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Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders / Victor KANG in Autism Research, 7-4 (August 2014)
[article]
Titre : Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Victor KANG, Auteur ; George C. WAGNER, Auteur ; Xue MING, Auteur Année de publication : 2014 Article en page(s) : p.501-506 Langues : Anglais (eng) Mots-clés : autism spectrum disorders gastrointestinal disorders comorbid disorders endoscopy colonoscopy inflammation Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) dysfunctions are frequently reported by parents of children with autism spectrum disorders (ASD) and have been recently recognized as a comorbid condition. However, the clinical significance of these GI dysfunctions remains to be delineated. This study describes the clinical characteristics, associated comorbid disorders, and endoscopic and colonoscopic evaluation of GI dysfunction in a cohort of 164 children with ASD evaluated at a pediatric neurology practice. Symptoms of GI dysfunction were prevalent: 49% of the children reported one or more chronic GI complaints, 22% exhibited diarrhea, 26% suffered from constipation. Furthermore 13% of the parents reported their children to suffer from bloating and/or being gassy and while 10% of the parents reported vomiting or gastroesophageal reflux problems. Similar rates of GI symptoms were reported among pre-school and school-aged children. Inflammation of the gut was found in 6 of the 12 subjects who underwent endoscopic and colonoscopic evaluations, however clinical symptoms did not predict the results of the evaluation. GI dysfunction was significantly associated with sleep disorders and food intolerance, but not with irritability or aggressiveness. In summary, GI dysfunction was prevalent in this cohort of children with ASD, observations consistent with the reports of parents and other clinicians. We conclude that the GI dysfunction in ASD requires proper evaluation and treatment. En ligne : http://dx.doi.org/10.1002/aur.1386 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238
in Autism Research > 7-4 (August 2014) . - p.501-506[article] Gastrointestinal Dysfunction in Children With Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Victor KANG, Auteur ; George C. WAGNER, Auteur ; Xue MING, Auteur . - 2014 . - p.501-506.
Langues : Anglais (eng)
in Autism Research > 7-4 (August 2014) . - p.501-506
Mots-clés : autism spectrum disorders gastrointestinal disorders comorbid disorders endoscopy colonoscopy inflammation Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) dysfunctions are frequently reported by parents of children with autism spectrum disorders (ASD) and have been recently recognized as a comorbid condition. However, the clinical significance of these GI dysfunctions remains to be delineated. This study describes the clinical characteristics, associated comorbid disorders, and endoscopic and colonoscopic evaluation of GI dysfunction in a cohort of 164 children with ASD evaluated at a pediatric neurology practice. Symptoms of GI dysfunction were prevalent: 49% of the children reported one or more chronic GI complaints, 22% exhibited diarrhea, 26% suffered from constipation. Furthermore 13% of the parents reported their children to suffer from bloating and/or being gassy and while 10% of the parents reported vomiting or gastroesophageal reflux problems. Similar rates of GI symptoms were reported among pre-school and school-aged children. Inflammation of the gut was found in 6 of the 12 subjects who underwent endoscopic and colonoscopic evaluations, however clinical symptoms did not predict the results of the evaluation. GI dysfunction was significantly associated with sleep disorders and food intolerance, but not with irritability or aggressiveness. In summary, GI dysfunction was prevalent in this cohort of children with ASD, observations consistent with the reports of parents and other clinicians. We conclude that the GI dysfunction in ASD requires proper evaluation and treatment. En ligne : http://dx.doi.org/10.1002/aur.1386 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 Overall severities of gastrointestinal symptoms in pediatric outpatients with and without autism spectrum disorder / V. THULASI in Autism, 23-2 (February 2019)
[article]
Titre : Overall severities of gastrointestinal symptoms in pediatric outpatients with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : V. THULASI, Auteur ; R. A. STEER, Auteur ; I. M. MONTEIRO, Auteur ; X. MING, Auteur Article en page(s) : p.524-530 Langues : Anglais (eng) Mots-clés : Gastrointestinal Severity Scale autism spectrum disorders constipation diarrhea gastrointestinal disorders Index. décimale : PER Périodiques Résumé : In order to determine the effectiveness of a Gastrointestinal Severity Index to screen for gastrointestinal disorders, the Gastrointestinal Severity Index was administered to 135 children with autism spectrum disorders and 146 comparisons with and without gastrointestinal disorders. The mean Gastrointestinal Severity Index scores of the groups were 3.53 +/- 1.78, 3.15 +/- 1.99, 0.81 +/- 1.25, and 0.29 +/- 0.76 (comparative pediatric patients with gastrointestinal disorder = autism spectrum disorder + gastrointestinal disorder > autism spectrum disorder-gastrointestinal disorder > comparative pediatric patients without gastrointestinal disorder, respectively), Ps < 0.05. Receiver operating characteristic curves and areas under the receiver operating characteristic curves were calculated to ascertain which Gastrointestinal Severity Index cutoff scores yielded the highest sensitivity and specificity rates for the diagnosis of gastrointestinal disorders. The area under the receiver operating characteristic curve (0.97) for the comparison group was higher (P < 0.001) than the area under the receiver operating characteristic curve (0.85) for autism spectrum disorder children indicating that the Gastrointestinal Severity Index was more effective in screening for gastrointestinal disorders in comparisons. However, the same Gastrointestinal Severity Index cutoff score of 2 and above yielded, respectively, sensitivity and specificity rates of 92% and 93% for comparisons and 80% and 79% for autism spectrum disorder children. The negative and positive predictive values based on these sensitivity and specificity rates were calculated for a range of prevalences of gastrointestinal disorders and indicated that the Gastrointestinal Severity Index may be useful for screening children with and without autism spectrum disorder for gastrointestinal symptoms. En ligne : http://dx.doi.org/10.1177/1362361318757564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383
in Autism > 23-2 (February 2019) . - p.524-530[article] Overall severities of gastrointestinal symptoms in pediatric outpatients with and without autism spectrum disorder [Texte imprimé et/ou numérique] / V. THULASI, Auteur ; R. A. STEER, Auteur ; I. M. MONTEIRO, Auteur ; X. MING, Auteur . - p.524-530.
Langues : Anglais (eng)
in Autism > 23-2 (February 2019) . - p.524-530
Mots-clés : Gastrointestinal Severity Scale autism spectrum disorders constipation diarrhea gastrointestinal disorders Index. décimale : PER Périodiques Résumé : In order to determine the effectiveness of a Gastrointestinal Severity Index to screen for gastrointestinal disorders, the Gastrointestinal Severity Index was administered to 135 children with autism spectrum disorders and 146 comparisons with and without gastrointestinal disorders. The mean Gastrointestinal Severity Index scores of the groups were 3.53 +/- 1.78, 3.15 +/- 1.99, 0.81 +/- 1.25, and 0.29 +/- 0.76 (comparative pediatric patients with gastrointestinal disorder = autism spectrum disorder + gastrointestinal disorder > autism spectrum disorder-gastrointestinal disorder > comparative pediatric patients without gastrointestinal disorder, respectively), Ps < 0.05. Receiver operating characteristic curves and areas under the receiver operating characteristic curves were calculated to ascertain which Gastrointestinal Severity Index cutoff scores yielded the highest sensitivity and specificity rates for the diagnosis of gastrointestinal disorders. The area under the receiver operating characteristic curve (0.97) for the comparison group was higher (P < 0.001) than the area under the receiver operating characteristic curve (0.85) for autism spectrum disorder children indicating that the Gastrointestinal Severity Index was more effective in screening for gastrointestinal disorders in comparisons. However, the same Gastrointestinal Severity Index cutoff score of 2 and above yielded, respectively, sensitivity and specificity rates of 92% and 93% for comparisons and 80% and 79% for autism spectrum disorder children. The negative and positive predictive values based on these sensitivity and specificity rates were calculated for a range of prevalences of gastrointestinal disorders and indicated that the Gastrointestinal Severity Index may be useful for screening children with and without autism spectrum disorder for gastrointestinal symptoms. En ligne : http://dx.doi.org/10.1177/1362361318757564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 Constipation prevalence and perceptions: Comparison of children and adolescents with ASD and other developmental-behavioral disorders / Carrie CUFFMAN in Research in Autism Spectrum Disorders, 80 (February 2021)
[article]
Titre : Constipation prevalence and perceptions: Comparison of children and adolescents with ASD and other developmental-behavioral disorders Type de document : Texte imprimé et/ou numérique Auteurs : Carrie CUFFMAN, Auteur ; Kimberly BURKHART, Auteur Article en page(s) : p.101710 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Constipation Gastrointestinal disorders Developmental disorders Index. décimale : PER Périodiques Résumé : Background Few studies have compared youth constipation in autism spectrum disorder (ASD) to constipation in other developmental-behavioral (DB) disorders. Methods Children and caregivers presenting to a DB pediatrics and psychology clinic completed written questionnaires on constipation. Comparison groups were ASD vs without ASD and caregiver vs child responses. Binary logistic regression were conducted to compare categorical variables. Results Caregivers of 169 toilet trained children and 26 non-toilet trained children completed the survey; 30 % of the toilet trained and 62 % of the non-toilet trained children had ASD. 88 toilet trained children completed the survey. Based on caregiver response, toilet trained youth with ASD were more likely to have been constipated in the past and to currently or previously taken medication to manage constipation. In both the total toilet trained and non-toilet trained sample, more caregivers endorsed their child meeting Rome IV criteria for functional constipation than endorsed current constipation. 37 % of parent/child pairs disagreed on whether the child met the Rome IV criteria. Caregivers of toilet trained youth with ASD were more likely to endorse specific barriers and impairment due to managing constipation in comparison to caregivers of youth without ASD. Conclusions Children with ASD may be at a higher lifetime risk of constipation and of needing medication compared to children with other DB disorders. Providers should use thorough questions to identify constipation and gather information from both caregiver and child when possible. Clinicians should consider targeting behavioral treatment recommendations to perceived caregiver concerns. En ligne : https://doi.org/10.1016/j.rasd.2020.101710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438
in Research in Autism Spectrum Disorders > 80 (February 2021) . - p.101710[article] Constipation prevalence and perceptions: Comparison of children and adolescents with ASD and other developmental-behavioral disorders [Texte imprimé et/ou numérique] / Carrie CUFFMAN, Auteur ; Kimberly BURKHART, Auteur . - p.101710.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 80 (February 2021) . - p.101710
Mots-clés : Autism spectrum disorder Constipation Gastrointestinal disorders Developmental disorders Index. décimale : PER Périodiques Résumé : Background Few studies have compared youth constipation in autism spectrum disorder (ASD) to constipation in other developmental-behavioral (DB) disorders. Methods Children and caregivers presenting to a DB pediatrics and psychology clinic completed written questionnaires on constipation. Comparison groups were ASD vs without ASD and caregiver vs child responses. Binary logistic regression were conducted to compare categorical variables. Results Caregivers of 169 toilet trained children and 26 non-toilet trained children completed the survey; 30 % of the toilet trained and 62 % of the non-toilet trained children had ASD. 88 toilet trained children completed the survey. Based on caregiver response, toilet trained youth with ASD were more likely to have been constipated in the past and to currently or previously taken medication to manage constipation. In both the total toilet trained and non-toilet trained sample, more caregivers endorsed their child meeting Rome IV criteria for functional constipation than endorsed current constipation. 37 % of parent/child pairs disagreed on whether the child met the Rome IV criteria. Caregivers of toilet trained youth with ASD were more likely to endorse specific barriers and impairment due to managing constipation in comparison to caregivers of youth without ASD. Conclusions Children with ASD may be at a higher lifetime risk of constipation and of needing medication compared to children with other DB disorders. Providers should use thorough questions to identify constipation and gather information from both caregiver and child when possible. Clinicians should consider targeting behavioral treatment recommendations to perceived caregiver concerns. En ligne : https://doi.org/10.1016/j.rasd.2020.101710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 The link between autism spectrum disorder and gut microbiota: A scoping review / Amanda NITSCHKE in Autism, 24-6 (August 2020)
[article]
Titre : The link between autism spectrum disorder and gut microbiota: A scoping review Type de document : Texte imprimé et/ou numérique Auteurs : Amanda NITSCHKE, Auteur ; Raywat DEONANDAN, Auteur ; Anne T. M. KONKLE, Auteur Article en page(s) : p.1328-1344 Langues : Anglais (eng) Mots-clés : autism spectrum disorder autism spectrum disorder behavior gastrointestinal disorders gut microbiota microbiota–gut–brain axis Index. décimale : PER Périodiques Résumé : Gastrointestinal distress and gut microbial imbalances are commonly found in children with autism spectrum disorder, and therefore may play a key role in the development of the disorder. This scoping review aimed to examine the extent, range and nature of research conducted in the past 6?years that focused on furthering our understanding of autism spectrum disorder and its association with gut microbiota. A literature review was performed with predetermined key words. Studies were screened and selected based on defined inclusion and exclusion criteria. A total of 19 studies were included for final analysis. While there are continuous reports of differences in gut microbiota between autism spectrum disorder and neurotypical individuals, knowledge about the consistency in the presence and abundance of bacterial species, as well as metabolites, remains deficient. Treatments such as special diets, vitamin, prebiotic, probiotic, and microbiota transfer therapy show promising therapeutic potential, yet are in their infancy of investigation. Overall, further research with rigorous methodologies is required to support and strengthen the reliability of existing findings. Future research should aim to increase sample sizes, eliminate biases, and subgroup autism spectrum disorder groups to help accommodate for inter-individual variation. As increasing evidence of a unique autism spectrum disorder microbiome and metabolome is acquired, autism spectrum disorder-specific biomarkers can be identified. These biomarkers have great implications in terms of elucidating the molecular mechanisms of autism spectrum disorder, preventing the onset of autism spectrum disorder, and improving treatments for individuals with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361320913364 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428
in Autism > 24-6 (August 2020) . - p.1328-1344[article] The link between autism spectrum disorder and gut microbiota: A scoping review [Texte imprimé et/ou numérique] / Amanda NITSCHKE, Auteur ; Raywat DEONANDAN, Auteur ; Anne T. M. KONKLE, Auteur . - p.1328-1344.
Langues : Anglais (eng)
in Autism > 24-6 (August 2020) . - p.1328-1344
Mots-clés : autism spectrum disorder autism spectrum disorder behavior gastrointestinal disorders gut microbiota microbiota–gut–brain axis Index. décimale : PER Périodiques Résumé : Gastrointestinal distress and gut microbial imbalances are commonly found in children with autism spectrum disorder, and therefore may play a key role in the development of the disorder. This scoping review aimed to examine the extent, range and nature of research conducted in the past 6?years that focused on furthering our understanding of autism spectrum disorder and its association with gut microbiota. A literature review was performed with predetermined key words. Studies were screened and selected based on defined inclusion and exclusion criteria. A total of 19 studies were included for final analysis. While there are continuous reports of differences in gut microbiota between autism spectrum disorder and neurotypical individuals, knowledge about the consistency in the presence and abundance of bacterial species, as well as metabolites, remains deficient. Treatments such as special diets, vitamin, prebiotic, probiotic, and microbiota transfer therapy show promising therapeutic potential, yet are in their infancy of investigation. Overall, further research with rigorous methodologies is required to support and strengthen the reliability of existing findings. Future research should aim to increase sample sizes, eliminate biases, and subgroup autism spectrum disorder groups to help accommodate for inter-individual variation. As increasing evidence of a unique autism spectrum disorder microbiome and metabolome is acquired, autism spectrum disorder-specific biomarkers can be identified. These biomarkers have great implications in terms of elucidating the molecular mechanisms of autism spectrum disorder, preventing the onset of autism spectrum disorder, and improving treatments for individuals with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361320913364 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428