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Probiotics, prebiotics, synbiotics, and fecal microbiota transplantation in the treatment of behavioral symptoms of autism spectrum disorder: A systematic review / Q. TAN in Autism Research, 14-9 (September 2021)
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[article]
Titre : Probiotics, prebiotics, synbiotics, and fecal microbiota transplantation in the treatment of behavioral symptoms of autism spectrum disorder: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Q. TAN, Auteur ; C. E. ORSSO, Auteur ; E. C. DEEHAN, Auteur ; J. Y. KUNG, Auteur ; H. M. TUN, Auteur ; E. WINE, Auteur ; K. L. MADSEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; A. M. HAQQ, Auteur Article en page(s) : p.1820-1836 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy Behavioral Symptoms Fecal Microbiota Transplantation Gastrointestinal Microbiome Humans Prebiotics Probiotics/therapeutic use Randomized Controlled Trials as Topic Synbiotics autism spectrum disorder fecal microbiota transplant gut microbiota prebiotic probiotic synbiotic Index. décimale : PER Périodiques Résumé : The emerging role of a microbiota-gut-brain axis in autism spectrum disorder (ASD) suggests that modulating gut microbial composition may offer a tractable approach to addressing the lifelong challenges of ASD. The aim of this systematic review was to provide an overview and critically evaluate the current evidence on the efficacy and safety of probiotic, prebiotic, synbiotic, and fecal microbiota transplantation therapies for core and co-occurring behavioral symptoms in individuals with ASD. Comprehensive searches of MEDLINE, EMBASE, Scopus, Web of Science Core Collection, Cochrane Library, and Google Scholar were performed from inception to March 5, 2020, and two update searches were completed on October 25, 2020, and April 22, 2021, respectively. A total of 4306 publications were identified, of which 14 articles met the inclusion criteria. Data were extracted independently by two reviewers using a preconstructed form. Results of probiotic studies do not confirm the supposed beneficial effect of probiotics on ASD, whereas prebiotics and synbiotic combinations appear to be efficacious in selective behavioral symptoms. Evidence of the efficacy of fecal microbiota transplantation in ASD is still scarce but supports further research. Overall, the current evidence base to suggest beneficial effects of these modalities in ASD is limited and inconclusive. More clinical trials are currently looking at the use of microbial-based therapies in ASD. With a robust double-blind randomized controlled protocol to investigate the efficacy, these trials should provide significant and definitive results. LAY SUMMARY: There is a link between altered gut bacteria and autism spectrum disorder. Some people believe that modulating bacterial composition in the gut may help reduce autism symptoms, but evidence from human studies suggesting beneficial effects of probiotic, prebiotic, and combination thereof as well as fecal transplants in autism spectrum disorder is limited and inconclusive. Current data should not encourage use of these modalities. Further clinical studies are needed. En ligne : http://dx.doi.org/10.1002/aur.2560 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1820-1836[article] Probiotics, prebiotics, synbiotics, and fecal microbiota transplantation in the treatment of behavioral symptoms of autism spectrum disorder: A systematic review [Texte imprimé et/ou numérique] / Q. TAN, Auteur ; C. E. ORSSO, Auteur ; E. C. DEEHAN, Auteur ; J. Y. KUNG, Auteur ; H. M. TUN, Auteur ; E. WINE, Auteur ; K. L. MADSEN, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; A. M. HAQQ, Auteur . - p.1820-1836.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1820-1836
Mots-clés : Autism Spectrum Disorder/therapy Behavioral Symptoms Fecal Microbiota Transplantation Gastrointestinal Microbiome Humans Prebiotics Probiotics/therapeutic use Randomized Controlled Trials as Topic Synbiotics autism spectrum disorder fecal microbiota transplant gut microbiota prebiotic probiotic synbiotic Index. décimale : PER Périodiques Résumé : The emerging role of a microbiota-gut-brain axis in autism spectrum disorder (ASD) suggests that modulating gut microbial composition may offer a tractable approach to addressing the lifelong challenges of ASD. The aim of this systematic review was to provide an overview and critically evaluate the current evidence on the efficacy and safety of probiotic, prebiotic, synbiotic, and fecal microbiota transplantation therapies for core and co-occurring behavioral symptoms in individuals with ASD. Comprehensive searches of MEDLINE, EMBASE, Scopus, Web of Science Core Collection, Cochrane Library, and Google Scholar were performed from inception to March 5, 2020, and two update searches were completed on October 25, 2020, and April 22, 2021, respectively. A total of 4306 publications were identified, of which 14 articles met the inclusion criteria. Data were extracted independently by two reviewers using a preconstructed form. Results of probiotic studies do not confirm the supposed beneficial effect of probiotics on ASD, whereas prebiotics and synbiotic combinations appear to be efficacious in selective behavioral symptoms. Evidence of the efficacy of fecal microbiota transplantation in ASD is still scarce but supports further research. Overall, the current evidence base to suggest beneficial effects of these modalities in ASD is limited and inconclusive. More clinical trials are currently looking at the use of microbial-based therapies in ASD. With a robust double-blind randomized controlled protocol to investigate the efficacy, these trials should provide significant and definitive results. LAY SUMMARY: There is a link between altered gut bacteria and autism spectrum disorder. Some people believe that modulating bacterial composition in the gut may help reduce autism symptoms, but evidence from human studies suggesting beneficial effects of probiotic, prebiotic, and combination thereof as well as fecal transplants in autism spectrum disorder is limited and inconclusive. Current data should not encourage use of these modalities. Further clinical studies are needed. En ligne : http://dx.doi.org/10.1002/aur.2560 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Reduced brain volume and white matter alterations in Shank3-deficient rats / C. E. M. GOLDEN in Autism Research, 14-9 (September 2021)
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Titre : Reduced brain volume and white matter alterations in Shank3-deficient rats Type de document : Texte imprimé et/ou numérique Auteurs : C. E. M. GOLDEN, Auteur ; V. X. WANG, Auteur ; Hala HARONY-NICOLAS, Auteur ; P. R. HOF, Auteur ; Joseph D. BUXBAUM, Auteur Article en page(s) : p.1837-1842 Langues : Anglais (eng) Mots-clés : Animals Autism Spectrum Disorder Brain/anatomy & histology/diagnostic imaging Chromosome Disorders Diffusion Tensor Imaging Male Nerve Tissue Proteins/genetics Rats White Matter/anatomy & histology/diagnostic imaging Shank3 diffusion tensor imaging magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Mutations and deletions in the SHANK3 gene cause the major neurodevelopmental features of Phelan-McDermid syndrome (PMS), which is characterized by intellectual disability, autism spectrum disorder, and sensory hyporeactivity. SHANK3 encodes a key structural component of excitatory synapses important for synaptogenesis. Clinical assessments and limited brain imaging studies of patients with PMS have uncovered regional volume reductions and white matter thinning. While these impairments have been replicated ex vivo in pups of a rat model, brain structure has not been assessed in rats in vivo or in adults. We assessed the brain structure of heterozygous and homozygous adult Shank3-deficient male rats in comparison to wild-type littermates with magnetic resonance imaging using both anatomical assessments and diffusion tensor imaging (DTI). Shank3-deficient rats showed a reduction in overall brain size and the absolute volume of the neocortex, piriform cortex, thalamus, forebrain, inferior and superior colliculi, internal capsule, and anterior commissure. The superior colliculus was decreased in relative volume. DTI revealed that axial diffusion and fractional anisotropy were reduced in the external capsule and mean diffusion was increased in the fornix, suggesting that restriction of diffusion perpendicular to the axis of the axonal fibers was impaired in these white matter tracts. Therefore, Shank3-deficient rats replicate the reduced brain volume and altered white matter phenotypes present in PMS. Our results indicate that the loss of a glutamatergic synaptic protein, Shank3, has structural consequences at the level of the whole brain. The brain regions that were altered represent potential cross-species structural biomarkers that warrant further study. En ligne : http://dx.doi.org/10.1002/aur.2568 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1837-1842[article] Reduced brain volume and white matter alterations in Shank3-deficient rats [Texte imprimé et/ou numérique] / C. E. M. GOLDEN, Auteur ; V. X. WANG, Auteur ; Hala HARONY-NICOLAS, Auteur ; P. R. HOF, Auteur ; Joseph D. BUXBAUM, Auteur . - p.1837-1842.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1837-1842
Mots-clés : Animals Autism Spectrum Disorder Brain/anatomy & histology/diagnostic imaging Chromosome Disorders Diffusion Tensor Imaging Male Nerve Tissue Proteins/genetics Rats White Matter/anatomy & histology/diagnostic imaging Shank3 diffusion tensor imaging magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Mutations and deletions in the SHANK3 gene cause the major neurodevelopmental features of Phelan-McDermid syndrome (PMS), which is characterized by intellectual disability, autism spectrum disorder, and sensory hyporeactivity. SHANK3 encodes a key structural component of excitatory synapses important for synaptogenesis. Clinical assessments and limited brain imaging studies of patients with PMS have uncovered regional volume reductions and white matter thinning. While these impairments have been replicated ex vivo in pups of a rat model, brain structure has not been assessed in rats in vivo or in adults. We assessed the brain structure of heterozygous and homozygous adult Shank3-deficient male rats in comparison to wild-type littermates with magnetic resonance imaging using both anatomical assessments and diffusion tensor imaging (DTI). Shank3-deficient rats showed a reduction in overall brain size and the absolute volume of the neocortex, piriform cortex, thalamus, forebrain, inferior and superior colliculi, internal capsule, and anterior commissure. The superior colliculus was decreased in relative volume. DTI revealed that axial diffusion and fractional anisotropy were reduced in the external capsule and mean diffusion was increased in the fornix, suggesting that restriction of diffusion perpendicular to the axis of the axonal fibers was impaired in these white matter tracts. Therefore, Shank3-deficient rats replicate the reduced brain volume and altered white matter phenotypes present in PMS. Our results indicate that the loss of a glutamatergic synaptic protein, Shank3, has structural consequences at the level of the whole brain. The brain regions that were altered represent potential cross-species structural biomarkers that warrant further study. En ligne : http://dx.doi.org/10.1002/aur.2568 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Early social rearing, the V1A arginine vasopressin receptor genotype, and autistic traits in chimpanzees / A. WEISS in Autism Research, 14-9 (September 2021)
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[article]
Titre : Early social rearing, the V1A arginine vasopressin receptor genotype, and autistic traits in chimpanzees Type de document : Texte imprimé et/ou numérique Auteurs : A. WEISS, Auteur ; Vanessa A. D. WILSON, Auteur ; W. D. HOPKINS, Auteur Article en page(s) : p.1843-1853 Langues : Anglais (eng) Mots-clés : Animals Autism Spectrum Disorder/genetics Autistic Disorder/genetics Genotype Pan troglodytes/genetics Receptors, Vasopressin/genetics Social Behavior Avpr1a autism development mother primate vasopressin Index. décimale : PER Périodiques Résumé : Previous studies found associations between autism-related phenotypes and both rearing and V1A arginine vasopressin receptor (AVPR1A) genotypes. We tested whether these exposures as well as their interaction were associated with autism-related phenotypes in 121 laboratory-housed chimpanzees. We used expert-derived weights to obtain autism scores from ratings on the 43-item Chimpanzee Personality Questionnaire; higher scores indicated more autistic-like traits. The first model included fixed effects for sex, age, and rearing, and a random effect that addressed the relatedness of subjects. The second model was the same except that it also included the rearing × AVPR1A genotype interaction as a fixed effect. Both models indicated that the phenotype was moderately heritable and that chimpanzees reared by their mothers had lower scores on the scale. The effect of genotype in both models indicated that chimpanzees with an indel deletion had higher scores on the scale, although the credible interval included zero. Moreover, the rearing × genotype interaction in the second model indicated that chimpanzees who possessed the non-deletion genotype and who were reared by their mother were at even greater risk. The credible interval for this effect did not include zero, but fit statistics indicated that the model without the interaction was marginally better, and the interaction was in the opposite direction than we expected based on previous work. These findings highlight the importance of rearing effects in the typical social development of our closet-living nonhuman relative. LAY SUMMARY: We tested whether, in chimpanzees, scores on a scale comprising traits that resembled aspects of autism were related to a gene associated with autism in prior research and/or early rearing. Human-reared chimpanzees had higher scores (indicating more autistic-like traits). Chimpanzees that possessed the gene also had higher scores, but we could not exclude the possibility that there was no effect of genotype. These findings suggest that we can measure autism-like characteristics in chimpanzees, and so study it in this species. En ligne : http://dx.doi.org/10.1002/aur.2550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1843-1853[article] Early social rearing, the V1A arginine vasopressin receptor genotype, and autistic traits in chimpanzees [Texte imprimé et/ou numérique] / A. WEISS, Auteur ; Vanessa A. D. WILSON, Auteur ; W. D. HOPKINS, Auteur . - p.1843-1853.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1843-1853
Mots-clés : Animals Autism Spectrum Disorder/genetics Autistic Disorder/genetics Genotype Pan troglodytes/genetics Receptors, Vasopressin/genetics Social Behavior Avpr1a autism development mother primate vasopressin Index. décimale : PER Périodiques Résumé : Previous studies found associations between autism-related phenotypes and both rearing and V1A arginine vasopressin receptor (AVPR1A) genotypes. We tested whether these exposures as well as their interaction were associated with autism-related phenotypes in 121 laboratory-housed chimpanzees. We used expert-derived weights to obtain autism scores from ratings on the 43-item Chimpanzee Personality Questionnaire; higher scores indicated more autistic-like traits. The first model included fixed effects for sex, age, and rearing, and a random effect that addressed the relatedness of subjects. The second model was the same except that it also included the rearing × AVPR1A genotype interaction as a fixed effect. Both models indicated that the phenotype was moderately heritable and that chimpanzees reared by their mothers had lower scores on the scale. The effect of genotype in both models indicated that chimpanzees with an indel deletion had higher scores on the scale, although the credible interval included zero. Moreover, the rearing × genotype interaction in the second model indicated that chimpanzees who possessed the non-deletion genotype and who were reared by their mother were at even greater risk. The credible interval for this effect did not include zero, but fit statistics indicated that the model without the interaction was marginally better, and the interaction was in the opposite direction than we expected based on previous work. These findings highlight the importance of rearing effects in the typical social development of our closet-living nonhuman relative. LAY SUMMARY: We tested whether, in chimpanzees, scores on a scale comprising traits that resembled aspects of autism were related to a gene associated with autism in prior research and/or early rearing. Human-reared chimpanzees had higher scores (indicating more autistic-like traits). Chimpanzees that possessed the gene also had higher scores, but we could not exclude the possibility that there was no effect of genotype. These findings suggest that we can measure autism-like characteristics in chimpanzees, and so study it in this species. En ligne : http://dx.doi.org/10.1002/aur.2550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Communication and social interaction in the cannabinoid-type 1 receptor null mouse: Implications for autism spectrum disorder / W. FYKE in Autism Research, 14-9 (September 2021)
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[article]
Titre : Communication and social interaction in the cannabinoid-type 1 receptor null mouse: Implications for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : W. FYKE, Auteur ; M. PREMOLI, Auteur ; V. ECHEVERRY ALZATE, Auteur ; J. A. LÓPEZ-MORENO, Auteur ; V. LEMAIRE-MAYO, Auteur ; W. E. CRUSIO, Auteur ; G. MARSICANO, Auteur ; M. WOHR, Auteur ; S. PIETROPAOLO, Auteur Article en page(s) : p.1854-1872 Langues : Anglais (eng) Mots-clés : Animals Autism Spectrum Disorder/genetics Communication Disease Models, Animal Female Male Mice Mice, Knockout Receptor, Cannabinoid, CB1/genetics Social Behavior Social Interaction cannabinoid receptor mouse models phenotype sex differences ultrasounds Index. décimale : PER Périodiques Résumé : Clinical and preclinical findings have suggested a role of the endocannabinoid system (ECS) in the etiopathology of autism spectrum disorder (ASD). Previous mouse studies have investigated the role of ECS in several behavioral domains; however, none of them has performed an extensive assessment of social and communication behaviors, that is, the main core features of ASD. This study employed a mouse line lacking the primary endocannabinoid receptor (CB1r) and characterized ultrasonic communication and social interaction in CB1(-/-) , CB1(+/-) , and CB1(+/+) males and females. Quantitative and qualitative alterations in ultrasonic vocalizations (USVs) were observed in CB1 null mice both during early development (i.e., between postnatal days 4 and 10), and at adulthood (i.e., at 3 months of age). Adult mutants also showed marked deficits in social interest in the three-chamber test and social investigation in the direct social interaction test. These behavioral alterations were mostly observed in both sexes and appeared more marked in CB1(-/-) than CB1(+/-) mutant mice. Importantly, the adult USV alterations could not be attributed to differences in anxiety or sensorimotor abilities, as assessed by the elevated plus maze and auditory startle tests. Our findings demonstrate the role of CB1r in social communication and behavior, supporting the use of the CB1 full knockout mouse in preclinical research on these ASD-relevant core domains. LAY SUMMARY: The endocannabinoid system (ECS) is important for brain development and neural function and is therefore likely to be involved in neurodevelopmental disorders such as Autism Spectrum Disorder (ASD). Here we investigated changes in social behavior and communication, which are core features of ASD, in male and female mice lacking the chief receptor of this system. Our results show that loss of this receptor results in several changes in social behavior and communication both during early development and in adulthood, thus supporting the role of the ECS in these ASD-core behavioral domains. En ligne : http://dx.doi.org/10.1002/aur.2562 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1854-1872[article] Communication and social interaction in the cannabinoid-type 1 receptor null mouse: Implications for autism spectrum disorder [Texte imprimé et/ou numérique] / W. FYKE, Auteur ; M. PREMOLI, Auteur ; V. ECHEVERRY ALZATE, Auteur ; J. A. LÓPEZ-MORENO, Auteur ; V. LEMAIRE-MAYO, Auteur ; W. E. CRUSIO, Auteur ; G. MARSICANO, Auteur ; M. WOHR, Auteur ; S. PIETROPAOLO, Auteur . - p.1854-1872.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1854-1872
Mots-clés : Animals Autism Spectrum Disorder/genetics Communication Disease Models, Animal Female Male Mice Mice, Knockout Receptor, Cannabinoid, CB1/genetics Social Behavior Social Interaction cannabinoid receptor mouse models phenotype sex differences ultrasounds Index. décimale : PER Périodiques Résumé : Clinical and preclinical findings have suggested a role of the endocannabinoid system (ECS) in the etiopathology of autism spectrum disorder (ASD). Previous mouse studies have investigated the role of ECS in several behavioral domains; however, none of them has performed an extensive assessment of social and communication behaviors, that is, the main core features of ASD. This study employed a mouse line lacking the primary endocannabinoid receptor (CB1r) and characterized ultrasonic communication and social interaction in CB1(-/-) , CB1(+/-) , and CB1(+/+) males and females. Quantitative and qualitative alterations in ultrasonic vocalizations (USVs) were observed in CB1 null mice both during early development (i.e., between postnatal days 4 and 10), and at adulthood (i.e., at 3 months of age). Adult mutants also showed marked deficits in social interest in the three-chamber test and social investigation in the direct social interaction test. These behavioral alterations were mostly observed in both sexes and appeared more marked in CB1(-/-) than CB1(+/-) mutant mice. Importantly, the adult USV alterations could not be attributed to differences in anxiety or sensorimotor abilities, as assessed by the elevated plus maze and auditory startle tests. Our findings demonstrate the role of CB1r in social communication and behavior, supporting the use of the CB1 full knockout mouse in preclinical research on these ASD-relevant core domains. LAY SUMMARY: The endocannabinoid system (ECS) is important for brain development and neural function and is therefore likely to be involved in neurodevelopmental disorders such as Autism Spectrum Disorder (ASD). Here we investigated changes in social behavior and communication, which are core features of ASD, in male and female mice lacking the chief receptor of this system. Our results show that loss of this receptor results in several changes in social behavior and communication both during early development and in adulthood, thus supporting the role of the ECS in these ASD-core behavioral domains. En ligne : http://dx.doi.org/10.1002/aur.2562 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Social attention as a cross-cultural transdiagnostic neurodevelopmental risk marker / T. W. FRAZIER in Autism Research, 14-9 (September 2021)
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[article]
Titre : Social attention as a cross-cultural transdiagnostic neurodevelopmental risk marker Type de document : Texte imprimé et/ou numérique Auteurs : T. W. FRAZIER, Auteur ; M. ULJAREVIC, Auteur ; I. GHAZAL, Auteur ; E. W. KLINGEMIER, Auteur ; J. LANGFUS, Auteur ; Eric A. YOUNGSTROM, Auteur ; Mohammed ALDOSARI, Auteur ; H. AL-SHAMMARI, Auteur ; S. EL-HAG, Auteur ; M. TOLEFAT, Auteur ; M. ALI, Auteur ; F. A. AL-SHABAN, Auteur Article en page(s) : p.1873-1885 Langues : Anglais (eng) Mots-clés : Adolescent Attention Autism Spectrum Disorder Child Child, Preschool Cross-Cultural Comparison Female Goals Humans Infant Male Mass Screening autism cross-cultural developmental disability risk marker social attention validation Index. décimale : PER Périodiques Résumé : The primary objectives of this study were to evaluate the structure and age-related stability of social attention in English and Arabic-speaking youth and to compare social attention between children with autism spectrum disorder (ASD), other developmental disabilities (DD), and typically-developing controls. Eye-tracking data were collected from US (N = 270) and Qatari (N = 242) youth ages 1-17, including children evaluated for possible ASD. Participants viewed 44 stimuli from seven social paradigms. Fixation was computed for areas of interest within each stimulus. Latent variable models examined the structure of social attention. Generalized estimating equation models examined the effect of age, sex, culture, and diagnostic group on social attention. The best-fitting model included a general social attention factor and six specific factors. Cultural differences in social attention were minimal and social attention was stable across age (r = 0.03), but females showed significantly greater social attention than males (d = 0.28). Social attention was weaker in DD (d = -0.17) and lowest in ASD (d = -0.38) relative to controls. Differences were of sufficient magnitude across areas-of-interest to reliably differentiate DD from controls (AUC = 0.80) and ASD-only from all other cases (AUC = 0.76). A social attention dimension that represents an early-life preference for socially salient information was identified. This preference was cross-culturally consistent and stable across development but stronger in females and weaker in DD, especially ASD. Given rapid and easy-to-collect remote eye tracking administration, social attention measurement may be useful for developmental monitoring. Acquisition of population norms, analogous to height/weight/head circumference, might enhance early screening and tracking of neurodevelopment. LAY SUMMARY: This research found that social attention is a single dimension of behavior that represents a strong preference for social stimuli, is consistent across cultures, stable across age, and stronger in females. Children with developmental disabilities had lower levels of social attention than neurotypical children and children with autism spectrum disorder had the lowest levels of social attention. En ligne : http://dx.doi.org/10.1002/aur.2532 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1873-1885[article] Social attention as a cross-cultural transdiagnostic neurodevelopmental risk marker [Texte imprimé et/ou numérique] / T. W. FRAZIER, Auteur ; M. ULJAREVIC, Auteur ; I. GHAZAL, Auteur ; E. W. KLINGEMIER, Auteur ; J. LANGFUS, Auteur ; Eric A. YOUNGSTROM, Auteur ; Mohammed ALDOSARI, Auteur ; H. AL-SHAMMARI, Auteur ; S. EL-HAG, Auteur ; M. TOLEFAT, Auteur ; M. ALI, Auteur ; F. A. AL-SHABAN, Auteur . - p.1873-1885.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1873-1885
Mots-clés : Adolescent Attention Autism Spectrum Disorder Child Child, Preschool Cross-Cultural Comparison Female Goals Humans Infant Male Mass Screening autism cross-cultural developmental disability risk marker social attention validation Index. décimale : PER Périodiques Résumé : The primary objectives of this study were to evaluate the structure and age-related stability of social attention in English and Arabic-speaking youth and to compare social attention between children with autism spectrum disorder (ASD), other developmental disabilities (DD), and typically-developing controls. Eye-tracking data were collected from US (N = 270) and Qatari (N = 242) youth ages 1-17, including children evaluated for possible ASD. Participants viewed 44 stimuli from seven social paradigms. Fixation was computed for areas of interest within each stimulus. Latent variable models examined the structure of social attention. Generalized estimating equation models examined the effect of age, sex, culture, and diagnostic group on social attention. The best-fitting model included a general social attention factor and six specific factors. Cultural differences in social attention were minimal and social attention was stable across age (r = 0.03), but females showed significantly greater social attention than males (d = 0.28). Social attention was weaker in DD (d = -0.17) and lowest in ASD (d = -0.38) relative to controls. Differences were of sufficient magnitude across areas-of-interest to reliably differentiate DD from controls (AUC = 0.80) and ASD-only from all other cases (AUC = 0.76). A social attention dimension that represents an early-life preference for socially salient information was identified. This preference was cross-culturally consistent and stable across development but stronger in females and weaker in DD, especially ASD. Given rapid and easy-to-collect remote eye tracking administration, social attention measurement may be useful for developmental monitoring. Acquisition of population norms, analogous to height/weight/head circumference, might enhance early screening and tracking of neurodevelopment. LAY SUMMARY: This research found that social attention is a single dimension of behavior that represents a strong preference for social stimuli, is consistent across cultures, stable across age, and stronger in females. Children with developmental disabilities had lower levels of social attention than neurotypical children and children with autism spectrum disorder had the lowest levels of social attention. En ligne : http://dx.doi.org/10.1002/aur.2532 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder / S. KITAMURA in Autism Research, 14-9 (September 2021)
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[article]
Titre : Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. KITAMURA, Auteur ; M. MAKINODAN, Auteur ; K. MATSUOKA, Auteur ; M. TAKAHASHI, Auteur ; H. YOSHIKAWA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; F. YASUNO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. MIYASAKA, Auteur ; K. KICHIKAWA, Auteur ; T. KISHIMOTO, Auteur Article en page(s) : p.1886-1895 Langues : Anglais (eng) Mots-clés : Adult Adverse Childhood Experiences Autism Spectrum Disorder/diagnostic imaging Brain/diagnostic imaging Child Gray Matter/diagnostic imaging Humans Magnetic Resonance Imaging Parietal Lobe/diagnostic imaging autism spectrum disorder gray matter parietal lobe post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1886-1895[article] Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder [Texte imprimé et/ou numérique] / S. KITAMURA, Auteur ; M. MAKINODAN, Auteur ; K. MATSUOKA, Auteur ; M. TAKAHASHI, Auteur ; H. YOSHIKAWA, Auteur ; R. ISHIDA, Auteur ; N. KISHIMOTO, Auteur ; F. YASUNO, Auteur ; Y. YASUDA, Auteur ; R. HASHIMOTO, Auteur ; T. MIYASAKA, Auteur ; K. KICHIKAWA, Auteur ; T. KISHIMOTO, Auteur . - p.1886-1895.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1886-1895
Mots-clés : Adult Adverse Childhood Experiences Autism Spectrum Disorder/diagnostic imaging Brain/diagnostic imaging Child Gray Matter/diagnostic imaging Humans Magnetic Resonance Imaging Parietal Lobe/diagnostic imaging autism spectrum disorder gray matter parietal lobe post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Health profiles of adults with autism spectrum disorder: Differences between women and men / Leann S. DAWALT in Autism Research, 14-9 (September 2021)
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Titre : Health profiles of adults with autism spectrum disorder: Differences between women and men Type de document : Texte imprimé et/ou numérique Auteurs : Leann S. DAWALT, Auteur ; Julie LOUNDS TAYLOR, Auteur ; A. MOVAGHAR, Auteur ; J. HONG, Auteur ; B. KIM, Auteur ; M. H. BRILLIANT, Auteur ; M. R. MAILICK, Auteur Article en page(s) : p.1896-1904 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/complications/epidemiology Autistic Disorder Electronic Health Records Female Humans Male Sleep Wake Disorders adults electronic health records health health care utilization sex differences Index. décimale : PER Périodiques Résumé : The purpose of the present study was to investigate the hypothesis that women with autism have poorer health compared with men with autism, and compared with women without autism. Utilizing electronic health records drawn from a single health care system serving over 2 million individuals, 2119 adults with diagnosed autism spectrum disorders were compared with age- and sex-matched controls. When considering health care utilization, we found evidence of multiplicative risk for conditions within some domains (i.e., nutrition conditions, neurologic disease, psychiatric conditions, and sleep disorders) such that women with autism spectrum disorder (ASD) experienced double jeopardy-meaning they had greater rates of health care utilization within a domain than what would separately be expected by virtue of being a woman and having ASD. For other domains (i.e., endocrine disorders, gastrointestinal disorders), the risk was additive such that being a female and having ASD were both associated with higher health care utilization, but there were no significant interaction effects. It was only with respect to one domain (cardiovascular) that rates of health care utilization were reflective of neither ASD diagnosis nor sex. Overall, our findings suggest that women with ASD are a vulnerable subgroup with high levels of health care utilization. LAY SUMMARY: This study asked whether women with autism have poorer health compared with men with autism, and compared with women without autism. To answer this question, we used data from electronic health records. We found that women with autism spectrum disorder (ASD) were at the greatest risk for health problems such as nutrition conditions, neurologic disease, psychiatric conditions, and sleep disorders. More research on health of women with ASD is needed. En ligne : http://dx.doi.org/10.1002/aur.2563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1896-1904[article] Health profiles of adults with autism spectrum disorder: Differences between women and men [Texte imprimé et/ou numérique] / Leann S. DAWALT, Auteur ; Julie LOUNDS TAYLOR, Auteur ; A. MOVAGHAR, Auteur ; J. HONG, Auteur ; B. KIM, Auteur ; M. H. BRILLIANT, Auteur ; M. R. MAILICK, Auteur . - p.1896-1904.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1896-1904
Mots-clés : Adult Autism Spectrum Disorder/complications/epidemiology Autistic Disorder Electronic Health Records Female Humans Male Sleep Wake Disorders adults electronic health records health health care utilization sex differences Index. décimale : PER Périodiques Résumé : The purpose of the present study was to investigate the hypothesis that women with autism have poorer health compared with men with autism, and compared with women without autism. Utilizing electronic health records drawn from a single health care system serving over 2 million individuals, 2119 adults with diagnosed autism spectrum disorders were compared with age- and sex-matched controls. When considering health care utilization, we found evidence of multiplicative risk for conditions within some domains (i.e., nutrition conditions, neurologic disease, psychiatric conditions, and sleep disorders) such that women with autism spectrum disorder (ASD) experienced double jeopardy-meaning they had greater rates of health care utilization within a domain than what would separately be expected by virtue of being a woman and having ASD. For other domains (i.e., endocrine disorders, gastrointestinal disorders), the risk was additive such that being a female and having ASD were both associated with higher health care utilization, but there were no significant interaction effects. It was only with respect to one domain (cardiovascular) that rates of health care utilization were reflective of neither ASD diagnosis nor sex. Overall, our findings suggest that women with ASD are a vulnerable subgroup with high levels of health care utilization. LAY SUMMARY: This study asked whether women with autism have poorer health compared with men with autism, and compared with women without autism. To answer this question, we used data from electronic health records. We found that women with autism spectrum disorder (ASD) were at the greatest risk for health problems such as nutrition conditions, neurologic disease, psychiatric conditions, and sleep disorders. More research on health of women with ASD is needed. En ligne : http://dx.doi.org/10.1002/aur.2563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Further developing the Frith-Happé animations: A quicker, more objective, and web-based test of theory of mind for autistic and neurotypical adults / L. A. LIVINGSTON in Autism Research, 14-9 (September 2021)
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Titre : Further developing the Frith-Happé animations: A quicker, more objective, and web-based test of theory of mind for autistic and neurotypical adults Type de document : Texte imprimé et/ou numérique Auteurs : L. A. LIVINGSTON, Auteur ; P. SHAH, Auteur ; S. J. WHITE, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.1905-1912 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder Autistic Disorder Humans Intelligence Tests Internet Theory of Mind Frith-Happé animations mentalising triangles test web-based research Index. décimale : PER Périodiques Résumé : The Frith-Happé Animations Test, depicting interactions between triangles, is widely used to measure theory of mind (ToM) ability in autism spectrum disorder (ASD). This test began with recording, transcribing, and subjectively scoring participants' verbal descriptions, which consistently found ToM-specific difficulties in ASD. More recently in 2011, White et al. created a more objective version of this ToM test using multiple-choice questions. However, there has been surprisingly little uptake of this test, hence it is currently unclear if White et al.'s findings replicate. Further, the lack of an online version of the test may be hampering its use in large-scale studies and outside of research settings. Addressing these issues, we report the development of a web-based version of the Frith-Happé Animations Test for autistic and neurotypical adults. An online version of the test was developed in a large general population sample (study 1; N = 285) and online data were compared with those collected in a lab-based setting (study 2; N = 339). The new online test was then administered to adults with a clinical diagnosis of ASD and matched neurotypical controls (study 3; N = 231). Results demonstrated that the test could successfully be administered online to autistic adults, who showed ToM difficulties compared to neurotypical adults, replicating White et al.'s findings. Overall, we have developed a quicker, more objective, and web-based version of the Frith-Happé Animations Test that will be useful for social cognition research within and beyond the field of autism, with potential utility for clinical settings. LAY SUMMARY: Many autistic people find it hard to understand what other people are thinking. There are many tests for this 'mentalising' ability, but they often take a long time to complete and cannot be used outside of research settings. In 2011, scientists used short silent animations of moving shapes to create a fast way to measure mentalising ability. We developed this into an online test to use in research and clinics to measure mentalising ability in autism. En ligne : http://dx.doi.org/10.1002/aur.2575 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1905-1912[article] Further developing the Frith-Happé animations: A quicker, more objective, and web-based test of theory of mind for autistic and neurotypical adults [Texte imprimé et/ou numérique] / L. A. LIVINGSTON, Auteur ; P. SHAH, Auteur ; S. J. WHITE, Auteur ; Francesca HAPPE, Auteur . - p.1905-1912.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1905-1912
Mots-clés : Adult Autism Spectrum Disorder Autistic Disorder Humans Intelligence Tests Internet Theory of Mind Frith-Happé animations mentalising triangles test web-based research Index. décimale : PER Périodiques Résumé : The Frith-Happé Animations Test, depicting interactions between triangles, is widely used to measure theory of mind (ToM) ability in autism spectrum disorder (ASD). This test began with recording, transcribing, and subjectively scoring participants' verbal descriptions, which consistently found ToM-specific difficulties in ASD. More recently in 2011, White et al. created a more objective version of this ToM test using multiple-choice questions. However, there has been surprisingly little uptake of this test, hence it is currently unclear if White et al.'s findings replicate. Further, the lack of an online version of the test may be hampering its use in large-scale studies and outside of research settings. Addressing these issues, we report the development of a web-based version of the Frith-Happé Animations Test for autistic and neurotypical adults. An online version of the test was developed in a large general population sample (study 1; N = 285) and online data were compared with those collected in a lab-based setting (study 2; N = 339). The new online test was then administered to adults with a clinical diagnosis of ASD and matched neurotypical controls (study 3; N = 231). Results demonstrated that the test could successfully be administered online to autistic adults, who showed ToM difficulties compared to neurotypical adults, replicating White et al.'s findings. Overall, we have developed a quicker, more objective, and web-based version of the Frith-Happé Animations Test that will be useful for social cognition research within and beyond the field of autism, with potential utility for clinical settings. LAY SUMMARY: Many autistic people find it hard to understand what other people are thinking. There are many tests for this 'mentalising' ability, but they often take a long time to complete and cannot be used outside of research settings. In 2011, scientists used short silent animations of moving shapes to create a fast way to measure mentalising ability. We developed this into an online test to use in research and clinics to measure mentalising ability in autism. En ligne : http://dx.doi.org/10.1002/aur.2575 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Measuring social-communication difficulties in school-age siblings of children with autism spectrum disorder: Standardized versus naturalistic assessment / D. N. GANGI in Autism Research, 14-9 (September 2021)
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[article]
Titre : Measuring social-communication difficulties in school-age siblings of children with autism spectrum disorder: Standardized versus naturalistic assessment Type de document : Texte imprimé et/ou numérique Auteurs : D. N. GANGI, Auteur ; M. M. HILL, Auteur ; S. MAQBOOL, Auteur ; Gregory S. YOUNG, Auteur ; S. OZONOFF, Auteur Article en page(s) : p.1913-1922 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder Child Communication Humans Schools Siblings broader autism phenotype high-risk siblings measurement social communication Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) are at elevated risk for developing the broader autism phenotype (BAP), which consists of subclinical features of ASD. We examined conversational skills in a naturalistic context and standardized assessments of pragmatic language and communication skills in high-risk and low-risk school-age children with BAP (n = 22) and ASD (n = 18) outcomes, as well as comparison children without ASD or BAP (n = 135). Children with BAP characteristics exhibited lower conversational skills than comparison children, but did not differ on any of three standardized measures. Only the conversational ratings significantly predicted membership in the BAP versus Comparison group. This suggests that naturalistic tasks are crucial when assessing social-communication difficulties in children with a family history of ASD. LAY SUMMARY: The broader autism phenotype (BAP) consists of subclinical features of autism spectrum disorder (ASD) and is more common among family members of those with ASD. School-age children with BAP characteristics exhibited lower conversational skills than comparison children, but did not differ on standardized language measures tapping similar abilities. This suggests that naturalistic tasks may be more sensitive to the social-communication difficulties seen in some children with a family history of ASD than the standardized language tests used in most evaluations. En ligne : http://dx.doi.org/10.1002/aur.2531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1913-1922[article] Measuring social-communication difficulties in school-age siblings of children with autism spectrum disorder: Standardized versus naturalistic assessment [Texte imprimé et/ou numérique] / D. N. GANGI, Auteur ; M. M. HILL, Auteur ; S. MAQBOOL, Auteur ; Gregory S. YOUNG, Auteur ; S. OZONOFF, Auteur . - p.1913-1922.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1913-1922
Mots-clés : Autism Spectrum Disorder Autistic Disorder Child Communication Humans Schools Siblings broader autism phenotype high-risk siblings measurement social communication Index. décimale : PER Périodiques Résumé : Younger siblings of children with autism spectrum disorder (ASD; high-risk siblings) are at elevated risk for developing the broader autism phenotype (BAP), which consists of subclinical features of ASD. We examined conversational skills in a naturalistic context and standardized assessments of pragmatic language and communication skills in high-risk and low-risk school-age children with BAP (n = 22) and ASD (n = 18) outcomes, as well as comparison children without ASD or BAP (n = 135). Children with BAP characteristics exhibited lower conversational skills than comparison children, but did not differ on any of three standardized measures. Only the conversational ratings significantly predicted membership in the BAP versus Comparison group. This suggests that naturalistic tasks are crucial when assessing social-communication difficulties in children with a family history of ASD. LAY SUMMARY: The broader autism phenotype (BAP) consists of subclinical features of autism spectrum disorder (ASD) and is more common among family members of those with ASD. School-age children with BAP characteristics exhibited lower conversational skills than comparison children, but did not differ on standardized language measures tapping similar abilities. This suggests that naturalistic tasks may be more sensitive to the social-communication difficulties seen in some children with a family history of ASD than the standardized language tests used in most evaluations. En ligne : http://dx.doi.org/10.1002/aur.2531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 The first five minutes: Initial impressions during autism spectrum disorder diagnostic evaluations in young children / A. T. WIECKOWSKI in Autism Research, 14-9 (September 2021)
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Titre : The first five minutes: Initial impressions during autism spectrum disorder diagnostic evaluations in young children Type de document : Texte imprimé et/ou numérique Auteurs : A. T. WIECKOWSKI, Auteur ; A. DE MARCHENA, Auteur ; Y. ALGUR, Auteur ; L. NICHOLS, Auteur ; S. FERNANDES, Auteur ; R. P. THOMAS, Auteur ; L. A. MCCLURE, Auteur ; S. DUFEK, Auteur ; Deborah A. FEIN, Auteur ; Lauren B. ADAMSON, Auteur ; A. STAHMER, Auteur ; Diana L. ROBINS, Auteur Article en page(s) : p.1923-1934 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Child Child, Preschool Early Diagnosis Family Humans autism spectrum disorder clinician confidence in diagnosis diagnosis early detection initial impression toddlers Index. décimale : PER Périodiques Résumé : Diagnosticians report that autism spectrum disorder (ASD) is immediately apparent in some, but not all, children ultimately diagnosed. Clinicians' initial diagnostic impressions have implications for ASD early detection, yet the literature raises questions about their accuracy. This study explores diagnostic impressions of ASD specialists made within the first 5?minutes of meeting a young child and investigates factors associated with the match between initial impressions and final diagnoses. Participants were children (n = 294, aged 12-53?months) referred for an ASD evaluation as part of multi-site ASD screening studies. After 5?minutes observing each child, clinicians with expertise diagnosing ASD recorded if they thought the child would meet criteria for ASD following a complete evaluation, and recorded their confidence in this impression. Clinicians' initial impressions matched the final diagnosis in 81% of cases. Ninety-two percent of cases initially thought to have ASD met criteria following a full evaluation; however, 24% of cases initially thought not to have ASD also met criteria, suggesting a high miss rate. Clinicians were generally confident in their initial impressions, reporting highest confidence for children initially thought correctly not to have ASD. ASD behavioral presentation, but not demographic characteristics or developmental level, were associated with matching initial impression and final diagnosis, and confidence. Brief observations indicating ASD should trigger referral to intervention services, but are likely to under-detect positive cases and should not be used to rule out ASD, highlighting the need to incorporate information beyond initial clinical impression. LAY SUMMARY: When children come in for an autism evaluation, clinicians often form early impressions-before doing any formal testing-about whether the child has autism. We studied how often these early impressions match the final diagnosis, and found that clinicians could not easily rule out autism (many children who initially appeared not to have autism were ultimately diagnosed), but were generally accurate ruling in autism (when a child appeared to have autism within 5?minutes, they were almost always so diagnosed). En ligne : http://dx.doi.org/10.1002/aur.2536 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1923-1934[article] The first five minutes: Initial impressions during autism spectrum disorder diagnostic evaluations in young children [Texte imprimé et/ou numérique] / A. T. WIECKOWSKI, Auteur ; A. DE MARCHENA, Auteur ; Y. ALGUR, Auteur ; L. NICHOLS, Auteur ; S. FERNANDES, Auteur ; R. P. THOMAS, Auteur ; L. A. MCCLURE, Auteur ; S. DUFEK, Auteur ; Deborah A. FEIN, Auteur ; Lauren B. ADAMSON, Auteur ; A. STAHMER, Auteur ; Diana L. ROBINS, Auteur . - p.1923-1934.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1923-1934
Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Child Child, Preschool Early Diagnosis Family Humans autism spectrum disorder clinician confidence in diagnosis diagnosis early detection initial impression toddlers Index. décimale : PER Périodiques Résumé : Diagnosticians report that autism spectrum disorder (ASD) is immediately apparent in some, but not all, children ultimately diagnosed. Clinicians' initial diagnostic impressions have implications for ASD early detection, yet the literature raises questions about their accuracy. This study explores diagnostic impressions of ASD specialists made within the first 5?minutes of meeting a young child and investigates factors associated with the match between initial impressions and final diagnoses. Participants were children (n = 294, aged 12-53?months) referred for an ASD evaluation as part of multi-site ASD screening studies. After 5?minutes observing each child, clinicians with expertise diagnosing ASD recorded if they thought the child would meet criteria for ASD following a complete evaluation, and recorded their confidence in this impression. Clinicians' initial impressions matched the final diagnosis in 81% of cases. Ninety-two percent of cases initially thought to have ASD met criteria following a full evaluation; however, 24% of cases initially thought not to have ASD also met criteria, suggesting a high miss rate. Clinicians were generally confident in their initial impressions, reporting highest confidence for children initially thought correctly not to have ASD. ASD behavioral presentation, but not demographic characteristics or developmental level, were associated with matching initial impression and final diagnosis, and confidence. Brief observations indicating ASD should trigger referral to intervention services, but are likely to under-detect positive cases and should not be used to rule out ASD, highlighting the need to incorporate information beyond initial clinical impression. LAY SUMMARY: When children come in for an autism evaluation, clinicians often form early impressions-before doing any formal testing-about whether the child has autism. We studied how often these early impressions match the final diagnosis, and found that clinicians could not easily rule out autism (many children who initially appeared not to have autism were ultimately diagnosed), but were generally accurate ruling in autism (when a child appeared to have autism within 5?minutes, they were almost always so diagnosed). En ligne : http://dx.doi.org/10.1002/aur.2536 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Clinical and individual features associated with maternal stress in young adolescents with autism spectrum disorder / F. SCIBELLI in Autism Research, 14-9 (September 2021)
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Titre : Clinical and individual features associated with maternal stress in young adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : F. SCIBELLI, Auteur ; E. FUCÀ, Auteur ; S. GUERRERA, Auteur ; E. LUPI, Auteur ; Paolo ALFIERI, Auteur ; G. VALERI, Auteur ; S. VICARI, Auteur Article en page(s) : p.1935-1947 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder/complications Child Female Humans Mothers Parenting Parents Problem Behavior Stress, Psychological/complications adolescence autism symptoms cognitive emotional and behavioral problems maternal stress parent mediated therapy socio-demographic features Index. décimale : PER Périodiques Résumé : Parents of people with autism spectrum disorder experience both negative stressful and positive events. Several clinical and socio-demographic features of children on the autism spectrum have been associated with parenting stress in their families. However, there have been few studies that focus on adolescents and the role of cognitive impairment has rarely been addressed. The main aim of the present research is to explore associations between autism symptoms, cognitive impairment, emotional and behavioral problems, socio-demographic features, and maternal stress in a sample of young adolescents with Autism Spectrum Disorder with and without cognitive impairment. Cognitive impairment and emotional and behavioral problems are associated with maternal stress, while autism symptoms seem to play a minor role. Maternal education and occupation are only associated with maternal stress in the group with cognitive impairment, while maternal age is stress-associated in the group of adolescents without cognitive impairment. Age-related implications for intervention and future research directions are discussed. LAY SUMMARY: Parents of individuals on the autism spectrum are exposed to both negative stressful and enriching experiences during their parenthood. While the influence of several child characteristics and socio-demographic features on parental stress during childhood has been widely explored in past studies, studies on teenagers are limited. The aim of the present research is to explore the influence of several characteristics on maternal stress levels in families with teenagers on the autism spectrum. We found that cognitive impairment and emotional and behavioral problems are associated with maternal stress, while autism symptoms seem to play a minor role. Socio-demographic features are not associated with maternal stress. Broadly speaking, the subjective perception of parental distress in both groups is less related to teenagers' characteristics then the perception of having a difficult interaction with the teenagers. We divided our participants into two groups (one group with cognitive impairment and the other group without). We found that mothers of teenagers with cognitive impairment are generally more stressed compared to the other group. Furthermore, we confirm that emotional and behavioral problems seem to play a major role in maternal stress (especially in the group without cognitive impairment), while autism symptoms seem to play a minor role. Furthermore, we found that maternal education/occupation and maternal age are associated with maternal stress in the group with and the group without cognitive impairment respectively. This research highlights the association between several variables and stress in mothers of adolescents on the spectrum. Results are discussed in the framework of previous findings highlighting the lack of adequate care and support services for families, especially for those of adolescents on the spectrum with cognitive impairment. En ligne : http://dx.doi.org/10.1002/aur.2539 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1935-1947[article] Clinical and individual features associated with maternal stress in young adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / F. SCIBELLI, Auteur ; E. FUCÀ, Auteur ; S. GUERRERA, Auteur ; E. LUPI, Auteur ; Paolo ALFIERI, Auteur ; G. VALERI, Auteur ; S. VICARI, Auteur . - p.1935-1947.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1935-1947
Mots-clés : Adolescent Autism Spectrum Disorder/complications Child Female Humans Mothers Parenting Parents Problem Behavior Stress, Psychological/complications adolescence autism symptoms cognitive emotional and behavioral problems maternal stress parent mediated therapy socio-demographic features Index. décimale : PER Périodiques Résumé : Parents of people with autism spectrum disorder experience both negative stressful and positive events. Several clinical and socio-demographic features of children on the autism spectrum have been associated with parenting stress in their families. However, there have been few studies that focus on adolescents and the role of cognitive impairment has rarely been addressed. The main aim of the present research is to explore associations between autism symptoms, cognitive impairment, emotional and behavioral problems, socio-demographic features, and maternal stress in a sample of young adolescents with Autism Spectrum Disorder with and without cognitive impairment. Cognitive impairment and emotional and behavioral problems are associated with maternal stress, while autism symptoms seem to play a minor role. Maternal education and occupation are only associated with maternal stress in the group with cognitive impairment, while maternal age is stress-associated in the group of adolescents without cognitive impairment. Age-related implications for intervention and future research directions are discussed. LAY SUMMARY: Parents of individuals on the autism spectrum are exposed to both negative stressful and enriching experiences during their parenthood. While the influence of several child characteristics and socio-demographic features on parental stress during childhood has been widely explored in past studies, studies on teenagers are limited. The aim of the present research is to explore the influence of several characteristics on maternal stress levels in families with teenagers on the autism spectrum. We found that cognitive impairment and emotional and behavioral problems are associated with maternal stress, while autism symptoms seem to play a minor role. Socio-demographic features are not associated with maternal stress. Broadly speaking, the subjective perception of parental distress in both groups is less related to teenagers' characteristics then the perception of having a difficult interaction with the teenagers. We divided our participants into two groups (one group with cognitive impairment and the other group without). We found that mothers of teenagers with cognitive impairment are generally more stressed compared to the other group. Furthermore, we confirm that emotional and behavioral problems seem to play a major role in maternal stress (especially in the group without cognitive impairment), while autism symptoms seem to play a minor role. Furthermore, we found that maternal education/occupation and maternal age are associated with maternal stress in the group with and the group without cognitive impairment respectively. This research highlights the association between several variables and stress in mothers of adolescents on the spectrum. Results are discussed in the framework of previous findings highlighting the lack of adequate care and support services for families, especially for those of adolescents on the spectrum with cognitive impairment. En ligne : http://dx.doi.org/10.1002/aur.2539 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Keep it simple: Identification of basic versus complex emotions in spoken language in individuals with autism spectrum disorder without intellectual disability: A meta-analysis study / M. ICHT in Autism Research, 14-9 (September 2021)
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[article]
Titre : Keep it simple: Identification of basic versus complex emotions in spoken language in individuals with autism spectrum disorder without intellectual disability: A meta-analysis study Type de document : Texte imprimé et/ou numérique Auteurs : M. ICHT, Auteur ; G. ZUKERMAN, Auteur ; Esther BEN-ITZCHAK, Auteur ; Boaz M. BEN-DAVID, Auteur Article en page(s) : p.1948-1964 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications Emotions Humans Intellectual Disability/complications Language ASD-without-ID emotions prosody social cognition speech perception Index. décimale : PER Périodiques Résumé : Daily functioning involves identifying emotions in spoken language, a fundamental aspect of social interactions. To date, there is inconsistent evidence in the literature on whether individuals with autism spectrum disorder without intellectual disability (ASD-without-ID) experience difficulties in identification of spoken emotions. We conducted a meta-analysis (literature search following the PRISMA guidelines), with 26 data sets (taken from 23 peer-reviewed journal articles) comparing individuals with ASD-without-ID (N =?614) and typically-developed (TD) controls (N =?640), from nine countries and in seven languages (published until February 2020). In our analyses there was no sufficient evidence to suggest that individuals with HF-ASD differ from matched controls in the identification of simple prosodic emotions (e.g., sadness, happiness). However, individuals with ASD-without-ID were found to perform significantly worse than controls in identification of complex prosodic emotions (e.g., envy and boredom). The level of the semantic content of the stimuli presented (e.g., sentences vs. strings of digits) was not found to have an impact on the results. In conclusion, the difference in findings between simple and complex emotions calls for a new-look on emotion processing in ASD-without-ID. Intervention programs may rely on the intact abilities of individuals with ASD-without-ID to process simple emotions and target improved performance with complex emotions. LAY SUMMARY: Individuals with autism spectrum disorder without intellectual disability (ASD-without-ID) do not differ from matched controls in the identification of simple prosodic emotions (e.g., sadness, happiness). However, they were found to perform significantly worse than controls in the identification of complex prosodic emotions (e.g., envy, boredom). This was found in a meta-analysis of 26 data sets with 1254 participants from nine countries and in seven languages. Intervention programs may rely on the intact abilities of individuals with ASD-without-ID to process simple emotions. En ligne : http://dx.doi.org/10.1002/aur.2551 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-9 (September 2021) . - p.1948-1964[article] Keep it simple: Identification of basic versus complex emotions in spoken language in individuals with autism spectrum disorder without intellectual disability: A meta-analysis study [Texte imprimé et/ou numérique] / M. ICHT, Auteur ; G. ZUKERMAN, Auteur ; Esther BEN-ITZCHAK, Auteur ; Boaz M. BEN-DAVID, Auteur . - p.1948-1964.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1948-1964
Mots-clés : Autism Spectrum Disorder/complications Emotions Humans Intellectual Disability/complications Language ASD-without-ID emotions prosody social cognition speech perception Index. décimale : PER Périodiques Résumé : Daily functioning involves identifying emotions in spoken language, a fundamental aspect of social interactions. To date, there is inconsistent evidence in the literature on whether individuals with autism spectrum disorder without intellectual disability (ASD-without-ID) experience difficulties in identification of spoken emotions. We conducted a meta-analysis (literature search following the PRISMA guidelines), with 26 data sets (taken from 23 peer-reviewed journal articles) comparing individuals with ASD-without-ID (N =?614) and typically-developed (TD) controls (N =?640), from nine countries and in seven languages (published until February 2020). In our analyses there was no sufficient evidence to suggest that individuals with HF-ASD differ from matched controls in the identification of simple prosodic emotions (e.g., sadness, happiness). However, individuals with ASD-without-ID were found to perform significantly worse than controls in identification of complex prosodic emotions (e.g., envy and boredom). The level of the semantic content of the stimuli presented (e.g., sentences vs. strings of digits) was not found to have an impact on the results. In conclusion, the difference in findings between simple and complex emotions calls for a new-look on emotion processing in ASD-without-ID. Intervention programs may rely on the intact abilities of individuals with ASD-without-ID to process simple emotions and target improved performance with complex emotions. LAY SUMMARY: Individuals with autism spectrum disorder without intellectual disability (ASD-without-ID) do not differ from matched controls in the identification of simple prosodic emotions (e.g., sadness, happiness). However, they were found to perform significantly worse than controls in the identification of complex prosodic emotions (e.g., envy, boredom). This was found in a meta-analysis of 26 data sets with 1254 participants from nine countries and in seven languages. Intervention programs may rely on the intact abilities of individuals with ASD-without-ID to process simple emotions. En ligne : http://dx.doi.org/10.1002/aur.2551 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Psychometric properties of the Cambridge-Mindreading Face-Voice Battery for Children in children with ASD / Jonathan D. RODGERS in Autism Research, 14-9 (September 2021)
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[article]
Titre : Psychometric properties of the Cambridge-Mindreading Face-Voice Battery for Children in children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Jonathan D. RODGERS, Auteur ; C. LOPATA, Auteur ; Adam J. BOOTH, Auteur ; M. L. THOMEER, Auteur ; James P. DONNELLY, Auteur ; C. J. RAJNISZ, Auteur ; J. T. WOOD, Auteur ; J. LODI-SMITH, Auteur ; K. F. KOZLOWSKI, Auteur Article en page(s) : p.1965-1974 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Child Emotions Facial Expression Facial Recognition Humans Psychometrics Reproducibility of Results Voice Cambridge-Mindreading Face-Voice Battery for Children children facial emotion recognition psychometrics social cognition vocal emotion recognition Index. décimale : PER Périodiques Résumé : This study examined the psychometric characteristics of the Cambridge-Mindreading Face-Voice Battery for Children (CAM-C) for a sample of 333 children, ages 6-12?years with ASD (with no intellectual disability). Internal consistency was very good for the Total score (0.81 for both Faces and Voices) and respectable for the Complex emotions score (0.72 for Faces and 0.74 for Voices); however, internal consistency was lower for Simple emotions (0.65 for Faces and 0.61 for Voices). Test-retest reliability at 18 and 36?weeks was very good for the faces and voices total (0.76-0.81) and good for simple and complex faces and voices (0.53-0.75). Significant correlations were found between CAM-C Faces and scores on another measure of face-emotion recognition (Diagnostic Analysis of Nonverbal Accuracy-Second Edition), and between Faces and Voices scores and child age, IQ (except perceptual IQ and Simple Voice emotions), and language ability. Parent-reported ASD symptom severity and the Emotion Recognition scale on the SRS-2 were not related to CAM-C scores. Suggestions for future studies and further development of the CAM-C are provided. LAY SUMMARY: Facial and vocal emotion recognition are important for social interaction and have been identified as a challenge for individuals with autism spectrum disorder. Emotion recognition is an area frequently targeted by interventions. This study evaluated a measure of emotion recognition (the CAM-C) for its consistency and validity in a large sample of children with autism. The study found the CAM-C showed many strengths needed to accurately measure the change in emotion recognition during intervention. En ligne : http://dx.doi.org/10.1002/aur.2546 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-9 (September 2021) . - p.1965-1974[article] Psychometric properties of the Cambridge-Mindreading Face-Voice Battery for Children in children with ASD [Texte imprimé et/ou numérique] / Jonathan D. RODGERS, Auteur ; C. LOPATA, Auteur ; Adam J. BOOTH, Auteur ; M. L. THOMEER, Auteur ; James P. DONNELLY, Auteur ; C. J. RAJNISZ, Auteur ; J. T. WOOD, Auteur ; J. LODI-SMITH, Auteur ; K. F. KOZLOWSKI, Auteur . - p.1965-1974.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1965-1974
Mots-clés : Autism Spectrum Disorder Child Emotions Facial Expression Facial Recognition Humans Psychometrics Reproducibility of Results Voice Cambridge-Mindreading Face-Voice Battery for Children children facial emotion recognition psychometrics social cognition vocal emotion recognition Index. décimale : PER Périodiques Résumé : This study examined the psychometric characteristics of the Cambridge-Mindreading Face-Voice Battery for Children (CAM-C) for a sample of 333 children, ages 6-12?years with ASD (with no intellectual disability). Internal consistency was very good for the Total score (0.81 for both Faces and Voices) and respectable for the Complex emotions score (0.72 for Faces and 0.74 for Voices); however, internal consistency was lower for Simple emotions (0.65 for Faces and 0.61 for Voices). Test-retest reliability at 18 and 36?weeks was very good for the faces and voices total (0.76-0.81) and good for simple and complex faces and voices (0.53-0.75). Significant correlations were found between CAM-C Faces and scores on another measure of face-emotion recognition (Diagnostic Analysis of Nonverbal Accuracy-Second Edition), and between Faces and Voices scores and child age, IQ (except perceptual IQ and Simple Voice emotions), and language ability. Parent-reported ASD symptom severity and the Emotion Recognition scale on the SRS-2 were not related to CAM-C scores. Suggestions for future studies and further development of the CAM-C are provided. LAY SUMMARY: Facial and vocal emotion recognition are important for social interaction and have been identified as a challenge for individuals with autism spectrum disorder. Emotion recognition is an area frequently targeted by interventions. This study evaluated a measure of emotion recognition (the CAM-C) for its consistency and validity in a large sample of children with autism. The study found the CAM-C showed many strengths needed to accurately measure the change in emotion recognition during intervention. En ligne : http://dx.doi.org/10.1002/aur.2546 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Puppets facilitate attention to social cues in children with ASD / S. MACARI in Autism Research, 14-9 (September 2021)
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[article]
Titre : Puppets facilitate attention to social cues in children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : S. MACARI, Auteur ; X. CHEN, Auteur ; Ludivine BRUNISSEN, Auteur ; E. YHANG, Auteur ; E. BRENNAN-WYDRA, Auteur ; A. VERNETTI, Auteur ; Fred R. VOLKMAR, Auteur ; J. CHANG, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.1975-1985 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder Child Child, Preschool Communication Cues Humans attention eye tracking puppets Index. décimale : PER Périodiques Résumé : Diminished visual attention to faces of social partners represents one of the early characteristics of autism spectrum disorder (ASD). Here we examine if the introduction of puppets as social partners alters attention to speakers' faces in young children with ASD and typically developing (TD) controls. Children with ASD (N = 37; M(age) = 49.44?months) and TD (N = 27; M(age) = 40.66?months) viewed a video depicting a puppet and a human engaged in a conversation. Dwell time on these faces was analyzed as a function of group and speaker's identity. Unlike TD controls, the ASD group exhibited limited visual attention to and chance-level visual preference for the human speaker. However, attention to and preference for the puppet speaker's face was greater than chance and comparable across the two groups. While there was a strong association between low human speaker preference and high autism severity, no association with autism severity was found for puppet speaker preference. Unlike humans, expressive and verbal puppets attracted the attention of children with ASD at levels comparable to that of TD controls. Considering that puppets can engage in reciprocal interactions and deliver simplified, salient social-communicative cues, they may facilitate therapeutic efforts in children with ASD. LAY SUMMARY: While studies have shown support for therapeutic uses of robots with children with autism, other similar agents such as puppets remain to be explored. When shown a video of a conversation between a puppet and a person, young children with ASD paid as much attention to the puppet's face as typically-developing (TD) children. Since puppets can engage in back-and-forth interactions and model social interactions and communication, they may play a promising role in therapeutic efforts for young children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-9 (September 2021) . - p.1975-1985[article] Puppets facilitate attention to social cues in children with ASD [Texte imprimé et/ou numérique] / S. MACARI, Auteur ; X. CHEN, Auteur ; Ludivine BRUNISSEN, Auteur ; E. YHANG, Auteur ; E. BRENNAN-WYDRA, Auteur ; A. VERNETTI, Auteur ; Fred R. VOLKMAR, Auteur ; J. CHANG, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.1975-1985.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1975-1985
Mots-clés : Autism Spectrum Disorder Autistic Disorder Child Child, Preschool Communication Cues Humans attention eye tracking puppets Index. décimale : PER Périodiques Résumé : Diminished visual attention to faces of social partners represents one of the early characteristics of autism spectrum disorder (ASD). Here we examine if the introduction of puppets as social partners alters attention to speakers' faces in young children with ASD and typically developing (TD) controls. Children with ASD (N = 37; M(age) = 49.44?months) and TD (N = 27; M(age) = 40.66?months) viewed a video depicting a puppet and a human engaged in a conversation. Dwell time on these faces was analyzed as a function of group and speaker's identity. Unlike TD controls, the ASD group exhibited limited visual attention to and chance-level visual preference for the human speaker. However, attention to and preference for the puppet speaker's face was greater than chance and comparable across the two groups. While there was a strong association between low human speaker preference and high autism severity, no association with autism severity was found for puppet speaker preference. Unlike humans, expressive and verbal puppets attracted the attention of children with ASD at levels comparable to that of TD controls. Considering that puppets can engage in reciprocal interactions and deliver simplified, salient social-communicative cues, they may facilitate therapeutic efforts in children with ASD. LAY SUMMARY: While studies have shown support for therapeutic uses of robots with children with autism, other similar agents such as puppets remain to be explored. When shown a video of a conversation between a puppet and a person, young children with ASD paid as much attention to the puppet's face as typically-developing (TD) children. Since puppets can engage in back-and-forth interactions and model social interactions and communication, they may play a promising role in therapeutic efforts for young children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 "Intolerance of uncertainty" mediates the relationship between social profile and anxiety in both Williams syndrome and autism / M. SOUTH in Autism Research, 14-9 (September 2021)
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[article]
Titre : "Intolerance of uncertainty" mediates the relationship between social profile and anxiety in both Williams syndrome and autism Type de document : Texte imprimé et/ou numérique Auteurs : M. SOUTH, Auteur ; M. HANLEY, Auteur ; K. NORMANSELL-MOSSA, Auteur ; N. C. C. RUSSELL, Auteur ; Thomas CAWTHORNE, Auteur ; D. M. RIBY, Auteur Article en page(s) : p.1986-1995 Langues : Anglais (eng) Mots-clés : Adolescent Adult Anxiety/complications Autism Spectrum Disorder/complications Autistic Disorder/complications Child Child, Preschool Cross-Sectional Studies Humans Uncertainty Williams Syndrome/complications Young Adult Intolerance of Uncertainty Williams syndrome anxiety autism children social function social profile Index. décimale : PER Périodiques Résumé : Anxiety is the most significant mental health concern for both Williams syndrome (WS) and autism. Whilst WS and autism are characterized by some syndrome-specific social differences, less is known about cross-syndrome profiles of anxiety symptoms. Previous research has shown that Intolerance of Uncertainty (IU) is a core mechanism of anxiety maintenance for clinically anxious populations and for autistic children, adolescents, and adults. The only published study in this area for WS has shown some similar patterns-with an added emphasis on the role of sensory sensitivities-in a sample of older teens and adults (mean age = 24), with the authors highlighting the need for younger samples to consider developmental influences. Here we report a cross-syndrome, cross-sectional mediation analyses of children diagnosed with WS or autism, including data from parent surveys of 90 children with WS (n = 48) or autism (n = 42). Group differences showed higher trait levels on all measures for the autism group. Importantly, the relationship between social profile and anxiety was fully mediated by IU level for both groups. This suggests possible similar core mechanisms underlying anxiety in these conditions, and the possibility of generalized intervention approaches especially related to managing distress related to uncertainty in multiple contexts. LAY SUMMARY: Autism and Williams Syndrome share some similarities in social profile and also in anxiety traits, but there are also some key differences as well. Comparing them side-by-side at the same time improved identification of ways to reduce feelings of anxiety. We found that the intolerance of uncertainty affected the relationship between social profile and anxiety in the same way for young children diagnosed with autism or Williams syndrome, meaning that intervention approaches could be similar for both. En ligne : http://dx.doi.org/10.1002/aur.2554 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-9 (September 2021) . - p.1986-1995[article] "Intolerance of uncertainty" mediates the relationship between social profile and anxiety in both Williams syndrome and autism [Texte imprimé et/ou numérique] / M. SOUTH, Auteur ; M. HANLEY, Auteur ; K. NORMANSELL-MOSSA, Auteur ; N. C. C. RUSSELL, Auteur ; Thomas CAWTHORNE, Auteur ; D. M. RIBY, Auteur . - p.1986-1995.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1986-1995
Mots-clés : Adolescent Adult Anxiety/complications Autism Spectrum Disorder/complications Autistic Disorder/complications Child Child, Preschool Cross-Sectional Studies Humans Uncertainty Williams Syndrome/complications Young Adult Intolerance of Uncertainty Williams syndrome anxiety autism children social function social profile Index. décimale : PER Périodiques Résumé : Anxiety is the most significant mental health concern for both Williams syndrome (WS) and autism. Whilst WS and autism are characterized by some syndrome-specific social differences, less is known about cross-syndrome profiles of anxiety symptoms. Previous research has shown that Intolerance of Uncertainty (IU) is a core mechanism of anxiety maintenance for clinically anxious populations and for autistic children, adolescents, and adults. The only published study in this area for WS has shown some similar patterns-with an added emphasis on the role of sensory sensitivities-in a sample of older teens and adults (mean age = 24), with the authors highlighting the need for younger samples to consider developmental influences. Here we report a cross-syndrome, cross-sectional mediation analyses of children diagnosed with WS or autism, including data from parent surveys of 90 children with WS (n = 48) or autism (n = 42). Group differences showed higher trait levels on all measures for the autism group. Importantly, the relationship between social profile and anxiety was fully mediated by IU level for both groups. This suggests possible similar core mechanisms underlying anxiety in these conditions, and the possibility of generalized intervention approaches especially related to managing distress related to uncertainty in multiple contexts. LAY SUMMARY: Autism and Williams Syndrome share some similarities in social profile and also in anxiety traits, but there are also some key differences as well. Comparing them side-by-side at the same time improved identification of ways to reduce feelings of anxiety. We found that the intolerance of uncertainty affected the relationship between social profile and anxiety in the same way for young children diagnosed with autism or Williams syndrome, meaning that intervention approaches could be similar for both. En ligne : http://dx.doi.org/10.1002/aur.2554 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Gastrointestinal symptoms and sensory abnormalities associated with behavioral problems in children with neurodevelopmental disorders / S. KUROKAWA in Autism Research, 14-9 (September 2021)
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[article]
Titre : Gastrointestinal symptoms and sensory abnormalities associated with behavioral problems in children with neurodevelopmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : S. KUROKAWA, Auteur ; K. NOMURA, Auteur ; K. MIYAHO, Auteur ; K. SANADA, Auteur ; C. IWAMOTO, Auteur ; M. NARAOKA, Auteur ; S. YONEDA, Auteur ; Y. TOMIZAWA, Auteur ; Y. SAWAE, Auteur ; R. IWANAGA, Auteur ; M. MIMURA, Auteur ; T. KISHIMOTO, Auteur Article en page(s) : p.1996-2001 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/complications Autism Spectrum Disorder/complications Child Cross-Sectional Studies Humans Problem Behavior Quality of Life Autism spectrum disorders attention-deficit/hyperactivity disorder behavioral problems gastrointestinal symptoms sensory abnormalities Index. décimale : PER Périodiques Résumé : Behavioral problems directly affect the quality of life of caregivers and children with autism spectrum disorder (ASD) and/or attention-deficit/hyperactivity disorder (ADHD), and is known to be associated with clinical factors such as gastrointestinal (GI) symptoms, sensory abnormalities, intellectual abilities, and use of medication. However, previous studies have not considered these relationships comprehensively. We conducted a cross-sectional study of 6-12-year-old children with diagnoses of ASD and/or ADHD at two hospitals in Japan. Scores for the aberrant behavior checklist (ABC), autism-spectrum quotient (AQ), and Conners 3, as well as information on daily sleep and exercise, GI symptoms, and Short Sensory Profile, were collected. Each factor was subjected to a correlation analysis to investigate its effect on ABC scores. A stepwise multiple linear regression analysis for the factors with p?0.05 was performed. Data were obtained from 60 patients with a mean age of 8.3?years; 21 had ASD alone, 18 had ADHD alone, and 21 had ASD?+?ADHD. The correlation analyses identified six factors associated with ABC severity: (a) methylphenidate use, (b) Conners hyperactivity score, (c) Conners inattention score, (d) AQ score, (e) SSP score, and (f) GI symptom score. The multiple regression showed that "GI symptoms" and "sensory abnormalities" were independently associated with ABC severity. Although further studies are needed to show a causal relationship, appropriate assessment of GI symptoms and sensory abnormalities may help alleviate some problematic behaviors and improve the quality of life of children with neurodevelopmental disorders and their families. LAY SUMMARY: Behavioral problems in children with neurodevelopmental disorders are known to be associated with many factors. This study aimed to comprehensively investigate the known factors. We have discovered that "gastrointestinal symptoms" and "sensory abnormalities" were independently associated with Behavioral problems. Our results suggest that it is important for clinicians and caregivers to pay more attention to children's GI symptoms and sensory abnormalities that may not present as obvious symptoms or complaints. En ligne : http://dx.doi.org/10.1002/aur.2549 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-9 (September 2021) . - p.1996-2001[article] Gastrointestinal symptoms and sensory abnormalities associated with behavioral problems in children with neurodevelopmental disorders [Texte imprimé et/ou numérique] / S. KUROKAWA, Auteur ; K. NOMURA, Auteur ; K. MIYAHO, Auteur ; K. SANADA, Auteur ; C. IWAMOTO, Auteur ; M. NARAOKA, Auteur ; S. YONEDA, Auteur ; Y. TOMIZAWA, Auteur ; Y. SAWAE, Auteur ; R. IWANAGA, Auteur ; M. MIMURA, Auteur ; T. KISHIMOTO, Auteur . - p.1996-2001.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.1996-2001
Mots-clés : Attention Deficit Disorder with Hyperactivity/complications Autism Spectrum Disorder/complications Child Cross-Sectional Studies Humans Problem Behavior Quality of Life Autism spectrum disorders attention-deficit/hyperactivity disorder behavioral problems gastrointestinal symptoms sensory abnormalities Index. décimale : PER Périodiques Résumé : Behavioral problems directly affect the quality of life of caregivers and children with autism spectrum disorder (ASD) and/or attention-deficit/hyperactivity disorder (ADHD), and is known to be associated with clinical factors such as gastrointestinal (GI) symptoms, sensory abnormalities, intellectual abilities, and use of medication. However, previous studies have not considered these relationships comprehensively. We conducted a cross-sectional study of 6-12-year-old children with diagnoses of ASD and/or ADHD at two hospitals in Japan. Scores for the aberrant behavior checklist (ABC), autism-spectrum quotient (AQ), and Conners 3, as well as information on daily sleep and exercise, GI symptoms, and Short Sensory Profile, were collected. Each factor was subjected to a correlation analysis to investigate its effect on ABC scores. A stepwise multiple linear regression analysis for the factors with p?0.05 was performed. Data were obtained from 60 patients with a mean age of 8.3?years; 21 had ASD alone, 18 had ADHD alone, and 21 had ASD?+?ADHD. The correlation analyses identified six factors associated with ABC severity: (a) methylphenidate use, (b) Conners hyperactivity score, (c) Conners inattention score, (d) AQ score, (e) SSP score, and (f) GI symptom score. The multiple regression showed that "GI symptoms" and "sensory abnormalities" were independently associated with ABC severity. Although further studies are needed to show a causal relationship, appropriate assessment of GI symptoms and sensory abnormalities may help alleviate some problematic behaviors and improve the quality of life of children with neurodevelopmental disorders and their families. LAY SUMMARY: Behavioral problems in children with neurodevelopmental disorders are known to be associated with many factors. This study aimed to comprehensively investigate the known factors. We have discovered that "gastrointestinal symptoms" and "sensory abnormalities" were independently associated with Behavioral problems. Our results suggest that it is important for clinicians and caregivers to pay more attention to children's GI symptoms and sensory abnormalities that may not present as obvious symptoms or complaints. En ligne : http://dx.doi.org/10.1002/aur.2549 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Maternal antibodies to gliadin and autism spectrum disorders in offspring-A population-based case-control study in Sweden / R. M. GARDNER in Autism Research, 14-9 (September 2021)
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Titre : Maternal antibodies to gliadin and autism spectrum disorders in offspring-A population-based case-control study in Sweden Type de document : Texte imprimé et/ou numérique Auteurs : R. M. GARDNER, Auteur ; I. SAMUELSSON, Auteur ; E. G. SEVERANCE, Auteur ; H. SJÖQVIST, Auteur ; R. H. YOLKEN, Auteur ; C. DALMAN, Auteur ; H. KARLSSON, Auteur Article en page(s) : p.2002-2016 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity Autism Spectrum Disorder/epidemiology Case-Control Studies Female Gliadin Humans Pregnancy Sweden/epidemiology attention deficit hyperactivity disorder autism spectrum disorder gliadin gluten-sensitivity intellectual disability Index. décimale : PER Périodiques Résumé : While individuals diagnosed with autism spectrum disorders (ASD) have higher levels of antibodies directed towards gliadin, a component of wheat gluten, no study has examined anti-gliadin antibodies (AGA) in etiologically relevant periods before diagnosis. The objective of this study was to investigate if maternal levels of AGA, during pregnancy and at the time of birth, are associated with ASD in offspring. We analyzed AGA in archived neonatal dried blood spots (NDBS) for 921 ASD cases and 1090 controls, and in paired maternal sera collected earlier in pregnancy for a subset of 547 cases and 428 controls. We examined associations with ASD diagnoses as a group and considering common comorbidities (intellectual disability [ID] and attention-deficit/hyperactivity disorder). We compared 206 cases to their unaffected siblings to examine the potential for confounding by shared familial factors. Odds of ASD tended to be lower among those with the highest levels (?90th percentile) of AGA compared to those with low levels (<80th percentile; OR 0.78, 95% CI 0.56-1.09, measured in NDBS). This pattern was more apparent for ASD with comorbid ID when measured in NDBS (0.51, 0.30-0.87), with a similar trend in maternal sera (0.55, 0.24-1.29). High levels of AGA were similarly associated with lower odds of ASD in the sibling comparison. In summary, we found little association between maternal antibodies raised against components of gluten and risk of ASD in general. Exposure to high levels of AGA in the pre- and perinatal periods may be protective in terms of risk for ASD with ID. LAY SUMMARY: There is a debate among both scientists and community members as to whether an immune reaction to gluten exposure could be considered a cause of autism. We examined antibodies that are directed against gliadin, a part of gluten, in samples collected from pregnant mothers and their newborn babies. We did not see any major differences in the antibody level among those children diagnosed with ASD or their mothers compared to children who were not diagnosed with ASD. High levels of the antibodies were in fact associated with a somewhat lower risk of ASD with co-occurring intellectual disabilities, though we cannot tell from this study why that might be the case. En ligne : http://dx.doi.org/10.1002/aur.2567 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-9 (September 2021) . - p.2002-2016[article] Maternal antibodies to gliadin and autism spectrum disorders in offspring-A population-based case-control study in Sweden [Texte imprimé et/ou numérique] / R. M. GARDNER, Auteur ; I. SAMUELSSON, Auteur ; E. G. SEVERANCE, Auteur ; H. SJÖQVIST, Auteur ; R. H. YOLKEN, Auteur ; C. DALMAN, Auteur ; H. KARLSSON, Auteur . - p.2002-2016.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.2002-2016
Mots-clés : Attention Deficit Disorder with Hyperactivity Autism Spectrum Disorder/epidemiology Case-Control Studies Female Gliadin Humans Pregnancy Sweden/epidemiology attention deficit hyperactivity disorder autism spectrum disorder gliadin gluten-sensitivity intellectual disability Index. décimale : PER Périodiques Résumé : While individuals diagnosed with autism spectrum disorders (ASD) have higher levels of antibodies directed towards gliadin, a component of wheat gluten, no study has examined anti-gliadin antibodies (AGA) in etiologically relevant periods before diagnosis. The objective of this study was to investigate if maternal levels of AGA, during pregnancy and at the time of birth, are associated with ASD in offspring. We analyzed AGA in archived neonatal dried blood spots (NDBS) for 921 ASD cases and 1090 controls, and in paired maternal sera collected earlier in pregnancy for a subset of 547 cases and 428 controls. We examined associations with ASD diagnoses as a group and considering common comorbidities (intellectual disability [ID] and attention-deficit/hyperactivity disorder). We compared 206 cases to their unaffected siblings to examine the potential for confounding by shared familial factors. Odds of ASD tended to be lower among those with the highest levels (?90th percentile) of AGA compared to those with low levels (<80th percentile; OR 0.78, 95% CI 0.56-1.09, measured in NDBS). This pattern was more apparent for ASD with comorbid ID when measured in NDBS (0.51, 0.30-0.87), with a similar trend in maternal sera (0.55, 0.24-1.29). High levels of AGA were similarly associated with lower odds of ASD in the sibling comparison. In summary, we found little association between maternal antibodies raised against components of gluten and risk of ASD in general. Exposure to high levels of AGA in the pre- and perinatal periods may be protective in terms of risk for ASD with ID. LAY SUMMARY: There is a debate among both scientists and community members as to whether an immune reaction to gluten exposure could be considered a cause of autism. We examined antibodies that are directed against gliadin, a part of gluten, in samples collected from pregnant mothers and their newborn babies. We did not see any major differences in the antibody level among those children diagnosed with ASD or their mothers compared to children who were not diagnosed with ASD. High levels of the antibodies were in fact associated with a somewhat lower risk of ASD with co-occurring intellectual disabilities, though we cannot tell from this study why that might be the case. En ligne : http://dx.doi.org/10.1002/aur.2567 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder / K. BERGER in Autism Research, 14-9 (September 2021)
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Titre : The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. BERGER, Auteur ; M. PEARL, Auteur ; M. KHARRAZI, Auteur ; Y. LI, Auteur ; J. DEGUZMAN, Auteur ; J. SHE, Auteur ; P. BEHNIWAL, Auteur ; K. LYALL, Auteur ; G. WINDHAM, Auteur Article en page(s) : p.2017-2026 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology/etiology Child Cotinine Female Humans Maternal Exposure/adverse effects Pregnancy Smoking Tobacco Smoke Pollution/adverse effects/analysis Autism Spectrum Disorder cotinine pregnancy smoking tobacco smoking Index. décimale : PER Périodiques Résumé : Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (?3.08?ng/ml vs. <3.08?ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. LAY SUMMARY: This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke. En ligne : http://dx.doi.org/10.1002/aur.2561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-9 (September 2021) . - p.2017-2026[article] The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder [Texte imprimé et/ou numérique] / K. BERGER, Auteur ; M. PEARL, Auteur ; M. KHARRAZI, Auteur ; Y. LI, Auteur ; J. DEGUZMAN, Auteur ; J. SHE, Auteur ; P. BEHNIWAL, Auteur ; K. LYALL, Auteur ; G. WINDHAM, Auteur . - p.2017-2026.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.2017-2026
Mots-clés : Autism Spectrum Disorder/epidemiology/etiology Child Cotinine Female Humans Maternal Exposure/adverse effects Pregnancy Smoking Tobacco Smoke Pollution/adverse effects/analysis Autism Spectrum Disorder cotinine pregnancy smoking tobacco smoking Index. décimale : PER Périodiques Résumé : Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (?3.08?ng/ml vs. <3.08?ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. LAY SUMMARY: This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke. En ligne : http://dx.doi.org/10.1002/aur.2561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Parent responsiveness mediates the association between hyporeactivity at age 1 year and communication at age 2 years in children at elevated likelihood of ASD / R. GRZADZINSKI in Autism Research, 14-9 (September 2021)
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[article]
Titre : Parent responsiveness mediates the association between hyporeactivity at age 1 year and communication at age 2 years in children at elevated likelihood of ASD Type de document : Texte imprimé et/ou numérique Auteurs : R. GRZADZINSKI, Auteur ; Sallie W. NOWELL, Auteur ; Elizabeth R. CRAIS, Auteur ; Grace T. BARANEK, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Linda R. WATSON, Auteur Article en page(s) : p.2027-2037 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Child Child Language Communication Humans Infant Male Parents autism mediation parents responsiveness sensory toddlers treatment to this study. Index. décimale : PER Périodiques Résumé : Studies suggest that higher parent responsiveness is associated with higher child language abilities. Infants and toddlers later diagnosed with autism spectrum disorder (ASD) often display hyporeactivity to sensory stimuli, which has also been associated with lower child communication abilities and lower parent responsiveness. Yet, whether parent responsiveness mediates the relationship between child hyporeactivity and later communication outcomes remains unexplored. This study is a secondary data analysis which includes children (n =?83; 56 males) identified as at elevated likelihood of later ASD. Children completed an observational measure of sensory reactivity and a standard developmental assessment at 14 (Time 1) and 23?months old (Time 2). At each time point, parents reported on the child's adaptive communication behaviors and sensory behaviors, and Parent Verbal Responsiveness (AvgPVR) was coded from parent-child free-play videos. Results indicated that the association between child sensory hyporeactivity at Time 1 (observed and parent-reported) and communication at Time 2 (observed and parent reported) was significantly mediated by AvgPVR. Although child hyporeactivity predicts poorer communication outcomes, increased parent verbal responsiveness may attenuate this negative impact. Parent responsiveness, a focus of many parent-mediated interventions, may be an important mechanism of treatment response that should be directly tested in future research. LAY SUMMARY: Toddlers at elevated likelihood of autism spectrum disorder (ASD) are often under-reactive (hyporeactive) to sensory stimuli. This hyporeactivity slows learning of communication skills and provides parents with fewer opportunities to respond to their children. In this study, children with hyporeactivity at 14?months generally had poorer communication at 23?months; however, the more responsive their parents were, the weaker the relationship between early hyporeactivity and later communication. Thus, increasing parent responsiveness may lead to better communication outcomes for toddlers with the early ASD symptom of hyporeactivity. En ligne : http://dx.doi.org/10.1002/aur.2557 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-9 (September 2021) . - p.2027-2037[article] Parent responsiveness mediates the association between hyporeactivity at age 1 year and communication at age 2 years in children at elevated likelihood of ASD [Texte imprimé et/ou numérique] / R. GRZADZINSKI, Auteur ; Sallie W. NOWELL, Auteur ; Elizabeth R. CRAIS, Auteur ; Grace T. BARANEK, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Linda R. WATSON, Auteur . - p.2027-2037.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.2027-2037
Mots-clés : Autism Spectrum Disorder Child Child Language Communication Humans Infant Male Parents autism mediation parents responsiveness sensory toddlers treatment to this study. Index. décimale : PER Périodiques Résumé : Studies suggest that higher parent responsiveness is associated with higher child language abilities. Infants and toddlers later diagnosed with autism spectrum disorder (ASD) often display hyporeactivity to sensory stimuli, which has also been associated with lower child communication abilities and lower parent responsiveness. Yet, whether parent responsiveness mediates the relationship between child hyporeactivity and later communication outcomes remains unexplored. This study is a secondary data analysis which includes children (n =?83; 56 males) identified as at elevated likelihood of later ASD. Children completed an observational measure of sensory reactivity and a standard developmental assessment at 14 (Time 1) and 23?months old (Time 2). At each time point, parents reported on the child's adaptive communication behaviors and sensory behaviors, and Parent Verbal Responsiveness (AvgPVR) was coded from parent-child free-play videos. Results indicated that the association between child sensory hyporeactivity at Time 1 (observed and parent-reported) and communication at Time 2 (observed and parent reported) was significantly mediated by AvgPVR. Although child hyporeactivity predicts poorer communication outcomes, increased parent verbal responsiveness may attenuate this negative impact. Parent responsiveness, a focus of many parent-mediated interventions, may be an important mechanism of treatment response that should be directly tested in future research. LAY SUMMARY: Toddlers at elevated likelihood of autism spectrum disorder (ASD) are often under-reactive (hyporeactive) to sensory stimuli. This hyporeactivity slows learning of communication skills and provides parents with fewer opportunities to respond to their children. In this study, children with hyporeactivity at 14?months generally had poorer communication at 23?months; however, the more responsive their parents were, the weaker the relationship between early hyporeactivity and later communication. Thus, increasing parent responsiveness may lead to better communication outcomes for toddlers with the early ASD symptom of hyporeactivity. En ligne : http://dx.doi.org/10.1002/aur.2557 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Comparison of fitness levels between elementary school children with autism spectrum disorder and age-matched neurotypically developing children / C. COFFEY in Autism Research, 14-9 (September 2021)
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Titre : Comparison of fitness levels between elementary school children with autism spectrum disorder and age-matched neurotypically developing children Type de document : Texte imprimé et/ou numérique Auteurs : C. COFFEY, Auteur ; D. SHEEHAN, Auteur ; A. D. FAIGENBAUM, Auteur ; S. HEALY, Auteur ; R. S. LLOYD, Auteur ; S. KINSELLA, Auteur Article en page(s) : p.2038-2046 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder Child Child, Preschool Exercise Humans Physical Fitness Schools autistic cross-sectional fitness deficit fitness measurement physical fitness youth Index. décimale : PER Périodiques Résumé : Low physical fitness is associated with reduced physical activity and increased cardiovascular diseases. To date, limited research has compared physical fitness levels between children with and without autism spectrum disorder (ASD). Therefore, the primary aim was to investigate if differences in fitness levels exist between children with ASD and age-matched neurotypically developing children (ND). The second aim was to examine if age, sex, height and weight could be used to predict potential fitness levels. The third aim was to examine if the developmental trajectory of fitness is comparable between children with ASD and ND children. The modified Eurofit test battery was used to compare fitness levels between 244 children aged 4-13?years old (n = 152 ND and n = 92 ASD). Independent samples t tests and regression analyses were used to investigate differences in fitness levels between the two groups. The results indicated that statistically significant differences exist in fitness levels between children with ASD when compared to ND children across all ages, favoring the ND children, with small to large effect sizes noted (p?0.05, d = 0.36-1.13). Regression analysis could not accurately predict fitness measurements in children with ASD but could for ND children. The developmental trajectories were significantly delayed on the 20?m sprint and standing broad jump for children with ASD when compared to ND children. Future studies should seek to address the disparities in physical fitness experienced by children with ASD by using relevant neuromuscular interventions. En ligne : http://dx.doi.org/10.1002/aur.2559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-9 (September 2021) . - p.2038-2046[article] Comparison of fitness levels between elementary school children with autism spectrum disorder and age-matched neurotypically developing children [Texte imprimé et/ou numérique] / C. COFFEY, Auteur ; D. SHEEHAN, Auteur ; A. D. FAIGENBAUM, Auteur ; S. HEALY, Auteur ; R. S. LLOYD, Auteur ; S. KINSELLA, Auteur . - p.2038-2046.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.2038-2046
Mots-clés : Adolescent Autism Spectrum Disorder Child Child, Preschool Exercise Humans Physical Fitness Schools autistic cross-sectional fitness deficit fitness measurement physical fitness youth Index. décimale : PER Périodiques Résumé : Low physical fitness is associated with reduced physical activity and increased cardiovascular diseases. To date, limited research has compared physical fitness levels between children with and without autism spectrum disorder (ASD). Therefore, the primary aim was to investigate if differences in fitness levels exist between children with ASD and age-matched neurotypically developing children (ND). The second aim was to examine if age, sex, height and weight could be used to predict potential fitness levels. The third aim was to examine if the developmental trajectory of fitness is comparable between children with ASD and ND children. The modified Eurofit test battery was used to compare fitness levels between 244 children aged 4-13?years old (n = 152 ND and n = 92 ASD). Independent samples t tests and regression analyses were used to investigate differences in fitness levels between the two groups. The results indicated that statistically significant differences exist in fitness levels between children with ASD when compared to ND children across all ages, favoring the ND children, with small to large effect sizes noted (p?0.05, d = 0.36-1.13). Regression analysis could not accurately predict fitness measurements in children with ASD but could for ND children. The developmental trajectories were significantly delayed on the 20?m sprint and standing broad jump for children with ASD when compared to ND children. Future studies should seek to address the disparities in physical fitness experienced by children with ASD by using relevant neuromuscular interventions. En ligne : http://dx.doi.org/10.1002/aur.2559 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450