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Signposting for diagnosis of Autism Spectrum Disorder using the Diagnostic Interview for Social and Communication Disorders (DISCO) / Sarah CARRINGTON in Research in Autism Spectrum Disorders, 9 (January 2015) 

Public ISBD [article]  in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.45-52 Titre : Signposting for diagnosis of Autism Spectrum Disorder using the Diagnostic Interview for Social and Communication Disorders (DISCO) Type de document : texte imprimé Auteurs : Sarah CARRINGTON, Auteur ; Susan LEEKAM, Auteur ; Rachel KENT, Auteur ; Jarymke MALJAARS, Auteur ; Judith GOULD, Auteur ; Lorna WING, Auteur ; Ann LE COUTEUR, Auteur ; Ina VAN BERCKELAER-ONNES, Auteur ; Ilse NOENS, Auteur Année de publication : 2015 Article en page(s) : p.45-52 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Diagnosis  DSM-5  ICD-10  Screening Index. décimale : PER Périodiques Résumé : Abstract Recent research has investigated the capability of the Diagnostic and Statistical Manual for Mental Disorders (DSM-5) descriptions to identify individuals who should receive a diagnosis of Autism Spectrum Disorder (ASD) using standardised diagnostic instruments. Building on previous research investigating behaviours essential for the diagnosis of DSM-5 ASD, the current study investigated the sensitivity and specificity of a set of 14 items derived from the Diagnostic Interview for Social and Communication Disorders (DISCO Signposting set) that have potential for signposting the diagnosis of autism according to both the new DSM-5 criteria for ASD and ICD-10 criteria for Childhood Autism. An algorithm threshold for the Signposting set was calculated in Sample 1 (n = 67), tested in an independent validation sample (Sample 2; n = 78), and applied across age and ability sub-groups in Sample 3 (n = 190). The algorithm had excellent predictive validity according to best estimate clinical diagnosis (Samples 1 and 2) and excellent agreement with established algorithms for both DSM-5 and ICD-10 (all samples). The signposting set has potential to inform our understanding of the profile of ASD in relation to other neurodevelopmental disorders and to form the basis of a Signposting Interview for use in clinical practice. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.003 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2432 [article] Signposting for diagnosis of Autism Spectrum Disorder using the Diagnostic Interview for Social and Communication Disorders (DISCO) [texte imprimé] / Sarah CARRINGTON, Auteur ; Susan LEEKAM, Auteur ; Rachel KENT, Auteur ; Jarymke MALJAARS, Auteur ; Judith GOULD, Auteur ; Lorna WING, Auteur ; Ann LE COUTEUR, Auteur ; Ina VAN BERCKELAER-ONNES, Auteur ; Ilse NOENS, Auteur . - 2015 . - p.45-52. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.45-52 Mots-clés : Autism Spectrum Disorder  Diagnosis  DSM-5  ICD-10  Screening Index. décimale : PER Périodiques Résumé : Abstract Recent research has investigated the capability of the Diagnostic and Statistical Manual for Mental Disorders (DSM-5) descriptions to identify individuals who should receive a diagnosis of Autism Spectrum Disorder (ASD) using standardised diagnostic instruments. Building on previous research investigating behaviours essential for the diagnosis of DSM-5 ASD, the current study investigated the sensitivity and specificity of a set of 14 items derived from the Diagnostic Interview for Social and Communication Disorders (DISCO Signposting set) that have potential for signposting the diagnosis of autism according to both the new DSM-5 criteria for ASD and ICD-10 criteria for Childhood Autism. An algorithm threshold for the Signposting set was calculated in Sample 1 (n = 67), tested in an independent validation sample (Sample 2; n = 78), and applied across age and ability sub-groups in Sample 3 (n = 190). The algorithm had excellent predictive validity according to best estimate clinical diagnosis (Samples 1 and 2) and excellent agreement with established algorithms for both DSM-5 and ICD-10 (all samples). The signposting set has potential to inform our understanding of the profile of ASD in relation to other neurodevelopmental disorders and to form the basis of a Signposting Interview for use in clinical practice. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.003 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2432

Treatment mechanism in the MRC preschool autism communication trial: implications for study design and parent-focussed therapy for children / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 56-2 (February 2015) 

Public ISBD [article]  in Journal of Child Psychology and Psychiatry > 56-2 (February 2015) . - p.162-170 Titre : Treatment mechanism in the MRC preschool autism communication trial: implications for study design and parent-focussed therapy for children Type de document : texte imprimé Auteurs : Andrew PICKLES, Auteur ; Victoria HARRIS, Auteur ; Jonathan GREEN, Auteur ; Catherine ALDRED, Auteur ; Helen McCONACHIE, Auteur ; Vicky SLONIMS, Auteur ; Ann LE COUTEUR, Auteur ; Kristelle HUDRY, Auteur ; Tony CHARMAN, Auteur ; THE PACT CONSORTIUM,, Auteur Article en page(s) : p.162-170 Langues : Anglais (eng) Mots-clés : Autism  measurement error  mediation  parent–child interaction  parent-focussed therapy Index. décimale : PER Périodiques Résumé : Background The PACT randomised-controlled trial evaluated a parent-mediated communication-focused treatment for children with autism, intended to reduce symptom severity as measured by a modified Autism Diagnostic Observation Schedule-Generic (ADOS-G) algorithm score. The therapy targeted parental behaviour, with no direct interaction between therapist and child. While nonsignificant group differences were found on ADOS-G score, significant group differences were found for both parent and child intermediate outcomes. This study aimed to better understand the mechanism by which the PACT treatment influenced changes in child behaviour though the targeted parent behaviour. Methods Mediation analysis was used to assess the direct and indirect effects of treatment via parent behaviour on child behaviour and via child behaviour on ADOS-G score. Alternative mediation was explored to study whether the treatment effect acted as hypothesised or via another plausible pathway. Mediation models typically assume no unobserved confounding between mediator and outcome and no measurement error in the mediator. We show how to better exploit the information often available within a trial to begin to address these issues, examining scope for instrumental variable and measurement error models. Results Estimates of mediation changed substantially when account was taken of the confounder effects of the baseline value of the mediator and of measurement error. Our best estimates that accounted for both suggested that the treatment effect on the ADOS-G score was very substantially mediated by parent synchrony and child initiations. Conclusions The results highlighted the value of repeated measurement of mediators during trials. The theoretical model underlying the PACT treatment was supported. However, the substantial fall-off in treatment effect highlighted both the need for additional data and for additional target behaviours for therapy. En ligne : http://dx.doi.org/10.1111/jcpp.12291 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2599 [article] Treatment mechanism in the MRC preschool autism communication trial: implications for study design and parent-focussed therapy for children [texte imprimé] / Andrew PICKLES, Auteur ; Victoria HARRIS, Auteur ; Jonathan GREEN, Auteur ; Catherine ALDRED, Auteur ; Helen McCONACHIE, Auteur ; Vicky SLONIMS, Auteur ; Ann LE COUTEUR, Auteur ; Kristelle HUDRY, Auteur ; Tony CHARMAN, Auteur ; THE PACT CONSORTIUM,, Auteur . - p.162-170. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-2 (February 2015) . - p.162-170 Mots-clés : Autism  measurement error  mediation  parent–child interaction  parent-focussed therapy Index. décimale : PER Périodiques Résumé : Background The PACT randomised-controlled trial evaluated a parent-mediated communication-focused treatment for children with autism, intended to reduce symptom severity as measured by a modified Autism Diagnostic Observation Schedule-Generic (ADOS-G) algorithm score. The therapy targeted parental behaviour, with no direct interaction between therapist and child. While nonsignificant group differences were found on ADOS-G score, significant group differences were found for both parent and child intermediate outcomes. This study aimed to better understand the mechanism by which the PACT treatment influenced changes in child behaviour though the targeted parent behaviour. Methods Mediation analysis was used to assess the direct and indirect effects of treatment via parent behaviour on child behaviour and via child behaviour on ADOS-G score. Alternative mediation was explored to study whether the treatment effect acted as hypothesised or via another plausible pathway. Mediation models typically assume no unobserved confounding between mediator and outcome and no measurement error in the mediator. We show how to better exploit the information often available within a trial to begin to address these issues, examining scope for instrumental variable and measurement error models. Results Estimates of mediation changed substantially when account was taken of the confounder effects of the baseline value of the mediator and of measurement error. Our best estimates that accounted for both suggested that the treatment effect on the ADOS-G score was very substantially mediated by parent synchrony and child initiations. Conclusions The results highlighted the value of repeated measurement of mediators during trials. The theoretical model underlying the PACT treatment was supported. However, the substantial fall-off in treatment effect highlighted both the need for additional data and for additional target behaviours for therapy. En ligne : http://dx.doi.org/10.1111/jcpp.12291 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2599

What is the Broader Autism Phenotype? / Jeremy R. PARR

Public ISBD in Autism Spectrum Conditions / Sven BÖLTE Titre : What is the Broader Autism Phenotype? Type de document : texte imprimé Auteurs : Jeremy R. PARR, Auteur ; Ann LE COUTEUR, Auteur Année de publication : 2011 Importance : p.98-99 Langues : Anglais (eng) Catégories : AUTISME DEVELOPPEMENT NEUROLOGIQUE PHENOTYPE TROUBLE DU COMPORTEMENT Index. décimale : AUT-B AUT-B L‘Autisme - Ouvrages généraux et scientifiques Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1389 in Autism Spectrum Conditions / Sven BÖLTE What is the Broader Autism Phenotype? [texte imprimé] / Jeremy R. PARR, Auteur ; Ann LE COUTEUR, Auteur . - 2011 . - p.98-99. Langues : Anglais (eng) Catégories : AUTISME DEVELOPPEMENT NEUROLOGIQUE PHENOTYPE TROUBLE DU COMPORTEMENT Index. décimale : AUT-B AUT-B L‘Autisme - Ouvrages généraux et scientifiques Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1389

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