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Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study / Elina JOKIRANTA in Journal of Autism and Developmental Disorders, 44-10 (October 2014)
[article]
Titre : Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study Type de document : Texte imprimé et/ou numérique Auteurs : Elina JOKIRANTA, Auteur ; Andre SOURANDER, Auteur ; Auli SUOMINEN, Auteur ; Laura TIMONEN-SOIVIO, Auteur ; Alan S. BROWN, Auteur ; Matti SILLANPAA, Auteur Article en page(s) : p.2547-2557 Langues : Anglais (eng) Mots-clés : Epilepsy Autism spectrum disorders Intellectual disability Gender Age at onset Population-based Index. décimale : PER Périodiques Résumé : The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger’s syndrome or pervasive developmental disorders—not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy’s age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability. En ligne : http://dx.doi.org/10.1007/s10803-014-2126-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240
in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2547-2557[article] Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study [Texte imprimé et/ou numérique] / Elina JOKIRANTA, Auteur ; Andre SOURANDER, Auteur ; Auli SUOMINEN, Auteur ; Laura TIMONEN-SOIVIO, Auteur ; Alan S. BROWN, Auteur ; Matti SILLANPAA, Auteur . - p.2547-2557.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2547-2557
Mots-clés : Epilepsy Autism spectrum disorders Intellectual disability Gender Age at onset Population-based Index. décimale : PER Périodiques Résumé : The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger’s syndrome or pervasive developmental disorders—not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy’s age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability. En ligne : http://dx.doi.org/10.1007/s10803-014-2126-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240 Serotonin system genes and obsessive-compulsive trait dimensions in a population-based, pediatric sample: a genetic association study / V. M. SINOPOLI in Journal of Child Psychology and Psychiatry, 60-12 (December 2019)
[article]
Titre : Serotonin system genes and obsessive-compulsive trait dimensions in a population-based, pediatric sample: a genetic association study Type de document : Texte imprimé et/ou numérique Auteurs : V. M. SINOPOLI, Auteur ; L. ERDMAN, Auteur ; C. L. BURTON, Auteur ; L. S. PARK, Auteur ; A. DUPUIS, Auteur ; J. SHAN, Auteur ; T. GOODALE, Auteur ; S. M. SHAHEEN, Auteur ; J. CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; P. D. ARNOLD, Auteur Article en page(s) : p.1289-1299 Langues : Anglais (eng) Mots-clés : 5-httlpr Htr1b Htr2a Obsessive-compulsive disorder Slc6a4 genetic association phenotypic heterogeneity population-based serotonin genes serotonin system symptom dimensions Index. décimale : PER Périodiques Résumé : BACKGROUND: Serotonin system genes are commonly studied in obsessive-compulsive disorder (OCD), but genetic studies to date have produced inconsistent results, possibly because phenotypic heterogeneity has not been adequately accounted for. In this paper, we studied candidate serotonergic genes and homogenous phenotypic subgroups as presented through obsessive-compulsive (OC) trait dimensions in a general population of children and adolescents. We hypothesized that different serotonergic gene variants are associated with different OC trait dimensions and, furthermore, that they vary by sex. METHODS: Obsessive-compulsive trait dimensions (Cleaning/Contamination, Counting/Checking, Symmetry/Ordering, Superstition, Rumination, and Hoarding) were examined in a total of 5,213 pediatric participants in the community using the Toronto Obsessive-Compulsive Scale (TOCS). We genotyped candidate serotonin genes (directly genotyping the 5-HTTLPR polymorphism in SLC6A4 for 2018 individuals and using single nucleotide polymorphism (SNP) array data for genes SLC6A4, HTR2A, and HTR1B for 4711 individuals). We assessed the association between variants across these genes and each of the OC trait dimensions, within males and females separately. We analyzed OC traits as both (a) dichotomized based on a threshold value and (b) quantitative scores. RESULTS: The [LG + S] variant in 5-HTTLPR was significantly associated with hoarding in males (p-value of 0.003 and 0.004 for categorical and continuous analyses, respectively). There were no significant findings for 5-HTTLPR in females. Using SNP array data, there were significant findings for rumination in males for HTR2A SNPs (p-value of 1.04e-6 to 5.20e-6). CONCLUSIONS: This represents the first genetic association study of OC trait dimensions in a community-based pediatric sample. Our strongest results indicate that hoarding and rumination may be distinct in their association with serotonin gene variants and that serotonin gene variation may be specific to sex. Future genetic association studies in OCD should properly account for heterogeneity, using homogenous subgroups stratified by symptom dimension, sex, and age group. En ligne : http://dx.doi.org/10.1111/jcpp.13079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412
in Journal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1289-1299[article] Serotonin system genes and obsessive-compulsive trait dimensions in a population-based, pediatric sample: a genetic association study [Texte imprimé et/ou numérique] / V. M. SINOPOLI, Auteur ; L. ERDMAN, Auteur ; C. L. BURTON, Auteur ; L. S. PARK, Auteur ; A. DUPUIS, Auteur ; J. SHAN, Auteur ; T. GOODALE, Auteur ; S. M. SHAHEEN, Auteur ; J. CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; P. D. ARNOLD, Auteur . - p.1289-1299.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1289-1299
Mots-clés : 5-httlpr Htr1b Htr2a Obsessive-compulsive disorder Slc6a4 genetic association phenotypic heterogeneity population-based serotonin genes serotonin system symptom dimensions Index. décimale : PER Périodiques Résumé : BACKGROUND: Serotonin system genes are commonly studied in obsessive-compulsive disorder (OCD), but genetic studies to date have produced inconsistent results, possibly because phenotypic heterogeneity has not been adequately accounted for. In this paper, we studied candidate serotonergic genes and homogenous phenotypic subgroups as presented through obsessive-compulsive (OC) trait dimensions in a general population of children and adolescents. We hypothesized that different serotonergic gene variants are associated with different OC trait dimensions and, furthermore, that they vary by sex. METHODS: Obsessive-compulsive trait dimensions (Cleaning/Contamination, Counting/Checking, Symmetry/Ordering, Superstition, Rumination, and Hoarding) were examined in a total of 5,213 pediatric participants in the community using the Toronto Obsessive-Compulsive Scale (TOCS). We genotyped candidate serotonin genes (directly genotyping the 5-HTTLPR polymorphism in SLC6A4 for 2018 individuals and using single nucleotide polymorphism (SNP) array data for genes SLC6A4, HTR2A, and HTR1B for 4711 individuals). We assessed the association between variants across these genes and each of the OC trait dimensions, within males and females separately. We analyzed OC traits as both (a) dichotomized based on a threshold value and (b) quantitative scores. RESULTS: The [LG + S] variant in 5-HTTLPR was significantly associated with hoarding in males (p-value of 0.003 and 0.004 for categorical and continuous analyses, respectively). There were no significant findings for 5-HTTLPR in females. Using SNP array data, there were significant findings for rumination in males for HTR2A SNPs (p-value of 1.04e-6 to 5.20e-6). CONCLUSIONS: This represents the first genetic association study of OC trait dimensions in a community-based pediatric sample. Our strongest results indicate that hoarding and rumination may be distinct in their association with serotonin gene variants and that serotonin gene variation may be specific to sex. Future genetic association studies in OCD should properly account for heterogeneity, using homogenous subgroups stratified by symptom dimension, sex, and age group. En ligne : http://dx.doi.org/10.1111/jcpp.13079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 Measuring use and cost of health sector and related care in a population of girls and young women with Rett syndrome / Delia HENDRIE in Research in Autism Spectrum Disorders, 5-2 (April-June 2011)
[article]
Titre : Measuring use and cost of health sector and related care in a population of girls and young women with Rett syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Delia HENDRIE, Auteur ; Ami BEBBINGTON, Auteur ; Carol BOWER, Auteur ; Helen LEONARD, Auteur Année de publication : 2011 Article en page(s) : p.901-909 Langues : Anglais (eng) Mots-clés : Rett syndrome Healthcare Costs Resources Population-based Index. décimale : PER Périodiques Résumé : This study measured use and cost of health sector and related services in Rett syndrome and effects of socio-demographic, clinical severity and genetic factors on costs. The study population consisted of individuals with Rett syndrome registered with the Australian Rett Syndrome Database in 2004. Descriptive analysis was used to examine patterns of resource use and costs, and logistic regression to analyse factors associated with higher costs. We found the use of health sector and related resources varied by type of resource. Mean annual cost per case was $21,158 (range $238–$85,776). High cost items included long-term residential care, therapy services out of school and paid home and community care. Factors associated with increasing odds of being above the median cost were clinical severity and the p.R255X mutation. Compared with the youngest cases, cases in the 5–14 year age group and the 15–24 year age group were at lower odds of being above the median cost. Needs relating to health sector and related resources can result in considerable costs for individuals with Rett syndrome. Many households caring for dependents with Rett syndrome are like to be facing undue financial pressures from the additional costs of disability. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.10.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114
in Research in Autism Spectrum Disorders > 5-2 (April-June 2011) . - p.901-909[article] Measuring use and cost of health sector and related care in a population of girls and young women with Rett syndrome [Texte imprimé et/ou numérique] / Delia HENDRIE, Auteur ; Ami BEBBINGTON, Auteur ; Carol BOWER, Auteur ; Helen LEONARD, Auteur . - 2011 . - p.901-909.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 5-2 (April-June 2011) . - p.901-909
Mots-clés : Rett syndrome Healthcare Costs Resources Population-based Index. décimale : PER Périodiques Résumé : This study measured use and cost of health sector and related services in Rett syndrome and effects of socio-demographic, clinical severity and genetic factors on costs. The study population consisted of individuals with Rett syndrome registered with the Australian Rett Syndrome Database in 2004. Descriptive analysis was used to examine patterns of resource use and costs, and logistic regression to analyse factors associated with higher costs. We found the use of health sector and related resources varied by type of resource. Mean annual cost per case was $21,158 (range $238–$85,776). High cost items included long-term residential care, therapy services out of school and paid home and community care. Factors associated with increasing odds of being above the median cost were clinical severity and the p.R255X mutation. Compared with the youngest cases, cases in the 5–14 year age group and the 15–24 year age group were at lower odds of being above the median cost. Needs relating to health sector and related resources can result in considerable costs for individuals with Rett syndrome. Many households caring for dependents with Rett syndrome are like to be facing undue financial pressures from the additional costs of disability. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.10.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 Prospective relationship between autistic traits and nutrient intakes among Japanese children: Results of the Shika study / Hiromasa TSUJIGUCHI in Autism, 27-2 (February 2023)
[article]
Titre : Prospective relationship between autistic traits and nutrient intakes among Japanese children: Results of the Shika study Type de document : Texte imprimé et/ou numérique Auteurs : Hiromasa TSUJIGUCHI, Auteur ; Akinori HARA, Auteur ; Sakae MIYAGI, Auteur ; Kim Oanh PHAM, Auteur ; Keita SUZUKI, Auteur ; Thao Thi Thu NGUYEN, Auteur ; Yasuki ONO, Auteur ; Yasuhiro KAMBAYASHI, Auteur ; Yukari SHIMIZU, Auteur ; Haruki NAKAMURA, Auteur ; Fumihiko SUZUKI, Auteur ; Aki SHIBATA, Auteur ; Koichi HAYASHI, Auteur ; Hirohito TSUBOI, Auteur ; Hiroyuki NAKAMURA, Auteur Article en page(s) : p.389-401 Langues : Anglais (eng) Mots-clés : ASD children longitudinal nutrient population-based Index. décimale : PER Périodiques Résumé : Increased food selectivity among children with autism spectrum disorder may lead to nutritional inadequacy. We designed this study to examine the prospective relationship between autistic traits in children and subsequent nutrient intake in later childhood and whether this relationship changes over time. We utilized longitudinal data obtained at two time points from the Shika study, an ongoing population-based study conducted in a rural area of Japan. Participants were 759 Japanese children aged between 7 and 12 years at baseline and between 10 and 15 years in the follow-up. The results obtained showed relatively lower intakes of sodium, calcium, magnesium, iron, vitamin D, vitamin B2, and vitamin B12 among children with than without autistic traits. Interactions were observed among autistic traits and time points for iron, vitamin B2, folic acid, and pantothenic acid. The results of this study suggest the importance of screening the nutrient intake of children with autistic traits across childhood in order to reduce the risk of restricted intake. En ligne : http://dx.doi.org/10.1177/13623613221097487 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493
in Autism > 27-2 (February 2023) . - p.389-401[article] Prospective relationship between autistic traits and nutrient intakes among Japanese children: Results of the Shika study [Texte imprimé et/ou numérique] / Hiromasa TSUJIGUCHI, Auteur ; Akinori HARA, Auteur ; Sakae MIYAGI, Auteur ; Kim Oanh PHAM, Auteur ; Keita SUZUKI, Auteur ; Thao Thi Thu NGUYEN, Auteur ; Yasuki ONO, Auteur ; Yasuhiro KAMBAYASHI, Auteur ; Yukari SHIMIZU, Auteur ; Haruki NAKAMURA, Auteur ; Fumihiko SUZUKI, Auteur ; Aki SHIBATA, Auteur ; Koichi HAYASHI, Auteur ; Hirohito TSUBOI, Auteur ; Hiroyuki NAKAMURA, Auteur . - p.389-401.
Langues : Anglais (eng)
in Autism > 27-2 (February 2023) . - p.389-401
Mots-clés : ASD children longitudinal nutrient population-based Index. décimale : PER Périodiques Résumé : Increased food selectivity among children with autism spectrum disorder may lead to nutritional inadequacy. We designed this study to examine the prospective relationship between autistic traits in children and subsequent nutrient intake in later childhood and whether this relationship changes over time. We utilized longitudinal data obtained at two time points from the Shika study, an ongoing population-based study conducted in a rural area of Japan. Participants were 759 Japanese children aged between 7 and 12 years at baseline and between 10 and 15 years in the follow-up. The results obtained showed relatively lower intakes of sodium, calcium, magnesium, iron, vitamin D, vitamin B2, and vitamin B12 among children with than without autistic traits. Interactions were observed among autistic traits and time points for iron, vitamin B2, folic acid, and pantothenic acid. The results of this study suggest the importance of screening the nutrient intake of children with autistic traits across childhood in order to reduce the risk of restricted intake. En ligne : http://dx.doi.org/10.1177/13623613221097487 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 Validation of Autism Spectrum Disorder Diagnoses in Large Healthcare Systems with Electronic Medical Records / Karen J. COLEMAN in Journal of Autism and Developmental Disorders, 45-7 (July 2015)
[article]
Titre : Validation of Autism Spectrum Disorder Diagnoses in Large Healthcare Systems with Electronic Medical Records Type de document : Texte imprimé et/ou numérique Auteurs : Karen J. COLEMAN, Auteur ; Marta A. LUTSKY, Auteur ; Vincent YAU, Auteur ; Yinge QIAN, Auteur ; Magdalena E. POMICHOWSKI, Auteur ; Phillip M. CRAWFORD, Auteur ; Frances L. LYNCH, Auteur ; Jeanne M. MADDEN, Auteur ; Ashli OWEN-SMITH, Auteur ; John A. PEARSON, Auteur ; Kathryn A. PEARSON, Auteur ; Donna RUSINAK, Auteur ; Virginia P. QUINN, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2015 Article en page(s) : p.1989-1996 Langues : Anglais (eng) Mots-clés : Population-based Racial/ethnic minorities Chart review Children Adolescents Index. décimale : PER Périodiques Résumé : To identify factors associated with valid Autism Spectrum Disorder (ASD) diagnoses from electronic sources in large healthcare systems. We examined 1,272 charts from ASD diagnosed youth <18 years old. Expert reviewers classified diagnoses as confirmed, probable, possible, ruled out, or not enough information. A total of 845 were classified with 81 % as a confirmed, probable, or possible ASD diagnosis. The predictors of valid ASD diagnoses were >2 diagnoses in the medical record (OR 2.94; 95 % CI 2.03–4.25; p < 0.001) and being male (OR 1.51; 95 % CI 1.05–2.17; p = 0.03). In large integrated healthcare settings, at least two diagnoses can be used to identify ASD patients for population-based research. En ligne : http://dx.doi.org/10.1007/s10803-015-2358-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261
in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.1989-1996[article] Validation of Autism Spectrum Disorder Diagnoses in Large Healthcare Systems with Electronic Medical Records [Texte imprimé et/ou numérique] / Karen J. COLEMAN, Auteur ; Marta A. LUTSKY, Auteur ; Vincent YAU, Auteur ; Yinge QIAN, Auteur ; Magdalena E. POMICHOWSKI, Auteur ; Phillip M. CRAWFORD, Auteur ; Frances L. LYNCH, Auteur ; Jeanne M. MADDEN, Auteur ; Ashli OWEN-SMITH, Auteur ; John A. PEARSON, Auteur ; Kathryn A. PEARSON, Auteur ; Donna RUSINAK, Auteur ; Virginia P. QUINN, Auteur ; Lisa A. CROEN, Auteur . - 2015 . - p.1989-1996.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.1989-1996
Mots-clés : Population-based Racial/ethnic minorities Chart review Children Adolescents Index. décimale : PER Périodiques Résumé : To identify factors associated with valid Autism Spectrum Disorder (ASD) diagnoses from electronic sources in large healthcare systems. We examined 1,272 charts from ASD diagnosed youth <18 years old. Expert reviewers classified diagnoses as confirmed, probable, possible, ruled out, or not enough information. A total of 845 were classified with 81 % as a confirmed, probable, or possible ASD diagnosis. The predictors of valid ASD diagnoses were >2 diagnoses in the medical record (OR 2.94; 95 % CI 2.03–4.25; p < 0.001) and being male (OR 1.51; 95 % CI 1.05–2.17; p = 0.03). In large integrated healthcare settings, at least two diagnoses can be used to identify ASD patients for population-based research. En ligne : http://dx.doi.org/10.1007/s10803-015-2358-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 Increasing autism prevalence in metropolitan New Jersey / Walter ZAHORODNY in Autism, 18-2 (February 2014)
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