Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur K. BERGER |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder / K. BERGER in Autism Research, 14-9 (September 2021)
[article]
Titre : The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. BERGER, Auteur ; M. PEARL, Auteur ; M. KHARRAZI, Auteur ; Y. LI, Auteur ; J. DEGUZMAN, Auteur ; J. SHE, Auteur ; P. BEHNIWAL, Auteur ; K. LYALL, Auteur ; G. WINDHAM, Auteur Article en page(s) : p.2017-2026 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology/etiology Child Cotinine Female Humans Maternal Exposure/adverse effects Pregnancy Smoking Tobacco Smoke Pollution/adverse effects/analysis Autism Spectrum Disorder cotinine pregnancy smoking tobacco smoking Index. décimale : PER Périodiques Résumé : Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (?3.08?ng/ml vs. <3.08?ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. LAY SUMMARY: This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke. En ligne : http://dx.doi.org/10.1002/aur.2561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-9 (September 2021) . - p.2017-2026[article] The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder [Texte imprimé et/ou numérique] / K. BERGER, Auteur ; M. PEARL, Auteur ; M. KHARRAZI, Auteur ; Y. LI, Auteur ; J. DEGUZMAN, Auteur ; J. SHE, Auteur ; P. BEHNIWAL, Auteur ; K. LYALL, Auteur ; G. WINDHAM, Auteur . - p.2017-2026.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.2017-2026
Mots-clés : Autism Spectrum Disorder/epidemiology/etiology Child Cotinine Female Humans Maternal Exposure/adverse effects Pregnancy Smoking Tobacco Smoke Pollution/adverse effects/analysis Autism Spectrum Disorder cotinine pregnancy smoking tobacco smoking Index. décimale : PER Périodiques Résumé : Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (?3.08?ng/ml vs. <3.08?ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. LAY SUMMARY: This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke. En ligne : http://dx.doi.org/10.1002/aur.2561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450