Dépouillements

Autism in adults / Anthony J. BAILEY in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.1-2 Titre : Autism in adults Type de document : Texte imprimé et/ou numérique Auteurs : Anthony J. BAILEY, Auteur Année de publication : 2012 Article en page(s) : p.1-2 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Autism in adults [Texte imprimé et/ou numérique] / Anthony J. BAILEY, Auteur . - 2012 . - p.1-2. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.1-2 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome / Clodagh M. MURPHY in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.3-12 Titre : Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Clodagh M. MURPHY, Auteur ; Quinton DEELEY, Auteur ; Eileen DALY, Auteur ; Christine ECKER, Auteur ; F. M. O'BRIEN, Auteur ; B. HALLAHAN, Auteur ; Eva LOTH, Auteur ; F. TOAL, Auteur ; S. REED, Auteur ; S. HALES, Auteur ; D. M. ROBERTSON, Auteur ; Michael C. CRAIG, Auteur ; D. MULLINS, Auteur ; Gareth J. BARKER, Auteur ; T. LAVENDER, Auteur ; P. JOHNSTON, Auteur ; Kieran C. MURPHY, Auteur ; Declan G. MURPHY, Auteur Année de publication : 2012 Article en page(s) : p.3-12 Langues : Anglais (eng) Mots-clés : Asperger syndrome  autism  amygdala  hippocampus  age Index. décimale : PER Périodiques Résumé : It has been proposed that people with autism spectrum disorder (ASD) have abnormal morphometry and development of the amygdala and hippocampus (AH). However, previous reports are inconsistent, perhaps because they included people of different ASD diagnoses, ages, and health. We compared, using magnetic resonance imaging, the in vivo anatomy of the AH in 32 healthy individuals with Asperger syndrome (12–47 years) and 32 healthy controls who did not differ significantly in age or IQ. We measured bulk (gray + white matter) volume of the AH using manual tracing (MEASURE). We first compared the volume of AH between individuals with Asperger syndrome and controls and then investigated age-related differences. We compared differences in anatomy before, and after, correcting for whole brain size. There was no significant between group differences in whole brain volume. However, individuals with Asperger syndrome had a significantly larger raw bulk volume of total (P<0.01), right (P<0.01), and left amygdala (P<0.05); and when corrected for overall brain size, total (P<0.05), and right amygdala (P<0.01). There was a significant group difference in aging of left amygdala; controls, but not individuals with Asperger syndrome, had a significant age-related increase in volume (r = 0.486, P<0.01, and r = 0.007, P = 0.97, z = 1.995). There were no significant group differences in volume or age-related effects in hippocampus. Individuals with Asperger syndrome have significant differences from controls in bulk volume and aging of the amygdala. En ligne : http://dx.doi.org/10.1002/aur.227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome [Texte imprimé et/ou numérique] / Clodagh M. MURPHY, Auteur ; Quinton DEELEY, Auteur ; Eileen DALY, Auteur ; Christine ECKER, Auteur ; F. M. O'BRIEN, Auteur ; B. HALLAHAN, Auteur ; Eva LOTH, Auteur ; F. TOAL, Auteur ; S. REED, Auteur ; S. HALES, Auteur ; D. M. ROBERTSON, Auteur ; Michael C. CRAIG, Auteur ; D. MULLINS, Auteur ; Gareth J. BARKER, Auteur ; T. LAVENDER, Auteur ; P. JOHNSTON, Auteur ; Kieran C. MURPHY, Auteur ; Declan G. MURPHY, Auteur . - 2012 . - p.3-12. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.3-12 Mots-clés : Asperger syndrome  autism  amygdala  hippocampus  age Index. décimale : PER Périodiques Résumé : It has been proposed that people with autism spectrum disorder (ASD) have abnormal morphometry and development of the amygdala and hippocampus (AH). However, previous reports are inconsistent, perhaps because they included people of different ASD diagnoses, ages, and health. We compared, using magnetic resonance imaging, the in vivo anatomy of the AH in 32 healthy individuals with Asperger syndrome (12–47 years) and 32 healthy controls who did not differ significantly in age or IQ. We measured bulk (gray + white matter) volume of the AH using manual tracing (MEASURE). We first compared the volume of AH between individuals with Asperger syndrome and controls and then investigated age-related differences. We compared differences in anatomy before, and after, correcting for whole brain size. There was no significant between group differences in whole brain volume. However, individuals with Asperger syndrome had a significantly larger raw bulk volume of total (P<0.01), right (P<0.01), and left amygdala (P<0.05); and when corrected for overall brain size, total (P<0.05), and right amygdala (P<0.01). There was a significant group difference in aging of left amygdala; controls, but not individuals with Asperger syndrome, had a significant age-related increase in volume (r = 0.486, P<0.01, and r = 0.007, P = 0.97, z = 1.995). There were no significant group differences in volume or age-related effects in hippocampus. Individuals with Asperger syndrome have significant differences from controls in bulk volume and aging of the amygdala. En ligne : http://dx.doi.org/10.1002/aur.227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Evidence for broader autism phenotype characteristics in parents from multiple-incidence autism families / Raphael BERNIER in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.13-20 Titre : Evidence for broader autism phenotype characteristics in parents from multiple-incidence autism families Type de document : Texte imprimé et/ou numérique Auteurs : Raphael BERNIER, Auteur ; Jennifer GERDTS, Auteur ; Jeffrey MUNSON, Auteur ; Geraldine DAWSON, Auteur ; Annette ESTES, Auteur Année de publication : 2012 Article en page(s) : p.13-20 Langues : Anglais (eng) Mots-clés : broader autism phenotype  autism spectrum disorders  genetics  autism assessment Index. décimale : PER Périodiques Résumé : The broader autism phenotype (BAP) was assessed in parents who have two or more children with autism spectrum disorder (ASD) (multiplex (MPX) autism), parents who have no more than one child with ASD (simplex autism), parents who have a child with developmental delay without ASD, and parents who have typically developing children. Clinicians, naive to parent group membership status, rated BAP characteristics from videotaped administration of the Broader Autism Phenotype Symptom Scale (BPASS). Differences among groups in BPASS scores in the four assessed domains (social motivation, conversational skills, expressiveness, and restricted interests) were examined using multivariate ANOVA and post hoc comparisons. Further, ratings of videotapes by observers naïve to family status were compared with live, non-naive ratings by observers who were aware of family status (non-naïve). Findings demonstrate that the BPASS is an instrument resistant to rater bias. Parents from MPX autism families showed significantly more autism phenotype characteristics than the parents in the other groups. Moreover, the parents from simplex autism families did not differ from the parents of children with developmental delay or typical development. Finally, no differences between live, non-naive ratings and videotaped, naive ratings were observed. These findings suggest that characteristics of the BAP, specifically in the social and communication domains, are present in MPX autism parents to a greater degree than simplex autism and control parents. Further, the results provide support for the notion that genetic transmission mechanisms may differ between families with more than one child with autism and families with only one child with autism. En ligne : http://dx.doi.org/10.1002/aur.226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Evidence for broader autism phenotype characteristics in parents from multiple-incidence autism families [Texte imprimé et/ou numérique] / Raphael BERNIER, Auteur ; Jennifer GERDTS, Auteur ; Jeffrey MUNSON, Auteur ; Geraldine DAWSON, Auteur ; Annette ESTES, Auteur . - 2012 . - p.13-20. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.13-20 Mots-clés : broader autism phenotype  autism spectrum disorders  genetics  autism assessment Index. décimale : PER Périodiques Résumé : The broader autism phenotype (BAP) was assessed in parents who have two or more children with autism spectrum disorder (ASD) (multiplex (MPX) autism), parents who have no more than one child with ASD (simplex autism), parents who have a child with developmental delay without ASD, and parents who have typically developing children. Clinicians, naive to parent group membership status, rated BAP characteristics from videotaped administration of the Broader Autism Phenotype Symptom Scale (BPASS). Differences among groups in BPASS scores in the four assessed domains (social motivation, conversational skills, expressiveness, and restricted interests) were examined using multivariate ANOVA and post hoc comparisons. Further, ratings of videotapes by observers naïve to family status were compared with live, non-naive ratings by observers who were aware of family status (non-naïve). Findings demonstrate that the BPASS is an instrument resistant to rater bias. Parents from MPX autism families showed significantly more autism phenotype characteristics than the parents in the other groups. Moreover, the parents from simplex autism families did not differ from the parents of children with developmental delay or typical development. Finally, no differences between live, non-naive ratings and videotaped, naive ratings were observed. These findings suggest that characteristics of the BAP, specifically in the social and communication domains, are present in MPX autism parents to a greater degree than simplex autism and control parents. Further, the results provide support for the notion that genetic transmission mechanisms may differ between families with more than one child with autism and families with only one child with autism. En ligne : http://dx.doi.org/10.1002/aur.226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the nurses' health study II / Kristen LYALL in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.21-30 Titre : Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the nurses' health study II Type de document : Texte imprimé et/ou numérique Auteurs : Kristen LYALL, Auteur ; David L. PAULS, Auteur ; Donna SPIEGELMAN, Auteur ; Alberto ASCHERIO, Auteur ; Susan L. SANTANGELO, Auteur Année de publication : 2012 Article en page(s) : p.21-30 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  gestational diabetes  obstetric complications  pregnancy complications Index. décimale : PER Périodiques Résumé : The authors examined pregnancy and obstetric complications in association with autism spectrum disorders (ASD) in children of participants from the Nurses' Health Study II, a prospective national cohort with information collected through biennial mailed questionnaires since 1989. Logistic regression was used to obtain crude and adjusted odds ratios for ASD, and by diagnostic subgroup. Seven hundred and ninety-three cases were reported among 66,445 pregnancies. Pregnancy complications and obstetric suboptimality factors were assessed by maternal report of occurrence in first birth and, in secondary analyses, in any birth. Complications and a suboptimality score were significantly associated with having a child with ASD (OR 1.49, 95% CI 1.26, 1.77, P<0.0001 for pregnancy complications in first birth and 2.76, 95% CI 2.04, 3.74, P<0.0001 comparing individuals with four or more obstetric suboptimality factors in first birth to those with none; results similar when assessed in any birth). In particular, gestational diabetes was associated with a significantly increased risk of ASD in results of primary and sensitivity analyses (OR in primary analysis = 1.76, 95% CI 1.34, 2.32, P<0.0001); suboptimal parity and suboptimal age-at-first-birth were also individual factors associated with ASD. Associations were similar by diagnostic subgroup, suggesting autism, Asperger syndrome, and other Pervasive Developmental Disorders are all associated with pregnancy complications. Consistent with previous research, the general class of pregnancy complications was associated with ASD as a whole. Additional work will be required to more fully assess the role of gestational diabetes. En ligne : http://dx.doi.org/10.1002/aur.228 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the nurses' health study II [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; David L. PAULS, Auteur ; Donna SPIEGELMAN, Auteur ; Alberto ASCHERIO, Auteur ; Susan L. SANTANGELO, Auteur . - 2012 . - p.21-30. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.21-30 Mots-clés : autism spectrum disorders  gestational diabetes  obstetric complications  pregnancy complications Index. décimale : PER Périodiques Résumé : The authors examined pregnancy and obstetric complications in association with autism spectrum disorders (ASD) in children of participants from the Nurses' Health Study II, a prospective national cohort with information collected through biennial mailed questionnaires since 1989. Logistic regression was used to obtain crude and adjusted odds ratios for ASD, and by diagnostic subgroup. Seven hundred and ninety-three cases were reported among 66,445 pregnancies. Pregnancy complications and obstetric suboptimality factors were assessed by maternal report of occurrence in first birth and, in secondary analyses, in any birth. Complications and a suboptimality score were significantly associated with having a child with ASD (OR 1.49, 95% CI 1.26, 1.77, P<0.0001 for pregnancy complications in first birth and 2.76, 95% CI 2.04, 3.74, P<0.0001 comparing individuals with four or more obstetric suboptimality factors in first birth to those with none; results similar when assessed in any birth). In particular, gestational diabetes was associated with a significantly increased risk of ASD in results of primary and sensitivity analyses (OR in primary analysis = 1.76, 95% CI 1.34, 2.32, P<0.0001); suboptimal parity and suboptimal age-at-first-birth were also individual factors associated with ASD. Associations were similar by diagnostic subgroup, suggesting autism, Asperger syndrome, and other Pervasive Developmental Disorders are all associated with pregnancy complications. Consistent with previous research, the general class of pregnancy complications was associated with ASD as a whole. Additional work will be required to more fully assess the role of gestational diabetes. En ligne : http://dx.doi.org/10.1002/aur.228 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Accuracy of phenotyping children with autism based on parent report: what specifically do we gain phenotyping “rapidly”? / Zachary WARREN in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.31-38 Titre : Accuracy of phenotyping children with autism based on parent report: what specifically do we gain phenotyping “rapidly”? Type de document : Texte imprimé et/ou numérique Auteurs : Zachary WARREN, Auteur ; Alison VEHORN, Auteur ; Elizabeth DOHRMANN, Auteur ; Amy NICHOLSON, Auteur ; James S. SUTCLIFFE, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Année de publication : 2012 Article en page(s) : p.31-38 Langues : Anglais (eng) Mots-clés : Autism  ASD  genetic studies  rapid phenotyping Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is considered among the most heritable of all neurodevelopmental and psychiatric disorders, but identification of etiologically significant genetic markers and risk variants has been hampered by a lack of sufficiently large samples. Rapid phenotyping procedures, where self-report measures are used instead of extensive clinical assessment, have been proposed as methods for amassing large genetic databases due to their hypothesized time-efficiency and affordability. We assessed the diagnostic accuracy of potential rapid phenotyping procedures using the Social Communication Questionnaire and the Social Responsiveness Scale in a sample of 333 children who also received extensive phenotypic assessments. While the rapid phenotyping measures were able to accurately identify a large number of children with ASD, they also frequently failed to differentiate children with ASD from children with other complex neurobehavioral profiles. These data support the continued need of expert clinical validation in combination with rapid phenotyping procedures in order to accurately amass large-scale genetic collections of children with ASD. En ligne : http://dx.doi.org/10.1002/aur.230 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Accuracy of phenotyping children with autism based on parent report: what specifically do we gain phenotyping “rapidly”? [Texte imprimé et/ou numérique] / Zachary WARREN, Auteur ; Alison VEHORN, Auteur ; Elizabeth DOHRMANN, Auteur ; Amy NICHOLSON, Auteur ; James S. SUTCLIFFE, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - 2012 . - p.31-38. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.31-38 Mots-clés : Autism  ASD  genetic studies  rapid phenotyping Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is considered among the most heritable of all neurodevelopmental and psychiatric disorders, but identification of etiologically significant genetic markers and risk variants has been hampered by a lack of sufficiently large samples. Rapid phenotyping procedures, where self-report measures are used instead of extensive clinical assessment, have been proposed as methods for amassing large genetic databases due to their hypothesized time-efficiency and affordability. We assessed the diagnostic accuracy of potential rapid phenotyping procedures using the Social Communication Questionnaire and the Social Responsiveness Scale in a sample of 333 children who also received extensive phenotypic assessments. While the rapid phenotyping measures were able to accurately identify a large number of children with ASD, they also frequently failed to differentiate children with ASD from children with other complex neurobehavioral profiles. These data support the continued need of expert clinical validation in combination with rapid phenotyping procedures in order to accurately amass large-scale genetic collections of children with ASD. En ligne : http://dx.doi.org/10.1002/aur.230 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

udiovisual speech integration in autism spectrum disorders: ERP evidence for atypicalities in lexical-semantic processing / Odette MEGNIN in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.39-48 Titre : udiovisual speech integration in autism spectrum disorders: ERP evidence for atypicalities in lexical-semantic processing Type de document : Texte imprimé et/ou numérique Auteurs : Odette MEGNIN, Auteur ; Atlanta FLITTON, Auteur ; Catherine R. G. JONES, Auteur ; Michelle DE HAAN, Auteur ; Torsten BALDEWEG, Auteur ; Tony CHARMAN, Auteur Année de publication : 2012 Article en page(s) : p.39-48 Langues : Anglais (eng) Mots-clés : auditory  ASD  ERP  language  multisensory  visual Index. décimale : PER Périodiques Résumé : In typically developing (TD) individuals, behavioral and event-related potential (ERP) studies suggest that audiovisual (AV) integration enables faster and more efficient processing of speech. However, little is known about AV speech processing in individuals with autism spectrum disorders (ASD). This study examined ERP responses to spoken words to elucidate the effects of visual speech (the lip movements accompanying a spoken word) on the range of auditory speech processing stages from sound onset detection to semantic integration. The study also included an AV condition, which paired spoken words with a dynamic scrambled face in order to highlight AV effects specific to visual speech. Fourteen adolescent boys with ASD (15–17 years old) and 14 age- and verbal IQ-matched TD boys participated. The ERP of the TD group showed a pattern and topography of AV interaction effects consistent with activity within the superior temporal plane, with two dissociable effects over frontocentral and centroparietal regions. The posterior effect (200–300?ms interval) was specifically sensitive to lip movements in TD boys, and no AV modulation was observed in this region for the ASD group. Moreover, the magnitude of the posterior AV effect to visual speech correlated inversely with ASD symptomatology. In addition, the ASD boys showed an unexpected effect (P2 time window) over the frontocentral region (pooled electrodes F3, Fz, F4, FC1, FC2, FC3, FC4), which was sensitive to scrambled face stimuli. These results suggest that the neural networks facilitating processing of spoken words by visual speech are altered in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] udiovisual speech integration in autism spectrum disorders: ERP evidence for atypicalities in lexical-semantic processing [Texte imprimé et/ou numérique] / Odette MEGNIN, Auteur ; Atlanta FLITTON, Auteur ; Catherine R. G. JONES, Auteur ; Michelle DE HAAN, Auteur ; Torsten BALDEWEG, Auteur ; Tony CHARMAN, Auteur . - 2012 . - p.39-48. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.39-48 Mots-clés : auditory  ASD  ERP  language  multisensory  visual Index. décimale : PER Périodiques Résumé : In typically developing (TD) individuals, behavioral and event-related potential (ERP) studies suggest that audiovisual (AV) integration enables faster and more efficient processing of speech. However, little is known about AV speech processing in individuals with autism spectrum disorders (ASD). This study examined ERP responses to spoken words to elucidate the effects of visual speech (the lip movements accompanying a spoken word) on the range of auditory speech processing stages from sound onset detection to semantic integration. The study also included an AV condition, which paired spoken words with a dynamic scrambled face in order to highlight AV effects specific to visual speech. Fourteen adolescent boys with ASD (15–17 years old) and 14 age- and verbal IQ-matched TD boys participated. The ERP of the TD group showed a pattern and topography of AV interaction effects consistent with activity within the superior temporal plane, with two dissociable effects over frontocentral and centroparietal regions. The posterior effect (200–300?ms interval) was specifically sensitive to lip movements in TD boys, and no AV modulation was observed in this region for the ASD group. Moreover, the magnitude of the posterior AV effect to visual speech correlated inversely with ASD symptomatology. In addition, the ASD boys showed an unexpected effect (P2 time window) over the frontocentral region (pooled electrodes F3, Fz, F4, FC1, FC2, FC3, FC4), which was sensitive to scrambled face stimuli. These results suggest that the neural networks facilitating processing of spoken words by visual speech are altered in individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Regional differences in grey and white matter in children and adults with autism spectrum disorders: an activation likelihood estimate (ALE) meta-analysis / Emma G. DUERDEN in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.49-66 Titre : Regional differences in grey and white matter in children and adults with autism spectrum disorders: an activation likelihood estimate (ALE) meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Emma G. DUERDEN, Auteur ; Kathleen M. MAK-FAN, Auteur ; Margot J. TAYLOR, Auteur ; Wendy ROBERTS, Auteur Année de publication : 2012 Article en page(s) : p.49-66 Langues : Anglais (eng) Mots-clés : structural MRI  pediatrics Index. décimale : PER Périodiques Résumé : Structural alterations in brain morphology have been inconsistently reported in children compared to adults with autism spectrum disorder (ASD). We assessed these differences by performing meta-analysis on the data from 19 voxel-based morphometry studies. Common findings across the age groups were grey matter reduction in left putamen and medial prefrontal cortex (mPFC) and grey matter increases in the lateral PFC, while white matter decreases were seen mainly in the children in frontostriatal pathways. In the ASD sample, children/adolescents were more likely than adults to have increased grey matter in bilateral fusiform gyrus, right cingulate and insula. Results show that clear maturational differences exist in social cognition and limbic processing regions only in children/adolescents and not in adults with ASD, and may underlie the emotional regulation that improves with age in this population. En ligne : http://dx.doi.org/10.1002/aur.235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Regional differences in grey and white matter in children and adults with autism spectrum disorders: an activation likelihood estimate (ALE) meta-analysis [Texte imprimé et/ou numérique] / Emma G. DUERDEN, Auteur ; Kathleen M. MAK-FAN, Auteur ; Margot J. TAYLOR, Auteur ; Wendy ROBERTS, Auteur . - 2012 . - p.49-66. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.49-66 Mots-clés : structural MRI  pediatrics Index. décimale : PER Périodiques Résumé : Structural alterations in brain morphology have been inconsistently reported in children compared to adults with autism spectrum disorder (ASD). We assessed these differences by performing meta-analysis on the data from 19 voxel-based morphometry studies. Common findings across the age groups were grey matter reduction in left putamen and medial prefrontal cortex (mPFC) and grey matter increases in the lateral PFC, while white matter decreases were seen mainly in the children in frontostriatal pathways. In the ASD sample, children/adolescents were more likely than adults to have increased grey matter in bilateral fusiform gyrus, right cingulate and insula. Results show that clear maturational differences exist in social cognition and limbic processing regions only in children/adolescents and not in adults with ASD, and may underlie the emotional regulation that improves with age in this population. En ligne : http://dx.doi.org/10.1002/aur.235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

The visual rooting reflex in individuals with autism spectrum disorders and co-occurring intellectual disability / Annelies A. DE BILDT in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.67-72 Titre : The visual rooting reflex in individuals with autism spectrum disorders and co-occurring intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : Annelies A. DE BILDT, Auteur ; Erik J. MULDER, Auteur ; Natasja D.J. VAN LANG, Auteur ; S. A. Jytte DE WITH, Auteur ; Ruud B. MINDERAA, Auteur ; Sherin S. STAHL, Auteur ; George M. ANDERSON, Auteur Année de publication : 2012 Article en page(s) : p.67-72 Langues : Anglais (eng) Mots-clés : primitive reflexes  visual rooting reflex  autism  intellectual disability Index. décimale : PER Périodiques Résumé : The rooting reflex has long been studied by neurologists and developmentalists and is defined as an orientation toward tactile stimulation in the perioral region or visual stimulation near the face. Nearly, all previous reports of the visual rooting reflex (VRR) concern its presence in adults with neurological dysfunction. Previously, the VRR was reported to be present in a majority of individuals with autism and absent in control subjects. In the present larger study, we examined the presence of the VRR in 155 individuals with ASD and co-occurring Intellectual Disability (ASD + ID: autism, N = 60; Pervasive Developmental Disorder-Not Otherwise Specified (PDD_NOS), N = 95) and in a contrast group of 65 individuals with ID only. The VRR was present significantly more often in the ASD + ID (43.9%) group than in the ID-only group (24.6%; = 7.19; P = 0.007). Individuals with autism displayed a VRR more often (55.0%) than individuals with PDD-NOS (36.8%; = 4.92; P = 0.026) and individuals with ID only (24.6%; = 12.09; P = 0.001). A positive VRR was associated with lower IQ and adaptive functioning; in the ASD + ID group, ADI-R/ADOS domain scores were significantly higher in the VRR-positive subgroup. The results replicate and extend the finding of an increased occurrence of the VRR in autism. Although some association with IQ was observed, the VRR occurred substantially more often in the autism group compared with an intellectually disabled group, indicating some degree of specificity. Additional studies of infants and children with typical development, ASD and ID are needed to determine the utility of the VRR in ASD risk assessment and to elucidate possible specific behavioral associations. En ligne : http://dx.doi.org/10.1002/aur.225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] The visual rooting reflex in individuals with autism spectrum disorders and co-occurring intellectual disability [Texte imprimé et/ou numérique] / Annelies A. DE BILDT, Auteur ; Erik J. MULDER, Auteur ; Natasja D.J. VAN LANG, Auteur ; S. A. Jytte DE WITH, Auteur ; Ruud B. MINDERAA, Auteur ; Sherin S. STAHL, Auteur ; George M. ANDERSON, Auteur . - 2012 . - p.67-72. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.67-72 Mots-clés : primitive reflexes  visual rooting reflex  autism  intellectual disability Index. décimale : PER Périodiques Résumé : The rooting reflex has long been studied by neurologists and developmentalists and is defined as an orientation toward tactile stimulation in the perioral region or visual stimulation near the face. Nearly, all previous reports of the visual rooting reflex (VRR) concern its presence in adults with neurological dysfunction. Previously, the VRR was reported to be present in a majority of individuals with autism and absent in control subjects. In the present larger study, we examined the presence of the VRR in 155 individuals with ASD and co-occurring Intellectual Disability (ASD + ID: autism, N = 60; Pervasive Developmental Disorder-Not Otherwise Specified (PDD_NOS), N = 95) and in a contrast group of 65 individuals with ID only. The VRR was present significantly more often in the ASD + ID (43.9%) group than in the ID-only group (24.6%; = 7.19; P = 0.007). Individuals with autism displayed a VRR more often (55.0%) than individuals with PDD-NOS (36.8%; = 4.92; P = 0.026) and individuals with ID only (24.6%; = 12.09; P = 0.001). A positive VRR was associated with lower IQ and adaptive functioning; in the ASD + ID group, ADI-R/ADOS domain scores were significantly higher in the VRR-positive subgroup. The results replicate and extend the finding of an increased occurrence of the VRR in autism. Although some association with IQ was observed, the VRR occurred substantially more often in the autism group compared with an intellectually disabled group, indicating some degree of specificity. Additional studies of infants and children with typical development, ASD and ID are needed to determine the utility of the VRR in ASD risk assessment and to elucidate possible specific behavioral associations. En ligne : http://dx.doi.org/10.1002/aur.225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Lay Abstracts in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.73-75 Titre : Lay Abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2012 Article en page(s) : p.73-75 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Lay Abstracts [Texte imprimé et/ou numérique] . - 2012 . - p.73-75. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.73-75 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

International Society for Autism Research News / Helen TAGER-FLUSBERG in Autism Research, 5-1 (February 2012)  

Public ISBD [article]  inAutism Research > 5-1 (February 2012) . - p.76 Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Auteurs : Helen TAGER-FLUSBERG, Auteur Année de publication : 2012 Article en page(s) : p.76 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1223 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] International Society for Autism Research News [Texte imprimé et/ou numérique] / Helen TAGER-FLUSBERG, Auteur . - 2012 . - p.76. Langues : Anglais (eng) in Autism Research > 5-1 (February 2012) . - p.76 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1223 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153