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Détail de l'auteur
Auteur Kevin A. PELPHREY |
Documents disponibles écrits par cet auteur (22)
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Revisiting Regression in Autism: Heller's Dementia Infantilis / Alexander WESTPHAL in Journal of Autism and Developmental Disorders, 43-2 (February 2013)
[article]
Titre : Revisiting Regression in Autism: Heller's Dementia Infantilis Type de document : Texte imprimé et/ou numérique Auteurs : Alexander WESTPHAL, Auteur ; Stefanie SCHELINSKI, Auteur ; Fred R. VOLKMAR, Auteur ; Kevin A. PELPHREY, Auteur Année de publication : 2013 Article en page(s) : p.265-271 Langues : (Eng) Mots-clés : Autism spectrum disorder Childhood disintegrative disorder Regression Index. décimale : PER Périodiques Résumé : Theodor Heller first described a severe regression of adaptive function in normally developing children, something he termed dementia infantilis, over one 100 years ago. Dementia infantilis is most closely related to the modern diagnosis, childhood disintegrative disorder. We translate Heller's paper, Über Dementia Infantilis, and discuss similarities in presentation between Heller's cases, and a group of children with childhood disintegrative disorder. In particular we discuss a prodromal period of affective dysregulation described by Heller, and also evident in our sample, but not previously described in any detail since the publication of Über Dementia Infantilis. En ligne : http://dx.doi.org/10.1007/s10803-012-1559-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188
in Journal of Autism and Developmental Disorders > 43-2 (February 2013) . - p.265-271[article] Revisiting Regression in Autism: Heller's Dementia Infantilis [Texte imprimé et/ou numérique] / Alexander WESTPHAL, Auteur ; Stefanie SCHELINSKI, Auteur ; Fred R. VOLKMAR, Auteur ; Kevin A. PELPHREY, Auteur . - 2013 . - p.265-271.
Langues : (Eng)
in Journal of Autism and Developmental Disorders > 43-2 (February 2013) . - p.265-271
Mots-clés : Autism spectrum disorder Childhood disintegrative disorder Regression Index. décimale : PER Périodiques Résumé : Theodor Heller first described a severe regression of adaptive function in normally developing children, something he termed dementia infantilis, over one 100 years ago. Dementia infantilis is most closely related to the modern diagnosis, childhood disintegrative disorder. We translate Heller's paper, Über Dementia Infantilis, and discuss similarities in presentation between Heller's cases, and a group of children with childhood disintegrative disorder. In particular we discuss a prodromal period of affective dysregulation described by Heller, and also evident in our sample, but not previously described in any detail since the publication of Über Dementia Infantilis. En ligne : http://dx.doi.org/10.1007/s10803-012-1559-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism / S. AYKAN in Journal of Autism and Developmental Disorders, 52-1 (January 2022)
[article]
Titre : Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism Type de document : Texte imprimé et/ou numérique Auteurs : S. AYKAN, Auteur ; M. H. PUGLIA, Auteur ; C. KALAYCIO?LU, Auteur ; Kevin A. PELPHREY, Auteur ; T. TUNCALI, Auteur ; E. NALÇACI, Auteur Article en page(s) : p.61-72 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/genetics Autistic Disorder/genetics Electroencephalography Humans Solute Carrier Family 12, Member 2 Symporters/genetics Autistic traits Coherence Excitation/inhibition imbalance Kcc2 Quantitative traits Theta oscillations Index. décimale : PER Périodiques Résumé : Our aim was to use theta coherence as a quantitative trait to investigate the relation of the polymorphisms in NKCC1 (rs3087889) and KCC2 (rs9074) channel protein genes to autistic traits (AQ) in neurotypicals. Coherence values for candidate connection regions were calculated from eyes-closed resting EEGs in two independent groups. Hypersynchrony within the right anterior region was related to AQ in both groups (p?0.05), and variability in this hypersynchrony was related to the rs9074 polymorphism in the total group (p?0.05). In conclusion, theta hypersynchrony within the right anterior region during eyes-closed rest can be considered a quantitative measure for autistic traits. Replicating our findings in two independent populations with different backgrounds strengthens the validity of the current study. En ligne : http://dx.doi.org/10.1007/s10803-021-04924-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454
in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.61-72[article] Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism [Texte imprimé et/ou numérique] / S. AYKAN, Auteur ; M. H. PUGLIA, Auteur ; C. KALAYCIO?LU, Auteur ; Kevin A. PELPHREY, Auteur ; T. TUNCALI, Auteur ; E. NALÇACI, Auteur . - p.61-72.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.61-72
Mots-clés : Autism Spectrum Disorder/genetics Autistic Disorder/genetics Electroencephalography Humans Solute Carrier Family 12, Member 2 Symporters/genetics Autistic traits Coherence Excitation/inhibition imbalance Kcc2 Quantitative traits Theta oscillations Index. décimale : PER Périodiques Résumé : Our aim was to use theta coherence as a quantitative trait to investigate the relation of the polymorphisms in NKCC1 (rs3087889) and KCC2 (rs9074) channel protein genes to autistic traits (AQ) in neurotypicals. Coherence values for candidate connection regions were calculated from eyes-closed resting EEGs in two independent groups. Hypersynchrony within the right anterior region was related to AQ in both groups (p?0.05), and variability in this hypersynchrony was related to the rs9074 polymorphism in the total group (p?0.05). In conclusion, theta hypersynchrony within the right anterior region during eyes-closed rest can be considered a quantitative measure for autistic traits. Replicating our findings in two independent populations with different backgrounds strengthens the validity of the current study. En ligne : http://dx.doi.org/10.1007/s10803-021-04924-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 Sex and gender differences in autism spectrum disorder: summarizing evidence gaps and identifying emerging areas of priority / Alycia K. HALLADAY in Molecular Autism, (June 2015)
[article]
Titre : Sex and gender differences in autism spectrum disorder: summarizing evidence gaps and identifying emerging areas of priority Type de document : Texte imprimé et/ou numérique Auteurs : Alycia K. HALLADAY, Auteur ; Somer L. BISHOP, Auteur ; John N. CONSTANTINO, Auteur ; Amy M. DANIELS, Auteur ; Kathleen KOENIG, Auteur ; Kate PALMER, Auteur ; Daniel MESSINGER, Auteur ; Kevin A. PELPHREY, Auteur ; Stephan J. SANDERS, Auteur ; Alison Tepper SINGER, Auteur ; Julie LOUNDS TAYLOR, Auteur ; Peter SZATMARI, Auteur Article en page(s) : p.1-5 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : One of the most consistent findings in autism spectrum disorder (ASD) research is a higher rate of ASD diagnosis in males than females. Despite this, remarkably little research has focused on the reasons for this disparity. Better understanding of this sex difference could lead to major advancements in the prevention or treatment of ASD in both males and females. In October of 2014, Autism Speaks and the Autism Science Foundation co-organized a meeting that brought together almost 60 clinicians, researchers, parents, and self-identified autistic individuals. Discussion at the meeting is summarized here with recommendations on directions of future research endeavors. En ligne : http://dx.doi.org/10.1186/s13229-015-0019-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277
in Molecular Autism > (June 2015) . - p.1-5[article] Sex and gender differences in autism spectrum disorder: summarizing evidence gaps and identifying emerging areas of priority [Texte imprimé et/ou numérique] / Alycia K. HALLADAY, Auteur ; Somer L. BISHOP, Auteur ; John N. CONSTANTINO, Auteur ; Amy M. DANIELS, Auteur ; Kathleen KOENIG, Auteur ; Kate PALMER, Auteur ; Daniel MESSINGER, Auteur ; Kevin A. PELPHREY, Auteur ; Stephan J. SANDERS, Auteur ; Alison Tepper SINGER, Auteur ; Julie LOUNDS TAYLOR, Auteur ; Peter SZATMARI, Auteur . - p.1-5.
Langues : Anglais (eng)
in Molecular Autism > (June 2015) . - p.1-5
Index. décimale : PER Périodiques Résumé : One of the most consistent findings in autism spectrum disorder (ASD) research is a higher rate of ASD diagnosis in males than females. Despite this, remarkably little research has focused on the reasons for this disparity. Better understanding of this sex difference could lead to major advancements in the prevention or treatment of ASD in both males and females. In October of 2014, Autism Speaks and the Autism Science Foundation co-organized a meeting that brought together almost 60 clinicians, researchers, parents, and self-identified autistic individuals. Discussion at the meeting is summarized here with recommendations on directions of future research endeavors. En ligne : http://dx.doi.org/10.1186/s13229-015-0019-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 Tactile Perception in Adults with Autism: a Multidimensional Psychophysical Study / Carissa J. CASCIO in Journal of Autism and Developmental Disorders, 38-1 (January 2008)
[article]
Titre : Tactile Perception in Adults with Autism: a Multidimensional Psychophysical Study Type de document : Texte imprimé et/ou numérique Auteurs : Carissa J. CASCIO, Auteur ; Grace T. BARANEK, Auteur ; Francis MCGLONE, Auteur ; Stephen FOLGER, Auteur ; Vinay TANNAN, Auteur ; Kevin A. PELPHREY, Auteur ; Gregory ESSICK, Auteur Année de publication : 2008 Article en page(s) : p.127-137 Langues : Anglais (eng) Mots-clés : Autism Sensory Tactile Psychophysics CT-afferents Index. décimale : PER Périodiques Résumé : Although sensory problems, including unusual tactile sensitivity, are heavily associated with autism, there is a dearth of rigorous psychophysical research. We compared tactile sensation in adults with autism to controls on the palm and forearm, the latter innervated by low-threshold unmyelinated afferents subserving a social/affiliative submodality of somatosensation. At both sites, the groups displayed similar thresholds for detecting light touch and innocuous sensations of warmth and cool, and provided similar hedonic ratings of the pleasantness of textures. In contrast, increased sensitivity to vibration was seen in the autism group on the forearm, along with increased sensitivity to thermal pain at both sites. These findings suggest normal perception along with certain areas of enhanced perception in autism, consistent with previous studies.
En ligne : http://dx.doi.org/10.1007/s10803-007-0370-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316
in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.127-137[article] Tactile Perception in Adults with Autism: a Multidimensional Psychophysical Study [Texte imprimé et/ou numérique] / Carissa J. CASCIO, Auteur ; Grace T. BARANEK, Auteur ; Francis MCGLONE, Auteur ; Stephen FOLGER, Auteur ; Vinay TANNAN, Auteur ; Kevin A. PELPHREY, Auteur ; Gregory ESSICK, Auteur . - 2008 . - p.127-137.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.127-137
Mots-clés : Autism Sensory Tactile Psychophysics CT-afferents Index. décimale : PER Périodiques Résumé : Although sensory problems, including unusual tactile sensitivity, are heavily associated with autism, there is a dearth of rigorous psychophysical research. We compared tactile sensation in adults with autism to controls on the palm and forearm, the latter innervated by low-threshold unmyelinated afferents subserving a social/affiliative submodality of somatosensation. At both sites, the groups displayed similar thresholds for detecting light touch and innocuous sensations of warmth and cool, and provided similar hedonic ratings of the pleasantness of textures. In contrast, increased sensitivity to vibration was seen in the autism group on the forearm, along with increased sensitivity to thermal pain at both sites. These findings suggest normal perception along with certain areas of enhanced perception in autism, consistent with previous studies.
En ligne : http://dx.doi.org/10.1007/s10803-007-0370-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 The gap between IQ and adaptive functioning in autism spectrum disorder: Disentangling diagnostic and sex differences / G. A. MCQUAID in Autism, 25-6 (August 2021)
[article]
Titre : The gap between IQ and adaptive functioning in autism spectrum disorder: Disentangling diagnostic and sex differences Type de document : Texte imprimé et/ou numérique Auteurs : G. A. MCQUAID, Auteur ; Kevin A. PELPHREY, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; S. J. WEBB, Auteur ; Raphael BERNIER, Auteur ; J. C. MCPARTLAND, Auteur ; J. D. VAN HORN, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.1565-1579 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder Autistic Disorder Female Humans Intellectual Disability Male Sex Characteristics Social Skills Iq adaptive functioning autism sex differences of interest with respect to the research, authorship, and/or publication of this article. Index. décimale : PER Périodiques Résumé : Adaptive functioning refers to skills that are vital to success in day-to-day life, including daily living (e.g. grocery shopping, food preparation, transportation use), communication (e.g. verbal expression of needs), and socialization skills (e.g. interpersonal skills, including expressing and recognizing emotions, and understanding turn-taking in conversation). Among autistic individuals without intellectual disability, adaptive functioning is not commensurate with intellectual ability (IQ), and instead a gap exists between these individuals' intellectual ability and their adaptive skills. Further, these autistic individuals show a widening of this gap with increasing age. Existing studies of the gap between IQ and adaptive functioning have studied predominantly male samples. Thus, we do not know if the gap also exists in autistic females. We therefore looked at adaptive functioning and the gap between IQ and adaptive functioning in a large sample of autistic girls and boys without intellectual disability. To disentangle effects of group (autistic vs typically developing) from effects of sex (girls vs boys), we compared autistic girls and boys to one another as well as to their same-sex typically developing peers. Analyses took into consideration differences in IQ between autistic and typically developing youth. We found autistic girls, like autistic boys, show lower adaptive functioning than their same-sex typically developing peers. Results underscore the need to evaluate adaptive functioning in autistic individuals without intellectual disability and to provide necessary supports. The large gap between intellectual ability and socialization skills, in particular, may be of critical importance in improving our understanding of outcomes and mental health difficulties among autistic females. En ligne : http://dx.doi.org/10.1177/1362361321995620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451
in Autism > 25-6 (August 2021) . - p.1565-1579[article] The gap between IQ and adaptive functioning in autism spectrum disorder: Disentangling diagnostic and sex differences [Texte imprimé et/ou numérique] / G. A. MCQUAID, Auteur ; Kevin A. PELPHREY, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; S. J. WEBB, Auteur ; Raphael BERNIER, Auteur ; J. C. MCPARTLAND, Auteur ; J. D. VAN HORN, Auteur ; Gregory L. WALLACE, Auteur . - p.1565-1579.
Langues : Anglais (eng)
in Autism > 25-6 (August 2021) . - p.1565-1579
Mots-clés : Adolescent Autism Spectrum Disorder Autistic Disorder Female Humans Intellectual Disability Male Sex Characteristics Social Skills Iq adaptive functioning autism sex differences of interest with respect to the research, authorship, and/or publication of this article. Index. décimale : PER Périodiques Résumé : Adaptive functioning refers to skills that are vital to success in day-to-day life, including daily living (e.g. grocery shopping, food preparation, transportation use), communication (e.g. verbal expression of needs), and socialization skills (e.g. interpersonal skills, including expressing and recognizing emotions, and understanding turn-taking in conversation). Among autistic individuals without intellectual disability, adaptive functioning is not commensurate with intellectual ability (IQ), and instead a gap exists between these individuals' intellectual ability and their adaptive skills. Further, these autistic individuals show a widening of this gap with increasing age. Existing studies of the gap between IQ and adaptive functioning have studied predominantly male samples. Thus, we do not know if the gap also exists in autistic females. We therefore looked at adaptive functioning and the gap between IQ and adaptive functioning in a large sample of autistic girls and boys without intellectual disability. To disentangle effects of group (autistic vs typically developing) from effects of sex (girls vs boys), we compared autistic girls and boys to one another as well as to their same-sex typically developing peers. Analyses took into consideration differences in IQ between autistic and typically developing youth. We found autistic girls, like autistic boys, show lower adaptive functioning than their same-sex typically developing peers. Results underscore the need to evaluate adaptive functioning in autistic individuals without intellectual disability and to provide necessary supports. The large gap between intellectual ability and socialization skills, in particular, may be of critical importance in improving our understanding of outcomes and mental health difficulties among autistic females. En ligne : http://dx.doi.org/10.1177/1362361321995620 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 The gap between IQ and adaptive functioning in autism spectrum disorder: Disentangling diagnostic and sex differences / Goldie A. MCQUAID in Autism, 26-6 (August 2022)
PermalinkThe Implications of Social Neuroscience for Social Disability / James C. MCPARTLAND in Journal of Autism and Developmental Disorders, 42-6 (June 2012)
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