Documents disponibles écrits par cet auteur

Brief Report: Mediation of Treatment Effect in a Communication Intervention for Pre-School Children with Autism / Catherine ALDRED in Journal of Autism and Developmental Disorders, 42-3 (March 2012) 

Public ISBD [article]  in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.447-454 Titre : Brief Report: Mediation of Treatment Effect in a Communication Intervention for Pre-School Children with Autism Type de document : texte imprimé Auteurs : Catherine ALDRED, Auteur ; Jonathan GREEN, Auteur ; Richard EMSLEY, Auteur ; Helen McCONACHIE, Auteur Année de publication : 2012 Article en page(s) : p.447-454 Langues : Anglais (eng) Mots-clés : Pre-school child  Intervention trial  Parental synchrony  Mediation Index. décimale : PER Périodiques Résumé : Tests of mediation in treatment trials can illuminate processes of change and suggest causal influences in development. We conducted a mediation analysis of a previously published randomised controlled trial of parent-mediated communication-focused treatment for autism against ordinary care, with 28 children aged 2–5 years (Aldred et al. in J Child Psychol Psychiatr 45:1–11, 2004). The hypothesised mediating process, targeted by the intervention, was an increase in parental synchronous response within parent–child interaction. The results showed partial mediation, with change in synchrony accounting for 34% of the positive intervention effect on autism symptomatology (Autism Diagnostic Observation Schedule communication and social domain algorithm); the result was confirmed by bootstrap estimation. Improved parental synchronous response to child communication can alter short-term autism symptom outcome with targeted therapy. En ligne : http://dx.doi.org/10.1007/s10803-011-1248-3 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1527 [article] Brief Report: Mediation of Treatment Effect in a Communication Intervention for Pre-School Children with Autism [texte imprimé] / Catherine ALDRED, Auteur ; Jonathan GREEN, Auteur ; Richard EMSLEY, Auteur ; Helen McCONACHIE, Auteur . - 2012 . - p.447-454. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.447-454 Mots-clés : Pre-school child  Intervention trial  Parental synchrony  Mediation Index. décimale : PER Périodiques Résumé : Tests of mediation in treatment trials can illuminate processes of change and suggest causal influences in development. We conducted a mediation analysis of a previously published randomised controlled trial of parent-mediated communication-focused treatment for autism against ordinary care, with 28 children aged 2–5 years (Aldred et al. in J Child Psychol Psychiatr 45:1–11, 2004). The hypothesised mediating process, targeted by the intervention, was an increase in parental synchronous response within parent–child interaction. The results showed partial mediation, with change in synchrony accounting for 34% of the positive intervention effect on autism symptomatology (Autism Diagnostic Observation Schedule communication and social domain algorithm); the result was confirmed by bootstrap estimation. Improved parental synchronous response to child communication can alter short-term autism symptom outcome with targeted therapy. En ligne : http://dx.doi.org/10.1007/s10803-011-1248-3 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1527

Service and Wider Societal Costs of Very Young Children with Autism in the UK / Barbara BARRETT in Journal of Autism and Developmental Disorders, 42-5 (May 2012) 

Public ISBD [article]  in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.797-804 Titre : Service and Wider Societal Costs of Very Young Children with Autism in the UK Type de document : texte imprimé Auteurs : Barbara BARRETT, Auteur ; Sarah BYFORD, Auteur ; Jessica SHARAC, Auteur ; Kristelle HUDRY, Auteur ; Kathy LEADBITTER, Auteur ; Kathryn TEMPLE, Auteur ; Catherine ALDRED, Auteur ; Vicky SLONIMS, Auteur ; Jonathan GREEN, Auteur ; PACT Consortium, Auteur Année de publication : 2012 Article en page(s) : p.797-804 Langues : Anglais (eng) Catégories : AUTISME ENFANT SOIN Mots-clés : Cost  Very young children  Autism  Service use Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with a substantial economic burden, but there is little evidence of the costs in the early years; the period in which children are increasingly likely to be diagnosed. We describe the services used by 152 children aged 24–60 months with autism, report family out-of-pocket expenses and productivity losses, and explore the relationship between family characteristics and costs. Children received a wide range of hospital and community services including relatively high levels of contact with speech and language therapists and paediatricians. Total service costs varied greatly (mean £430 per month; range £53 to £1,116), with some families receiving little statutory support. Higher costs were associated with increasing age and symptom severity. En ligne : http://dx.doi.org/10.1007/s10803-011-1306-x Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1546 [article] Service and Wider Societal Costs of Very Young Children with Autism in the UK [texte imprimé] / Barbara BARRETT, Auteur ; Sarah BYFORD, Auteur ; Jessica SHARAC, Auteur ; Kristelle HUDRY, Auteur ; Kathy LEADBITTER, Auteur ; Kathryn TEMPLE, Auteur ; Catherine ALDRED, Auteur ; Vicky SLONIMS, Auteur ; Jonathan GREEN, Auteur ; PACT Consortium, Auteur . - 2012 . - p.797-804. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-5 (May 2012) . - p.797-804 Catégories : AUTISME ENFANT SOIN Mots-clés : Cost  Very young children  Autism  Service use Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with a substantial economic burden, but there is little evidence of the costs in the early years; the period in which children are increasingly likely to be diagnosed. We describe the services used by 152 children aged 24–60 months with autism, report family out-of-pocket expenses and productivity losses, and explore the relationship between family characteristics and costs. Children received a wide range of hospital and community services including relatively high levels of contact with speech and language therapists and paediatricians. Total service costs varied greatly (mean £430 per month; range £53 to £1,116), with some families receiving little statutory support. Higher costs were associated with increasing age and symptom severity. En ligne : http://dx.doi.org/10.1007/s10803-011-1306-x Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1546

Treatment mechanism in the MRC preschool autism communication trial: implications for study design and parent-focussed therapy for children / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 56-2 (February 2015) 

Public ISBD [article]  in Journal of Child Psychology and Psychiatry > 56-2 (February 2015) . - p.162-170 Titre : Treatment mechanism in the MRC preschool autism communication trial: implications for study design and parent-focussed therapy for children Type de document : texte imprimé Auteurs : Andrew PICKLES, Auteur ; Victoria HARRIS, Auteur ; Jonathan GREEN, Auteur ; Catherine ALDRED, Auteur ; Helen McCONACHIE, Auteur ; Vicky SLONIMS, Auteur ; Ann LE COUTEUR, Auteur ; Kristelle HUDRY, Auteur ; Tony CHARMAN, Auteur ; THE PACT CONSORTIUM,, Auteur Article en page(s) : p.162-170 Langues : Anglais (eng) Mots-clés : Autism  measurement error  mediation  parent–child interaction  parent-focussed therapy Index. décimale : PER Périodiques Résumé : Background The PACT randomised-controlled trial evaluated a parent-mediated communication-focused treatment for children with autism, intended to reduce symptom severity as measured by a modified Autism Diagnostic Observation Schedule-Generic (ADOS-G) algorithm score. The therapy targeted parental behaviour, with no direct interaction between therapist and child. While nonsignificant group differences were found on ADOS-G score, significant group differences were found for both parent and child intermediate outcomes. This study aimed to better understand the mechanism by which the PACT treatment influenced changes in child behaviour though the targeted parent behaviour. Methods Mediation analysis was used to assess the direct and indirect effects of treatment via parent behaviour on child behaviour and via child behaviour on ADOS-G score. Alternative mediation was explored to study whether the treatment effect acted as hypothesised or via another plausible pathway. Mediation models typically assume no unobserved confounding between mediator and outcome and no measurement error in the mediator. We show how to better exploit the information often available within a trial to begin to address these issues, examining scope for instrumental variable and measurement error models. Results Estimates of mediation changed substantially when account was taken of the confounder effects of the baseline value of the mediator and of measurement error. Our best estimates that accounted for both suggested that the treatment effect on the ADOS-G score was very substantially mediated by parent synchrony and child initiations. Conclusions The results highlighted the value of repeated measurement of mediators during trials. The theoretical model underlying the PACT treatment was supported. However, the substantial fall-off in treatment effect highlighted both the need for additional data and for additional target behaviours for therapy. En ligne : http://dx.doi.org/10.1111/jcpp.12291 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2599 [article] Treatment mechanism in the MRC preschool autism communication trial: implications for study design and parent-focussed therapy for children [texte imprimé] / Andrew PICKLES, Auteur ; Victoria HARRIS, Auteur ; Jonathan GREEN, Auteur ; Catherine ALDRED, Auteur ; Helen McCONACHIE, Auteur ; Vicky SLONIMS, Auteur ; Ann LE COUTEUR, Auteur ; Kristelle HUDRY, Auteur ; Tony CHARMAN, Auteur ; THE PACT CONSORTIUM,, Auteur . - p.162-170. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-2 (February 2015) . - p.162-170 Mots-clés : Autism  measurement error  mediation  parent–child interaction  parent-focussed therapy Index. décimale : PER Périodiques Résumé : Background The PACT randomised-controlled trial evaluated a parent-mediated communication-focused treatment for children with autism, intended to reduce symptom severity as measured by a modified Autism Diagnostic Observation Schedule-Generic (ADOS-G) algorithm score. The therapy targeted parental behaviour, with no direct interaction between therapist and child. While nonsignificant group differences were found on ADOS-G score, significant group differences were found for both parent and child intermediate outcomes. This study aimed to better understand the mechanism by which the PACT treatment influenced changes in child behaviour though the targeted parent behaviour. Methods Mediation analysis was used to assess the direct and indirect effects of treatment via parent behaviour on child behaviour and via child behaviour on ADOS-G score. Alternative mediation was explored to study whether the treatment effect acted as hypothesised or via another plausible pathway. Mediation models typically assume no unobserved confounding between mediator and outcome and no measurement error in the mediator. We show how to better exploit the information often available within a trial to begin to address these issues, examining scope for instrumental variable and measurement error models. Results Estimates of mediation changed substantially when account was taken of the confounder effects of the baseline value of the mediator and of measurement error. Our best estimates that accounted for both suggested that the treatment effect on the ADOS-G score was very substantially mediated by parent synchrony and child initiations. Conclusions The results highlighted the value of repeated measurement of mediators during trials. The theoretical model underlying the PACT treatment was supported. However, the substantial fall-off in treatment effect highlighted both the need for additional data and for additional target behaviours for therapy. En ligne : http://dx.doi.org/10.1111/jcpp.12291 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2599