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Auteur Jan K. BUITELAAR |
Documents disponibles écrits par cet auteur (111)
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Processing of Emotion Words by Patients with Autism Spectrum Disorders: Evidence from Reaction Times and EEG / Alina LARTSEVA in Journal of Autism and Developmental Disorders, 44-11 (November 2014)
[article]
Titre : Processing of Emotion Words by Patients with Autism Spectrum Disorders: Evidence from Reaction Times and EEG Type de document : Texte imprimé et/ou numérique Auteurs : Alina LARTSEVA, Auteur ; Ton DIJKSTRA, Auteur ; Cornelis C. KAN, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : p.2882-2894 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders EEG ERP Emotion words LPC Lexical decision task Index. décimale : PER Périodiques Résumé : This study investigated processing of emotion words in autism spectrum disorders (ASD) using reaction times and event-related potentials (ERP). Adults with (n = 21) and without (n = 20) ASD performed a lexical decision task on emotion and neutral words while their brain activity was recorded. Both groups showed faster responses to emotion words compared to neutral, suggesting intact early processing of emotion in ASD. In the ERPs, the control group showed a typical late positive component (LPC) at 400–600 ms for emotion words compared to neutral, while the ASD group showed no LPC. The between-group difference in LPC amplitude was significant, suggesting that emotion words were processed differently by individuals with ASD, although their behavioral performance was similar to that of typical individuals. En ligne : http://dx.doi.org/10.1007/s10803-014-2149-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2882-2894[article] Processing of Emotion Words by Patients with Autism Spectrum Disorders: Evidence from Reaction Times and EEG [Texte imprimé et/ou numérique] / Alina LARTSEVA, Auteur ; Ton DIJKSTRA, Auteur ; Cornelis C. KAN, Auteur ; Jan K. BUITELAAR, Auteur . - p.2882-2894.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2882-2894
Mots-clés : Autism spectrum disorders EEG ERP Emotion words LPC Lexical decision task Index. décimale : PER Périodiques Résumé : This study investigated processing of emotion words in autism spectrum disorders (ASD) using reaction times and event-related potentials (ERP). Adults with (n = 21) and without (n = 20) ASD performed a lexical decision task on emotion and neutral words while their brain activity was recorded. Both groups showed faster responses to emotion words compared to neutral, suggesting intact early processing of emotion in ASD. In the ERPs, the control group showed a typical late positive component (LPC) at 400–600 ms for emotion words compared to neutral, while the ASD group showed no LPC. The between-group difference in LPC amplitude was significant, suggesting that emotion words were processed differently by individuals with ASD, although their behavioral performance was similar to that of typical individuals. En ligne : http://dx.doi.org/10.1007/s10803-014-2149-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11 / Judith S. NIJMEIJER in Journal of Autism and Developmental Disorders, 44-7 (July 2014)
[article]
Titre : Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11 Type de document : Texte imprimé et/ou numérique Auteurs : Judith S. NIJMEIJER, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Nanda N. ROMMELSE, Auteur ; Marieke E. ALTINK, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Ellen A. FLIERS, Auteur ; Barbara FRANKE, Auteur ; Ruud B. MINDERAA, Auteur ; Joseph A. SERGEANT, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur Article en page(s) : p.1671-1680 Langues : Anglais (eng) Mots-clés : ASD ADHD Comorbidity Genetics Index. décimale : PER Périodiques Résumé : We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children’s Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing. En ligne : http://dx.doi.org/10.1007/s10803-014-2039-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236
in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1671-1680[article] Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11 [Texte imprimé et/ou numérique] / Judith S. NIJMEIJER, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Nanda N. ROMMELSE, Auteur ; Marieke E. ALTINK, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Ellen A. FLIERS, Auteur ; Barbara FRANKE, Auteur ; Ruud B. MINDERAA, Auteur ; Joseph A. SERGEANT, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur . - p.1671-1680.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1671-1680
Mots-clés : ASD ADHD Comorbidity Genetics Index. décimale : PER Périodiques Résumé : We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children’s Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing. En ligne : http://dx.doi.org/10.1007/s10803-014-2039-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 A randomised controlled trial (MindChamp) of a mindfulness-based intervention for children with ADHD and their parents / N. M. SIEBELINK in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)
[article]
Titre : A randomised controlled trial (MindChamp) of a mindfulness-based intervention for children with ADHD and their parents Type de document : Texte imprimé et/ou numérique Auteurs : N. M. SIEBELINK, Auteur ; Susan M. BOGELS, Auteur ; A. E. M. SPECKENS, Auteur ; J. T. DAMMERS, Auteur ; T. WOLFERS, Auteur ; Jan K. BUITELAAR, Auteur ; C. U. GREVEN, Auteur Article en page(s) : p.165-177 Langues : Anglais (eng) Mots-clés : Adhd executive functions mindfulness parenting Index. décimale : PER Périodiques Résumé : BACKGROUND: Family mindfulness-based intervention (MBI) for child attention-deficit/hyperactivity disorder (ADHD) targets child self-control, parenting and parental mental health, but its effectiveness is still unclear. METHODS: MindChamp is a pre-registered randomised controlled trial comparing an 8-week family MBI (called 'MYmind') in addition to care-as-usual (CAU) (n?=?55) with CAU-only (n?=?48). Children aged 8-16?years with remaining ADHD symptoms after CAU were enrolled together with a parent. Primary outcome was post-treatment parent-rated child self-control deficits (BRIEF); post hoc, Reliable Change Indexes were explored. Secondary child outcomes included ADHD symptoms (parent/teacher-rated Conners' and SWAN; teacher-rated BRIEF), other psychological symptoms (parent/teacher-rated), well-being (parent-rated) and mindfulness (self-rated). Secondary parent outcomes included self-ratings of ADHD symptoms, other psychological symptoms, well-being, self-compassion and mindful parenting. Assessments were conducted at post-treatment, 2- and 6-month follow-up. RESULTS: Relative to CAU-only, MBI+CAU resulted in a small, statistically non-significant post-treatment improvement on the BRIEF (intention-to-treat: d?=?0.27, p?=?.18; per protocol: d?=?0.33, p?=?.11). Significantly more children showed reliable post-treatment improvement following MBI+CAU versus CAU-only (32% versus 11%, p?.05, Number-Needed-to-Treat?=?4.7). ADHD symptoms significantly reduced post-treatment according to parent (Conners' and SWAN) and teacher ratings (BRIEF) per protocol. Only parent-rated hyperactivity impulsivity (SWAN) remained significantly reduced at 6-month follow-up. Post-treatment group differences on other secondary child outcomes were consistently favour of MBI+CAU, but mostly non-significant; no significant differences were found at follow-ups. Regarding parent outcomes, significant post-treatment improvements were found for their own ADHD symptoms, well-being and mindful parenting. At follow-ups, some significant effects remained (ADHD symptoms, mindful parenting), some additional significant effects appeared (other psychological symptoms, self-compassion) and others disappeared/remained non-significant. CONCLUSIONS: Family MBI+CAU did not outperform CAU-only in reducing child self-control deficits on a group level but more children reliably improved. Effects on parents were larger and more durable. When CAU for ADHD is insufficient, family MBI could be a valuable addition. En ligne : http://dx.doi.org/10.1111/jcpp.13430 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457
in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.165-177[article] A randomised controlled trial (MindChamp) of a mindfulness-based intervention for children with ADHD and their parents [Texte imprimé et/ou numérique] / N. M. SIEBELINK, Auteur ; Susan M. BOGELS, Auteur ; A. E. M. SPECKENS, Auteur ; J. T. DAMMERS, Auteur ; T. WOLFERS, Auteur ; Jan K. BUITELAAR, Auteur ; C. U. GREVEN, Auteur . - p.165-177.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.165-177
Mots-clés : Adhd executive functions mindfulness parenting Index. décimale : PER Périodiques Résumé : BACKGROUND: Family mindfulness-based intervention (MBI) for child attention-deficit/hyperactivity disorder (ADHD) targets child self-control, parenting and parental mental health, but its effectiveness is still unclear. METHODS: MindChamp is a pre-registered randomised controlled trial comparing an 8-week family MBI (called 'MYmind') in addition to care-as-usual (CAU) (n?=?55) with CAU-only (n?=?48). Children aged 8-16?years with remaining ADHD symptoms after CAU were enrolled together with a parent. Primary outcome was post-treatment parent-rated child self-control deficits (BRIEF); post hoc, Reliable Change Indexes were explored. Secondary child outcomes included ADHD symptoms (parent/teacher-rated Conners' and SWAN; teacher-rated BRIEF), other psychological symptoms (parent/teacher-rated), well-being (parent-rated) and mindfulness (self-rated). Secondary parent outcomes included self-ratings of ADHD symptoms, other psychological symptoms, well-being, self-compassion and mindful parenting. Assessments were conducted at post-treatment, 2- and 6-month follow-up. RESULTS: Relative to CAU-only, MBI+CAU resulted in a small, statistically non-significant post-treatment improvement on the BRIEF (intention-to-treat: d?=?0.27, p?=?.18; per protocol: d?=?0.33, p?=?.11). Significantly more children showed reliable post-treatment improvement following MBI+CAU versus CAU-only (32% versus 11%, p?.05, Number-Needed-to-Treat?=?4.7). ADHD symptoms significantly reduced post-treatment according to parent (Conners' and SWAN) and teacher ratings (BRIEF) per protocol. Only parent-rated hyperactivity impulsivity (SWAN) remained significantly reduced at 6-month follow-up. Post-treatment group differences on other secondary child outcomes were consistently favour of MBI+CAU, but mostly non-significant; no significant differences were found at follow-ups. Regarding parent outcomes, significant post-treatment improvements were found for their own ADHD symptoms, well-being and mindful parenting. At follow-ups, some significant effects remained (ADHD symptoms, mindful parenting), some additional significant effects appeared (other psychological symptoms, self-compassion) and others disappeared/remained non-significant. CONCLUSIONS: Family MBI+CAU did not outperform CAU-only in reducing child self-control deficits on a group level but more children reliably improved. Effects on parents were larger and more durable. When CAU for ADHD is insufficient, family MBI could be a valuable addition. En ligne : http://dx.doi.org/10.1111/jcpp.13430 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 Randomized Controlled Trial of the Focus Parent Training for Toddlers with Autism: 1-Year Outcome / Iris J. OOSTERLING in Journal of Autism and Developmental Disorders, 40-12 (December 2010)
[article]
Titre : Randomized Controlled Trial of the Focus Parent Training for Toddlers with Autism: 1-Year Outcome Type de document : Texte imprimé et/ou numérique Auteurs : Iris J. OOSTERLING, Auteur ; Janne C. VISSER, Auteur ; Sophie H. N. SWINKELS, Auteur ; Nanda N. ROMMELSE, Auteur ; Rogier DONDERS, Auteur ; Tim WOUDENBERG, Auteur ; Sascha ROOS, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur Année de publication : 2010 Article en page(s) : p.1447-1458 Langues : Anglais (eng) Mots-clés : Autism Parent training Toddler Early intervention Randomized controlled trial Index. décimale : PER Périodiques Résumé : This randomized controlled trial compared results obtained after 12 months of nonintensive parent training plus care-as-usual and care-as-usual alone. The training focused on stimulating joint attention and language skills and was based on the intervention described by Drew et al. (Eur Child Adolesc Psychiatr 11:266–272, 2002). Seventy-five toddlers with autism spectrum disorder (65 autism, 10 PDD-NOS, mean age = 34.4 months, SD = 6.2) were enrolled. Analyses were conducted on a final sample of 67 children (lost to follow-up = 8). No significant intervention effects were found for any of the primary (language), secondary (global clinical improvement), or mediating (child engagement, early precursors of social communication, or parental skills) outcome variables, suggesting that the ‘Focus parent training’ was not of additional value to the more general care-as-usual. En ligne : http://dx.doi.org/10.1007/s10803-010-1004-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114
in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1447-1458[article] Randomized Controlled Trial of the Focus Parent Training for Toddlers with Autism: 1-Year Outcome [Texte imprimé et/ou numérique] / Iris J. OOSTERLING, Auteur ; Janne C. VISSER, Auteur ; Sophie H. N. SWINKELS, Auteur ; Nanda N. ROMMELSE, Auteur ; Rogier DONDERS, Auteur ; Tim WOUDENBERG, Auteur ; Sascha ROOS, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur . - 2010 . - p.1447-1458.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1447-1458
Mots-clés : Autism Parent training Toddler Early intervention Randomized controlled trial Index. décimale : PER Périodiques Résumé : This randomized controlled trial compared results obtained after 12 months of nonintensive parent training plus care-as-usual and care-as-usual alone. The training focused on stimulating joint attention and language skills and was based on the intervention described by Drew et al. (Eur Child Adolesc Psychiatr 11:266–272, 2002). Seventy-five toddlers with autism spectrum disorder (65 autism, 10 PDD-NOS, mean age = 34.4 months, SD = 6.2) were enrolled. Analyses were conducted on a final sample of 67 children (lost to follow-up = 8). No significant intervention effects were found for any of the primary (language), secondary (global clinical improvement), or mediating (child engagement, early precursors of social communication, or parental skills) outcome variables, suggesting that the ‘Focus parent training’ was not of additional value to the more general care-as-usual. En ligne : http://dx.doi.org/10.1007/s10803-010-1004-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 Research Review: The role of diet in the treatment of attention-deficit/hyperactivity disorder – an appraisal of the evidence on efficacy and recommendations on the design of future studies / Jim STEVENSON in Journal of Child Psychology and Psychiatry, 55-5 (May 2014)
[article]
Titre : Research Review: The role of diet in the treatment of attention-deficit/hyperactivity disorder – an appraisal of the evidence on efficacy and recommendations on the design of future studies Type de document : Texte imprimé et/ou numérique Auteurs : Jim STEVENSON, Auteur ; Jan K. BUITELAAR, Auteur ; Samuele CORTESE, Auteur ; Maite FERRIN, Auteur ; Eric KONOFAL, Auteur ; Michel LECENDREUX, Auteur ; Emily SIMONOFF, Auteur ; Ian C. K. WONG, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Adhd Guidelines Group THE EUROPEAN, Auteur Article en page(s) : p.416-427 Mots-clés : ADHD meta-analysis food colours fatty acid elimination diet food supplements Index. décimale : PER Périodiques Résumé : Background The efficacy of three dietary treatments for ADHD has been repeatedly tested in randomized controlled trials (RCTs). These interventions are restricted elimination diets (RED), artificial food colour elimination (AFCE) and supplementation with free fatty acids (SFFA). There have been three systematic reviews and associated meta-analyses of the RCTs for each of these treatments. Scope The aim of this review is to critically appraise the studies on the dietary treatments of ADHD, to compare the various meta-analyses of their efficacy that have been published and to identify where the design of such RCTs could be improved and where further investigations are needed. Findings The meta-analyses differ in the inclusion and exclusion criteria applied to potentially eligible studies. The range of average effect sizes in standard deviation units is RED (0.29–1.2), AFCE (0.18–0.42) and SFFA (0.17–0.31). The methodology of many of the trials on which the meta-analyses are based is weak. Conclusions Nevertheless, there is evidence from well-conducted studies for a small effect of SFFA. Restricted elimination diets may be beneficial, but large-scale studies are needed on unselected children, using blind assessment and including assessment of long-term outcome. Artificial food colour elimination is a potentially valuable treatment but its effect size remains uncertain, as does the type of child for whom it is likely to be efficacious. There are additional dietary supplements that have been used with children with ADHD. A systematic search identified 11 RCTs that investigated the effects of these food supplements. Despite positive results for some individual trials, more studies are required before conclusions can be reached on the value in reducing ADHD symptoms of any of these additional supplements. En ligne : http://dx.doi.org/10.1111/jcpp.12215 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=231
in Journal of Child Psychology and Psychiatry > 55-5 (May 2014) . - p.416-427[article] Research Review: The role of diet in the treatment of attention-deficit/hyperactivity disorder – an appraisal of the evidence on efficacy and recommendations on the design of future studies [Texte imprimé et/ou numérique] / Jim STEVENSON, Auteur ; Jan K. BUITELAAR, Auteur ; Samuele CORTESE, Auteur ; Maite FERRIN, Auteur ; Eric KONOFAL, Auteur ; Michel LECENDREUX, Auteur ; Emily SIMONOFF, Auteur ; Ian C. K. WONG, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Adhd Guidelines Group THE EUROPEAN, Auteur . - p.416-427.
in Journal of Child Psychology and Psychiatry > 55-5 (May 2014) . - p.416-427
Mots-clés : ADHD meta-analysis food colours fatty acid elimination diet food supplements Index. décimale : PER Périodiques Résumé : Background The efficacy of three dietary treatments for ADHD has been repeatedly tested in randomized controlled trials (RCTs). These interventions are restricted elimination diets (RED), artificial food colour elimination (AFCE) and supplementation with free fatty acids (SFFA). There have been three systematic reviews and associated meta-analyses of the RCTs for each of these treatments. Scope The aim of this review is to critically appraise the studies on the dietary treatments of ADHD, to compare the various meta-analyses of their efficacy that have been published and to identify where the design of such RCTs could be improved and where further investigations are needed. Findings The meta-analyses differ in the inclusion and exclusion criteria applied to potentially eligible studies. The range of average effect sizes in standard deviation units is RED (0.29–1.2), AFCE (0.18–0.42) and SFFA (0.17–0.31). The methodology of many of the trials on which the meta-analyses are based is weak. Conclusions Nevertheless, there is evidence from well-conducted studies for a small effect of SFFA. Restricted elimination diets may be beneficial, but large-scale studies are needed on unselected children, using blind assessment and including assessment of long-term outcome. Artificial food colour elimination is a potentially valuable treatment but its effect size remains uncertain, as does the type of child for whom it is likely to be efficacious. There are additional dietary supplements that have been used with children with ADHD. A systematic search identified 11 RCTs that investigated the effects of these food supplements. Despite positive results for some individual trials, more studies are required before conclusions can be reached on the value in reducing ADHD symptoms of any of these additional supplements. En ligne : http://dx.doi.org/10.1111/jcpp.12215 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=231 Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis / Pilar GARCES in Molecular Autism, 13 (2022)
PermalinkSelf-initiations in young children with autism during Pivotal Response Treatment with and without robot assistance / Manon DE KORTE in Autism, 24-8 (November 2020)
PermalinkSensory salience processing moderates attenuated gazes on faces in autism spectrum disorder: a case-control study / Luke MASON ; Christine ECKER ; Sarah BAUMEISTER ; Tobias BANASCHEWSKI ; Emily J. H. JONES ; Declan G. M. MURPHY ; Jan K. BUITELAAR ; Eva LOTH ; Gahan PANDINA ; Christine M. FREITAG in Molecular Autism, 14 (2023)
PermalinkSimplex and Multiplex Stratification in ASD and ADHD Families: A Promising Approach for Identifying Overlapping and Unique Underpinnings of ASD and ADHD? / Anoek M. OERLEMANS in Journal of Autism and Developmental Disorders, 45-3 (March 2015)
PermalinkSLC2A3 single-nucleotide polymorphism and duplication influence cognitive processing and population-specific risk for attention-deficit/hyperactivity disorder / Sören MERKER in Journal of Child Psychology and Psychiatry, 58-7 (July 2017)
PermalinkSocial brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project / Carolin MOESSNANG in Molecular Autism, 11 (2020)
PermalinkStandardized ADOS Scores: Measuring Severity of Autism Spectrum Disorders in a Dutch Sample / Annelies A. DE BILDT in Journal of Autism and Developmental Disorders, 41-3 (March 2011)
PermalinkSubstance use and nicotine dependence in persistent, remittent, and late-onset ADHD: a 10-year longitudinal study from childhood to young adulthood / S. ILBEGI in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)
PermalinkSustainability of an early detection program for autism spectrum disorder over the course of 8 years / M. K. PIJL in Autism, 22-8 (November 2018)
PermalinkTemperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants / M. K. J. PIJL in Journal of Autism and Developmental Disorders, 49-5 (May 2019)
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