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Auteur Jan K. BUITELAAR |
Documents disponibles écrits par cet auteur (111)
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Towards robust and replicable sex differences in the intrinsic brain function of autism / D. L. FLORIS in Molecular Autism, 12 (2021)
[article]
Titre : Towards robust and replicable sex differences in the intrinsic brain function of autism Type de document : Texte imprimé et/ou numérique Auteurs : D. L. FLORIS, Auteur ; J. O. A. FILHO, Auteur ; Meng-Chuan LAI, Auteur ; S. GIAVASIS, Auteur ; M. OLDEHINKEL, Auteur ; M. MENNES, Auteur ; Tony CHARMAN, Auteur ; J. TILLMANN, Auteur ; G. DUMAS, Auteur ; C. ECKER, Auteur ; F. DELL'ACQUA, Auteur ; Tobias BANASCHEWSKI, Auteur ; C. MOESSNANG, Auteur ; Simon BARON-COHEN, Auteur ; S. DURSTON, Auteur ; E. LOTH, Auteur ; D. G. M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Christian F. BECKMANN, Auteur ; M. P. MILHAM, Auteur ; A. DI MARTINO, Auteur Article en page(s) : 19 p. Langues : Anglais (eng) Mots-clés : Adolescent Autistic Disorder/diagnostic imaging/physiopathology Brain/diagnostic imaging/physiopathology Child Female Humans Magnetic Resonance Imaging Male Sex Characteristics Autism spectrum disorder Replication Resting-state functional connectivity Robustness Sex differences Voxel-mirrored homotopic connectivity Responsiveness Scale—Child Version by Organization Speciali, Italy. JKB has been a consultant to, advisory board member of, and a speaker for Takeda/Shire, Medice, Roche, and Servier. He is not an employee of any of these companies and not a stock shareholder of any of these companies. He has no other financial or material support, including expert testimony, patents, or royalties. CFB is director and shareholder in SBGneuro Ltd. TC has received consultancy from Roche and Servier and received book royalties from Guildford Press and Sage. DM has been a consultant to, and advisory board member, for Roche and Servier. He is not an employee of any of these companies, and not a stock shareholder of any of these companies. TB served in an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Shire, and Infectopharm. He received conference support or speaker’s fee by Lilly, Medice, and Shire. He received royalties from Hogrefe, Kohlhammer, CIP Medien, Oxford University Press the present work is unrelated to these relationships. JT is a consultant to Roche. The remaining authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Marked sex differences in autism prevalence accentuate the need to understand the role of biological sex-related factors in autism. Efforts to unravel sex differences in the brain organization of autism have, however, been challenged by the limited availability of female data. METHODS: We addressed this gap by using a large sample of males and females with autism and neurotypical (NT) control individuals (ABIDE; Autism: 362 males, 82 females; NT: 409 males, 166 females; 7-18 years). Discovery analyses examined main effects of diagnosis, sex and their interaction across five resting-state fMRI (R-fMRI) metrics (voxel-level Z?>?3.1, cluster-level P?0.01, gaussian random field corrected). Secondary analyses assessed the robustness of the results to different pre-processing approaches and their replicability in two independent samples: the EU-AIMS Longitudinal European Autism Project (LEAP) and the Gender Explorations of Neurogenetics and Development to Advance Autism Research. RESULTS: Discovery analyses in ABIDE revealed significant main effects of diagnosis and sex across the intrinsic functional connectivity of the posterior cingulate cortex, regional homogeneity and voxel-mirrored homotopic connectivity (VMHC) in several cortical regions, largely converging in the default network midline. Sex-by-diagnosis interactions were confined to the dorsolateral occipital cortex, with reduced VMHC in females with autism. All findings were robust to different pre-processing steps. Replicability in independent samples varied by R-fMRI measures and effects with the targeted sex-by-diagnosis interaction being replicated in the larger of the two replication samples-EU-AIMS LEAP. LIMITATIONS: Given the lack of a priori harmonization among the discovery and replication datasets available to date, sample-related variation remained and may have affected replicability. CONCLUSIONS: Atypical cross-hemispheric interactions are neurobiologically relevant to autism. They likely result from the combination of sex-dependent and sex-independent factors with a differential effect across functional cortical networks. Systematic assessments of the factors contributing to replicability are needed and necessitate coordinated large-scale data collection across studies. En ligne : http://dx.doi.org/10.1186/s13229-021-00415-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 19 p.[article] Towards robust and replicable sex differences in the intrinsic brain function of autism [Texte imprimé et/ou numérique] / D. L. FLORIS, Auteur ; J. O. A. FILHO, Auteur ; Meng-Chuan LAI, Auteur ; S. GIAVASIS, Auteur ; M. OLDEHINKEL, Auteur ; M. MENNES, Auteur ; Tony CHARMAN, Auteur ; J. TILLMANN, Auteur ; G. DUMAS, Auteur ; C. ECKER, Auteur ; F. DELL'ACQUA, Auteur ; Tobias BANASCHEWSKI, Auteur ; C. MOESSNANG, Auteur ; Simon BARON-COHEN, Auteur ; S. DURSTON, Auteur ; E. LOTH, Auteur ; D. G. M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Christian F. BECKMANN, Auteur ; M. P. MILHAM, Auteur ; A. DI MARTINO, Auteur . - 19 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 19 p.
Mots-clés : Adolescent Autistic Disorder/diagnostic imaging/physiopathology Brain/diagnostic imaging/physiopathology Child Female Humans Magnetic Resonance Imaging Male Sex Characteristics Autism spectrum disorder Replication Resting-state functional connectivity Robustness Sex differences Voxel-mirrored homotopic connectivity Responsiveness Scale—Child Version by Organization Speciali, Italy. JKB has been a consultant to, advisory board member of, and a speaker for Takeda/Shire, Medice, Roche, and Servier. He is not an employee of any of these companies and not a stock shareholder of any of these companies. He has no other financial or material support, including expert testimony, patents, or royalties. CFB is director and shareholder in SBGneuro Ltd. TC has received consultancy from Roche and Servier and received book royalties from Guildford Press and Sage. DM has been a consultant to, and advisory board member, for Roche and Servier. He is not an employee of any of these companies, and not a stock shareholder of any of these companies. TB served in an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Shire, and Infectopharm. He received conference support or speaker’s fee by Lilly, Medice, and Shire. He received royalties from Hogrefe, Kohlhammer, CIP Medien, Oxford University Press the present work is unrelated to these relationships. JT is a consultant to Roche. The remaining authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Marked sex differences in autism prevalence accentuate the need to understand the role of biological sex-related factors in autism. Efforts to unravel sex differences in the brain organization of autism have, however, been challenged by the limited availability of female data. METHODS: We addressed this gap by using a large sample of males and females with autism and neurotypical (NT) control individuals (ABIDE; Autism: 362 males, 82 females; NT: 409 males, 166 females; 7-18 years). Discovery analyses examined main effects of diagnosis, sex and their interaction across five resting-state fMRI (R-fMRI) metrics (voxel-level Z?>?3.1, cluster-level P?0.01, gaussian random field corrected). Secondary analyses assessed the robustness of the results to different pre-processing approaches and their replicability in two independent samples: the EU-AIMS Longitudinal European Autism Project (LEAP) and the Gender Explorations of Neurogenetics and Development to Advance Autism Research. RESULTS: Discovery analyses in ABIDE revealed significant main effects of diagnosis and sex across the intrinsic functional connectivity of the posterior cingulate cortex, regional homogeneity and voxel-mirrored homotopic connectivity (VMHC) in several cortical regions, largely converging in the default network midline. Sex-by-diagnosis interactions were confined to the dorsolateral occipital cortex, with reduced VMHC in females with autism. All findings were robust to different pre-processing steps. Replicability in independent samples varied by R-fMRI measures and effects with the targeted sex-by-diagnosis interaction being replicated in the larger of the two replication samples-EU-AIMS LEAP. LIMITATIONS: Given the lack of a priori harmonization among the discovery and replication datasets available to date, sample-related variation remained and may have affected replicability. CONCLUSIONS: Atypical cross-hemispheric interactions are neurobiologically relevant to autism. They likely result from the combination of sex-dependent and sex-independent factors with a differential effect across functional cortical networks. Systematic assessments of the factors contributing to replicability are needed and necessitate coordinated large-scale data collection across studies. En ligne : http://dx.doi.org/10.1186/s13229-021-00415-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Unique dynamic profiles of social attention in autistic females / Teresa DEL BIANCO in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)
[article]
Titre : Unique dynamic profiles of social attention in autistic females Type de document : Texte imprimé et/ou numérique Auteurs : Teresa DEL BIANCO, Auteur ; Luke MASON, Auteur ; Meng-Chuan LAI, Auteur ; Eva LOTH, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Hannah HAYWARD, Auteur ; Teresa GLEISSL, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G. M. MURPHY, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur Article en page(s) : p.1602-1614 Langues : Anglais (eng) Mots-clés : Female Humans Attention Autistic Disorder/diagnosis Cohort Studies Learning Sex Characteristics Child Adolescent Young Adult Adult Autism eye-tracking male sex differences social attention Index. décimale : PER Périodiques Résumé : BACKGROUND: Social attention affords learning opportunities across development and may contribute to individual differences in developmental trajectories, such as between male and female individuals, and in neurodevelopmental conditions, such as autism. METHODS: Using eye-tracking, we measured social attention in a large cohort of autistic (n=123) and nonautistic females (n=107), and autistic (n=330) and nonautistic males (n=204), aged 6-30 years. Using mixed Growth Curve Analysis, we modelled sex and diagnostic effects on the temporal dynamics of proportional looking time to three types of social stimuli (lean-static, naturalistic-static, and naturalistic-dynamic) and examined the link between individual differences and dimensional social and nonsocial autistic traits in autistic females and males. RESULTS: In the lean-static stimulus, average face-looking was higher in females than in males of both autistic and nonautistic groups. Differences in the dynamic pattern of face-looking were seen in autistic vs. nonautistic females, but not males, with face-looking peaking later in the trial in autistic females. In the naturalistic-dynamic stimulus, average face-looking was higher in females than in males of both groups; changes in the dynamic pattern of face looking were seen in autistic vs. nonautistic males, but not in females, with a steeper peak in nonautistic males. Lower average face-looking was associated with higher observer-measured autistic characteristics in autistic females, but not in males. CONCLUSIONS: Overall, we found stronger social attention in females to a similar degree in both autistic and nonautistic groups. Nonetheless, the dynamic profiles of social attention differed in different ways in autistic females and males compared to their nonautistic peers, and autistic traits predicted trends of average face-looking in autistic females. These findings support the role of social attention in the emergence of sex-related differences in autistic characteristics, suggesting an avenue to phenotypic stratification. En ligne : http://dx.doi.org/10.1111/jcpp.13630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1602-1614[article] Unique dynamic profiles of social attention in autistic females [Texte imprimé et/ou numérique] / Teresa DEL BIANCO, Auteur ; Luke MASON, Auteur ; Meng-Chuan LAI, Auteur ; Eva LOTH, Auteur ; Julian TILLMANN, Auteur ; Tony CHARMAN, Auteur ; Hannah HAYWARD, Auteur ; Teresa GLEISSL, Auteur ; Jan K. BUITELAAR, Auteur ; Declan G. M. MURPHY, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur . - p.1602-1614.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1602-1614
Mots-clés : Female Humans Attention Autistic Disorder/diagnosis Cohort Studies Learning Sex Characteristics Child Adolescent Young Adult Adult Autism eye-tracking male sex differences social attention Index. décimale : PER Périodiques Résumé : BACKGROUND: Social attention affords learning opportunities across development and may contribute to individual differences in developmental trajectories, such as between male and female individuals, and in neurodevelopmental conditions, such as autism. METHODS: Using eye-tracking, we measured social attention in a large cohort of autistic (n=123) and nonautistic females (n=107), and autistic (n=330) and nonautistic males (n=204), aged 6-30 years. Using mixed Growth Curve Analysis, we modelled sex and diagnostic effects on the temporal dynamics of proportional looking time to three types of social stimuli (lean-static, naturalistic-static, and naturalistic-dynamic) and examined the link between individual differences and dimensional social and nonsocial autistic traits in autistic females and males. RESULTS: In the lean-static stimulus, average face-looking was higher in females than in males of both autistic and nonautistic groups. Differences in the dynamic pattern of face-looking were seen in autistic vs. nonautistic females, but not males, with face-looking peaking later in the trial in autistic females. In the naturalistic-dynamic stimulus, average face-looking was higher in females than in males of both groups; changes in the dynamic pattern of face looking were seen in autistic vs. nonautistic males, but not in females, with a steeper peak in nonautistic males. Lower average face-looking was associated with higher observer-measured autistic characteristics in autistic females, but not in males. CONCLUSIONS: Overall, we found stronger social attention in females to a similar degree in both autistic and nonautistic groups. Nonetheless, the dynamic profiles of social attention differed in different ways in autistic females and males compared to their nonautistic peers, and autistic traits predicted trends of average face-looking in autistic females. These findings support the role of social attention in the emergence of sex-related differences in autistic characteristics, suggesting an avenue to phenotypic stratification. En ligne : http://dx.doi.org/10.1111/jcpp.13630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Use of early intervention for young children with autism spectrum disorder across Europe / Erica SALOMONE in Autism, 20-2 (February 2016)
[article]
Titre : Use of early intervention for young children with autism spectrum disorder across Europe Type de document : Texte imprimé et/ou numérique Auteurs : Erica SALOMONE, Auteur ; Št?pánka BERANOVÁ, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Marlene BRICIET LAURITSEN, Auteur ; Magdalena BUDISTEANU, Auteur ; Jan K. BUITELAAR, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Gabriella FELHOSI, Auteur ; Sue FLETCHER-WATSON, Auteur ; Christine FREITAG, Auteur ; Joaquin FUENTES, Auteur ; Louise GALLAGHER, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Fotinica GLIGA, Auteur ; Marie GOMOT, Auteur ; Jonathan GREEN, Auteur ; Mikael HEIMANN, Auteur ; Sigrídur Lóa JONSDOTTIR, Auteur ; Anett KAALE, Auteur ; Rafal KAWA, Auteur ; Anneli KYLLIAINEN, Auteur ; Sanne LEMCKE, Auteur ; Silvana MARKOVSKA-SIMOSKA, Auteur ; Peter B MARSCHIK, Auteur ; Helen MCCONACHIE, Auteur ; Irma MOILANEN, Auteur ; Filippo MURATORI, Auteur ; Antonio NARZISI, Auteur ; Michele NOTERDAEME, Auteur ; Guiomar OLIVEIRA, Auteur ; Iris OOSTERLING, Auteur ; Mirjam PIJL, Auteur ; Nada POP-JORDANOVA, Auteur ; Luise POUSTKA, Auteur ; Herbert ROEYERS, Auteur ; Bernadette ROGE, Auteur ; Judith SINZIG, Auteur ; Astrid VICENTE, Auteur ; Petra WARREYN, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.233-249 Langues : Anglais (eng) Mots-clés : autism Europe intervention use of early intervention Index. décimale : PER Périodiques Résumé : Little is known about use of early interventions for autism spectrum disorder in Europe. Parents of children with autism spectrum disorder aged 7?years or younger (N?=?1680) were recruited through parent organisations in 18 European countries and completed an online survey about the interventions their child received. There was considerable variation in use of interventions, and in some countries more than 20% of children received no intervention at all. The most frequently reported interventions were speech and language therapy (64%) and behavioural, developmental and relationship-based interventions (55%). In some parts of Europe, use of behavioural, developmental and relationship-based interventions was associated with higher parental educational level and time passed since diagnosis, rather than with child characteristics. These findings highlight the need to monitor use of intervention for children with autism spectrum disorder in Europe in order to contrast inequalities. En ligne : http://dx.doi.org/10.1177/1362361315577218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278
in Autism > 20-2 (February 2016) . - p.233-249[article] Use of early intervention for young children with autism spectrum disorder across Europe [Texte imprimé et/ou numérique] / Erica SALOMONE, Auteur ; Št?pánka BERANOVÁ, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Marlene BRICIET LAURITSEN, Auteur ; Magdalena BUDISTEANU, Auteur ; Jan K. BUITELAAR, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Gabriella FELHOSI, Auteur ; Sue FLETCHER-WATSON, Auteur ; Christine FREITAG, Auteur ; Joaquin FUENTES, Auteur ; Louise GALLAGHER, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Fotinica GLIGA, Auteur ; Marie GOMOT, Auteur ; Jonathan GREEN, Auteur ; Mikael HEIMANN, Auteur ; Sigrídur Lóa JONSDOTTIR, Auteur ; Anett KAALE, Auteur ; Rafal KAWA, Auteur ; Anneli KYLLIAINEN, Auteur ; Sanne LEMCKE, Auteur ; Silvana MARKOVSKA-SIMOSKA, Auteur ; Peter B MARSCHIK, Auteur ; Helen MCCONACHIE, Auteur ; Irma MOILANEN, Auteur ; Filippo MURATORI, Auteur ; Antonio NARZISI, Auteur ; Michele NOTERDAEME, Auteur ; Guiomar OLIVEIRA, Auteur ; Iris OOSTERLING, Auteur ; Mirjam PIJL, Auteur ; Nada POP-JORDANOVA, Auteur ; Luise POUSTKA, Auteur ; Herbert ROEYERS, Auteur ; Bernadette ROGE, Auteur ; Judith SINZIG, Auteur ; Astrid VICENTE, Auteur ; Petra WARREYN, Auteur ; Tony CHARMAN, Auteur . - p.233-249.
Langues : Anglais (eng)
in Autism > 20-2 (February 2016) . - p.233-249
Mots-clés : autism Europe intervention use of early intervention Index. décimale : PER Périodiques Résumé : Little is known about use of early interventions for autism spectrum disorder in Europe. Parents of children with autism spectrum disorder aged 7?years or younger (N?=?1680) were recruited through parent organisations in 18 European countries and completed an online survey about the interventions their child received. There was considerable variation in use of interventions, and in some countries more than 20% of children received no intervention at all. The most frequently reported interventions were speech and language therapy (64%) and behavioural, developmental and relationship-based interventions (55%). In some parts of Europe, use of behavioural, developmental and relationship-based interventions was associated with higher parental educational level and time passed since diagnosis, rather than with child characteristics. These findings highlight the need to monitor use of intervention for children with autism spectrum disorder in Europe in order to contrast inequalities. En ligne : http://dx.doi.org/10.1177/1362361315577218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 Verbal Memory and Performance IQ Predict Theory of Mind and Emotion Recognition Ability in Children with Autistic Spectrum Disorders and in Psychiatric Control Children / Jan K. BUITELAAR in Journal of Child Psychology and Psychiatry, 40-6 (September 1999)
[article]
Titre : Verbal Memory and Performance IQ Predict Theory of Mind and Emotion Recognition Ability in Children with Autistic Spectrum Disorders and in Psychiatric Control Children Type de document : Texte imprimé et/ou numérique Auteurs : Jan K. BUITELAAR, Auteur ; Marleen VAN DER WEES, Auteur ; Hanna SWAAB, Auteur ; Rutger Jan VAN DER GAAG, Auteur Année de publication : 1999 Article en page(s) : p.869-881 Langues : Anglais (eng) Mots-clés : Autistic disorder emotion recognition intelligence memory pervasive developmental disorder theory of mind Index. décimale : PER Périodiques Résumé : This study was designed to examine the developmental and cognitive correlates of theory of mind (ToM) and emotion recognition ability in children with autism (N= 20), with pervasive developmental disorder-not otherwise specified (PDD-NOS) (N= 20), and in psychiatric control children (N= 20). The diagnostic groups were person-to-person matched on age and verbal IQ. The age of the children was between 8 and 18 years; their Full Scale IQ was at least 65. The test battery included tasks for the matching and the context recognition of emotional expressions, and a set of first- and second-order ToM tasks. The relationships between composite domain scores and the subjects' age, Verbal IQ, Performance IQ, verbal memory, visual memory, and gender were examined in bivariate and multivariate analyses. Further, the subjects who reliably and consistently passed the tasks of a domain and those who could not were compared on developmental and cognitive characteristics. Overall, the results of the various analyses converged and indicated that verbal memory, Performance IQ, age and gender were the best predictors of social cognitive ability. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124
in Journal of Child Psychology and Psychiatry > 40-6 (September 1999) . - p.869-881[article] Verbal Memory and Performance IQ Predict Theory of Mind and Emotion Recognition Ability in Children with Autistic Spectrum Disorders and in Psychiatric Control Children [Texte imprimé et/ou numérique] / Jan K. BUITELAAR, Auteur ; Marleen VAN DER WEES, Auteur ; Hanna SWAAB, Auteur ; Rutger Jan VAN DER GAAG, Auteur . - 1999 . - p.869-881.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 40-6 (September 1999) . - p.869-881
Mots-clés : Autistic disorder emotion recognition intelligence memory pervasive developmental disorder theory of mind Index. décimale : PER Périodiques Résumé : This study was designed to examine the developmental and cognitive correlates of theory of mind (ToM) and emotion recognition ability in children with autism (N= 20), with pervasive developmental disorder-not otherwise specified (PDD-NOS) (N= 20), and in psychiatric control children (N= 20). The diagnostic groups were person-to-person matched on age and verbal IQ. The age of the children was between 8 and 18 years; their Full Scale IQ was at least 65. The test battery included tasks for the matching and the context recognition of emotional expressions, and a set of first- and second-order ToM tasks. The relationships between composite domain scores and the subjects' age, Verbal IQ, Performance IQ, verbal memory, visual memory, and gender were examined in bivariate and multivariate analyses. Further, the subjects who reliably and consistently passed the tasks of a domain and those who could not were compared on developmental and cognitive characteristics. Overall, the results of the various analyses converged and indicated that verbal memory, Performance IQ, age and gender were the best predictors of social cognitive ability. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124 White matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder / Winke FRANCX in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)
[article]
Titre : White matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Winke FRANCX, Auteur ; Marcel P. ZWIERS, Auteur ; Maarten MENNES, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur ; Barbara FRANKE, Auteur ; Stephen V. FARAONE, Auteur ; Laurence O'DWYER, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : p.1289-1297 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder hyperactivity/impulsivity white matter diffusion tensor imaging recovery development Index. décimale : PER Périodiques Résumé : Background A developmental improvement of symptoms in attention-deficit/hyperactivity disorder (ADHD) is frequently reported, but the underlying neurobiological substrate has not been identified. The aim of this study was to determine whether white matter microstructure is related to developmental improvement of ADHD symptoms. Methods A cross-sectional magnetic resonance imaging (MRI) analysis was embedded in a prospective follow-up of an adolescent cohort of ADHD and control subjects (NeuroIMAGE). Mean age at baseline was 11.9 years, mean interval of follow-up was 5.9 years. About 75.3% of the original cohort was retained successfully. Data of 101 participants with ADHD combined type at baseline and 40 healthy controls were analysed. ADHD symptoms were measured with semistructured, investigator-based interviews and Conners' questionnaires, on the basis of DSM-IV criteria. Fractional anisotropy (FA) and mean diffusivity (MD) indices of white matter microstructure were measured using whole brain diffusion tensor imaging at follow-up only. In a dimensional analysis FA and MD were related to change in ADHD symptoms. To link this analysis to DSM-IV diagnoses, a post hoc categorical group analysis was conducted comparing participants with persistent (n = 59) versus remittent (n = 42) ADHD and controls. Results Over time, participants with ADHD showed improvement mainly in hyperactive/impulsive symptoms. This improvement was associated with lower FA and higher MD values in the left corticospinal tract at follow-up. Findings of the dimensional and the categorical analysis strongly converged. Changes in inattentive symptoms over time were minimal and not related to white matter microstructure. Conclusions The corticospinal tract is important in the control of voluntary movements, suggesting the importance of the motor system in the persistence of hyperactive/impulsive symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12379 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273
in Journal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1289-1297[article] White matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Winke FRANCX, Auteur ; Marcel P. ZWIERS, Auteur ; Maarten MENNES, Auteur ; Jaap OOSTERLAAN, Auteur ; Dirk J. HESLENFELD, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur ; Barbara FRANKE, Auteur ; Stephen V. FARAONE, Auteur ; Laurence O'DWYER, Auteur ; Jan K. BUITELAAR, Auteur . - p.1289-1297.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-12 (December 2015) . - p.1289-1297
Mots-clés : Attention-deficit/hyperactivity disorder hyperactivity/impulsivity white matter diffusion tensor imaging recovery development Index. décimale : PER Périodiques Résumé : Background A developmental improvement of symptoms in attention-deficit/hyperactivity disorder (ADHD) is frequently reported, but the underlying neurobiological substrate has not been identified. The aim of this study was to determine whether white matter microstructure is related to developmental improvement of ADHD symptoms. Methods A cross-sectional magnetic resonance imaging (MRI) analysis was embedded in a prospective follow-up of an adolescent cohort of ADHD and control subjects (NeuroIMAGE). Mean age at baseline was 11.9 years, mean interval of follow-up was 5.9 years. About 75.3% of the original cohort was retained successfully. Data of 101 participants with ADHD combined type at baseline and 40 healthy controls were analysed. ADHD symptoms were measured with semistructured, investigator-based interviews and Conners' questionnaires, on the basis of DSM-IV criteria. Fractional anisotropy (FA) and mean diffusivity (MD) indices of white matter microstructure were measured using whole brain diffusion tensor imaging at follow-up only. In a dimensional analysis FA and MD were related to change in ADHD symptoms. To link this analysis to DSM-IV diagnoses, a post hoc categorical group analysis was conducted comparing participants with persistent (n = 59) versus remittent (n = 42) ADHD and controls. Results Over time, participants with ADHD showed improvement mainly in hyperactive/impulsive symptoms. This improvement was associated with lower FA and higher MD values in the left corticospinal tract at follow-up. Findings of the dimensional and the categorical analysis strongly converged. Changes in inattentive symptoms over time were minimal and not related to white matter microstructure. Conclusions The corticospinal tract is important in the control of voluntary movements, suggesting the importance of the motor system in the persistence of hyperactive/impulsive symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12379 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273 Working memory training in young children with ADHD: a randomized placebo-controlled trial / Martine VAN DONGEN-BOOMSMA in Journal of Child Psychology and Psychiatry, 55-8 (August 2014)
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