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The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder / K. BERGER in Autism Research, 14-9 (September 2021)
[article]
Titre : The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. BERGER, Auteur ; M. PEARL, Auteur ; M. KHARRAZI, Auteur ; Y. LI, Auteur ; J. DEGUZMAN, Auteur ; J. SHE, Auteur ; P. BEHNIWAL, Auteur ; K. LYALL, Auteur ; G. WINDHAM, Auteur Article en page(s) : p.2017-2026 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology/etiology Child Cotinine Female Humans Maternal Exposure/adverse effects Pregnancy Smoking Tobacco Smoke Pollution/adverse effects/analysis Autism Spectrum Disorder cotinine pregnancy smoking tobacco smoking Index. décimale : PER Périodiques Résumé : Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (?3.08?ng/ml vs. <3.08?ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. LAY SUMMARY: This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke. En ligne : http://dx.doi.org/10.1002/aur.2561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-9 (September 2021) . - p.2017-2026[article] The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder [Texte imprimé et/ou numérique] / K. BERGER, Auteur ; M. PEARL, Auteur ; M. KHARRAZI, Auteur ; Y. LI, Auteur ; J. DEGUZMAN, Auteur ; J. SHE, Auteur ; P. BEHNIWAL, Auteur ; K. LYALL, Auteur ; G. WINDHAM, Auteur . - p.2017-2026.
Langues : Anglais (eng)
in Autism Research > 14-9 (September 2021) . - p.2017-2026
Mots-clés : Autism Spectrum Disorder/epidemiology/etiology Child Cotinine Female Humans Maternal Exposure/adverse effects Pregnancy Smoking Tobacco Smoke Pollution/adverse effects/analysis Autism Spectrum Disorder cotinine pregnancy smoking tobacco smoking Index. décimale : PER Périodiques Résumé : Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (?3.08?ng/ml vs. <3.08?ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. LAY SUMMARY: This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke. En ligne : http://dx.doi.org/10.1002/aur.2561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort / K. CHESLACK-POSTAVA in Autism Research, 14-11 (November 2021)
[article]
Titre : A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort Type de document : Texte imprimé et/ou numérique Auteurs : K. CHESLACK-POSTAVA, Auteur ; A. SOURANDER, Auteur ; S. HINKKA-YLI-SALOMÄKI, Auteur ; I. W. MCKEAGUE, Auteur ; H. M. SURCEL, Auteur ; A. S. BROWN, Auteur Article en page(s) : p.2444-2453 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder Biomarkers Case-Control Studies Child Female Finland/epidemiology Humans Maternal Exposure Pregnancy Prenatal Exposure Delayed Effects/epidemiology Smoking autism cotinine prenatal exposure delayed effects smoking Index. décimale : PER Périodiques Résumé : Maternal exposure to tobacco smoke during pregnancy is a common and persistent exposure linked to adverse neurodevelopmental outcomes in the offspring. However, previous studies provide mixed evidence regarding the relationship between prenatal smoking and offspring autism. This study used cotinine level, a biomarker for nicotine, to investigate the relationship between prenatal smoking and autism. The authors conducted a population-based case-control study nested in a national cohort of all births in Finland from 1987 to 2005. Cases diagnosed with childhood autism (ICD-10/9 code F84.0/299.0) through 2007 were identified using data from linked national registers. Each case was matched with a control on date of birth (±30?days), sex, and place of birth (N =?962 pairs). Maternal serum cotinine levels were prospectively measured in first- to early second-trimester serum samples archived in a national biobank using a quantitative immunoassay. Data were analyzed using conditional logistic regression. Prenatal maternal levels of serum cotinine were not associated with the odds of autism, whether cotinine was classified continuously, by deciles, or using previously defined categories corresponding to probable maternal smoking status. After adjusting for maternal age, paternal age, previous births, and any history of parental psychiatric disorder, the odds ratio for categorical high versus low cotinine, using a 3-level exposure variable, was 0.98 (95% CI = 0.76, 1.26; p = 0.88). In conclusion, this national birth cohort-based study does not provide evidence for an association between maternal cotinine, a biomarker of maternal smoking, and risk of autism. LAY SUMMARY: This study explored whether prenatal exposure to tobacco smoke in mothers is related to the diagnosis of autism in their children, by measuring the levels of cotinine, a biomarker for tobacco exposure, in stored serum samples drawn from mothers during pregnancy. The levels of cotinine in the mothers of children diagnosed with autism were similar to those in the mothers of control children of similar age and gender distribution. En ligne : http://dx.doi.org/10.1002/aur.2608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2444-2453[article] A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort [Texte imprimé et/ou numérique] / K. CHESLACK-POSTAVA, Auteur ; A. SOURANDER, Auteur ; S. HINKKA-YLI-SALOMÄKI, Auteur ; I. W. MCKEAGUE, Auteur ; H. M. SURCEL, Auteur ; A. S. BROWN, Auteur . - p.2444-2453.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2444-2453
Mots-clés : Autism Spectrum Disorder Autistic Disorder Biomarkers Case-Control Studies Child Female Finland/epidemiology Humans Maternal Exposure Pregnancy Prenatal Exposure Delayed Effects/epidemiology Smoking autism cotinine prenatal exposure delayed effects smoking Index. décimale : PER Périodiques Résumé : Maternal exposure to tobacco smoke during pregnancy is a common and persistent exposure linked to adverse neurodevelopmental outcomes in the offspring. However, previous studies provide mixed evidence regarding the relationship between prenatal smoking and offspring autism. This study used cotinine level, a biomarker for nicotine, to investigate the relationship between prenatal smoking and autism. The authors conducted a population-based case-control study nested in a national cohort of all births in Finland from 1987 to 2005. Cases diagnosed with childhood autism (ICD-10/9 code F84.0/299.0) through 2007 were identified using data from linked national registers. Each case was matched with a control on date of birth (±30?days), sex, and place of birth (N =?962 pairs). Maternal serum cotinine levels were prospectively measured in first- to early second-trimester serum samples archived in a national biobank using a quantitative immunoassay. Data were analyzed using conditional logistic regression. Prenatal maternal levels of serum cotinine were not associated with the odds of autism, whether cotinine was classified continuously, by deciles, or using previously defined categories corresponding to probable maternal smoking status. After adjusting for maternal age, paternal age, previous births, and any history of parental psychiatric disorder, the odds ratio for categorical high versus low cotinine, using a 3-level exposure variable, was 0.98 (95% CI = 0.76, 1.26; p = 0.88). In conclusion, this national birth cohort-based study does not provide evidence for an association between maternal cotinine, a biomarker of maternal smoking, and risk of autism. LAY SUMMARY: This study explored whether prenatal exposure to tobacco smoke in mothers is related to the diagnosis of autism in their children, by measuring the levels of cotinine, a biomarker for tobacco exposure, in stored serum samples drawn from mothers during pregnancy. The levels of cotinine in the mothers of children diagnosed with autism were similar to those in the mothers of control children of similar age and gender distribution. En ligne : http://dx.doi.org/10.1002/aur.2608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450