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Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the nurses' health study II / Kristen LYALL in Autism Research, 5-1 (February 2012)
[article]
Titre : Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the nurses' health study II Type de document : Texte imprimé et/ou numérique Auteurs : Kristen LYALL, Auteur ; David L. PAULS, Auteur ; Donna SPIEGELMAN, Auteur ; Alberto ASCHERIO, Auteur ; Susan L. SANTANGELO, Auteur Année de publication : 2012 Article en page(s) : p.21-30 Langues : Anglais (eng) Mots-clés : autism spectrum disorders gestational diabetes obstetric complications pregnancy complications Index. décimale : PER Périodiques Résumé : The authors examined pregnancy and obstetric complications in association with autism spectrum disorders (ASD) in children of participants from the Nurses' Health Study II, a prospective national cohort with information collected through biennial mailed questionnaires since 1989. Logistic regression was used to obtain crude and adjusted odds ratios for ASD, and by diagnostic subgroup. Seven hundred and ninety-three cases were reported among 66,445 pregnancies. Pregnancy complications and obstetric suboptimality factors were assessed by maternal report of occurrence in first birth and, in secondary analyses, in any birth. Complications and a suboptimality score were significantly associated with having a child with ASD (OR 1.49, 95% CI 1.26, 1.77, P<0.0001 for pregnancy complications in first birth and 2.76, 95% CI 2.04, 3.74, P<0.0001 comparing individuals with four or more obstetric suboptimality factors in first birth to those with none; results similar when assessed in any birth). In particular, gestational diabetes was associated with a significantly increased risk of ASD in results of primary and sensitivity analyses (OR in primary analysis = 1.76, 95% CI 1.34, 2.32, P<0.0001); suboptimal parity and suboptimal age-at-first-birth were also individual factors associated with ASD. Associations were similar by diagnostic subgroup, suggesting autism, Asperger syndrome, and other Pervasive Developmental Disorders are all associated with pregnancy complications. Consistent with previous research, the general class of pregnancy complications was associated with ASD as a whole. Additional work will be required to more fully assess the role of gestational diabetes. En ligne : http://dx.doi.org/10.1002/aur.228 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153
in Autism Research > 5-1 (February 2012) . - p.21-30[article] Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the nurses' health study II [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; David L. PAULS, Auteur ; Donna SPIEGELMAN, Auteur ; Alberto ASCHERIO, Auteur ; Susan L. SANTANGELO, Auteur . - 2012 . - p.21-30.
Langues : Anglais (eng)
in Autism Research > 5-1 (February 2012) . - p.21-30
Mots-clés : autism spectrum disorders gestational diabetes obstetric complications pregnancy complications Index. décimale : PER Périodiques Résumé : The authors examined pregnancy and obstetric complications in association with autism spectrum disorders (ASD) in children of participants from the Nurses' Health Study II, a prospective national cohort with information collected through biennial mailed questionnaires since 1989. Logistic regression was used to obtain crude and adjusted odds ratios for ASD, and by diagnostic subgroup. Seven hundred and ninety-three cases were reported among 66,445 pregnancies. Pregnancy complications and obstetric suboptimality factors were assessed by maternal report of occurrence in first birth and, in secondary analyses, in any birth. Complications and a suboptimality score were significantly associated with having a child with ASD (OR 1.49, 95% CI 1.26, 1.77, P<0.0001 for pregnancy complications in first birth and 2.76, 95% CI 2.04, 3.74, P<0.0001 comparing individuals with four or more obstetric suboptimality factors in first birth to those with none; results similar when assessed in any birth). In particular, gestational diabetes was associated with a significantly increased risk of ASD in results of primary and sensitivity analyses (OR in primary analysis = 1.76, 95% CI 1.34, 2.32, P<0.0001); suboptimal parity and suboptimal age-at-first-birth were also individual factors associated with ASD. Associations were similar by diagnostic subgroup, suggesting autism, Asperger syndrome, and other Pervasive Developmental Disorders are all associated with pregnancy complications. Consistent with previous research, the general class of pregnancy complications was associated with ASD as a whole. Additional work will be required to more fully assess the role of gestational diabetes. En ligne : http://dx.doi.org/10.1002/aur.228 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 Prenatal pregnancy complications and psychiatric symptoms: Children with ASD versus clinic controls / Megan E. TUDOR in Research in Autism Spectrum Disorders, 6-4 (October-December 2012)
[article]
Titre : Prenatal pregnancy complications and psychiatric symptoms: Children with ASD versus clinic controls Type de document : Texte imprimé et/ou numérique Auteurs : Megan E. TUDOR, Auteur ; Carla DEVINCENT, Auteur ; Kenneth D. GADOW, Auteur Année de publication : 2012 Article en page(s) : p.1401-1405 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Pregnancy complications Psychiatric co-morbidity Attention-deficit hyperactivity disorder Generalized anxiety disorderDepression Index. décimale : PER Périodiques Résumé : The current study examined the association between prenatal pregnancy complications (PPC) and childhood psychiatric symptoms in children with an autism spectrum disorder (ASD) and non-ASD children who were referred to a psychiatric clinic (Controls). Parents completed a DSM-IV-referenced rating scale and developmental history questionnaire. Participants were classified as having ≥1 PPC (+PPC) versus none (−PPC). Children with ASD were significantly more likely to have PPC than Controls. Intra-group comparisons demonstrated that children in the ASD + PPC group had more severe anxiety than ASD/−PPC group. The Control + PPC group obtained higher symptom ratings of inattention, hyperactivity, and oppositional behavior than Control/−PPC. Children in the ASD + PPC group were rated as having more severe anxiety and depression symptoms than Control + PPC. Dissimilar associations in ASD and non-ASD samples were found, suggesting divergent pathogenic processes in different clinical phenotypes. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.06.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=165
in Research in Autism Spectrum Disorders > 6-4 (October-December 2012) . - p.1401-1405[article] Prenatal pregnancy complications and psychiatric symptoms: Children with ASD versus clinic controls [Texte imprimé et/ou numérique] / Megan E. TUDOR, Auteur ; Carla DEVINCENT, Auteur ; Kenneth D. GADOW, Auteur . - 2012 . - p.1401-1405.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 6-4 (October-December 2012) . - p.1401-1405
Mots-clés : Autism spectrum disorder Pregnancy complications Psychiatric co-morbidity Attention-deficit hyperactivity disorder Generalized anxiety disorderDepression Index. décimale : PER Périodiques Résumé : The current study examined the association between prenatal pregnancy complications (PPC) and childhood psychiatric symptoms in children with an autism spectrum disorder (ASD) and non-ASD children who were referred to a psychiatric clinic (Controls). Parents completed a DSM-IV-referenced rating scale and developmental history questionnaire. Participants were classified as having ≥1 PPC (+PPC) versus none (−PPC). Children with ASD were significantly more likely to have PPC than Controls. Intra-group comparisons demonstrated that children in the ASD + PPC group had more severe anxiety than ASD/−PPC group. The Control + PPC group obtained higher symptom ratings of inattention, hyperactivity, and oppositional behavior than Control/−PPC. Children in the ASD + PPC group were rated as having more severe anxiety and depression symptoms than Control + PPC. Dissimilar associations in ASD and non-ASD samples were found, suggesting divergent pathogenic processes in different clinical phenotypes. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.06.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=165 Brief Report: Pregnancy, Birth and Infant Feeding Practices: A Survey-Based Investigation into Risk Factors for Autism Spectrum Disorder / Aleesha WHITELY in Journal of Autism and Developmental Disorders, 52-11 (November 2022)
[article]
Titre : Brief Report: Pregnancy, Birth and Infant Feeding Practices: A Survey-Based Investigation into Risk Factors for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Aleesha WHITELY, Auteur ; Kerrie SHANDLEY, Auteur ; Minh HUYNH, Auteur ; Christine M. BROWN, Auteur ; David W. AUSTIN, Auteur ; Jahar BHOWMIK, Auteur Article en page(s) : p.5072-5078 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/etiology Child Female Humans Infant Male Meperidine Mothers Pregnancy Risk Factors Surveys and Questionnaires Analgesia Autism spectrum disorder Breastfeeding Labour interventions Pregnancy complications Index. décimale : PER Périodiques Résumé : A succession of interconnected environmental factors is believed to contribute substantially to the development of autism spectrum disorder (ASD). This exploratory study therefore aims to identify potential risk factors for ASD that are associated with pregnancy, birth and infant feeding. Demographic and health-related data on children aged 3-13Â years (N=4306) was collected through an online survey completed by biological mothers. A fitted logistic regression model identified advanced maternal age, prenatal bleeding, pre-eclampsia, perinatal pethidine usage, foetal distress before birth and male sex of child as associated with an increased risk of ASD, whereas longer gestational duration demonstrated a protective effect. These findings highlight potential risk factors and predictor interrelationships which may contribute to overall ASD risk. En ligne : http://dx.doi.org/10.1007/s10803-021-05348-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.5072-5078[article] Brief Report: Pregnancy, Birth and Infant Feeding Practices: A Survey-Based Investigation into Risk Factors for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Aleesha WHITELY, Auteur ; Kerrie SHANDLEY, Auteur ; Minh HUYNH, Auteur ; Christine M. BROWN, Auteur ; David W. AUSTIN, Auteur ; Jahar BHOWMIK, Auteur . - p.5072-5078.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.5072-5078
Mots-clés : Autism Spectrum Disorder/complications/etiology Child Female Humans Infant Male Meperidine Mothers Pregnancy Risk Factors Surveys and Questionnaires Analgesia Autism spectrum disorder Breastfeeding Labour interventions Pregnancy complications Index. décimale : PER Périodiques Résumé : A succession of interconnected environmental factors is believed to contribute substantially to the development of autism spectrum disorder (ASD). This exploratory study therefore aims to identify potential risk factors for ASD that are associated with pregnancy, birth and infant feeding. Demographic and health-related data on children aged 3-13Â years (N=4306) was collected through an online survey completed by biological mothers. A fitted logistic regression model identified advanced maternal age, prenatal bleeding, pre-eclampsia, perinatal pethidine usage, foetal distress before birth and male sex of child as associated with an increased risk of ASD, whereas longer gestational duration demonstrated a protective effect. These findings highlight potential risk factors and predictor interrelationships which may contribute to overall ASD risk. En ligne : http://dx.doi.org/10.1007/s10803-021-05348-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 Maternal risk factors vary between subpopulations of children with autism spectrum disorder / Genevieve GRIVAS in Autism Research, 15-11 (November 2022)
[article]
Titre : Maternal risk factors vary between subpopulations of children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Genevieve GRIVAS, Auteur ; Richard E. FRYE, Auteur ; Juergen HAHN, Auteur Article en page(s) : p.2038-2055 Langues : Anglais (eng) Mots-clés : Child Pregnancy Female Humans Autism Spectrum Disorder/complications/epidemiology/diagnosis Case-Control Studies Pregnancy Complications Risk Factors Immune System Diseases/complications Seizures/complications associated risk autism spectrum disorder co-occurring conditions logistic regression medical claims retrospective analysis subgroups Index. décimale : PER Périodiques Résumé : Previous work identified three subgroups of children with ASD based upon co-occurring conditions (COCs) diagnosed during the first 5 years of life. This work examines prenatal risk factors, given by maternal medical claims, for each of the three subgroups: children with a High-Prevalence of COCs, children with mainly developmental delay and seizures (DD/Seizure COCs), and children with a Low-Prevalence of COCs. While some risk factors are shared by all three subgroups, the majority of the factors identified for each subgroup were unique; infections, anti-inflammatory and other complex medications were associated with the High-Prevalence COCs group; immune deregulatory conditions such as asthma and joint disorders were associated with the DD/Seizure COCs group; and overall pregnancy complications were associated with the Low-Prevalence COCs group. Thus, we have found that the previously identified subgroups of children with ASD have distinct associated prenatal risk factors. As such, this work supports subgrouping children with ASD based upon COCs, which may provide a framework for elucidating some of the heterogeneity associated with ASD. En ligne : http://dx.doi.org/10.1002/aur.2809 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism Research > 15-11 (November 2022) . - p.2038-2055[article] Maternal risk factors vary between subpopulations of children with autism spectrum disorder [Texte imprimé et/ou numérique] / Genevieve GRIVAS, Auteur ; Richard E. FRYE, Auteur ; Juergen HAHN, Auteur . - p.2038-2055.
Langues : Anglais (eng)
in Autism Research > 15-11 (November 2022) . - p.2038-2055
Mots-clés : Child Pregnancy Female Humans Autism Spectrum Disorder/complications/epidemiology/diagnosis Case-Control Studies Pregnancy Complications Risk Factors Immune System Diseases/complications Seizures/complications associated risk autism spectrum disorder co-occurring conditions logistic regression medical claims retrospective analysis subgroups Index. décimale : PER Périodiques Résumé : Previous work identified three subgroups of children with ASD based upon co-occurring conditions (COCs) diagnosed during the first 5 years of life. This work examines prenatal risk factors, given by maternal medical claims, for each of the three subgroups: children with a High-Prevalence of COCs, children with mainly developmental delay and seizures (DD/Seizure COCs), and children with a Low-Prevalence of COCs. While some risk factors are shared by all three subgroups, the majority of the factors identified for each subgroup were unique; infections, anti-inflammatory and other complex medications were associated with the High-Prevalence COCs group; immune deregulatory conditions such as asthma and joint disorders were associated with the DD/Seizure COCs group; and overall pregnancy complications were associated with the Low-Prevalence COCs group. Thus, we have found that the previously identified subgroups of children with ASD have distinct associated prenatal risk factors. As such, this work supports subgrouping children with ASD based upon COCs, which may provide a framework for elucidating some of the heterogeneity associated with ASD. En ligne : http://dx.doi.org/10.1002/aur.2809 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Prenatal maternal infection and risk for autism in offspring: A meta-analysis / N. TIOLECO in Autism Research, 14-6 (June 2021)
[article]
Titre : Prenatal maternal infection and risk for autism in offspring: A meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : N. TIOLECO, Auteur ; A. E. SILBERMAN, Auteur ; K. STRATIGOS, Auteur ; Sharmila BANERJEE-BASU, Auteur ; M. N. SPANN, Auteur ; A. H. WHITAKER, Auteur ; J. Blake TURNER, Auteur Article en page(s) : p.1296-1316 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder/epidemiology Causality Female Humans Pregnancy Pregnancy Complications Prenatal Exposure Delayed Effects/epidemiology Risk Factors autism infections pregnancy prenatal risk factors Index. décimale : PER Périodiques Résumé : While prenatal maternal infection has received attention as a preventable and treatable risk factor for autism, findings have been inconsistent. This paper presents the results of a meta-analysis to determine whether the weight of the evidence supports such an association. Studies with a categorical diagnosis of autism as the outcome and an assessment of its association with prenatal maternal infection or fever (or the data necessary to compute this association) were included. A total of 36 studies met these criteria. Two independent reviewers extracted data on study design, methods of assessment, type of infectious agent, site of infection, trimester of exposure, definition of autism, and effect size. Analyses demonstrated a statistically significant association of maternal infection/fever with autism in offspring (OR = 1.32; 95% CI = 1.20-1.46). Adjustment for evident publication bias slightly weakened this association. There was little variation in effect sizes across agent or site of infection. Small differences across trimester of exposure were not statistically significant. There was some evidence that recall bias associated with status on the outcome variable leads to differential misclassification of exposure status. Nonetheless, the overall association is only modestly reduced when studies potentially contaminated by such bias are removed. Although causality has not been firmly established, these findings suggest maternal infection during pregnancy confers an increase in risk for autism in offspring. Given the prevalence of this risk factor, it is possible that the incidence of autism would be reduced by 12%-17% if maternal infections could be prevented or safely treated in a timely manner. LAY SUMMARY: This study is a meta-analysis of the association of maternal infection during pregnancy and subsequent autism in offspring. In combining the results from 36 studies of this association we find that a significant relationship is present. The association does not vary much across the types of infections or when they occur during pregnancy. We conclude that the incidence of autism could be substantially reduced if maternal infections could be prevented or safely treated in a timely manner. En ligne : http://dx.doi.org/10.1002/aur.2499 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-6 (June 2021) . - p.1296-1316[article] Prenatal maternal infection and risk for autism in offspring: A meta-analysis [Texte imprimé et/ou numérique] / N. TIOLECO, Auteur ; A. E. SILBERMAN, Auteur ; K. STRATIGOS, Auteur ; Sharmila BANERJEE-BASU, Auteur ; M. N. SPANN, Auteur ; A. H. WHITAKER, Auteur ; J. Blake TURNER, Auteur . - p.1296-1316.
Langues : Anglais (eng)
in Autism Research > 14-6 (June 2021) . - p.1296-1316
Mots-clés : Autism Spectrum Disorder Autistic Disorder/epidemiology Causality Female Humans Pregnancy Pregnancy Complications Prenatal Exposure Delayed Effects/epidemiology Risk Factors autism infections pregnancy prenatal risk factors Index. décimale : PER Périodiques Résumé : While prenatal maternal infection has received attention as a preventable and treatable risk factor for autism, findings have been inconsistent. This paper presents the results of a meta-analysis to determine whether the weight of the evidence supports such an association. Studies with a categorical diagnosis of autism as the outcome and an assessment of its association with prenatal maternal infection or fever (or the data necessary to compute this association) were included. A total of 36 studies met these criteria. Two independent reviewers extracted data on study design, methods of assessment, type of infectious agent, site of infection, trimester of exposure, definition of autism, and effect size. Analyses demonstrated a statistically significant association of maternal infection/fever with autism in offspring (OR = 1.32; 95% CI = 1.20-1.46). Adjustment for evident publication bias slightly weakened this association. There was little variation in effect sizes across agent or site of infection. Small differences across trimester of exposure were not statistically significant. There was some evidence that recall bias associated with status on the outcome variable leads to differential misclassification of exposure status. Nonetheless, the overall association is only modestly reduced when studies potentially contaminated by such bias are removed. Although causality has not been firmly established, these findings suggest maternal infection during pregnancy confers an increase in risk for autism in offspring. Given the prevalence of this risk factor, it is possible that the incidence of autism would be reduced by 12%-17% if maternal infections could be prevented or safely treated in a timely manner. LAY SUMMARY: This study is a meta-analysis of the association of maternal infection during pregnancy and subsequent autism in offspring. In combining the results from 36 studies of this association we find that a significant relationship is present. The association does not vary much across the types of infections or when they occur during pregnancy. We conclude that the incidence of autism could be substantially reduced if maternal infections could be prevented or safely treated in a timely manner. En ligne : http://dx.doi.org/10.1002/aur.2499 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Editorial: Money cannot buy happiness - but can it prevent depression? A commentary on Su et al / M. NASIR in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)
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