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Auteur Tony CHARMAN |
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Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project / J. TILLMANN in Autism Research, 12-4 (April 2019)
[article]
Titre : Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project Type de document : Texte imprimé et/ou numérique Auteurs : J. TILLMANN, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Christopher H. CHATHAM, Auteur ; D. CRAWLEY, Auteur ; R. HOLT, Auteur ; B. OAKLEY, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; S. DURSTON, Auteur ; L. HAM, Auteur ; E. LOTH, Auteur ; E. SIMONOFF, Auteur ; W. SPOOREN, Auteur ; D. G. MURPHY, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.645-657 Langues : Anglais (eng) Mots-clés : adaptive functioning autism spectrum disorder intellectual functioning psychiatric symptoms symptom severity Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced discrepancy between level of cognitive ability and adaptive functioning, and this is particularly prominent among higher-ability individuals. However, the key clinical and demographic associations of these discrepancies remain unclear. This study included a sample of 417 children, adolescents, and adults with ASD as part of the EU-AIMS LEAP cohort. We examined how age, sex, IQ, levels of ASD symptom and autistic trait severity and psychiatric symptomatology are associated with adaptive functioning as measured by the Vineland Adaptive Behavior Scales-Second Edition and IQ-adaptive functioning discrepancies. Older age, lower IQ and higher social-communication symptoms were associated with lower adaptive functioning. Results also demonstrate that older age, higher IQ and higher social-communication symptoms are associated with greater IQ-adaptive functioning discrepancy scores. By contrast, sensory ASD symptoms, repetitive and restricted behaviors, as well as symptoms of attention deficit/hyperactivity disorder (ADHD), anxiety and depression, were not associated with adaptive functioning or IQ-adaptive functioning discrepancy scores. These findings suggest that it is the core social communication problems that define ASD that contribute to adaptive function impairments that people with ASD experience. They show for the first time that sensory symptoms, repetitive behavior and associated psychiatric symptoms do not independently contribute to adaptive function impairments. Individuals with ASD require supportive interventions across the lifespan that take account of social-communicative ASD symptom severity. Autism Res 2019, 12: 645-657. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: This study investigated key clinical and demographic associations of adaptive functioning impairments in individuals with autism. We found that older age, lower IQ and more severe social-communicative symptoms, but not sensory or repetitive symptoms or co-occurring psychiatric symptoms, are associated with lower adaptive functioning and greater ability-adaptive function discrepancies. This suggests that interventions targeting adaptive skills acquisition should be flexible in their timing and intensity across developmental periods, levels of cognitive ability and take account of social-communicative ASD symptom severity. En ligne : https://dx.doi.org/10.1002/aur.2081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Autism Research > 12-4 (April 2019) . - p.645-657[article] Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project [Texte imprimé et/ou numérique] / J. TILLMANN, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Christopher H. CHATHAM, Auteur ; D. CRAWLEY, Auteur ; R. HOLT, Auteur ; B. OAKLEY, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; S. DURSTON, Auteur ; L. HAM, Auteur ; E. LOTH, Auteur ; E. SIMONOFF, Auteur ; W. SPOOREN, Auteur ; D. G. MURPHY, Auteur ; Tony CHARMAN, Auteur . - p.645-657.
Langues : Anglais (eng)
in Autism Research > 12-4 (April 2019) . - p.645-657
Mots-clés : adaptive functioning autism spectrum disorder intellectual functioning psychiatric symptoms symptom severity Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced discrepancy between level of cognitive ability and adaptive functioning, and this is particularly prominent among higher-ability individuals. However, the key clinical and demographic associations of these discrepancies remain unclear. This study included a sample of 417 children, adolescents, and adults with ASD as part of the EU-AIMS LEAP cohort. We examined how age, sex, IQ, levels of ASD symptom and autistic trait severity and psychiatric symptomatology are associated with adaptive functioning as measured by the Vineland Adaptive Behavior Scales-Second Edition and IQ-adaptive functioning discrepancies. Older age, lower IQ and higher social-communication symptoms were associated with lower adaptive functioning. Results also demonstrate that older age, higher IQ and higher social-communication symptoms are associated with greater IQ-adaptive functioning discrepancy scores. By contrast, sensory ASD symptoms, repetitive and restricted behaviors, as well as symptoms of attention deficit/hyperactivity disorder (ADHD), anxiety and depression, were not associated with adaptive functioning or IQ-adaptive functioning discrepancy scores. These findings suggest that it is the core social communication problems that define ASD that contribute to adaptive function impairments that people with ASD experience. They show for the first time that sensory symptoms, repetitive behavior and associated psychiatric symptoms do not independently contribute to adaptive function impairments. Individuals with ASD require supportive interventions across the lifespan that take account of social-communicative ASD symptom severity. Autism Res 2019, 12: 645-657. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: This study investigated key clinical and demographic associations of adaptive functioning impairments in individuals with autism. We found that older age, lower IQ and more severe social-communicative symptoms, but not sensory or repetitive symptoms or co-occurring psychiatric symptoms, are associated with lower adaptive functioning and greater ability-adaptive function discrepancies. This suggests that interventions targeting adaptive skills acquisition should be flexible in their timing and intensity across developmental periods, levels of cognitive ability and take account of social-communicative ASD symptom severity. En ligne : https://dx.doi.org/10.1002/aur.2081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 Language growth in children with heterogeneous language disorders: a population study / Courtenay F. NORBURY in Journal of Child Psychology and Psychiatry, 58-10 (October 2017)
[article]
Titre : Language growth in children with heterogeneous language disorders: a population study Type de document : Texte imprimé et/ou numérique Auteurs : Courtenay F. NORBURY, Auteur ; George VAMVAKAS, Auteur ; Debbie GOOCH, Auteur ; Gillian BAIRD, Auteur ; Tony CHARMAN, Auteur ; Emily SIMONOFF, Auteur ; Andrew PICKLES, Auteur Article en page(s) : p.1092-1105 Langues : Anglais (eng) Mots-clés : Language disorder language trajectories longitudinal study comorbidity Index. décimale : PER Périodiques Résumé : Background Language development has been characterised by significant individual stability from school entry. However, the extent to which trajectories of language growth vary in children with language disorder as a function of co-occurring developmental challenges is a question of theoretical import, with implications for service provision. Methods SCALES employed a population-based survey design with sample weighting procedures to estimate growth in core language skills over the first three years of school. A stratified sample (n = 529) received comprehensive assessment of language, nonverbal IQ, and social, emotional and behavioural difficulties at 5–6 years of age and 95% of the sample (n = 499) were assessed again at ages 7–8. Language growth was measured using both raw and standard scores in children with typical development, children with language disorder of unknown origin, and children with language disorders associated with a known clinical condition and/or intellectual disability. Results Overall, language was stable at the individual level (estimated ICC = 0.95) over the first three years of school. Linear mixed effects models highlighted steady growth in language raw scores across all three groups, including those with multiple developmental challenges. There was little evidence, however, that children with language disorders were narrowing the gap with peers (z-scores). Adjusted models indicated that while nonverbal ability, socioeconomic status and social, emotional and behavioural deficits predicted initial language score (intercept), none predicted language growth (slope). Conclusions These findings corroborate previous studies suggesting stable language trajectories after ages 5–6 years, but add considerably to previous work by demonstrating similar developmental patterns in children with additional nonverbal cognitive deficits, social, emotional, and behavioural challenges, social disadvantage or clinical diagnoses. En ligne : http://dx.doi.org/10.1111/jcpp.12793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=321
in Journal of Child Psychology and Psychiatry > 58-10 (October 2017) . - p.1092-1105[article] Language growth in children with heterogeneous language disorders: a population study [Texte imprimé et/ou numérique] / Courtenay F. NORBURY, Auteur ; George VAMVAKAS, Auteur ; Debbie GOOCH, Auteur ; Gillian BAIRD, Auteur ; Tony CHARMAN, Auteur ; Emily SIMONOFF, Auteur ; Andrew PICKLES, Auteur . - p.1092-1105.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 58-10 (October 2017) . - p.1092-1105
Mots-clés : Language disorder language trajectories longitudinal study comorbidity Index. décimale : PER Périodiques Résumé : Background Language development has been characterised by significant individual stability from school entry. However, the extent to which trajectories of language growth vary in children with language disorder as a function of co-occurring developmental challenges is a question of theoretical import, with implications for service provision. Methods SCALES employed a population-based survey design with sample weighting procedures to estimate growth in core language skills over the first three years of school. A stratified sample (n = 529) received comprehensive assessment of language, nonverbal IQ, and social, emotional and behavioural difficulties at 5–6 years of age and 95% of the sample (n = 499) were assessed again at ages 7–8. Language growth was measured using both raw and standard scores in children with typical development, children with language disorder of unknown origin, and children with language disorders associated with a known clinical condition and/or intellectual disability. Results Overall, language was stable at the individual level (estimated ICC = 0.95) over the first three years of school. Linear mixed effects models highlighted steady growth in language raw scores across all three groups, including those with multiple developmental challenges. There was little evidence, however, that children with language disorders were narrowing the gap with peers (z-scores). Adjusted models indicated that while nonverbal ability, socioeconomic status and social, emotional and behavioural deficits predicted initial language score (intercept), none predicted language growth (slope). Conclusions These findings corroborate previous studies suggesting stable language trajectories after ages 5–6 years, but add considerably to previous work by demonstrating similar developmental patterns in children with additional nonverbal cognitive deficits, social, emotional, and behavioural challenges, social disadvantage or clinical diagnoses. En ligne : http://dx.doi.org/10.1111/jcpp.12793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=321 Latent trajectories of adaptive behaviour in infants at high and low familial risk for autism spectrum disorder / G. BUSSU in Molecular Autism, 10 (2019)
[article]
Titre : Latent trajectories of adaptive behaviour in infants at high and low familial risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : G. BUSSU, Auteur ; E. J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : 13 p. Langues : Anglais (eng) Mots-clés : Adaptive behaviour Autism Infant siblings Subgroups Trajectories Central NREC (approval codes 06/MRE02/73, 08/H0718/76), and one or both parents gave informed consent to participate in the study.Not applicable.JKB has been a consultant to/member of, an advisory board of, and/or a speaker for Janssen Cilag BV, Eli Lilly, Lundbeck, Shire, Roche, Novartis, Medice, and Servier. He is neither an employee nor a stock shareholder of any of these companies. TC has received research grant support from the Medical Research Council (UK), the National Institute of Health Research, Horizon 2020 and the Innovative Medicines Initiative (both European Commission), MQ, Autistica, FP7 (European Commission), the Charles Hawkins Fund, and the Waterloo Foundation. He has served as a consultant to F. Hoffmann-La Roche, Ltd. He has received royalties from Sage Publications and Guilford Publications. The present work is unrelated to these relationships. The other authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is characterised by persisting difficulties in everyday functioning. Adaptive behaviour is heterogeneous across individuals with ASD, and it is not clear to what extent early development of adaptive behaviour relates to ASD outcome in toddlerhood. This study aims to identify subgroups of infants based on early development of adaptive skills and investigate their association with later ASD outcome. Methods: Adaptive behaviour was assessed on infants at high (n = 166) and low (n = 74) familial risk for ASD between 8 and 36 months using the Vineland Adaptive Behavior Scales (VABS-II). The four domains of VABS-II were modelled in parallel using growth mixture modelling to identify distinct classes of infants based on adaptive behaviour. Then, we associated class membership with clinical outcome and ASD symptoms at 36 months and longitudinal measures of cognitive development. Results: We observed three classes characterised by decreasing trajectories below age-appropriate norms (8.3%), stable trajectories around age-appropriate norms (73.8%), and increasing trajectories reaching average scores by age 2 (17.9%). Infants with declining adaptive behaviour had a higher risk (odds ratio (OR) = 4.40; confidence interval (CI) 1.90; 12.98) for ASD and higher parent-reported symptoms in the social, communication, and repetitive behaviour domains at 36 months. Furthermore, there was a discrepancy between adaptive and cognitive functioning as the class with improving adaptive skills showed stable cognitive development around average scores. Conclusions: Findings confirm the heterogeneity of trajectories of adaptive functioning in infancy, with a higher risk for ASD in toddlerhood linked to a plateau in the development of adaptive functioning after the first year of life. En ligne : https://dx.doi.org/10.1186/s13229-019-0264-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Molecular Autism > 10 (2019) . - 13 p.[article] Latent trajectories of adaptive behaviour in infants at high and low familial risk for autism spectrum disorder [Texte imprimé et/ou numérique] / G. BUSSU, Auteur ; E. J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; M. H. JOHNSON, Auteur ; Jan K. BUITELAAR, Auteur . - 13 p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 13 p.
Mots-clés : Adaptive behaviour Autism Infant siblings Subgroups Trajectories Central NREC (approval codes 06/MRE02/73, 08/H0718/76), and one or both parents gave informed consent to participate in the study.Not applicable.JKB has been a consultant to/member of, an advisory board of, and/or a speaker for Janssen Cilag BV, Eli Lilly, Lundbeck, Shire, Roche, Novartis, Medice, and Servier. He is neither an employee nor a stock shareholder of any of these companies. TC has received research grant support from the Medical Research Council (UK), the National Institute of Health Research, Horizon 2020 and the Innovative Medicines Initiative (both European Commission), MQ, Autistica, FP7 (European Commission), the Charles Hawkins Fund, and the Waterloo Foundation. He has served as a consultant to F. Hoffmann-La Roche, Ltd. He has received royalties from Sage Publications and Guilford Publications. The present work is unrelated to these relationships. The other authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is characterised by persisting difficulties in everyday functioning. Adaptive behaviour is heterogeneous across individuals with ASD, and it is not clear to what extent early development of adaptive behaviour relates to ASD outcome in toddlerhood. This study aims to identify subgroups of infants based on early development of adaptive skills and investigate their association with later ASD outcome. Methods: Adaptive behaviour was assessed on infants at high (n = 166) and low (n = 74) familial risk for ASD between 8 and 36 months using the Vineland Adaptive Behavior Scales (VABS-II). The four domains of VABS-II were modelled in parallel using growth mixture modelling to identify distinct classes of infants based on adaptive behaviour. Then, we associated class membership with clinical outcome and ASD symptoms at 36 months and longitudinal measures of cognitive development. Results: We observed three classes characterised by decreasing trajectories below age-appropriate norms (8.3%), stable trajectories around age-appropriate norms (73.8%), and increasing trajectories reaching average scores by age 2 (17.9%). Infants with declining adaptive behaviour had a higher risk (odds ratio (OR) = 4.40; confidence interval (CI) 1.90; 12.98) for ASD and higher parent-reported symptoms in the social, communication, and repetitive behaviour domains at 36 months. Furthermore, there was a discrepancy between adaptive and cognitive functioning as the class with improving adaptive skills showed stable cognitive development around average scores. Conclusions: Findings confirm the heterogeneity of trajectories of adaptive functioning in infancy, with a higher risk for ASD in toddlerhood linked to a plateau in the development of adaptive functioning after the first year of life. En ligne : https://dx.doi.org/10.1186/s13229-019-0264-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 Lateral glances toward moving stimuli among young children with autism: Early regulation of locally oriented perception? / Laurent MOTTRON in Development and Psychopathology, 19-1 (Winter 2007)
[article]
Titre : Lateral glances toward moving stimuli among young children with autism: Early regulation of locally oriented perception? Type de document : Texte imprimé et/ou numérique Auteurs : Laurent MOTTRON, Auteur ; Tony CHARMAN, Auteur ; Sylvain PALARDY, Auteur ; Michel LEMAY, Auteur ; Michelle DAWSON, Auteur ; Claude BERTHIAUME, Auteur ; Catherine ST-CHARLES BERNIER, Auteur ; Geneviève MARTEL, Auteur ; Suzanne MINEAU, Auteur ; Jocelyn FAUBERT, Auteur Année de publication : 2007 Article en page(s) : p. 23-36 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autistic adults display enhanced and locally oriented low-level perception of static visual information, but diminished perception of some types of movement. The identification of potential precursors, such as atypical perceptual processing, among very young children would be an initial step toward understanding the development of these phenomena. The purpose of this study was to provide an initial measure and interpretation of atypical visual exploratory behaviors toward inanimate objects (AVEBIOs) among young children with autism. A coding system for AVEBIOs was constructed from a corpus of 40 semistandardized assessments of autistic children. The most frequent atypical visual behavior among 15 children aged 33–73 months was lateral glance that was mostly oriented toward moving stimuli and was detected reliably by the experimenters (intraclass correlation > .90). This behavior was more common among autistic than typically developing children of similar verbal mental age and chronological age. As lateral vision is associated with the filtering of high spatial frequency (detail perception) information and the facilitation of high temporal frequencies (movement perception), its high prevalence among very young autistic children may reflect early attempts to regulate and/or optimize both excessive amounts of local information and diminished perception of movement. These findings are initial evidence for the need to consider the neural bases and development of atypical behaviors and their implications for intervention strategies. En ligne : http://dx.doi.org/10.1017/s0954579407070022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583
in Development and Psychopathology > 19-1 (Winter 2007) . - p. 23-36[article] Lateral glances toward moving stimuli among young children with autism: Early regulation of locally oriented perception? [Texte imprimé et/ou numérique] / Laurent MOTTRON, Auteur ; Tony CHARMAN, Auteur ; Sylvain PALARDY, Auteur ; Michel LEMAY, Auteur ; Michelle DAWSON, Auteur ; Claude BERTHIAUME, Auteur ; Catherine ST-CHARLES BERNIER, Auteur ; Geneviève MARTEL, Auteur ; Suzanne MINEAU, Auteur ; Jocelyn FAUBERT, Auteur . - 2007 . - p. 23-36.
Langues : Anglais (eng)
in Development and Psychopathology > 19-1 (Winter 2007) . - p. 23-36
Index. décimale : PER Périodiques Résumé : Autistic adults display enhanced and locally oriented low-level perception of static visual information, but diminished perception of some types of movement. The identification of potential precursors, such as atypical perceptual processing, among very young children would be an initial step toward understanding the development of these phenomena. The purpose of this study was to provide an initial measure and interpretation of atypical visual exploratory behaviors toward inanimate objects (AVEBIOs) among young children with autism. A coding system for AVEBIOs was constructed from a corpus of 40 semistandardized assessments of autistic children. The most frequent atypical visual behavior among 15 children aged 33–73 months was lateral glance that was mostly oriented toward moving stimuli and was detected reliably by the experimenters (intraclass correlation > .90). This behavior was more common among autistic than typically developing children of similar verbal mental age and chronological age. As lateral vision is associated with the filtering of high spatial frequency (detail perception) information and the facilitation of high temporal frequencies (movement perception), its high prevalence among very young autistic children may reflect early attempts to regulate and/or optimize both excessive amounts of local information and diminished perception of movement. These findings are initial evidence for the need to consider the neural bases and development of atypical behaviors and their implications for intervention strategies. En ligne : http://dx.doi.org/10.1017/s0954579407070022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study / Alberto LLERA ; Ting MEI ; Koen HAAK ; Christina ISAKOGLOU ; Dorothea L. FLORIS ; Sarah DURSTON ; Carolin MOESSNANG ; Tobias BANASCHEWSKI ; Simon BARON-COHEN ; Eva LOTH ; Flavio DELL'ACQUA ; Tony CHARMAN ; Declan G. M. MURPHY ; Christine ECKER ; Jan K. BUITELAAR ; Christian F. BECKMANN in Molecular Autism, 14 (2023)
[article]
Titre : Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study Type de document : Texte imprimé et/ou numérique Auteurs : Alberto LLERA, Auteur ; Ting MEI, Auteur ; Koen HAAK, Auteur ; Christina ISAKOGLOU, Auteur ; Dorothea L. FLORIS, Auteur ; Sarah DURSTON, Auteur ; Carolin MOESSNANG, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Eva LOTH, Auteur ; Flavio DELL'ACQUA, Auteur ; Tony CHARMAN, Auteur ; Declan G. M. MURPHY, Auteur ; Christine ECKER, Auteur ; Jan K. BUITELAAR, Auteur ; Christian F. BECKMANN, Auteur Article en page(s) : 32 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Neuroimaging analyses of brain structure and function in autism have typically been conducted in isolation, missing the sensitivity gains of linking data across modalities. Here we focus on the integration of structural and functional organisational properties of brain regions. We aim to identify novel brain-organisation phenotypes of autism. We utilised multimodal MRI (T1-, diffusion-weighted and resting state functional), behavioural and clinical data from the EU AIMS Longitudinal European Autism Project (LEAP) from autistic (n=206) and non-autistic (n=196) participants. Of these, 97 had data from 2 timepoints resulting in a total scan number of 466. Grey matter density maps, probabilistic tractography connectivity matrices and connectopic maps were extracted from respective MRI modalities and were then integrated with Linked Independent Component Analysis. Linear mixed-effects models were used to evaluate the relationship between components and group while accounting for covariates and non-independence of participants with longitudinal data. Additional models were run to investigate associations with dimensional measures of behaviour. We identified one component that differed significantly between groups (coefficient=0.33, p(adj)=0.02). This was driven (99%) by variance of the right fusiform gyrus connectopic map 2. While there were multiple nominal (uncorrected p<0.05) associations with behavioural measures, none were significant following multiple comparison correction. Our analysis considered the relative contributions of both structural and functional brain phenotypes simultaneously, finding that functional phenotypes drive associations with autism. These findings expanded on previous unimodal studies by revealing the topographic organisation of functional connectivity patterns specific to autism and warrant further investigation. En ligne : http://dx.doi.org/10.1186/s13229-023-00564-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513
in Molecular Autism > 14 (2023) . - 32 p.[article] Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study [Texte imprimé et/ou numérique] / Alberto LLERA, Auteur ; Ting MEI, Auteur ; Koen HAAK, Auteur ; Christina ISAKOGLOU, Auteur ; Dorothea L. FLORIS, Auteur ; Sarah DURSTON, Auteur ; Carolin MOESSNANG, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Eva LOTH, Auteur ; Flavio DELL'ACQUA, Auteur ; Tony CHARMAN, Auteur ; Declan G. M. MURPHY, Auteur ; Christine ECKER, Auteur ; Jan K. BUITELAAR, Auteur ; Christian F. BECKMANN, Auteur . - 32 p.
Langues : Anglais (eng)
in Molecular Autism > 14 (2023) . - 32 p.
Index. décimale : PER Périodiques Résumé : Neuroimaging analyses of brain structure and function in autism have typically been conducted in isolation, missing the sensitivity gains of linking data across modalities. Here we focus on the integration of structural and functional organisational properties of brain regions. We aim to identify novel brain-organisation phenotypes of autism. We utilised multimodal MRI (T1-, diffusion-weighted and resting state functional), behavioural and clinical data from the EU AIMS Longitudinal European Autism Project (LEAP) from autistic (n=206) and non-autistic (n=196) participants. Of these, 97 had data from 2 timepoints resulting in a total scan number of 466. Grey matter density maps, probabilistic tractography connectivity matrices and connectopic maps were extracted from respective MRI modalities and were then integrated with Linked Independent Component Analysis. Linear mixed-effects models were used to evaluate the relationship between components and group while accounting for covariates and non-independence of participants with longitudinal data. Additional models were run to investigate associations with dimensional measures of behaviour. We identified one component that differed significantly between groups (coefficient=0.33, p(adj)=0.02). This was driven (99%) by variance of the right fusiform gyrus connectopic map 2. While there were multiple nominal (uncorrected p<0.05) associations with behavioural measures, none were significant following multiple comparison correction. Our analysis considered the relative contributions of both structural and functional brain phenotypes simultaneously, finding that functional phenotypes drive associations with autism. These findings expanded on previous unimodal studies by revealing the topographic organisation of functional connectivity patterns specific to autism and warrant further investigation. En ligne : http://dx.doi.org/10.1186/s13229-023-00564-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 Look duration at the face as a developmental endophenotype: elucidating pathways to autism and ADHD / Anna GUI in Development and Psychopathology, 32-4 (October 2020)
PermalinkLoss of language in early development of autism and specific language impairment / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 50-7 (July 2009)
PermalinkMaking the future together: Shaping autism research through meaningful participation / Sue FLETCHER-WATSON in Autism, 23-4 (May 2019)
PermalinkMapping the link between socio-economic factors, autistic traits and mental health across different settings / Teresa DEL BIANCO in Autism, 28-5 (May 2024)
PermalinkMeasurement of urine indolylacroylglycine is not useful in the diagnosis or dietary management of autism / Neil R. DALTON in Autism Research, 10-3 (March 2017)
PermalinkMediation of 6-year mid-childhood follow-up outcomes after pre-school social communication (PACT) therapy for autistic children: randomised controlled trial / Andrew PICKLES ; Tony CHARMAN ; Helen MCCONACHIE ; Ann LE COUTEUR ; Vicky SLONIMS ; Patricia HOWLIN ; Rachel COLLUM ; Erica SALOMONE ; Hannah TOBIN ; Isobel GAMMER ; Jessica MAXWELL ; Catherine ALDRED ; Jeremy PARR ; Kathy LEADBITTER ; Jonathan GREEN in Journal of Child Psychology and Psychiatry, 65-2 (February 2024)
PermalinkMid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder / Elizabeth SHEPHARD in Autism Research, 10-3 (March 2017)
PermalinkMise en place d'un programme régional de dépistage par le CHAT / Peter DOEHRING
PermalinkMotor development in children at risk of autism: A follow-up study of infant siblings / Hayley C. LEONARD in Autism, 18-3 (April 2014)
PermalinkA multimodal approach to emotion recognition ability in autism spectrum disorders / Catherine R. G. JONES in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)
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