Differences in Developmental Functioning Profiles Between Male and Female Preschoolers Children With Autism Spectrum Disorder / Francesco CRAIG in Autism Research, 13-9 (September 2020)  

Public ISBD [article]  inAutism Research > 13-9 (September 2020) . - p.1537-1547 Titre : Differences in Developmental Functioning Profiles Between Male and Female Preschoolers Children With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Francesco CRAIG, Auteur ; Alessandro CRIPPA, Auteur ; Andrea DE GIACOMO, Auteur ; Marta RUGGIERO, Auteur ; Veronica RIZZATO, Auteur ; Alessandro LORENZO, Auteur ; Isabella FANIZZA, Auteur ; Lucia MARGARI, Auteur ; Antonio TRABACCA, Auteur Article en page(s) : p.1537-1547 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This study investigated differences in clinical symptoms and developmental functioning profiles as well as sex-specific correlations of clinical characteristics and communication abilities, motor skills, and maladaptive behaviors in male and female preschoolers with autism spectrum disorder (ASD). Fifty-two females (mean age 4.5?±?2.16?years old) and 62 males (mean age 4.2?±?1.17?years old) with ASD were enrolled and assessed by measures including the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) and Psychoeducational Profile-Third Edition (PEP-3). We found intellectual disability in 91.2% of the children. While preschoolers with ASD showed comparable severity of restricted and repetitive behaviors (P = 0.17), females with ASD were less severely affected than age and intelligence quotient-matched males with ASD in the ADOS-2 social affect domain (P value = 0.001) and calibrated severity scores (P = 0.002). Interestingly, sex-specific linear regressions revealed that fine motor skills were predictive of impaired social affect in males but not in females. Specifically, motor skills might be the core feature for sex differences in ASD. Although preliminary, this finding suggests the need for more sex-specific diagnostic and intervention strategies in order to improve early identification efforts and specific intervention targets. Lay Summary Little is known about differences in developmental and functional profiles in males and females with autism spectrum disorder (ASD). We found important similarities and differences in the core ASD symptoms between male and female preschoolers. In addition, fine motor skills seem to predict social affect impairment and ASD symptom severity in males with ASD. Autism Res 2020, 13: 1537–1547. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2305 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Differences in Developmental Functioning Profiles Between Male and Female Preschoolers Children With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Francesco CRAIG, Auteur ; Alessandro CRIPPA, Auteur ; Andrea DE GIACOMO, Auteur ; Marta RUGGIERO, Auteur ; Veronica RIZZATO, Auteur ; Alessandro LORENZO, Auteur ; Isabella FANIZZA, Auteur ; Lucia MARGARI, Auteur ; Antonio TRABACCA, Auteur . - p.1537-1547. Langues : Anglais (eng) in Autism Research > 13-9 (September 2020) . - p.1537-1547 Index. décimale : PER Périodiques Résumé : Abstract This study investigated differences in clinical symptoms and developmental functioning profiles as well as sex-specific correlations of clinical characteristics and communication abilities, motor skills, and maladaptive behaviors in male and female preschoolers with autism spectrum disorder (ASD). Fifty-two females (mean age 4.5?±?2.16?years old) and 62 males (mean age 4.2?±?1.17?years old) with ASD were enrolled and assessed by measures including the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) and Psychoeducational Profile-Third Edition (PEP-3). We found intellectual disability in 91.2% of the children. While preschoolers with ASD showed comparable severity of restricted and repetitive behaviors (P = 0.17), females with ASD were less severely affected than age and intelligence quotient-matched males with ASD in the ADOS-2 social affect domain (P value = 0.001) and calibrated severity scores (P = 0.002). Interestingly, sex-specific linear regressions revealed that fine motor skills were predictive of impaired social affect in males but not in females. Specifically, motor skills might be the core feature for sex differences in ASD. Although preliminary, this finding suggests the need for more sex-specific diagnostic and intervention strategies in order to improve early identification efforts and specific intervention targets. Lay Summary Little is known about differences in developmental and functional profiles in males and females with autism spectrum disorder (ASD). We found important similarities and differences in the core ASD symptoms between male and female preschoolers. In addition, fine motor skills seem to predict social affect impairment and ASD symptom severity in males with ASD. Autism Res 2020, 13: 1537–1547. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2305 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

A systematic review of problematic video-game use in people with Autism Spectrum Disorders / Francesco CRAIG in Research in Autism Spectrum Disorders, 82 (April 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 82 (April 2021) . - 101726 Titre : A systematic review of problematic video-game use in people with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Francesco CRAIG, Auteur ; Flaviana TENUTA, Auteur ; Andrea DE GIACOMO, Auteur ; Antonio TRABACCA, Auteur ; Angela COSTABILE, Auteur Article en page(s) : 101726 Langues : Anglais (eng) Mots-clés : Autism  Video-gaming  Addiction  Gaming disorders  Systematic review Index. décimale : PER Périodiques Résumé : Background In recent years, an increasing number of studies documented potential links between gaming disorders (GD; including “digital-gaming” or “video-gaming”) and Autism Spectrum Disorders (ASD). Therefore, the aim of this systematic review was to summarize current research about problematic video game (PVG) use in people with ASD and identify specific factors associated with problematic video gaming behavior. Method We searched for articles indexed in PubMed, Scopus, Web of Science, and EBSCOhost electronic databases; using a combination of expressions including “autism spectrum disorder” OR “autism” OR “ASD” AND “video games” OR “gaming disorder” OR “Internet Gaming Disorder” OR “game addiction”. Results Twelve articles were included in this systematic review. The majority of them indicate that children, adolescents and adults with ASD may be at greater risk of PVG use than youths without ASD. Findings also suggested that several internal (sex, attention and oppositional behavior problems) and external factors (social aspects, access and time spent playing video, parental rules, and game genre) were significant predictors of problematic video game use in people with ASD. In addition, this review highlights the paucity of the literature on the consequences and individual effects of excessive video gaming in people with ASD. Conclusions We discuss unanswered questions and future directions and provide recommendations for improving clinicians and parents’ engagement in the prevention and management of problematic video game use in people with ASD. En ligne : https://doi.org/10.1016/j.rasd.2021.101726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] A systematic review of problematic video-game use in people with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Francesco CRAIG, Auteur ; Flaviana TENUTA, Auteur ; Andrea DE GIACOMO, Auteur ; Antonio TRABACCA, Auteur ; Angela COSTABILE, Auteur . - 101726. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 82 (April 2021) . - 101726 Mots-clés : Autism  Video-gaming  Addiction  Gaming disorders  Systematic review Index. décimale : PER Périodiques Résumé : Background In recent years, an increasing number of studies documented potential links between gaming disorders (GD; including “digital-gaming” or “video-gaming”) and Autism Spectrum Disorders (ASD). Therefore, the aim of this systematic review was to summarize current research about problematic video game (PVG) use in people with ASD and identify specific factors associated with problematic video gaming behavior. Method We searched for articles indexed in PubMed, Scopus, Web of Science, and EBSCOhost electronic databases; using a combination of expressions including “autism spectrum disorder” OR “autism” OR “ASD” AND “video games” OR “gaming disorder” OR “Internet Gaming Disorder” OR “game addiction”. Results Twelve articles were included in this systematic review. The majority of them indicate that children, adolescents and adults with ASD may be at greater risk of PVG use than youths without ASD. Findings also suggested that several internal (sex, attention and oppositional behavior problems) and external factors (social aspects, access and time spent playing video, parental rules, and game genre) were significant predictors of problematic video game use in people with ASD. In addition, this review highlights the paucity of the literature on the consequences and individual effects of excessive video gaming in people with ASD. Conclusions We discuss unanswered questions and future directions and provide recommendations for improving clinicians and parents’ engagement in the prevention and management of problematic video game use in people with ASD. En ligne : https://doi.org/10.1016/j.rasd.2021.101726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

The urinary 1H-NMR metabolomics profile of an italian autistic children population and their unaffected siblings / Milena LUSSU in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1058-1066 Titre : The urinary 1H-NMR metabolomics profile of an italian autistic children population and their unaffected siblings Type de document : Texte imprimé et/ou numérique Auteurs : Milena LUSSU, Auteur ; Antonio NOTO, Auteur ; Alice MASILI, Auteur ; Andrea C. RINALDI, Auteur ; Angelica DESSÌ, Auteur ; Maria DE ANGELIS, Auteur ; Andrea DE GIACOMO, Auteur ; Vassilios FANOS, Auteur ; Luigi ATZORI, Auteur ; Ruggiero FRANCAVILLA, Auteur Article en page(s) : p.1058-1066 Langues : Anglais (eng) Mots-clés : metabolomics  autistic children  siblings  biomarkers Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) make a dishomogeneous group of psychiatric diseases having either genetic and environmental components, including changes of the microbiota. The rate of diagnosis, based on a series of psychological tests and observed behavior, dramatically increased in the past few decades. Currently, no biological markers are available and the pathogenesis is not defined. The purpose of this study was to evaluate the potential use of 1H-NMR metabolomics to analyze the global biochemical signature of ASD patients (n?=?21) and controls (n?=?21), these being siblings of autistic patients. A multivariate model has been used to extrapolate the variables of importance. The discriminating urinary metabolites were identified; in particular, significantly increased levels of hippurate, glycine, creatine, tryptophan, and d-threitol and decreased concentrations of glutamate, creatinine, lactate, valine, betaine, and taurine were observed in ASD patients. Based on the identified discriminant metabolites, the attention was focused on two possible mechanisms that could be involved in ASD: oxidative stress conditions and gut microflora modifications. In conclusion, nuclear magnetic resonance-based metabolomics analysis of the urine seems to have the potential for the identification of a metabolic fingerprint of ASD phenotypes and appears to be suitable for further investigation of the disease mechanisms. En ligne : http://dx.doi.org/10.1002/aur.1748 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] The urinary 1H-NMR metabolomics profile of an italian autistic children population and their unaffected siblings [Texte imprimé et/ou numérique] / Milena LUSSU, Auteur ; Antonio NOTO, Auteur ; Alice MASILI, Auteur ; Andrea C. RINALDI, Auteur ; Angelica DESSÌ, Auteur ; Maria DE ANGELIS, Auteur ; Andrea DE GIACOMO, Auteur ; Vassilios FANOS, Auteur ; Luigi ATZORI, Auteur ; Ruggiero FRANCAVILLA, Auteur . - p.1058-1066. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1058-1066 Mots-clés : metabolomics  autistic children  siblings  biomarkers Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) make a dishomogeneous group of psychiatric diseases having either genetic and environmental components, including changes of the microbiota. The rate of diagnosis, based on a series of psychological tests and observed behavior, dramatically increased in the past few decades. Currently, no biological markers are available and the pathogenesis is not defined. The purpose of this study was to evaluate the potential use of 1H-NMR metabolomics to analyze the global biochemical signature of ASD patients (n?=?21) and controls (n?=?21), these being siblings of autistic patients. A multivariate model has been used to extrapolate the variables of importance. The discriminating urinary metabolites were identified; in particular, significantly increased levels of hippurate, glycine, creatine, tryptophan, and d-threitol and decreased concentrations of glutamate, creatinine, lactate, valine, betaine, and taurine were observed in ASD patients. Based on the identified discriminant metabolites, the attention was focused on two possible mechanisms that could be involved in ASD: oxidative stress conditions and gut microflora modifications. In conclusion, nuclear magnetic resonance-based metabolomics analysis of the urine seems to have the potential for the identification of a metabolic fingerprint of ASD phenotypes and appears to be suitable for further investigation of the disease mechanisms. En ligne : http://dx.doi.org/10.1002/aur.1748 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

The usefulness of the Revised Psychoeducational Profile for the assessment of preschool children with pervasive developmental disorders / Claudia PORTOGHESE in Autism, 13-2 (March 2009)  

Public ISBD [article]  inAutism > 13-2 (March 2009) . - p.179-191 Titre : The usefulness of the Revised Psychoeducational Profile for the assessment of preschool children with pervasive developmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : Claudia PORTOGHESE, Auteur ; Maura BUTTIGLIONE, Auteur ; Francesca PAVONE, Auteur ; Vito LOZITO, Auteur ; Andrea DE GIACOMO, Auteur ; Domenico MARTINELLI, Auteur ; Lucia MARGARI, Auteur Année de publication : 2009 Article en page(s) : p.179-191 Langues : Anglais (eng) Mots-clés : PEP—R pervasive-disorders preschool Index. décimale : PER Périodiques Résumé : Data from the Psychoeducational Profile—Revised (PEP—R) were analysed in a sample of 46 children, aged from 1.7 to 5.11 years, of whom 21 had autistic disorder (AD) and 25 had pervasive developmental disorder not otherwise specified (PDD-NOS). Analysis with a t-test for independent samples revealed a significant difference (p < 0.05) between children with AD and those with PDD-NOS on both developmental and behavioural PEP—R scales, supporting the utility of the PEP—R in discriminating between two diagnostic groups. This study emphasizes the effectiveness of the PEP—R as a tool for the early assessment of children with pervasive developmental disorders. En ligne : http://dx.doi.org/10.1177/1362361308100687 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=705 [article] The usefulness of the Revised Psychoeducational Profile for the assessment of preschool children with pervasive developmental disorders [Texte imprimé et/ou numérique] / Claudia PORTOGHESE, Auteur ; Maura BUTTIGLIONE, Auteur ; Francesca PAVONE, Auteur ; Vito LOZITO, Auteur ; Andrea DE GIACOMO, Auteur ; Domenico MARTINELLI, Auteur ; Lucia MARGARI, Auteur . - 2009 . - p.179-191. Langues : Anglais (eng) in Autism > 13-2 (March 2009) . - p.179-191 Mots-clés : PEP—R pervasive-disorders preschool Index. décimale : PER Périodiques Résumé : Data from the Psychoeducational Profile—Revised (PEP—R) were analysed in a sample of 46 children, aged from 1.7 to 5.11 years, of whom 21 had autistic disorder (AD) and 25 had pervasive developmental disorder not otherwise specified (PDD-NOS). Analysis with a t-test for independent samples revealed a significant difference (p < 0.05) between children with AD and those with PDD-NOS on both developmental and behavioural PEP—R scales, supporting the utility of the PEP—R in discriminating between two diagnostic groups. This study emphasizes the effectiveness of the PEP—R as a tool for the early assessment of children with pervasive developmental disorders. En ligne : http://dx.doi.org/10.1177/1362361308100687 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=705

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