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A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort / K. CHESLACK-POSTAVA in Autism Research, 14-11 (November 2021)
[article]
Titre : A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort Type de document : Texte imprimé et/ou numérique Auteurs : K. CHESLACK-POSTAVA, Auteur ; A. SOURANDER, Auteur ; S. HINKKA-YLI-SALOMÄKI, Auteur ; I. W. MCKEAGUE, Auteur ; H. M. SURCEL, Auteur ; A. S. BROWN, Auteur Article en page(s) : p.2444-2453 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder Biomarkers Case-Control Studies Child Female Finland/epidemiology Humans Maternal Exposure Pregnancy Prenatal Exposure Delayed Effects/epidemiology Smoking autism cotinine prenatal exposure delayed effects smoking Index. décimale : PER Périodiques Résumé : Maternal exposure to tobacco smoke during pregnancy is a common and persistent exposure linked to adverse neurodevelopmental outcomes in the offspring. However, previous studies provide mixed evidence regarding the relationship between prenatal smoking and offspring autism. This study used cotinine level, a biomarker for nicotine, to investigate the relationship between prenatal smoking and autism. The authors conducted a population-based case-control study nested in a national cohort of all births in Finland from 1987 to 2005. Cases diagnosed with childhood autism (ICD-10/9 code F84.0/299.0) through 2007 were identified using data from linked national registers. Each case was matched with a control on date of birth (±30?days), sex, and place of birth (N =?962 pairs). Maternal serum cotinine levels were prospectively measured in first- to early second-trimester serum samples archived in a national biobank using a quantitative immunoassay. Data were analyzed using conditional logistic regression. Prenatal maternal levels of serum cotinine were not associated with the odds of autism, whether cotinine was classified continuously, by deciles, or using previously defined categories corresponding to probable maternal smoking status. After adjusting for maternal age, paternal age, previous births, and any history of parental psychiatric disorder, the odds ratio for categorical high versus low cotinine, using a 3-level exposure variable, was 0.98 (95% CI = 0.76, 1.26; p = 0.88). In conclusion, this national birth cohort-based study does not provide evidence for an association between maternal cotinine, a biomarker of maternal smoking, and risk of autism. LAY SUMMARY: This study explored whether prenatal exposure to tobacco smoke in mothers is related to the diagnosis of autism in their children, by measuring the levels of cotinine, a biomarker for tobacco exposure, in stored serum samples drawn from mothers during pregnancy. The levels of cotinine in the mothers of children diagnosed with autism were similar to those in the mothers of control children of similar age and gender distribution. En ligne : http://dx.doi.org/10.1002/aur.2608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2444-2453[article] A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort [Texte imprimé et/ou numérique] / K. CHESLACK-POSTAVA, Auteur ; A. SOURANDER, Auteur ; S. HINKKA-YLI-SALOMÄKI, Auteur ; I. W. MCKEAGUE, Auteur ; H. M. SURCEL, Auteur ; A. S. BROWN, Auteur . - p.2444-2453.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2444-2453
Mots-clés : Autism Spectrum Disorder Autistic Disorder Biomarkers Case-Control Studies Child Female Finland/epidemiology Humans Maternal Exposure Pregnancy Prenatal Exposure Delayed Effects/epidemiology Smoking autism cotinine prenatal exposure delayed effects smoking Index. décimale : PER Périodiques Résumé : Maternal exposure to tobacco smoke during pregnancy is a common and persistent exposure linked to adverse neurodevelopmental outcomes in the offspring. However, previous studies provide mixed evidence regarding the relationship between prenatal smoking and offspring autism. This study used cotinine level, a biomarker for nicotine, to investigate the relationship between prenatal smoking and autism. The authors conducted a population-based case-control study nested in a national cohort of all births in Finland from 1987 to 2005. Cases diagnosed with childhood autism (ICD-10/9 code F84.0/299.0) through 2007 were identified using data from linked national registers. Each case was matched with a control on date of birth (±30?days), sex, and place of birth (N =?962 pairs). Maternal serum cotinine levels were prospectively measured in first- to early second-trimester serum samples archived in a national biobank using a quantitative immunoassay. Data were analyzed using conditional logistic regression. Prenatal maternal levels of serum cotinine were not associated with the odds of autism, whether cotinine was classified continuously, by deciles, or using previously defined categories corresponding to probable maternal smoking status. After adjusting for maternal age, paternal age, previous births, and any history of parental psychiatric disorder, the odds ratio for categorical high versus low cotinine, using a 3-level exposure variable, was 0.98 (95% CI = 0.76, 1.26; p = 0.88). In conclusion, this national birth cohort-based study does not provide evidence for an association between maternal cotinine, a biomarker of maternal smoking, and risk of autism. LAY SUMMARY: This study explored whether prenatal exposure to tobacco smoke in mothers is related to the diagnosis of autism in their children, by measuring the levels of cotinine, a biomarker for tobacco exposure, in stored serum samples drawn from mothers during pregnancy. The levels of cotinine in the mothers of children diagnosed with autism were similar to those in the mothers of control children of similar age and gender distribution. En ligne : http://dx.doi.org/10.1002/aur.2608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Interaction between Maternal Immune Activation and Antibiotic Use during Pregnancy and Child Risk of Autism Spectrum Disorder / Calliope HOLINGUE in Autism Research, 13-12 (December 2020)
[article]
Titre : Interaction between Maternal Immune Activation and Antibiotic Use during Pregnancy and Child Risk of Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Calliope HOLINGUE, Auteur ; Martha BRUCATO, Auteur ; Christine LADD-ACOSTA, Auteur ; Xiumei HONG, Auteur ; Heather E. VOLK, Auteur ; Noel T. MUELLER, Auteur ; Xiaobin WANG, Auteur ; M. Daniele FALLIN, Auteur Article en page(s) : p.2230-2241 Langues : Anglais (eng) Mots-clés : anti-bacterial agents autism spectrum disorder environmental exposure epidemiology maternal exposure minority health risk factors Index. décimale : PER Périodiques Résumé : Prenatal exposure to maternal immune activation (MIA) has been implicated as a risk factor for the development of autism spectrum disorder (ASD), though the conditions under which this elevated risk occurs are unclear. Animal literature demonstrates that antibiotic use, which affects the composition of the maternal gut microbiota, modifies the effect of MIA on neurodevelopmental outcomes in the offspring. The aim of this study was to assess whether antibiotic use during pregnancy modifies the association between MIA and subsequent risk of ASD, in a prospective birth cohort with 116 ASD cases and 860 typically developing (TD) child controls. There was no evidence of interaction between fever or genitourinary infection and antibiotic use on the odds of ASD in unadjusted or adjusted analyzes. However, we found evidence of an interaction between flu, specifically in second trimester, and antibiotic use at any point during pregnancy on the odds of ASD in the child. Among women who received an antibiotic during pregnancy, flu in trimester two was not associated with ASD (adjusted odds ratio [aOR] = 0.99 [0.43-2.28]). Among women who were not exposed to an antibiotic at any point during pregnancy, flu in second trimester was significantly associated with increased odds of ASD (aOR = 4.05 [1.14-14.38], P = .03), after adjustment for child sex, child birth year, maternal age, gestational age, C-section delivery, and low birthweight. These findings should be treated as hypothesis-generating and suggest that antibiotic use may modify the influence that MIA has on autism risk in the child. LAY SUMMARY: We looked at whether the association between activation of the immune system during pregnancy and risk of the child developing autism spectrum disorder (ASD) differed among women who did or did not take an antibiotic at any point during pregnancy. We examined 116 children with ASD and 860 without ASD and found that flu in second trimester was associated with increased ASD, but only among women who did not take an antibiotic during pregnancy. No other immune activation exposures seemed to interact with antibiotic use. En ligne : http://dx.doi.org/10.1002/aur.2411 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Autism Research > 13-12 (December 2020) . - p.2230-2241[article] Interaction between Maternal Immune Activation and Antibiotic Use during Pregnancy and Child Risk of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Calliope HOLINGUE, Auteur ; Martha BRUCATO, Auteur ; Christine LADD-ACOSTA, Auteur ; Xiumei HONG, Auteur ; Heather E. VOLK, Auteur ; Noel T. MUELLER, Auteur ; Xiaobin WANG, Auteur ; M. Daniele FALLIN, Auteur . - p.2230-2241.
Langues : Anglais (eng)
in Autism Research > 13-12 (December 2020) . - p.2230-2241
Mots-clés : anti-bacterial agents autism spectrum disorder environmental exposure epidemiology maternal exposure minority health risk factors Index. décimale : PER Périodiques Résumé : Prenatal exposure to maternal immune activation (MIA) has been implicated as a risk factor for the development of autism spectrum disorder (ASD), though the conditions under which this elevated risk occurs are unclear. Animal literature demonstrates that antibiotic use, which affects the composition of the maternal gut microbiota, modifies the effect of MIA on neurodevelopmental outcomes in the offspring. The aim of this study was to assess whether antibiotic use during pregnancy modifies the association between MIA and subsequent risk of ASD, in a prospective birth cohort with 116 ASD cases and 860 typically developing (TD) child controls. There was no evidence of interaction between fever or genitourinary infection and antibiotic use on the odds of ASD in unadjusted or adjusted analyzes. However, we found evidence of an interaction between flu, specifically in second trimester, and antibiotic use at any point during pregnancy on the odds of ASD in the child. Among women who received an antibiotic during pregnancy, flu in trimester two was not associated with ASD (adjusted odds ratio [aOR] = 0.99 [0.43-2.28]). Among women who were not exposed to an antibiotic at any point during pregnancy, flu in second trimester was significantly associated with increased odds of ASD (aOR = 4.05 [1.14-14.38], P = .03), after adjustment for child sex, child birth year, maternal age, gestational age, C-section delivery, and low birthweight. These findings should be treated as hypothesis-generating and suggest that antibiotic use may modify the influence that MIA has on autism risk in the child. LAY SUMMARY: We looked at whether the association between activation of the immune system during pregnancy and risk of the child developing autism spectrum disorder (ASD) differed among women who did or did not take an antibiotic at any point during pregnancy. We examined 116 children with ASD and 860 without ASD and found that flu in second trimester was associated with increased ASD, but only among women who did not take an antibiotic during pregnancy. No other immune activation exposures seemed to interact with antibiotic use. En ligne : http://dx.doi.org/10.1002/aur.2411 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 Prenatal exposure to fever is associated with autism spectrum disorder in the boston birth cohort / Martha BRUCATO in Autism Research, 10-11 (November 2017)
[article]
Titre : Prenatal exposure to fever is associated with autism spectrum disorder in the boston birth cohort Type de document : Texte imprimé et/ou numérique Auteurs : Martha BRUCATO, Auteur ; Christine LADD-ACOSTA, Auteur ; Mengying LI, Auteur ; Deanna CARUSO, Auteur ; Xiumei HONG, Auteur ; Jamie KACZANIUK, Auteur ; Elizabeth A. STUART, Auteur ; M. Daniele FALLIN, Auteur ; Xiaobin WANG, Auteur Article en page(s) : p.1878-1890 Langues : Anglais (eng) Mots-clés : autism spectrum disorder (ASD) environmental exposure maternal exposure fever epidemiology risk factors minority health Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is phenotypically and etiologically heterogeneous, with evidence for genetic and environmental contributions to disease risk. Research has focused on the prenatal period as a time where environmental exposures are likely to influence risk for ASD. Epidemiological studies have shown significant associations between prenatal exposure to maternal immune activation (MIA), caused by infections and fever, and ASD. However, due to differences in study design and exposure measurements no consistent patterns have emerged revealing specific times or type of MIA exposure that are most important to ASD risk. No prior studies have examined prenatal MIA exposure and ASD risk in an under-represented minority population of African ancestry. To overcome these limitations, we estimated the association between prenatal exposure to fever and maternal infections and ASD in a prospective birth cohort of an understudied minority population in a city in the United States. No association was found between prenatal exposure to genitourinary infections or flu and the risk of ASD in a nested sample of 116 ASD cases and 988 typically developing controls in crude or adjusted analyses. Prenatal exposure to fever was associated with increased ASD risk (aOR 2.02 [1.04–3.92]) after adjustment for educational attainment, marital status, race, child sex, maternal age, birth year, gestational age, and maternal smoking. This effect may be specific to fever during the third trimester (aOR 2.70 [1.00–7.29]). Our findings provide a focus for future research efforts and ASD prevention strategies across diverse populations. Autism Res 2017, 10: 1878–1890. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We looked at whether activation of the immune system during pregnancy increases the chance a child will develop ASD. We examined 116 children with ASD and 988 children without ASD that came from a predominantly low income, urban, minority population. We found that having the flu or genitourinary tract infections during pregnancy is not related to the child being diagnosed with ASD. However, we did find children were at increased risk for ASD when their mothers had a fever during pregnancy. En ligne : http://dx.doi.org/10.1002/aur.1841 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-11 (November 2017) . - p.1878-1890[article] Prenatal exposure to fever is associated with autism spectrum disorder in the boston birth cohort [Texte imprimé et/ou numérique] / Martha BRUCATO, Auteur ; Christine LADD-ACOSTA, Auteur ; Mengying LI, Auteur ; Deanna CARUSO, Auteur ; Xiumei HONG, Auteur ; Jamie KACZANIUK, Auteur ; Elizabeth A. STUART, Auteur ; M. Daniele FALLIN, Auteur ; Xiaobin WANG, Auteur . - p.1878-1890.
Langues : Anglais (eng)
in Autism Research > 10-11 (November 2017) . - p.1878-1890
Mots-clés : autism spectrum disorder (ASD) environmental exposure maternal exposure fever epidemiology risk factors minority health Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is phenotypically and etiologically heterogeneous, with evidence for genetic and environmental contributions to disease risk. Research has focused on the prenatal period as a time where environmental exposures are likely to influence risk for ASD. Epidemiological studies have shown significant associations between prenatal exposure to maternal immune activation (MIA), caused by infections and fever, and ASD. However, due to differences in study design and exposure measurements no consistent patterns have emerged revealing specific times or type of MIA exposure that are most important to ASD risk. No prior studies have examined prenatal MIA exposure and ASD risk in an under-represented minority population of African ancestry. To overcome these limitations, we estimated the association between prenatal exposure to fever and maternal infections and ASD in a prospective birth cohort of an understudied minority population in a city in the United States. No association was found between prenatal exposure to genitourinary infections or flu and the risk of ASD in a nested sample of 116 ASD cases and 988 typically developing controls in crude or adjusted analyses. Prenatal exposure to fever was associated with increased ASD risk (aOR 2.02 [1.04–3.92]) after adjustment for educational attainment, marital status, race, child sex, maternal age, birth year, gestational age, and maternal smoking. This effect may be specific to fever during the third trimester (aOR 2.70 [1.00–7.29]). Our findings provide a focus for future research efforts and ASD prevention strategies across diverse populations. Autism Res 2017, 10: 1878–1890. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We looked at whether activation of the immune system during pregnancy increases the chance a child will develop ASD. We examined 116 children with ASD and 988 children without ASD that came from a predominantly low income, urban, minority population. We found that having the flu or genitourinary tract infections during pregnancy is not related to the child being diagnosed with ASD. However, we did find children were at increased risk for ASD when their mothers had a fever during pregnancy. En ligne : http://dx.doi.org/10.1002/aur.1841 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322