Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder / Rebecca A. LUNDWALL in Research in Autism Spectrum Disorders, 34 (February 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 34 (February 2017) . - p.44-51 Titre : Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder Type de document : texte imprimé Auteurs : Rebecca A. LUNDWALL, Auteur ; Kevin G. STEPHENSON, Auteur ; E. Shannon NEELEY-TASS, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Emily I. ANDERBERG, Auteur ; Molly D. PRIGGE, Auteur ; Blake D. HANSEN, Auteur ; Janet E. LAINHART, Auteur ; Ryan O. KELLEMS, Auteur ; Jo Ann PETRIE, Auteur ; Terisa P. GABRIELSEN, Auteur Article en page(s) : p.44-51 Langues : Anglais (eng) Mots-clés : Autism  Aggression  Imaging  Brainstem  Structural MRI Index. décimale : PER Périodiques Résumé : AbstractBackground Aggressive behaviors are common in individuals diagnosed with autism spectrum disorder (ASD) and may be phenotypic indicators of different subtypes within ASD. In current research literature for non-ASD samples, aggression has been linked to several brain structures associated with emotion and behavioral control. However, few if any studies exist investigating brain volume differences in individuals with ASD who have comorbid aggression as indicated by standardized diagnostic and behavioral measures. Method We examined neuroimaging data from individuals rigorously diagnosed with ASD versus typically developing (TD) controls. We began with data from brain volume regions of interest (ROI) taken from previous literature on aggression including the brainstem, amygdala, orbitofrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex. We defined aggression status using the Irritability subscale of the Aberrant Behavior Checklist and used lasso logistic regression to select among these predictor variables. Brainstem volume was the only variable shown to be a predictor of aggression status. Results We found that smaller brainstem volumes are associated with higher odds of being in the high aggression group. Conclusions Understanding brain differences in individuals with ASD who engage in aggressive behavior from those with ASD who do not can inform treatment approaches. Future research should investigate brainstem structure and function in ASD to identify possible mechanisms related to arousal and aggression. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Relationship between brain stem volume and aggression in children diagnosed with autism spectrum disorder [texte imprimé] / Rebecca A. LUNDWALL, Auteur ; Kevin G. STEPHENSON, Auteur ; E. Shannon NEELEY-TASS, Auteur ; Jonathan C. COX, Auteur ; Mikle SOUTH, Auteur ; Erin D. BIGLER, Auteur ; Emily I. ANDERBERG, Auteur ; Molly D. PRIGGE, Auteur ; Blake D. HANSEN, Auteur ; Janet E. LAINHART, Auteur ; Ryan O. KELLEMS, Auteur ; Jo Ann PETRIE, Auteur ; Terisa P. GABRIELSEN, Auteur . - p.44-51. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 34 (February 2017) . - p.44-51 Mots-clés : Autism  Aggression  Imaging  Brainstem  Structural MRI Index. décimale : PER Périodiques Résumé : AbstractBackground Aggressive behaviors are common in individuals diagnosed with autism spectrum disorder (ASD) and may be phenotypic indicators of different subtypes within ASD. In current research literature for non-ASD samples, aggression has been linked to several brain structures associated with emotion and behavioral control. However, few if any studies exist investigating brain volume differences in individuals with ASD who have comorbid aggression as indicated by standardized diagnostic and behavioral measures. Method We examined neuroimaging data from individuals rigorously diagnosed with ASD versus typically developing (TD) controls. We began with data from brain volume regions of interest (ROI) taken from previous literature on aggression including the brainstem, amygdala, orbitofrontal cortex, anterior cingulate cortex, and dorsolateral prefrontal cortex. We defined aggression status using the Irritability subscale of the Aberrant Behavior Checklist and used lasso logistic regression to select among these predictor variables. Brainstem volume was the only variable shown to be a predictor of aggression status. Results We found that smaller brainstem volumes are associated with higher odds of being in the high aggression group. Conclusions Understanding brain differences in individuals with ASD who engage in aggressive behavior from those with ASD who do not can inform treatment approaches. Future research should investigate brainstem structure and function in ASD to identify possible mechanisms related to arousal and aggression. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.12.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Silently screaming: A collective case study of non-suicidal self-injury in women with autistic traits / Rebecca A. LUNDWALL in Research in Autism, 128 (October 2025)  

Public ISBD [article]  inResearch in Autism > 128 (October 2025) . - p.202725 Titre : Silently screaming: A collective case study of non-suicidal self-injury in women with autistic traits Type de document : texte imprimé Auteurs : Rebecca A. LUNDWALL, Auteur ; Elizabeth A. CUTRER-PÁRRAGA, Auteur ; Rachel LUNDWALL, Auteur ; Megan E. SQUIRES, Auteur ; Jonathan S. BECK, Auteur ; Terisa P. GABRIELSEN, Auteur Article en page(s) : p.202725 Langues : Anglais (eng) Mots-clés : Autism  Self-harm  Non-suicidal self-injury  Deliberate self-harm  Female Index. décimale : PER Périodiques Résumé : Introduction Recognition of autism in females has been growing, with concerns that NSSI is more common in this group. Listening to autistic women who self-harm can expand understanding and improve support. Methods Adult autistic females and those with a clinical best estimate of autism completed a developmental screener, the Suicide Behavior Questionnaire-Revised (SBQ-R), and follow-up interviews prompting collective case study analysis of 23 transcriptions (n = 13 autism; n = 10 clinical best estimate of autism). Insider and external autism experts reviewed analyses. Results Eighteen of the 23 participants self-injured. We found younger ages of onset for self-injury (as early as 8 years old) than previously reported in other studies. Powerlessness, self-punishment for social mistakes, and difficulty displaying the “right” emotions were common themes related to reasons why autistic women self-injured. Experiences of NSSI aligned with literature linking it to the need for emotional regulation and focus when overwhelmed. Cutting was sometimes associated with suicidal thoughts/behaviors. Our inside experts were people with lived experience of autism, and they reviewed the study’s findings. Conclusion Participants reported that parents, therapists, and clergy who listened without judgment and validated social stressors were helpful. Dismissive reactions, assumptions regarding motivations, and hospitalization were described as not helpful. Overall, participants expressed a desire for greater self-control over quality of life. En ligne : https://doi.org/10.1016/j.reia.2025.202725 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Silently screaming: A collective case study of non-suicidal self-injury in women with autistic traits [texte imprimé] / Rebecca A. LUNDWALL, Auteur ; Elizabeth A. CUTRER-PÁRRAGA, Auteur ; Rachel LUNDWALL, Auteur ; Megan E. SQUIRES, Auteur ; Jonathan S. BECK, Auteur ; Terisa P. GABRIELSEN, Auteur . - p.202725. Langues : Anglais (eng) in Research in Autism > 128 (October 2025) . - p.202725 Mots-clés : Autism  Self-harm  Non-suicidal self-injury  Deliberate self-harm  Female Index. décimale : PER Périodiques Résumé : Introduction Recognition of autism in females has been growing, with concerns that NSSI is more common in this group. Listening to autistic women who self-harm can expand understanding and improve support. Methods Adult autistic females and those with a clinical best estimate of autism completed a developmental screener, the Suicide Behavior Questionnaire-Revised (SBQ-R), and follow-up interviews prompting collective case study analysis of 23 transcriptions (n = 13 autism; n = 10 clinical best estimate of autism). Insider and external autism experts reviewed analyses. Results Eighteen of the 23 participants self-injured. We found younger ages of onset for self-injury (as early as 8 years old) than previously reported in other studies. Powerlessness, self-punishment for social mistakes, and difficulty displaying the “right” emotions were common themes related to reasons why autistic women self-injured. Experiences of NSSI aligned with literature linking it to the need for emotional regulation and focus when overwhelmed. Cutting was sometimes associated with suicidal thoughts/behaviors. Our inside experts were people with lived experience of autism, and they reviewed the study’s findings. Conclusion Participants reported that parents, therapists, and clergy who listened without judgment and validated social stressors were helpful. Dismissive reactions, assumptions regarding motivations, and hospitalization were described as not helpful. Overall, participants expressed a desire for greater self-control over quality of life. En ligne : https://doi.org/10.1016/j.reia.2025.202725 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

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