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An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions / Y. C. CHEN in Autism Research, 14-11 (November 2021)
[article]
Titre : An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions Type de document : Texte imprimé et/ou numérique Auteurs : Y. C. CHEN, Auteur ; C. CHEN, Auteur ; R. M. MARTÍNEZ, Auteur ; Y. T. FAN, Auteur ; C. C. LIU, Auteur ; C. Y. CHEN, Auteur ; Y. CHENG, Auteur Article en page(s) : p.2287-2299 Langues : Anglais (eng) Mots-clés : Adolescent Amygdala/diagnostic imaging Anxiety/complications Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder Case-Control Studies Facial Recognition Humans Magnetic Resonance Imaging amygdala autism spectrum condition (ASC) explicit implicit threat Index. décimale : PER Périodiques Résumé : Anxiety is exceedingly prevalent among individuals with an autism spectrum condition (ASC). While recent literature postulates anxiety as a mechanism encompassing an underlying amygdala-related elevated baseline level of arousal even to nonthreatening cues, whether this same mechanism contributes to anxiety in those with an ASC and supports the transdiagnostic nature of anxiety remains elusive. In this case-control study of 51 youths (26 ASC), we assessed autism and anxiety via the Autism-Spectrum Quotient and the State-Trait Anxiety Inventory, respectively. Hemodynamic responses, including amygdala reactivity, to explicit and implicit (backwardly masked) perception of threatening faces were acquired using functional Magnetic Resonance Imaging (fMRI). For explicit fear, ASC individuals showed significantly greater negative correlations between the amygdala and the attentional deployment-parietal network. For implicit fear, ASC individuals showed significantly stronger correlations of the amygdala with the prefrontal networks, temporal pole, and hippocampus. Additionally, an fMRI-based neurologic signature for anxiety in ASCs was identified via the LibSVM machine learning model using amygdala-centered functional connectivity during the emotional processing of explicit and implicit stimuli. Hypervigilance to implicit threat in ASCs comorbid with anxiety might exacerbate explicit threat reactivity; hence the use of attentional avoidance patterns to restrict affective hyperarousal for explicitly perceived socioemotional stimuli. Consequently, developing an attention-independent behavioral/neural marker identifying anxiety in ASCs is highly warranted. LAY SUMMARY: This study identifies a dissociation of amygdala reactivity dependent on explicit and implicit threat processing. Implicit anxiety in individuals with an autism spectrum condition (ASC) could outweigh explicitly induced threat. When explicitly perceiving socioemotional stimuli, ASC individuals with anxiety might use attentional avoidance patterns to restrict affective hyperarousal. En ligne : http://dx.doi.org/10.1002/aur.2595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2287-2299[article] An amygdala-centered hyper-connectivity signature of threatening face processing predicts anxiety in youths with autism spectrum conditions [Texte imprimé et/ou numérique] / Y. C. CHEN, Auteur ; C. CHEN, Auteur ; R. M. MARTÍNEZ, Auteur ; Y. T. FAN, Auteur ; C. C. LIU, Auteur ; C. Y. CHEN, Auteur ; Y. CHENG, Auteur . - p.2287-2299.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2287-2299
Mots-clés : Adolescent Amygdala/diagnostic imaging Anxiety/complications Autism Spectrum Disorder/complications/diagnostic imaging Autistic Disorder Case-Control Studies Facial Recognition Humans Magnetic Resonance Imaging amygdala autism spectrum condition (ASC) explicit implicit threat Index. décimale : PER Périodiques Résumé : Anxiety is exceedingly prevalent among individuals with an autism spectrum condition (ASC). While recent literature postulates anxiety as a mechanism encompassing an underlying amygdala-related elevated baseline level of arousal even to nonthreatening cues, whether this same mechanism contributes to anxiety in those with an ASC and supports the transdiagnostic nature of anxiety remains elusive. In this case-control study of 51 youths (26 ASC), we assessed autism and anxiety via the Autism-Spectrum Quotient and the State-Trait Anxiety Inventory, respectively. Hemodynamic responses, including amygdala reactivity, to explicit and implicit (backwardly masked) perception of threatening faces were acquired using functional Magnetic Resonance Imaging (fMRI). For explicit fear, ASC individuals showed significantly greater negative correlations between the amygdala and the attentional deployment-parietal network. For implicit fear, ASC individuals showed significantly stronger correlations of the amygdala with the prefrontal networks, temporal pole, and hippocampus. Additionally, an fMRI-based neurologic signature for anxiety in ASCs was identified via the LibSVM machine learning model using amygdala-centered functional connectivity during the emotional processing of explicit and implicit stimuli. Hypervigilance to implicit threat in ASCs comorbid with anxiety might exacerbate explicit threat reactivity; hence the use of attentional avoidance patterns to restrict affective hyperarousal for explicitly perceived socioemotional stimuli. Consequently, developing an attention-independent behavioral/neural marker identifying anxiety in ASCs is highly warranted. LAY SUMMARY: This study identifies a dissociation of amygdala reactivity dependent on explicit and implicit threat processing. Implicit anxiety in individuals with an autism spectrum condition (ASC) could outweigh explicitly induced threat. When explicitly perceiving socioemotional stimuli, ASC individuals with anxiety might use attentional avoidance patterns to restrict affective hyperarousal. En ligne : http://dx.doi.org/10.1002/aur.2595 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Deprivation and psychopathology in the Fragile Families Study: A 15-year longitudinal investigation / Adam Bryant MILLER in Journal of Child Psychology and Psychiatry, 62-4 (April 2021)
[article]
Titre : Deprivation and psychopathology in the Fragile Families Study: A 15-year longitudinal investigation Type de document : Texte imprimé et/ou numérique Auteurs : Adam Bryant MILLER, Auteur ; Laura MACHLIN, Auteur ; Katie A. MCLAUGHLIN, Auteur ; Margaret A. SHERIDAN, Auteur Article en page(s) : p.382-391 Langues : Anglais (eng) Mots-clés : Deprivation adversity externalizing psychopathology internalizing psychopathology language threat Index. décimale : PER Périodiques Résumé : BACKGROUND: Early adversity consistently predicts youth psychopathology. However, the pathways linking unique dimensions of early adversity, such as deprivation, to psychopathology are understudied. Here, we evaluate a theoretical model linking early deprivation exposure with psychopathology prospectively through language ability. METHODS: Participants included 2,301 youth (47.5% female) enrolled in the Fragile Families and Child Wellbeing Study. We include data from assessment points at ages 1, 3, 5, 9, and 15. Latent factors for deprivation and threat were modeled from multiple indicators at ages 1 and 3. Youth language ability was assessed at Age 5. Indicators of psychopathology were assessed at ages 5, 9, and 15. A structural equation model tested longitudinal paths to internalizing and externalizing psychopathology from experiences of deprivation and threat. RESULTS: Deprivation from birth to Age 3 was associated with an indirect effect on internalizing and externalizing symptoms in early childhood (Age 5), later childhood (Age 9), and adolescence (Age 15) via language ability in early childhood (Age 5). Early threat exposure was associated with increased internalizing and externalizing psychopathology across all ages. There was no significant indirect effect from threat to psychopathology via language ability. CONCLUSIONS: The effects of deprivation on psychopathology during early childhood, late childhood, and adolescence are explained, in part, through early childhood language ability. Results provide insight into language ability as a possible opportunity for intervention. En ligne : http://dx.doi.org/10.1111/jcpp.13260 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445
in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.382-391[article] Deprivation and psychopathology in the Fragile Families Study: A 15-year longitudinal investigation [Texte imprimé et/ou numérique] / Adam Bryant MILLER, Auteur ; Laura MACHLIN, Auteur ; Katie A. MCLAUGHLIN, Auteur ; Margaret A. SHERIDAN, Auteur . - p.382-391.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.382-391
Mots-clés : Deprivation adversity externalizing psychopathology internalizing psychopathology language threat Index. décimale : PER Périodiques Résumé : BACKGROUND: Early adversity consistently predicts youth psychopathology. However, the pathways linking unique dimensions of early adversity, such as deprivation, to psychopathology are understudied. Here, we evaluate a theoretical model linking early deprivation exposure with psychopathology prospectively through language ability. METHODS: Participants included 2,301 youth (47.5% female) enrolled in the Fragile Families and Child Wellbeing Study. We include data from assessment points at ages 1, 3, 5, 9, and 15. Latent factors for deprivation and threat were modeled from multiple indicators at ages 1 and 3. Youth language ability was assessed at Age 5. Indicators of psychopathology were assessed at ages 5, 9, and 15. A structural equation model tested longitudinal paths to internalizing and externalizing psychopathology from experiences of deprivation and threat. RESULTS: Deprivation from birth to Age 3 was associated with an indirect effect on internalizing and externalizing symptoms in early childhood (Age 5), later childhood (Age 9), and adolescence (Age 15) via language ability in early childhood (Age 5). Early threat exposure was associated with increased internalizing and externalizing psychopathology across all ages. There was no significant indirect effect from threat to psychopathology via language ability. CONCLUSIONS: The effects of deprivation on psychopathology during early childhood, late childhood, and adolescence are explained, in part, through early childhood language ability. Results provide insight into language ability as a possible opportunity for intervention. En ligne : http://dx.doi.org/10.1111/jcpp.13260 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 Difficulties with emotion regulation as a transdiagnostic mechanism linking child maltreatment with the emergence of psychopathology / David G. WEISSMAN in Development and Psychopathology, 31-3 (August 2019)
[article]
Titre : Difficulties with emotion regulation as a transdiagnostic mechanism linking child maltreatment with the emergence of psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : David G. WEISSMAN, Auteur ; Debbie BITRAN, Auteur ; Adam Bryant MILLER, Auteur ; Jonathan D. SCHAEFER, Auteur ; Margaret A. SHERIDAN, Auteur ; Katie A. MCLAUGHLIN, Auteur Article en page(s) : p.899-915 Langues : Anglais (eng) Mots-clés : adversity attention bias p factor rumination threat Index. décimale : PER Périodiques Résumé : Childhood maltreatment is associated with increased risk for most forms of psychopathology. We examine emotion dysregulation as a transdiagnostic mechanism linking maltreatment with general psychopathology. A sample of 262 children and adolescents participated; 162 (61.8%) experienced abuse or exposure to domestic violence. We assessed four emotion regulation processes (cognitive reappraisal, attention bias to threat, expressive suppression, and rumination) and emotional reactivity. Psychopathology symptoms were assessed concurrently and at a 2-year longitudinal follow-up. A general psychopathology factor (p factor), representing co-occurrence of psychopathology symptoms across multiple internalizing and externalizing domains, was estimated using confirmatory factor analysis. Maltreatment was associated with heightened emotional reactivity and greater use of expressive suppression and rumination. The association of maltreatment with attention bias varied across development, with maltreated children exhibiting a bias toward threat and adolescents a bias away from threat. Greater emotional reactivity and engagement in rumination mediated the longitudinal association between maltreatment and increased general psychopathology over time. Emotion dysregulation following childhood maltreatment occurs at multiple stages of the emotion generation process, in some cases varies across development, and serves as a transdiagnostic mechanism linking child maltreatment with general psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579419000348 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403
in Development and Psychopathology > 31-3 (August 2019) . - p.899-915[article] Difficulties with emotion regulation as a transdiagnostic mechanism linking child maltreatment with the emergence of psychopathology [Texte imprimé et/ou numérique] / David G. WEISSMAN, Auteur ; Debbie BITRAN, Auteur ; Adam Bryant MILLER, Auteur ; Jonathan D. SCHAEFER, Auteur ; Margaret A. SHERIDAN, Auteur ; Katie A. MCLAUGHLIN, Auteur . - p.899-915.
Langues : Anglais (eng)
in Development and Psychopathology > 31-3 (August 2019) . - p.899-915
Mots-clés : adversity attention bias p factor rumination threat Index. décimale : PER Périodiques Résumé : Childhood maltreatment is associated with increased risk for most forms of psychopathology. We examine emotion dysregulation as a transdiagnostic mechanism linking maltreatment with general psychopathology. A sample of 262 children and adolescents participated; 162 (61.8%) experienced abuse or exposure to domestic violence. We assessed four emotion regulation processes (cognitive reappraisal, attention bias to threat, expressive suppression, and rumination) and emotional reactivity. Psychopathology symptoms were assessed concurrently and at a 2-year longitudinal follow-up. A general psychopathology factor (p factor), representing co-occurrence of psychopathology symptoms across multiple internalizing and externalizing domains, was estimated using confirmatory factor analysis. Maltreatment was associated with heightened emotional reactivity and greater use of expressive suppression and rumination. The association of maltreatment with attention bias varied across development, with maltreated children exhibiting a bias toward threat and adolescents a bias away from threat. Greater emotional reactivity and engagement in rumination mediated the longitudinal association between maltreatment and increased general psychopathology over time. Emotion dysregulation following childhood maltreatment occurs at multiple stages of the emotion generation process, in some cases varies across development, and serves as a transdiagnostic mechanism linking child maltreatment with general psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579419000348 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 Dimensions of adversity in association with adolescents' depression symptoms: Distinct moderating roles of cognitive and autonomic function / Rachel A. VAUGHN-COAXUM in Development and Psychopathology, 32-3 (August 2020)
[article]
Titre : Dimensions of adversity in association with adolescents' depression symptoms: Distinct moderating roles of cognitive and autonomic function Type de document : Texte imprimé et/ou numérique Auteurs : Rachel A. VAUGHN-COAXUM, Auteur ; Neha DHAWAN, Auteur ; Margaret A. SHERIDAN, Auteur ; Mackenzie J. HART, Auteur ; John R. WEISZ, Auteur Article en page(s) : p.817-830 Langues : Anglais (eng) Mots-clés : childhood adversity depression deprivation psychophysiology threat Index. décimale : PER Périodiques Résumé : Exposure to adverse events is prevalent among youths and robustly associated with risk for depression, particularly during adolescence. The Dimensional Model of Adversity and Psychopathology (DMAP) distinguishes between adverse events that expose youths to deprivation versus threat, positing unique mechanisms of risk (cognitive functioning deficits for deprivation, and altered fear and emotion learning for threat) that may require different approaches to intervention. We examined whether deprivation and threat were distinctly associated with behavioral measures of cognitive processes and autonomic nervous system function in relation to depression symptom severity in a community sample of early adolescents (n = 117; mean age 12.73 years; 54.7% male). Consistent with DMAP, associations between threat and depression symptoms, and between economic deprivation and depression symptoms, were distinctly moderated by physiological and cognitive functions, respectively, at baseline but not follow-up. Under conditions of greater cognitive inhibition, less exposure to deprivation was associated with lower symptom severity. Under conditions of blunted resting-state autonomic response (electrodermal activity and respiratory sinus arrhythmia), greater exposure to threat was associated with higher symptom severity. Our findings support the view that understanding risk for youth depression requires parsing adversity: examining distinct roles played by deprivation and threat, and the associated cognitive and biological processes. En ligne : http://dx.doi.org/10.1017/s0954579419001172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429
in Development and Psychopathology > 32-3 (August 2020) . - p.817-830[article] Dimensions of adversity in association with adolescents' depression symptoms: Distinct moderating roles of cognitive and autonomic function [Texte imprimé et/ou numérique] / Rachel A. VAUGHN-COAXUM, Auteur ; Neha DHAWAN, Auteur ; Margaret A. SHERIDAN, Auteur ; Mackenzie J. HART, Auteur ; John R. WEISZ, Auteur . - p.817-830.
Langues : Anglais (eng)
in Development and Psychopathology > 32-3 (August 2020) . - p.817-830
Mots-clés : childhood adversity depression deprivation psychophysiology threat Index. décimale : PER Périodiques Résumé : Exposure to adverse events is prevalent among youths and robustly associated with risk for depression, particularly during adolescence. The Dimensional Model of Adversity and Psychopathology (DMAP) distinguishes between adverse events that expose youths to deprivation versus threat, positing unique mechanisms of risk (cognitive functioning deficits for deprivation, and altered fear and emotion learning for threat) that may require different approaches to intervention. We examined whether deprivation and threat were distinctly associated with behavioral measures of cognitive processes and autonomic nervous system function in relation to depression symptom severity in a community sample of early adolescents (n = 117; mean age 12.73 years; 54.7% male). Consistent with DMAP, associations between threat and depression symptoms, and between economic deprivation and depression symptoms, were distinctly moderated by physiological and cognitive functions, respectively, at baseline but not follow-up. Under conditions of greater cognitive inhibition, less exposure to deprivation was associated with lower symptom severity. Under conditions of blunted resting-state autonomic response (electrodermal activity and respiratory sinus arrhythmia), greater exposure to threat was associated with higher symptom severity. Our findings support the view that understanding risk for youth depression requires parsing adversity: examining distinct roles played by deprivation and threat, and the associated cognitive and biological processes. En ligne : http://dx.doi.org/10.1017/s0954579419001172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 Does reward processing moderate or mediate the link between childhood adversity and psychopathology: A longitudinal study / Lindsay C. HANFORD ; Steven W. KASPAREK ; Liliana J. LENGUA ; Katie A. MCLAUGHLIN ; Margaret A. SHERIDAN in Development and Psychopathology, 35-5 (December 2023)
[article]
Titre : Does reward processing moderate or mediate the link between childhood adversity and psychopathology: A longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay C. HANFORD, Auteur ; Steven W. KASPAREK, Auteur ; Liliana J. LENGUA, Auteur ; Katie A. MCLAUGHLIN, Auteur ; Margaret A. SHERIDAN, Auteur Article en page(s) : p.2338-2351 Mots-clés : depression deprivation externalizing reward processing threat Index. décimale : PER Périodiques Résumé : Childhood adversity is common and associated with elevated risk for transdiagnostic psychopathology. Reward processing has been implicated in the link between adversity and psychopathology, but whether it serves as a mediator or moderator is unclear. This study examined whether alterations in behavioral and neural reward processing function as a mechanism or moderator of psychopathology outcomes following adversity experiences, including threat (i.e., trauma) and deprivation. A longitudinal community sample of 10?15-year-old youths was assessed across two waves (Wave 1: n = 228; Wave 2: n = 206). Wave 1 assessed adverse experiences, psychopathology symptoms, reward processing on a monetary incentive delay task, and resting-state fMRI. At Wave 2, psychopathology symptoms were reassessed. Greater threat experiences were associated with blunted behavioral reward sensitivity, which, in turn, predicted increases in depression symptoms over time and mediated the prospective association between threat and depression symptoms. In contrast, reward sensitivity moderated the association between deprivation experiences and prospective externalizing symptoms such that the positive association of deprivation with increasing externalizing symptoms was absent for children with high levels of reward sensitivity. En ligne : https://dx.doi.org/10.1017/S0954579423000962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519
in Development and Psychopathology > 35-5 (December 2023) . - p.2338-2351[article] Does reward processing moderate or mediate the link between childhood adversity and psychopathology: A longitudinal study [Texte imprimé et/ou numérique] / Lindsay C. HANFORD, Auteur ; Steven W. KASPAREK, Auteur ; Liliana J. LENGUA, Auteur ; Katie A. MCLAUGHLIN, Auteur ; Margaret A. SHERIDAN, Auteur . - p.2338-2351.
in Development and Psychopathology > 35-5 (December 2023) . - p.2338-2351
Mots-clés : depression deprivation externalizing reward processing threat Index. décimale : PER Périodiques Résumé : Childhood adversity is common and associated with elevated risk for transdiagnostic psychopathology. Reward processing has been implicated in the link between adversity and psychopathology, but whether it serves as a mediator or moderator is unclear. This study examined whether alterations in behavioral and neural reward processing function as a mechanism or moderator of psychopathology outcomes following adversity experiences, including threat (i.e., trauma) and deprivation. A longitudinal community sample of 10?15-year-old youths was assessed across two waves (Wave 1: n = 228; Wave 2: n = 206). Wave 1 assessed adverse experiences, psychopathology symptoms, reward processing on a monetary incentive delay task, and resting-state fMRI. At Wave 2, psychopathology symptoms were reassessed. Greater threat experiences were associated with blunted behavioral reward sensitivity, which, in turn, predicted increases in depression symptoms over time and mediated the prospective association between threat and depression symptoms. In contrast, reward sensitivity moderated the association between deprivation experiences and prospective externalizing symptoms such that the positive association of deprivation with increasing externalizing symptoms was absent for children with high levels of reward sensitivity. En ligne : https://dx.doi.org/10.1017/S0954579423000962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 Impact of dimensions of early adversity on adult health and functioning: A 2-decade, longitudinal study / Ellen W. MCGINNIS in Development and Psychopathology, 34-2 (May 2022)
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