Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'indexation
PER : Périodiques |
Ouvrages de la bibliothèque en indexation PER (25018)
Faire une suggestion Affiner la recherche
Reputation Management: Evidence for Ability But Reduced Propensity in Autism / Eilidh CAGE in Autism Research, 6-5 (October 2013)
[article]
Titre : Reputation Management: Evidence for Ability But Reduced Propensity in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Eilidh CAGE, Auteur ; Elizabeth PELLICANO, Auteur ; Punit SHAH, Auteur ; Geoffrey BIRD, Auteur Article en page(s) : p.433-442 Langues : Anglais (eng) Mots-clés : reputation management theory of mind reward reciprocity autism Index. décimale : PER Périodiques Résumé : Previous research has reported that autistic adults do not manage their reputation, purportedly due to problems with theory of mind [Izuma, Matsumoto, Camerer, Adolphs]. The current study aimed to test alternative explanations for this apparent lack of reputation management. Twenty typical and 19 autistic adults donated to charity and to a person, both when alone and when observed. In an additional manipulation, for half of the participants, the observer was also the recipient of their donations, and participants were told that this observer would subsequently have the opportunity to donate to them (motivation condition). This manipulation was designed to encourage an expectation of a reciprocal “tit-for-tat” strategy in the participant, which may motivate participants to change their behavior to receive more donations. The remaining participants were told that the person watching was just observing the procedure (no motivation condition). Our results replicated Izuma et?al.'s finding that autistic adults did not donate more to charity when observed. Yet, in the motivation condition, both typical and autistic adults donated significantly more to the observer when watched, although this effect was significantly attenuated in autistic individuals. Results indicate that, while individuals with autism may have the ability to think about reputation, a reduced expectation of reciprocal behavior from others may reduce the degree to which they engage in reputation management. En ligne : http://dx.doi.org/10.1002/aur.1313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218
in Autism Research > 6-5 (October 2013) . - p.433-442[article] Reputation Management: Evidence for Ability But Reduced Propensity in Autism [Texte imprimé et/ou numérique] / Eilidh CAGE, Auteur ; Elizabeth PELLICANO, Auteur ; Punit SHAH, Auteur ; Geoffrey BIRD, Auteur . - p.433-442.
Langues : Anglais (eng)
in Autism Research > 6-5 (October 2013) . - p.433-442
Mots-clés : reputation management theory of mind reward reciprocity autism Index. décimale : PER Périodiques Résumé : Previous research has reported that autistic adults do not manage their reputation, purportedly due to problems with theory of mind [Izuma, Matsumoto, Camerer, Adolphs]. The current study aimed to test alternative explanations for this apparent lack of reputation management. Twenty typical and 19 autistic adults donated to charity and to a person, both when alone and when observed. In an additional manipulation, for half of the participants, the observer was also the recipient of their donations, and participants were told that this observer would subsequently have the opportunity to donate to them (motivation condition). This manipulation was designed to encourage an expectation of a reciprocal “tit-for-tat” strategy in the participant, which may motivate participants to change their behavior to receive more donations. The remaining participants were told that the person watching was just observing the procedure (no motivation condition). Our results replicated Izuma et?al.'s finding that autistic adults did not donate more to charity when observed. Yet, in the motivation condition, both typical and autistic adults donated significantly more to the observer when watched, although this effect was significantly attenuated in autistic individuals. Results indicate that, while individuals with autism may have the ability to think about reputation, a reduced expectation of reciprocal behavior from others may reduce the degree to which they engage in reputation management. En ligne : http://dx.doi.org/10.1002/aur.1313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 Reputation Management in Children on the Autism Spectrum / Eilidh CAGE in Journal of Autism and Developmental Disorders, 46-12 (December 2016)
[article]
Titre : Reputation Management in Children on the Autism Spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Eilidh CAGE, Auteur ; Geoffrey BIRD, Auteur ; Elizabeth PELLICANO, Auteur Article en page(s) : p.3798-3811 Langues : Anglais (eng) Mots-clés : Autism Reputation management Theory of mind Social motivation Inhibitory control Reciprocity Index. décimale : PER Périodiques Résumé : Being able to manage reputation is an important social skill, but it is unclear whether autistic children can manage reputation. This study investigated whether 33 autistic children matched to 33 typical children could implicitly or explicitly manage reputation. Further, we examined whether cognitive processes—theory of mind, social motivation, inhibitory control and reciprocity—contribute to reputation management. Results showed that neither group implicitly managed reputation, and there was no group difference in explicit reputation management. Results suggested different mechanisms contribute to reputation management in these groups—social motivation in typical children and reciprocity in autistic children. Explicit reputation management is achievable for autistic children, and there are individual differences in its relationship to underlying cognitive processes. En ligne : http://dx.doi.org/10.1007/s10803-016-2923-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297
in Journal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3798-3811[article] Reputation Management in Children on the Autism Spectrum [Texte imprimé et/ou numérique] / Eilidh CAGE, Auteur ; Geoffrey BIRD, Auteur ; Elizabeth PELLICANO, Auteur . - p.3798-3811.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3798-3811
Mots-clés : Autism Reputation management Theory of mind Social motivation Inhibitory control Reciprocity Index. décimale : PER Périodiques Résumé : Being able to manage reputation is an important social skill, but it is unclear whether autistic children can manage reputation. This study investigated whether 33 autistic children matched to 33 typical children could implicitly or explicitly manage reputation. Further, we examined whether cognitive processes—theory of mind, social motivation, inhibitory control and reciprocity—contribute to reputation management. Results showed that neither group implicitly managed reputation, and there was no group difference in explicit reputation management. Results suggested different mechanisms contribute to reputation management in these groups—social motivation in typical children and reciprocity in autistic children. Explicit reputation management is achievable for autistic children, and there are individual differences in its relationship to underlying cognitive processes. En ligne : http://dx.doi.org/10.1007/s10803-016-2923-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K) / S. BERETTA in Molecular Autism, 13 (2022)
[article]
Titre : Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K) Type de document : Texte imprimé et/ou numérique Auteurs : S. BERETTA, Auteur ; L. GRITTI, Auteur ; L. PONZONI, Auteur ; P. SCALMANI, Auteur ; M. MANTEGAZZA, Auteur ; M. SALA, Auteur ; C. VERPELLI, Auteur ; C. SALA, Auteur Article en page(s) : 1p. Langues : Anglais (eng) Mots-clés : Eeg Inhibitory synapses Protein translation SCN1A gene Index. décimale : PER Périodiques Résumé : BACKGROUND: Dravet Syndrome is a severe childhood pharmaco-resistant epileptic disorder mainly caused by mutations in the SCN1A gene, which encodes for the ?1 subunit of the type I voltage-gated sodium channel (Na(V)1.1), that causes imbalance between excitation and inhibition in the brain. We recently found that eEF2K knock out mice displayed enhanced GABAergic transmission and tonic inhibition and were less susceptible to epileptic seizures. Thus, we investigated the effect of inhibition of eEF2K on the epileptic and behavioral phenotype of Scn1a?±?mice, a murine model of Dravet Syndrome. METHODS: To elucidate the role of eEF2K pathway in the etiopathology of Dravet syndrome we generated a new mouse model deleting the eEF2K gene in Scn1a?±?mice. By crossing Scn1a?±?mice with eEF2K-/- mice we obtained the three main genotypes needed for our studies, Scn1a+/+ eEF2K+/+ (WT mice), Scn1a?±?eEF2K+/+ mice (Scn1a?±?mice) and Scn1a?±?eEF2K-/- mice, that were fully characterized for EEG and behavioral phenotype. Furthermore, we tested the ability of a pharmacological inhibitor of eEF2K in rescuing EEG alterations of the Scn1a?±?mice. RESULTS: We showed that the activity of eEF2K/eEF2 pathway was enhanced in Scn1a?±?mice. Then, we demonstrated that both genetic deletion and pharmacological inhibition of eEF2K were sufficient to ameliorate the epileptic phenotype of Scn1a?±?mice. Interestingly we also found that motor coordination defect, memory impairments, and stereotyped behavior of the Scn1a?±?mice were reverted by eEF2K deletion. The analysis of spontaneous inhibitory postsynaptic currents (sIPSCs) suggested that the rescue of the pathological phenotype was driven by the potentiation of GABAergic synapses. LIMITATIONS: Even if we found that eEF2K deletion was able to increase inhibitory synapses function, the molecular mechanism underlining the inhibition of eEF2K/eEF2 pathway in rescuing epileptic and behavioral alterations in the Scn1a?±?needs further investigations. CONCLUSIONS: Our data indicate that pharmacological inhibition of eEF2K could represent a novel therapeutic intervention for treating epilepsy and related comorbidities in the Dravet syndrome. En ligne : http://dx.doi.org/10.1186/s13229-021-00484-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 13 (2022) . - 1p.[article] Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K) [Texte imprimé et/ou numérique] / S. BERETTA, Auteur ; L. GRITTI, Auteur ; L. PONZONI, Auteur ; P. SCALMANI, Auteur ; M. MANTEGAZZA, Auteur ; M. SALA, Auteur ; C. VERPELLI, Auteur ; C. SALA, Auteur . - 1p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 1p.
Mots-clés : Eeg Inhibitory synapses Protein translation SCN1A gene Index. décimale : PER Périodiques Résumé : BACKGROUND: Dravet Syndrome is a severe childhood pharmaco-resistant epileptic disorder mainly caused by mutations in the SCN1A gene, which encodes for the ?1 subunit of the type I voltage-gated sodium channel (Na(V)1.1), that causes imbalance between excitation and inhibition in the brain. We recently found that eEF2K knock out mice displayed enhanced GABAergic transmission and tonic inhibition and were less susceptible to epileptic seizures. Thus, we investigated the effect of inhibition of eEF2K on the epileptic and behavioral phenotype of Scn1a?±?mice, a murine model of Dravet Syndrome. METHODS: To elucidate the role of eEF2K pathway in the etiopathology of Dravet syndrome we generated a new mouse model deleting the eEF2K gene in Scn1a?±?mice. By crossing Scn1a?±?mice with eEF2K-/- mice we obtained the three main genotypes needed for our studies, Scn1a+/+ eEF2K+/+ (WT mice), Scn1a?±?eEF2K+/+ mice (Scn1a?±?mice) and Scn1a?±?eEF2K-/- mice, that were fully characterized for EEG and behavioral phenotype. Furthermore, we tested the ability of a pharmacological inhibitor of eEF2K in rescuing EEG alterations of the Scn1a?±?mice. RESULTS: We showed that the activity of eEF2K/eEF2 pathway was enhanced in Scn1a?±?mice. Then, we demonstrated that both genetic deletion and pharmacological inhibition of eEF2K were sufficient to ameliorate the epileptic phenotype of Scn1a?±?mice. Interestingly we also found that motor coordination defect, memory impairments, and stereotyped behavior of the Scn1a?±?mice were reverted by eEF2K deletion. The analysis of spontaneous inhibitory postsynaptic currents (sIPSCs) suggested that the rescue of the pathological phenotype was driven by the potentiation of GABAergic synapses. LIMITATIONS: Even if we found that eEF2K deletion was able to increase inhibitory synapses function, the molecular mechanism underlining the inhibition of eEF2K/eEF2 pathway in rescuing epileptic and behavioral alterations in the Scn1a?±?needs further investigations. CONCLUSIONS: Our data indicate that pharmacological inhibition of eEF2K could represent a novel therapeutic intervention for treating epilepsy and related comorbidities in the Dravet syndrome. En ligne : http://dx.doi.org/10.1186/s13229-021-00484-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Research Hypothesis in Autism: The Role of Therapeutical Ozone / Dario SINISCALCO in Autism - Open Access, 5-1 ([01/01/2015])
[article]
Titre : Research Hypothesis in Autism: The Role of Therapeutical Ozone Type de document : Texte imprimé et/ou numérique Auteurs : Dario SINISCALCO, Auteur ; Carlo LUONGO, Auteur Article en page(s) : 1 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
in Autism - Open Access > 5-1 [01/01/2015] . - 1 p.[article] Research Hypothesis in Autism: The Role of Therapeutical Ozone [Texte imprimé et/ou numérique] / Dario SINISCALCO, Auteur ; Carlo LUONGO, Auteur . - 1 p.
Langues : Anglais (eng)
in Autism - Open Access > 5-1 [01/01/2015] . - 1 p.
Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000e129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
[périodique] Voir les bulletins disponibles Rechercher dans ce périodique
Titre : Research in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Editeur : Issy les Moulineaux [France] : Elsevier ISBN/ISSN/EAN : 1750-9467 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://www.sciencedirect.com/science/journal/17509467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [périodique] Voir les bulletins disponibles Rechercher dans ce périodique Research in Autism Spectrum Disorders [Texte imprimé et/ou numérique] . - Issy les Moulineaux [France] : Elsevier.
ISSN : 1750-9467
Langues : Anglais (eng)
Index. décimale : PER Périodiques En ligne : http://www.sciencedirect.com/science/journal/17509467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 PermalinkResearch in Brief: Biochemical Parameters in Autism by Rosemary H. Waring / Rosemary H. WARING in Autism, 1-2 (November 1997)
PermalinkResearch in Brief: The Potential Benefits of Daily Life Therapy for Children with Autism by Helen C. Richardson and T.A. Langley / Helen C. RICHARDSON in Autism, 1-2 (November 1997)
PermalinkResearch in people with psychosis risk syndrome: a review of the current evidence and future directions / Christoph U. CORRELL in Journal of Child Psychology and Psychiatry, 51-4 (April 2010)
PermalinkResearch into Early Intervention for Children with Autism and Related Disorders: Methodological and Design Issues: Report on a Workshop Funded by the Wellcome Trust, Institute of Child Health, London, UK, November 2001 / Silvio LODDO in Autism, 7-2 (June 2003)
PermalinkResearch needs and priorities for transition and employment in autism: Considerations reflected in a “Special Interest Group” at the International Meeting for Autism Research / David B NICHOLAS in Autism Research, 10-1 (January 2017)
PermalinkResearch Objectives / David H. SUTHERLAND in Developmental Medicine & Child Neurology, 26-5 (October 1984)
PermalinkResearch on community integration in autism spectrum disorder: Recommendations from research on psychosis / Anke M. SCHEEREN in Research in Autism Spectrum Disorders, 17 (September 2015)
PermalinkResearch on social attention in autism and the challenges of the research domain criteria (RDoC) framework / Peter MUNDY in Autism Research, 16-4 (April 2023)
PermalinkResearch priorities of the autism community: A systematic review of key stakeholder perspectives / Laura ROCHE in Autism, 25-2 (February 2021)
Permalink