Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
3 recherche sur le mot-clé 'Hospitals'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Genetic Testing in Patients with Neurodevelopmental Disorders: Experience of 511 Patients at Cincinnati Children's Hospital Medical Center / Xiaoli DU in Journal of Autism and Developmental Disorders, 52-11 (November 2022)
[article]
Titre : Genetic Testing in Patients with Neurodevelopmental Disorders: Experience of 511 Patients at Cincinnati Children's Hospital Medical Center Type de document : Texte imprimé et/ou numérique Auteurs : Xiaoli DU, Auteur ; Jennifer Elaine GLASS, Auteur ; Stephanie BALOW, Auteur ; Lisa M. DYER, Auteur ; Pamela A. RATHBUN, Auteur ; Qiaoning GUAN, Auteur ; Jie LIU, Auteur ; Yaning WU, Auteur ; D. Brian DAWSON, Auteur ; Lauren WALTERS-SEN, Auteur ; Teresa A. SMOLAREK, Auteur ; Wenying ZHANG, Auteur Article en page(s) : p.4828-4842 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Child DNA Copy Number Variations Female Fragile X Mental Retardation Protein/genetics Fragile X Syndrome/diagnosis/genetics Genetic Testing Hospitals Humans Male Mutation Neurodevelopmental Disorders/diagnosis/genetics Retrospective Studies Trinucleotide Repeat Expansion Autism spectrum disorder (ASD) Copy number variant (CNV) Fragile X Mecp2 Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : Our institution developed and continuously improved a Neurodevelopmental Reflex (NDR) algorithm to help physicians with genetic test ordering for neurodevelopmental disorders (NDDs). To assess its performance, we performed a retrospective study of 511 patients tested through NDR from 2018 to 2019. SNP Microarray identified pathogenic/likely pathogenic copy number variations in 27/511 cases (5.28%). Among the 484 patients tested for Fragile X FMR1 CGG repeats, a diagnosis (0.20%) was established for one male mosaic for a full mutation, a premutation, and a one-CGG allele. Within the 101 normocephalic female patients tested for MECP2, two patients were found to carry pathogenic variants (1.98%). This retrospective study suggested the NDR algorithm effectively established diagnoses for patients with NDDs with a yield of 5.87%. En ligne : http://dx.doi.org/10.1007/s10803-021-05337-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4828-4842[article] Genetic Testing in Patients with Neurodevelopmental Disorders: Experience of 511 Patients at Cincinnati Children's Hospital Medical Center [Texte imprimé et/ou numérique] / Xiaoli DU, Auteur ; Jennifer Elaine GLASS, Auteur ; Stephanie BALOW, Auteur ; Lisa M. DYER, Auteur ; Pamela A. RATHBUN, Auteur ; Qiaoning GUAN, Auteur ; Jie LIU, Auteur ; Yaning WU, Auteur ; D. Brian DAWSON, Auteur ; Lauren WALTERS-SEN, Auteur ; Teresa A. SMOLAREK, Auteur ; Wenying ZHANG, Auteur . - p.4828-4842.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4828-4842
Mots-clés : Autism Spectrum Disorder/diagnosis Child DNA Copy Number Variations Female Fragile X Mental Retardation Protein/genetics Fragile X Syndrome/diagnosis/genetics Genetic Testing Hospitals Humans Male Mutation Neurodevelopmental Disorders/diagnosis/genetics Retrospective Studies Trinucleotide Repeat Expansion Autism spectrum disorder (ASD) Copy number variant (CNV) Fragile X Mecp2 Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : Our institution developed and continuously improved a Neurodevelopmental Reflex (NDR) algorithm to help physicians with genetic test ordering for neurodevelopmental disorders (NDDs). To assess its performance, we performed a retrospective study of 511 patients tested through NDR from 2018 to 2019. SNP Microarray identified pathogenic/likely pathogenic copy number variations in 27/511 cases (5.28%). Among the 484 patients tested for Fragile X FMR1 CGG repeats, a diagnosis (0.20%) was established for one male mosaic for a full mutation, a premutation, and a one-CGG allele. Within the 101 normocephalic female patients tested for MECP2, two patients were found to carry pathogenic variants (1.98%). This retrospective study suggested the NDR algorithm effectively established diagnoses for patients with NDDs with a yield of 5.87%. En ligne : http://dx.doi.org/10.1007/s10803-021-05337-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 Preliminary Validation and Feasibility of the Autism Detection in Early Childhood-Virtual (ADEC-V) for Autism Telehealth Evaluations in a Hospital Setting / Elizabeth M. KRYSZAK in Journal of Autism and Developmental Disorders, 52-12 (December 2022)
[article]
Titre : Preliminary Validation and Feasibility of the Autism Detection in Early Childhood-Virtual (ADEC-V) for Autism Telehealth Evaluations in a Hospital Setting Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth M. KRYSZAK, Auteur ; Charles M. ALBRIGHT, Auteur ; Kevin G. STEPHENSON, Auteur ; Rose E. NEVILL, Auteur ; Darren HEDLEY, Auteur ; Claire O. BURNS, Auteur ; Robyn L. YOUNG, Auteur ; Eric M. BUTTER, Auteur ; Kerrigan VARGO, Auteur ; James A. MULICK, Auteur Année de publication : 2022 Article en page(s) : p.5139-5149 Langues : Anglais (eng) Mots-clés : Child Child, Preschool Humans Female Male Autistic Disorder/diagnosis Autism Spectrum Disorder/diagnosis Feasibility Studies Telemedicine/methods Hospitals Assessment Autism spectrum disorder Psychometrics Screening Telemedicine Young children for sales of the ADEC. The remaining authors declare no other actual or potential conflict of interest. Index. décimale : PER Périodiques Résumé : This study provided preliminary validation of the Autism Detection in Early Childhood-Virtual (ADEC-V) for telehealth assessment of possible autism. Participants were 121 children (24.79% female) aged 18-47Â months who completed telehealth evaluations at a large pediatric hospital in the Midwestern United States between October 2020 and February 2021. The ADEC-V showed good sensitivity (0.82) and specificity (0.78) and was significantly correlated with other ASD symptom measures (i.e., CARS-2, ADI-R). Internal consistency was acceptable (Î+=0.77). These results need replication in a larger and broader sample including more children without ASD. This preliminary validation study identifies the ADEC-V as a promising measure for telehealth ASD assessments in young children. En ligne : http://dx.doi.org/10.1007/s10803-022-05433-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Journal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5139-5149[article] Preliminary Validation and Feasibility of the Autism Detection in Early Childhood-Virtual (ADEC-V) for Autism Telehealth Evaluations in a Hospital Setting [Texte imprimé et/ou numérique] / Elizabeth M. KRYSZAK, Auteur ; Charles M. ALBRIGHT, Auteur ; Kevin G. STEPHENSON, Auteur ; Rose E. NEVILL, Auteur ; Darren HEDLEY, Auteur ; Claire O. BURNS, Auteur ; Robyn L. YOUNG, Auteur ; Eric M. BUTTER, Auteur ; Kerrigan VARGO, Auteur ; James A. MULICK, Auteur . - 2022 . - p.5139-5149.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5139-5149
Mots-clés : Child Child, Preschool Humans Female Male Autistic Disorder/diagnosis Autism Spectrum Disorder/diagnosis Feasibility Studies Telemedicine/methods Hospitals Assessment Autism spectrum disorder Psychometrics Screening Telemedicine Young children for sales of the ADEC. The remaining authors declare no other actual or potential conflict of interest. Index. décimale : PER Périodiques Résumé : This study provided preliminary validation of the Autism Detection in Early Childhood-Virtual (ADEC-V) for telehealth assessment of possible autism. Participants were 121 children (24.79% female) aged 18-47Â months who completed telehealth evaluations at a large pediatric hospital in the Midwestern United States between October 2020 and February 2021. The ADEC-V showed good sensitivity (0.82) and specificity (0.78) and was significantly correlated with other ASD symptom measures (i.e., CARS-2, ADI-R). Internal consistency was acceptable (Î+=0.77). These results need replication in a larger and broader sample including more children without ASD. This preliminary validation study identifies the ADEC-V as a promising measure for telehealth ASD assessments in young children. En ligne : http://dx.doi.org/10.1007/s10803-022-05433-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 The early course and treatment of posttraumatic stress disorder in very young children: diagnostic prevalence and predictors in hospital-attending children and a randomized controlled proof-of-concept trial of trauma-focused cognitive therapy, for 3- to 8-year-olds / C. HITCHCOCK in Journal of Child Psychology and Psychiatry, 63-1 (January 2022)
[article]
Titre : The early course and treatment of posttraumatic stress disorder in very young children: diagnostic prevalence and predictors in hospital-attending children and a randomized controlled proof-of-concept trial of trauma-focused cognitive therapy, for 3- to 8-year-olds Type de document : Texte imprimé et/ou numérique Auteurs : C. HITCHCOCK, Auteur ; B. GOODALL, Auteur ; I. M. WRIGHT, Auteur ; A. BOYLE, Auteur ; D. JOHNSTON, Auteur ; D. DUNNING, Auteur ; J. GILLARD, Auteur ; K. GRIFFITHS, Auteur ; A. HUMPHREY, Auteur ; A. MCKINNON, Auteur ; I. K. PANESAR, Auteur ; A. WERNER-SEIDLER, Auteur ; P. WATSON, Auteur ; P. SMITH, Auteur ; R. MEISER-STEDMAN, Auteur ; Tim DALGLEISH, Auteur Article en page(s) : p.58-67 Langues : Anglais (eng) Mots-clés : Adult Child Child, Preschool Cognitive Behavioral Therapy Hospitals Humans Prevalence Psychotherapy Stress Disorders, Post-Traumatic/diagnosis/epidemiology/therapy Posttraumatic stress disorder randomized control trial young children Index. décimale : PER Périodiques Résumé : BACKGROUND: The introduction of developmentally adapted criteria for posttraumatic stress disorder (PTSD) has improved the identification of ?6-year-old children with clinical needs. Across two studies, we assess predictors of the development of PTSD in young children (PTSD-YC), including the adult-led acute stress disorder (ASD) diagnosis, and provide proof of principle for cognitive-focused therapy for this age range, with the aim of increasing treatment options for children diagnosed with PTSD-YC. METHOD: Study 1 (N?=?105) assessed ASD and PTSD-YC diagnosis in 3- to 8-year-old children within one month and at around three months following attendance at an emergency room. Study 2 (N?=?37) was a preregistered (www.isrctn.com/ISRCTN35018680) randomized controlled early-phase trial comparing CBT-3M, a cognitive-focused intervention, to treatment-as-usual (TAU) delivered within the UK NHS to 3- to 8-year-olds diagnosed with PTSD-YC. RESULTS: In Study 1, the ASD diagnosis failed to identify any young children. In contrast, prevalence of acute PTSD-YC (minus the duration requirement) was 8.6% in the first month post-trauma and 10.1% at 3?months. Length of hospital stay, but no other demographic or trauma-related characteristics, predicted development of later PTSD-YC. Early (within one month) diagnosis of acute PTSD-YC had a positive predictive value of 50% for later PTSD-YC. In Study 2, most children lost their PTSD-YC diagnosis following completion of CBT-3M (84.6%) relative to TAU (6.7%) and CBT-3M was acceptable to recipient families. Effect sizes were also in favor of CBT-3M for secondary outcome measures. CONCLUSIONS: The ASD diagnosis is not fit for purpose in this age-group. There was a strong and encouraging signal of putative efficacy for young children treated using a cognitive-focused treatment for PTSD, and a larger trial of CBT-3M is now warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13460 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.58-67[article] The early course and treatment of posttraumatic stress disorder in very young children: diagnostic prevalence and predictors in hospital-attending children and a randomized controlled proof-of-concept trial of trauma-focused cognitive therapy, for 3- to 8-year-olds [Texte imprimé et/ou numérique] / C. HITCHCOCK, Auteur ; B. GOODALL, Auteur ; I. M. WRIGHT, Auteur ; A. BOYLE, Auteur ; D. JOHNSTON, Auteur ; D. DUNNING, Auteur ; J. GILLARD, Auteur ; K. GRIFFITHS, Auteur ; A. HUMPHREY, Auteur ; A. MCKINNON, Auteur ; I. K. PANESAR, Auteur ; A. WERNER-SEIDLER, Auteur ; P. WATSON, Auteur ; P. SMITH, Auteur ; R. MEISER-STEDMAN, Auteur ; Tim DALGLEISH, Auteur . - p.58-67.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.58-67
Mots-clés : Adult Child Child, Preschool Cognitive Behavioral Therapy Hospitals Humans Prevalence Psychotherapy Stress Disorders, Post-Traumatic/diagnosis/epidemiology/therapy Posttraumatic stress disorder randomized control trial young children Index. décimale : PER Périodiques Résumé : BACKGROUND: The introduction of developmentally adapted criteria for posttraumatic stress disorder (PTSD) has improved the identification of ?6-year-old children with clinical needs. Across two studies, we assess predictors of the development of PTSD in young children (PTSD-YC), including the adult-led acute stress disorder (ASD) diagnosis, and provide proof of principle for cognitive-focused therapy for this age range, with the aim of increasing treatment options for children diagnosed with PTSD-YC. METHOD: Study 1 (N?=?105) assessed ASD and PTSD-YC diagnosis in 3- to 8-year-old children within one month and at around three months following attendance at an emergency room. Study 2 (N?=?37) was a preregistered (www.isrctn.com/ISRCTN35018680) randomized controlled early-phase trial comparing CBT-3M, a cognitive-focused intervention, to treatment-as-usual (TAU) delivered within the UK NHS to 3- to 8-year-olds diagnosed with PTSD-YC. RESULTS: In Study 1, the ASD diagnosis failed to identify any young children. In contrast, prevalence of acute PTSD-YC (minus the duration requirement) was 8.6% in the first month post-trauma and 10.1% at 3?months. Length of hospital stay, but no other demographic or trauma-related characteristics, predicted development of later PTSD-YC. Early (within one month) diagnosis of acute PTSD-YC had a positive predictive value of 50% for later PTSD-YC. In Study 2, most children lost their PTSD-YC diagnosis following completion of CBT-3M (84.6%) relative to TAU (6.7%) and CBT-3M was acceptable to recipient families. Effect sizes were also in favor of CBT-3M for secondary outcome measures. CONCLUSIONS: The ASD diagnosis is not fit for purpose in this age-group. There was a strong and encouraging signal of putative efficacy for young children treated using a cognitive-focused treatment for PTSD, and a larger trial of CBT-3M is now warranted. En ligne : http://dx.doi.org/10.1111/jcpp.13460 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456