auteur ; N. LANGE, Auteur ; B. ZIELINSKI, Auteur ; J. E. LAINHART, Auteur ; Jeffrey S. ANDERSON, Auteur
Article en page(s) :	27 p.
Langues :	Anglais (eng)
Mots-clés :	Autism spectrum conditions  Functional connectivity MRI  Replicability  Reproducibility  Resting-state  fMRI
Index. décimale :	PER Périodiques
Résumé :	Background: Autism is hypothesized to represent a disorder of brain connectivity, yet patterns of atypical functional connectivity show marked heterogeneity across individuals. Methods: We used a large multi-site dataset comprised of a heterogeneous population of individuals with autism and typically developing individuals to compare a number of resting-state functional connectivity features of autism. These features were also tested in a single site sample that utilized a high-temporal resolution, long-duration resting-state acquisition technique. Results: No one method of analysis provided reproducible results across research sites, combined samples, and the high-resolution dataset. Distinct categories of functional connectivity features that differed in autism such as homotopic, default network, salience network, long-range connections, and corticostriatal connectivity, did not align with differences in clinical and behavioral traits in individuals with autism. One method, lag-based functional connectivity, was not correlated to other methods in describing patterns of resting-state functional connectivity and their relationship to autism traits. Conclusion: Overall, functional connectivity features predictive of autism demonstrated limited generalizability across sites, with consistent results only for large samples. Different types of functional connectivity features do not consistently predict different symptoms of autism. Rather, specific features that predict autism symptoms are distributed across feature types.
En ligne :	https://dx.doi.org/10.1186/s13229-019-0273-5
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

[article] Generalizability and reproducibility of functional connectivity in autism [Texte imprimé et/ou numérique] / J. B. KING, Auteur ; M. B. D. PRIGGE, Auteur ; C. K. KING, Auteur ; J. MORGAN, Auteur ; F. WEATHERSBY, Auteur ; J. C. FOX, Auteur ; D. C. DEAN, Auteur ; A. FREEMAN, Auteur ; J. A. M. VILLARUZ, Auteur ; Karen L. KANE, Auteur ; Erin D. BIGLER, Auteur ; A. L. ALEXANDER, Auteur ; N. LANGE, Auteur ; B. ZIELINSKI, Auteur ; J. E. LAINHART, Auteur ; Jeffrey S. ANDERSON, Auteur . - 27 p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 27 p.

Mots-clés :	Autism spectrum conditions  Functional connectivity MRI  Replicability  Reproducibility  Resting-state  fMRI
Index. décimale :	PER Périodiques
Résumé :	Background: Autism is hypothesized to represent a disorder of brain connectivity, yet patterns of atypical functional connectivity show marked heterogeneity across individuals. Methods: We used a large multi-site dataset comprised of a heterogeneous population of individuals with autism and typically developing individuals to compare a number of resting-state functional connectivity features of autism. These features were also tested in a single site sample that utilized a high-temporal resolution, long-duration resting-state acquisition technique. Results: No one method of analysis provided reproducible results across research sites, combined samples, and the high-resolution dataset. Distinct categories of functional connectivity features that differed in autism such as homotopic, default network, salience network, long-range connections, and corticostriatal connectivity, did not align with differences in clinical and behavioral traits in individuals with autism. One method, lag-based functional connectivity, was not correlated to other methods in describing patterns of resting-state functional connectivity and their relationship to autism traits. Conclusion: Overall, functional connectivity features predictive of autism demonstrated limited generalizability across sites, with consistent results only for large samples. Different types of functional connectivity features do not consistently predict different symptoms of autism. Rather, specific features that predict autism symptoms are distributed across feature types.
En ligne :	https://dx.doi.org/10.1186/s13229-019-0273-5
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408