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Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study / Ulrika ROINE in Autism Research, 6-6 (December 2013)
[article]
Titre : Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study Type de document : Texte imprimé et/ou numérique Auteurs : Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Pekka TANI, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur Année de publication : 2013 Article en page(s) : p.642-650 Langues : Anglais (eng) Mots-clés : diffusion tensor imaging (DTI) clinical psychiatry neuroimaging autism spectrum disorder Index. décimale : PER Périodiques Résumé : To investigate whether there are global white matter (WM) differences between autistic and healthy adults, we performed diffusion tensor imaging (DTI) in 14 male adults with Asperger syndrome (AS) and 19 gender-, age-, and intelligence quotient-matched controls. We focused on individuals with high-functioning autism spectrum disorder (ASD), AS, to decrease heterogeneity caused by large variation in the cognitive profile. Previous DTI studies of ASD have mainly focused on finding local changes in fractional anisotropy (FA) and mean diffusivity (MD), two indexes used to characterize microstructural properties of WM. Although the local or voxel-based approaches may be able to provide detailed information in terms of location of the observed differences, such results are known to be highly sensitive to partial volume effects, registration errors, or placement of the regions of interest. Therefore, we performed global histogram analyses of (a) whole-brain tractography results and (b) skeletonized WM masks. In addition to the FA and MD, the planar diffusion coefficient (CP) was computed as it can provide more specific information of the complexity of the neural structure. Our main finding indicated that adults with AS had higher mean FA values than controls. A less complex neural structure in adults with AS could have explained the results, but no significant difference in CP was found. Our results suggest that there are global abnormalities in the WM tissue of adults with AS. En ligne : http://dx.doi.org/10.1002/aur.1332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221
in Autism Research > 6-6 (December 2013) . - p.642-650[article] Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study [Texte imprimé et/ou numérique] / Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Pekka TANI, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur . - 2013 . - p.642-650.
Langues : Anglais (eng)
in Autism Research > 6-6 (December 2013) . - p.642-650
Mots-clés : diffusion tensor imaging (DTI) clinical psychiatry neuroimaging autism spectrum disorder Index. décimale : PER Périodiques Résumé : To investigate whether there are global white matter (WM) differences between autistic and healthy adults, we performed diffusion tensor imaging (DTI) in 14 male adults with Asperger syndrome (AS) and 19 gender-, age-, and intelligence quotient-matched controls. We focused on individuals with high-functioning autism spectrum disorder (ASD), AS, to decrease heterogeneity caused by large variation in the cognitive profile. Previous DTI studies of ASD have mainly focused on finding local changes in fractional anisotropy (FA) and mean diffusivity (MD), two indexes used to characterize microstructural properties of WM. Although the local or voxel-based approaches may be able to provide detailed information in terms of location of the observed differences, such results are known to be highly sensitive to partial volume effects, registration errors, or placement of the regions of interest. Therefore, we performed global histogram analyses of (a) whole-brain tractography results and (b) skeletonized WM masks. In addition to the FA and MD, the planar diffusion coefficient (CP) was computed as it can provide more specific information of the complexity of the neural structure. Our main finding indicated that adults with AS had higher mean FA values than controls. A less complex neural structure in adults with AS could have explained the results, but no significant difference in CP was found. Our results suggest that there are global abnormalities in the WM tissue of adults with AS. En ligne : http://dx.doi.org/10.1002/aur.1332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 Exposure to prenatal maternal distress and infant white matter neurodevelopment / Catherine H. DEMERS in Development and Psychopathology, 33-5 (December 2021)
[article]
Titre : Exposure to prenatal maternal distress and infant white matter neurodevelopment Type de document : Texte imprimé et/ou numérique Auteurs : Catherine H. DEMERS, Auteur ; Maria M. BAGONIS, Auteur ; Khalid AL-ALI, Auteur ; Sarah E. GARCIA, Auteur ; Martin A. STYNER, Auteur ; John H. GILMORE, Auteur ; M. Camille HOFFMAN, Auteur ; Benjamin L. HANKIN, Auteur ; Elysia Poggi DAVIS, Auteur Article en page(s) : p.1526-1538 Langues : Anglais (eng) Mots-clés : pregnancy white matter microstructure magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) anxiety Index. décimale : PER Périodiques Résumé : The prenatal period represents a critical time for brain growth and development. These rapid neurological advances render the fetus susceptible to various influences with life-long implications for mental health. Maternal distress signals are a dominant early life influence, contributing to birth outcomes and risk for offspring psychopathology. This prospective longitudinal study evaluated the association between prenatal maternal distress and infant white matter microstructure. Participants included a racially and socioeconomically diverse sample of 85 mother–infant dyads. Prenatal distress was assessed at 17 and 29 weeks’ gestational age (GA). Infant structural data were collected via diffusion tensor imaging (DTI) at 42–45 weeks’ postconceptional age. Findings demonstrated that higher prenatal maternal distress at 29 weeks’ GA was associated with increased fractional anisotropy, b = .283, t(64) = 2.319, p = .024, and with increased axial diffusivity, b = .254, t(64) = 2.067, p = .043, within the right anterior cingulate white matter tract. No other significant associations were found with prenatal distress exposure and tract fractional anisotropy or axial diffusivity at 29 weeks’ GA, or earlier in gestation. En ligne : http://dx.doi.org/10.1017/S0954579421000742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457
in Development and Psychopathology > 33-5 (December 2021) . - p.1526-1538[article] Exposure to prenatal maternal distress and infant white matter neurodevelopment [Texte imprimé et/ou numérique] / Catherine H. DEMERS, Auteur ; Maria M. BAGONIS, Auteur ; Khalid AL-ALI, Auteur ; Sarah E. GARCIA, Auteur ; Martin A. STYNER, Auteur ; John H. GILMORE, Auteur ; M. Camille HOFFMAN, Auteur ; Benjamin L. HANKIN, Auteur ; Elysia Poggi DAVIS, Auteur . - p.1526-1538.
Langues : Anglais (eng)
in Development and Psychopathology > 33-5 (December 2021) . - p.1526-1538
Mots-clés : pregnancy white matter microstructure magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) anxiety Index. décimale : PER Périodiques Résumé : The prenatal period represents a critical time for brain growth and development. These rapid neurological advances render the fetus susceptible to various influences with life-long implications for mental health. Maternal distress signals are a dominant early life influence, contributing to birth outcomes and risk for offspring psychopathology. This prospective longitudinal study evaluated the association between prenatal maternal distress and infant white matter microstructure. Participants included a racially and socioeconomically diverse sample of 85 mother–infant dyads. Prenatal distress was assessed at 17 and 29 weeks’ gestational age (GA). Infant structural data were collected via diffusion tensor imaging (DTI) at 42–45 weeks’ postconceptional age. Findings demonstrated that higher prenatal maternal distress at 29 weeks’ GA was associated with increased fractional anisotropy, b = .283, t(64) = 2.319, p = .024, and with increased axial diffusivity, b = .254, t(64) = 2.067, p = .043, within the right anterior cingulate white matter tract. No other significant associations were found with prenatal distress exposure and tract fractional anisotropy or axial diffusivity at 29 weeks’ GA, or earlier in gestation. En ligne : http://dx.doi.org/10.1017/S0954579421000742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 Visual search for feature conjunctions: an fMRI study comparing alcohol-related neurodevelopmental disorder (ARND) to ADHD / C. R. O'CONAILL in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)
[article]
Titre : Visual search for feature conjunctions: an fMRI study comparing alcohol-related neurodevelopmental disorder (ARND) to ADHD Type de document : Texte imprimé et/ou numérique Auteurs : C. R. O'CONAILL, Auteur ; K. L. MALISZA, Auteur ; J. L. BUSS, Auteur ; R. B. BOLSTER, Auteur ; C. CLANCY, Auteur ; P. D. DE GERVAI, Auteur ; A. E. CHUDLEY, Auteur ; S. LONGSTAFFE, Auteur Article en page(s) : p.10 Langues : Anglais (eng) Mots-clés : Alcohol-related neurodevelopmental disorder (ARND) Attention Attention-deficit/hyperactivity disorder (ADHD) Diffusion tensor imaging (DTI) Fetal alcohol spectrum disorder (FASD) Functional magnetic resonance imaging (fMRI) Gray matter Inferior longitudinal fasciculus (ILF) Tract-based spatial statistics (TBSS) White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Alcohol-related neurodevelopmental disorder (ARND) falls under the umbrella of fetal alcohol spectrum disorder (FASD). Diagnosis of ARND is difficult because individuals do not demonstrate the characteristic facial features associated with fetal alcohol syndrome (FAS). While attentional problems in ARND are similar to those found in attention-deficit/hyperactivity disorder (ADHD), the underlying impairment in attention pathways may be different. METHODS: Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) was conducted at 3 T. Sixty-three children aged 10 to 14 years diagnosed with ARND, ADHD, and typically developing (TD) controls performed a single-feature and a feature-conjunction visual search task. RESULTS: Dorsal and ventral attention pathways were activated during both attention tasks in all groups. Significantly greater activation was observed in ARND subjects during a single-feature search as compared to TD and ADHD groups, suggesting ARND subjects require greater neural recruitment to perform this simple task. ARND subjects appear unable to effectively use the very efficient automatic perceptual 'pop-out' mechanism employed by TD and ADHD groups during presentation of the disjunction array. By comparison, activation was lower in ARND compared to TD and ADHD subjects during the more difficult conjunction search task as compared to the single-feature search. Analysis of DTI data using tract-based spatial statistics (TBSS) showed areas of significantly lower fractional anisotropy (FA) and higher mean diffusivity (MD) in the right inferior longitudinal fasciculus (ILF) in ARND compared to TD subjects. Damage to the white matter of the ILF may compromise the ventral attention pathway and may require subjects to use the dorsal attention pathway, which is associated with effortful top-down processing, for tasks that should be automatic. Decreased functional activity in the right temporoparietal junction (TPJ) of ARND subjects may be due to a reduction in the white matter tract's ability to efficiently convey information critical to performance of the attention tasks. CONCLUSIONS: Limited activation patterns in ARND suggest problems in information processing along the ventral frontoparietal attention pathway. Poor integrity of the ILF, which connects the functional components of the ventral attention network, in ARND subjects may contribute to the attention deficits characteristic of the disorder. En ligne : http://dx.doi.org/10.1186/s11689-015-9106-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.10[article] Visual search for feature conjunctions: an fMRI study comparing alcohol-related neurodevelopmental disorder (ARND) to ADHD [Texte imprimé et/ou numérique] / C. R. O'CONAILL, Auteur ; K. L. MALISZA, Auteur ; J. L. BUSS, Auteur ; R. B. BOLSTER, Auteur ; C. CLANCY, Auteur ; P. D. DE GERVAI, Auteur ; A. E. CHUDLEY, Auteur ; S. LONGSTAFFE, Auteur . - p.10.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.10
Mots-clés : Alcohol-related neurodevelopmental disorder (ARND) Attention Attention-deficit/hyperactivity disorder (ADHD) Diffusion tensor imaging (DTI) Fetal alcohol spectrum disorder (FASD) Functional magnetic resonance imaging (fMRI) Gray matter Inferior longitudinal fasciculus (ILF) Tract-based spatial statistics (TBSS) White matter Index. décimale : PER Périodiques Résumé : BACKGROUND: Alcohol-related neurodevelopmental disorder (ARND) falls under the umbrella of fetal alcohol spectrum disorder (FASD). Diagnosis of ARND is difficult because individuals do not demonstrate the characteristic facial features associated with fetal alcohol syndrome (FAS). While attentional problems in ARND are similar to those found in attention-deficit/hyperactivity disorder (ADHD), the underlying impairment in attention pathways may be different. METHODS: Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) was conducted at 3 T. Sixty-three children aged 10 to 14 years diagnosed with ARND, ADHD, and typically developing (TD) controls performed a single-feature and a feature-conjunction visual search task. RESULTS: Dorsal and ventral attention pathways were activated during both attention tasks in all groups. Significantly greater activation was observed in ARND subjects during a single-feature search as compared to TD and ADHD groups, suggesting ARND subjects require greater neural recruitment to perform this simple task. ARND subjects appear unable to effectively use the very efficient automatic perceptual 'pop-out' mechanism employed by TD and ADHD groups during presentation of the disjunction array. By comparison, activation was lower in ARND compared to TD and ADHD subjects during the more difficult conjunction search task as compared to the single-feature search. Analysis of DTI data using tract-based spatial statistics (TBSS) showed areas of significantly lower fractional anisotropy (FA) and higher mean diffusivity (MD) in the right inferior longitudinal fasciculus (ILF) in ARND compared to TD subjects. Damage to the white matter of the ILF may compromise the ventral attention pathway and may require subjects to use the dorsal attention pathway, which is associated with effortful top-down processing, for tasks that should be automatic. Decreased functional activity in the right temporoparietal junction (TPJ) of ARND subjects may be due to a reduction in the white matter tract's ability to efficiently convey information critical to performance of the attention tasks. CONCLUSIONS: Limited activation patterns in ARND suggest problems in information processing along the ventral frontoparietal attention pathway. Poor integrity of the ILF, which connects the functional components of the ventral attention network, in ARND subjects may contribute to the attention deficits characteristic of the disorder. En ligne : http://dx.doi.org/10.1186/s11689-015-9106-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 Fronto-Temporal Connectivity is Preserved During Sung but Not Spoken Word Listening, Across the Autism Spectrum / Megha SHARDA in Autism Research, 8-2 (April 2015)
[article]
Titre : Fronto-Temporal Connectivity is Preserved During Sung but Not Spoken Word Listening, Across the Autism Spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Megha SHARDA, Auteur ; Rashi MIDHA, Auteur ; Supriya MALIK, Auteur ; Shaneel MUKERJI, Auteur ; Nandini C. SINGH, Auteur Article en page(s) : p.174-186 Langues : Anglais (eng) Mots-clés : functional MRI diffusion tensor imaging (DTI) cognitive neuroscience pediatrics Index. décimale : PER Périodiques Résumé : Co-occurrence of preserved musical function with language and socio-communicative impairments is a common but understudied feature of Autism Spectrum Disorders (ASD). Given the significant overlap in neural organization of these processes, investigating brain mechanisms underlying speech and music may not only help dissociate the nature of these auditory processes in ASD but also provide a neurobiological basis for development of interventions. Using a passive-listening functional magnetic resonance imaging paradigm with spoken words, sung words and piano tones, we found that 22 children with ASD, with varying levels of functioning, activated bilateral temporal brain networks during sung-word perception, similarly to an age and gender-matched control group. In contrast, spoken-word perception was right-lateralized in ASD and elicited reduced inferior frontal gyrus (IFG) activity which varied as a function of language ability. Diffusion tensor imaging analysis reflected reduced integrity of the left hemisphere fronto-temporal tract in the ASD group and further showed that the hypoactivation in IFG was predicted by integrity of this tract. Subsequent psychophysiological interactions revealed that functional fronto-temporal connectivity, disrupted during spoken-word perception, was preserved during sung-word listening in ASD, suggesting alternate mechanisms of speech and music processing in ASD. Our results thus demonstrate the ability of song to overcome the structural deficit for speech across the autism spectrum and provide a mechanistic basis for efficacy of song-based interventions in ASD. Autism Res 2015, 8: 174–186. En ligne : http://dx.doi.org/10.1002/aur.1437 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256
in Autism Research > 8-2 (April 2015) . - p.174-186[article] Fronto-Temporal Connectivity is Preserved During Sung but Not Spoken Word Listening, Across the Autism Spectrum [Texte imprimé et/ou numérique] / Megha SHARDA, Auteur ; Rashi MIDHA, Auteur ; Supriya MALIK, Auteur ; Shaneel MUKERJI, Auteur ; Nandini C. SINGH, Auteur . - p.174-186.
Langues : Anglais (eng)
in Autism Research > 8-2 (April 2015) . - p.174-186
Mots-clés : functional MRI diffusion tensor imaging (DTI) cognitive neuroscience pediatrics Index. décimale : PER Périodiques Résumé : Co-occurrence of preserved musical function with language and socio-communicative impairments is a common but understudied feature of Autism Spectrum Disorders (ASD). Given the significant overlap in neural organization of these processes, investigating brain mechanisms underlying speech and music may not only help dissociate the nature of these auditory processes in ASD but also provide a neurobiological basis for development of interventions. Using a passive-listening functional magnetic resonance imaging paradigm with spoken words, sung words and piano tones, we found that 22 children with ASD, with varying levels of functioning, activated bilateral temporal brain networks during sung-word perception, similarly to an age and gender-matched control group. In contrast, spoken-word perception was right-lateralized in ASD and elicited reduced inferior frontal gyrus (IFG) activity which varied as a function of language ability. Diffusion tensor imaging analysis reflected reduced integrity of the left hemisphere fronto-temporal tract in the ASD group and further showed that the hypoactivation in IFG was predicted by integrity of this tract. Subsequent psychophysiological interactions revealed that functional fronto-temporal connectivity, disrupted during spoken-word perception, was preserved during sung-word listening in ASD, suggesting alternate mechanisms of speech and music processing in ASD. Our results thus demonstrate the ability of song to overcome the structural deficit for speech across the autism spectrum and provide a mechanistic basis for efficacy of song-based interventions in ASD. Autism Res 2015, 8: 174–186. En ligne : http://dx.doi.org/10.1002/aur.1437 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 Left-Hemispheric Microstructural Abnormalities in Children With High-Functioning Autism Spectrum Disorder / Daniel PETERSON in Autism Research, 8-1 (February 2015)
[article]
Titre : Left-Hemispheric Microstructural Abnormalities in Children With High-Functioning Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Daniel PETERSON, Auteur ; Rajneesh MAHAJAN, Auteur ; Deana CROCETTI, Auteur ; Amanda MEJIA, Auteur ; Stewart MOSTOFSKY, Auteur Article en page(s) : p.61-72 Langues : Anglais (eng) Mots-clés : diffusion tensor imaging (DTI) neuroimaging laterality white matter Index. décimale : PER Périodiques Résumé : Current theories of the neurobiological basis of autism spectrum disorder (ASD) posit an altered pattern of connectivity in large-scale brain networks. Here we used diffusion tensor imaging to investigate the microstructural properties of the white matter (WM) that mediates interregional connectivity in 36 high-functioning children with ASD (HF-ASD) as compared with 37 controls. By employing an atlas-based analysis using large deformation diffeometric morphic mapping registration, a widespread but left-lateralized pattern of abnormalities was revealed. The mean diffusivity (MD) of water in the WM of HF-ASD children was significantly elevated throughout the left hemisphere, particularly in the outer-zone cortical WM. Across diagnostic groups, there was a significant effect of age on left-hemisphere MD, with a similar reduction in MD during childhood in both typically developing and HF-ASD children. The increased MD in children with HF-ASD suggests hypomyelination and may reflect increased short-range cortico-cortical connections subsequent to early WM overgrowth. These findings also highlight left-hemispheric connectivity as relevant to the pathophysiology of ASD and indicate that the spatial distribution of microstructural abnormalities in HF-ASD is widespread and left-lateralized. This altered left-hemispheric connectivity may contribute to deficits in communication and praxis observed in ASD. Autism Res 2015, 8: 61–72. En ligne : http://dx.doi.org/10.1002/aur.1413 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256
in Autism Research > 8-1 (February 2015) . - p.61-72[article] Left-Hemispheric Microstructural Abnormalities in Children With High-Functioning Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Daniel PETERSON, Auteur ; Rajneesh MAHAJAN, Auteur ; Deana CROCETTI, Auteur ; Amanda MEJIA, Auteur ; Stewart MOSTOFSKY, Auteur . - p.61-72.
Langues : Anglais (eng)
in Autism Research > 8-1 (February 2015) . - p.61-72
Mots-clés : diffusion tensor imaging (DTI) neuroimaging laterality white matter Index. décimale : PER Périodiques Résumé : Current theories of the neurobiological basis of autism spectrum disorder (ASD) posit an altered pattern of connectivity in large-scale brain networks. Here we used diffusion tensor imaging to investigate the microstructural properties of the white matter (WM) that mediates interregional connectivity in 36 high-functioning children with ASD (HF-ASD) as compared with 37 controls. By employing an atlas-based analysis using large deformation diffeometric morphic mapping registration, a widespread but left-lateralized pattern of abnormalities was revealed. The mean diffusivity (MD) of water in the WM of HF-ASD children was significantly elevated throughout the left hemisphere, particularly in the outer-zone cortical WM. Across diagnostic groups, there was a significant effect of age on left-hemisphere MD, with a similar reduction in MD during childhood in both typically developing and HF-ASD children. The increased MD in children with HF-ASD suggests hypomyelination and may reflect increased short-range cortico-cortical connections subsequent to early WM overgrowth. These findings also highlight left-hemispheric connectivity as relevant to the pathophysiology of ASD and indicate that the spatial distribution of microstructural abnormalities in HF-ASD is widespread and left-lateralized. This altered left-hemispheric connectivity may contribute to deficits in communication and praxis observed in ASD. Autism Res 2015, 8: 61–72. En ligne : http://dx.doi.org/10.1002/aur.1413 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256