Evidence for machine learning guided early prediction of acute outcomes in the treatment of depressed children and adolescents with antidepressants / Arjun P. ATHREYA in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1347-1358 Titre : Evidence for machine learning guided early prediction of acute outcomes in the treatment of depressed children and adolescents with antidepressants Type de document : texte imprimé Auteurs : Arjun P. ATHREYA, Auteur ; Jennifer L. VANDE VOORT, Auteur ; Julia SHEKUNOV, Auteur ; Sandra J. RACKLEY, Auteur ; Jarrod M. LEFFLER, Auteur ; Alastair J. MCKEAN, Auteur ; Magdalena ROMANOWICZ, Auteur ; Betsy KENNARD, Auteur ; Graham J. EMSLIE, Auteur ; Taryn MAYES, Auteur ; Madhukar TRIVEDI, Auteur ; Liewei WANG, Auteur ; Richard M. WEINSHILBOUM, Auteur ; William V. BOBO, Auteur ; Paul E. CROARKIN, Auteur Article en page(s) : p.1347-1358 Langues : Anglais (eng) Mots-clés : Child  Humans  Adolescent  Fluoxetine/therapeutic use  Depressive Disorder, Major/therapy  Duloxetine Hydrochloride/therapeutic use  Artificial Intelligence  Double-Blind Method  Antidepressive Agents  Treatment Outcome  Machine Learning  Depression  adolescents  decision support tools Index. décimale : PER Périodiques Résumé : BACKGROUND: The treatment of depression in children and adolescents is a substantial public health challenge. This study examined artificial intelligence tools for the prediction of early outcomes in depressed children and adolescents treated with fluoxetine, duloxetine, or placebo. METHODS: The study samples included training datasets (N=271) from patients with major depressive disorder (MDD) treated with fluoxetine and testing datasets from patients with MDD treated with duloxetine (N=255) or placebo (N=265). Treatment trajectories were generated using probabilistic graphical models (PGMs). Unsupervised machine learning identified specific depressive symptom profiles and related thresholds of improvement during acute treatment. RESULTS: Variation in six depressive symptoms (difficulty having fun, social withdrawal, excessive fatigue, irritability, low self-esteem, and depressed feelings) assessed with the Children's Depression Rating Scale-Revised at 4-6 weeks predicted treatment outcomes with fluoxetine at 10-12 weeks with an average accuracy of 73% in the training dataset. The same six symptoms predicted 10-12 week outcomes at 4-6 weeks in (a) duloxetine testing datasets with an average accuracy of 76% and (b) placebo-treated patients with accuracies of 67%. In placebo-treated patients, the accuracies of predicting response and remission were similar to antidepressants. Accuracies for predicting nonresponse to placebo treatment were significantly lower than antidepressants. CONCLUSIONS: PGMs provided clinically meaningful predictions in samples of depressed children and adolescents treated with fluoxetine or duloxetine. Future work should augment PGMs with biological data for refined predictions to guide the selection of pharmacological and psychotherapeutic treatment in children and adolescents with depression. En ligne : http://dx.doi.org/10.1111/jcpp.13580 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Evidence for machine learning guided early prediction of acute outcomes in the treatment of depressed children and adolescents with antidepressants [texte imprimé] / Arjun P. ATHREYA, Auteur ; Jennifer L. VANDE VOORT, Auteur ; Julia SHEKUNOV, Auteur ; Sandra J. RACKLEY, Auteur ; Jarrod M. LEFFLER, Auteur ; Alastair J. MCKEAN, Auteur ; Magdalena ROMANOWICZ, Auteur ; Betsy KENNARD, Auteur ; Graham J. EMSLIE, Auteur ; Taryn MAYES, Auteur ; Madhukar TRIVEDI, Auteur ; Liewei WANG, Auteur ; Richard M. WEINSHILBOUM, Auteur ; William V. BOBO, Auteur ; Paul E. CROARKIN, Auteur . - p.1347-1358. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1347-1358 Mots-clés : Child  Humans  Adolescent  Fluoxetine/therapeutic use  Depressive Disorder, Major/therapy  Duloxetine Hydrochloride/therapeutic use  Artificial Intelligence  Double-Blind Method  Antidepressive Agents  Treatment Outcome  Machine Learning  Depression  adolescents  decision support tools Index. décimale : PER Périodiques Résumé : BACKGROUND: The treatment of depression in children and adolescents is a substantial public health challenge. This study examined artificial intelligence tools for the prediction of early outcomes in depressed children and adolescents treated with fluoxetine, duloxetine, or placebo. METHODS: The study samples included training datasets (N=271) from patients with major depressive disorder (MDD) treated with fluoxetine and testing datasets from patients with MDD treated with duloxetine (N=255) or placebo (N=265). Treatment trajectories were generated using probabilistic graphical models (PGMs). Unsupervised machine learning identified specific depressive symptom profiles and related thresholds of improvement during acute treatment. RESULTS: Variation in six depressive symptoms (difficulty having fun, social withdrawal, excessive fatigue, irritability, low self-esteem, and depressed feelings) assessed with the Children's Depression Rating Scale-Revised at 4-6 weeks predicted treatment outcomes with fluoxetine at 10-12 weeks with an average accuracy of 73% in the training dataset. The same six symptoms predicted 10-12 week outcomes at 4-6 weeks in (a) duloxetine testing datasets with an average accuracy of 76% and (b) placebo-treated patients with accuracies of 67%. In placebo-treated patients, the accuracies of predicting response and remission were similar to antidepressants. Accuracies for predicting nonresponse to placebo treatment were significantly lower than antidepressants. CONCLUSIONS: PGMs provided clinically meaningful predictions in samples of depressed children and adolescents treated with fluoxetine or duloxetine. Future work should augment PGMs with biological data for refined predictions to guide the selection of pharmacological and psychotherapeutic treatment in children and adolescents with depression. En ligne : http://dx.doi.org/10.1111/jcpp.13580 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Examining sensory modulation in individuals with autism as compared to community controls / Janet K. KERN in Research in Autism Spectrum Disorders, 2-1 (January/March 2008)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 2-1 (January/March 2008) . - p.85-94 Titre : Examining sensory modulation in individuals with autism as compared to community controls Type de document : texte imprimé Auteurs : Janet K. KERN, Auteur ; Madhukar H. TRIVEDI, Auteur ; Carolyn R. GARVER, Auteur ; Alonzo A. ANDREWS, Auteur ; Jyutika A. MEHTA, Auteur ; Thomas CARMODY, Auteur Année de publication : 2008 Article en page(s) : p.85-94 Langues : Anglais (eng) Mots-clés : Autism Sensory-Profile Sensory-modulation Community-controls Index. décimale : PER Périodiques Résumé : The purpose of the study was to examine sensory modulation items on the Sensory Profile in individuals with autism as compared to community controls. The data for this study were collected as part of a cross-sectional study that examined sensory processing, using the Sensory Profile, in 103 individuals with autism and/or pervasive developmental disorder (PDD), 3–43 years of age, compared to 103 age- and gender-matched community controls. Specifically, this study examined sensory modulation items on the Sensory Profile: Modulation Related to Body Position and Movement; Modulation of Movement Affecting Activity Level; Modulation of Sensory Input Affecting Emotional Responses; and Modulation of Visual Input Affecting Emotional Responses and Activity Level. Sensory modulation in individuals with autism was significantly different than community controls on all four modulation sections of the Sensory Profile, with individuals with autism engaging in the behaviors more frequently than the controls. In addition, a trend was noted in three of the four areas that the older individuals with autism were closer to the community controls than the younger individuals with autism. The results suggest that there are differences between individuals with autism and community controls in their ability to modulate sensory stimuli in areas that affect movement, emotional response, and activity level. En ligne : http://dx.doi.org/10.1016/j.rasd.2007.03.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Examining sensory modulation in individuals with autism as compared to community controls [texte imprimé] / Janet K. KERN, Auteur ; Madhukar H. TRIVEDI, Auteur ; Carolyn R. GARVER, Auteur ; Alonzo A. ANDREWS, Auteur ; Jyutika A. MEHTA, Auteur ; Thomas CARMODY, Auteur . - 2008 . - p.85-94. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 2-1 (January/March 2008) . - p.85-94 Mots-clés : Autism Sensory-Profile Sensory-modulation Community-controls Index. décimale : PER Périodiques Résumé : The purpose of the study was to examine sensory modulation items on the Sensory Profile in individuals with autism as compared to community controls. The data for this study were collected as part of a cross-sectional study that examined sensory processing, using the Sensory Profile, in 103 individuals with autism and/or pervasive developmental disorder (PDD), 3–43 years of age, compared to 103 age- and gender-matched community controls. Specifically, this study examined sensory modulation items on the Sensory Profile: Modulation Related to Body Position and Movement; Modulation of Movement Affecting Activity Level; Modulation of Sensory Input Affecting Emotional Responses; and Modulation of Visual Input Affecting Emotional Responses and Activity Level. Sensory modulation in individuals with autism was significantly different than community controls on all four modulation sections of the Sensory Profile, with individuals with autism engaging in the behaviors more frequently than the controls. In addition, a trend was noted in three of the four areas that the older individuals with autism were closer to the community controls than the younger individuals with autism. The results suggest that there are differences between individuals with autism and community controls in their ability to modulate sensory stimuli in areas that affect movement, emotional response, and activity level. En ligne : http://dx.doi.org/10.1016/j.rasd.2007.03.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Examining sensory quadrants in autism / Janet K. KERN in Research in Autism Spectrum Disorders, 1-2 (April/June 2007)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 1-2 (April/June 2007) . - p.185-193 Titre : Examining sensory quadrants in autism Type de document : texte imprimé Auteurs : Janet K. KERN, Auteur ; Madhukar H. TRIVEDI, Auteur ; Carolyn R. GARVER, Auteur ; Alonzo A. ANDREWS, Auteur ; Jyutika A. MEHTA, Auteur ; Thomas CARMODY, Auteur Année de publication : 2007 Article en page(s) : p.185-193 Langues : Anglais (eng) Mots-clés : Autism Sensory-quadrants Sensory-Profile Low-Registration Sensation-Seeking Sensation-Sensitivity Sensation-Avoidance Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine sensory quadrants in autism based on Dunn's Theory of Sensory Processing. The data for this study was collected as part of a cross-sectional study that examined sensory processing (using the Sensory Profile) in 103 persons with autism, 3–43 years of age, compared to 103 age- and gender-matched community controls. Sensory quadrants (Low Registration, Sensation Seeking, Sensation Sensitivity, and Sensation Avoidance) on the Sensory Profile are different in persons with autism as compared to community controls, with persons with autism engaging in the behaviors more frequently than the controls. This study provides further evidence of sensory differences in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2006.09.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147 [article] Examining sensory quadrants in autism [texte imprimé] / Janet K. KERN, Auteur ; Madhukar H. TRIVEDI, Auteur ; Carolyn R. GARVER, Auteur ; Alonzo A. ANDREWS, Auteur ; Jyutika A. MEHTA, Auteur ; Thomas CARMODY, Auteur . - 2007 . - p.185-193. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 1-2 (April/June 2007) . - p.185-193 Mots-clés : Autism Sensory-quadrants Sensory-Profile Low-Registration Sensation-Seeking Sensation-Sensitivity Sensation-Avoidance Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine sensory quadrants in autism based on Dunn's Theory of Sensory Processing. The data for this study was collected as part of a cross-sectional study that examined sensory processing (using the Sensory Profile) in 103 persons with autism, 3–43 years of age, compared to 103 age- and gender-matched community controls. Sensory quadrants (Low Registration, Sensation Seeking, Sensation Sensitivity, and Sensation Avoidance) on the Sensory Profile are different in persons with autism as compared to community controls, with persons with autism engaging in the behaviors more frequently than the controls. This study provides further evidence of sensory differences in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2006.09.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147

Remission of Maternal Depression: Relations to Family Functioning and Youth Internalizing and Externalizing Symptoms / Cynthia EWELL FOSTER in Journal of Clinical Child & Adolescent Psychology, 37-4 (October-December 2008)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 37-4 (October-December 2008) . - p.714-724 Titre : Remission of Maternal Depression: Relations to Family Functioning and Youth Internalizing and Externalizing Symptoms Type de document : texte imprimé Auteurs : Cynthia EWELL FOSTER, Auteur ; Madhukar H. TRIVEDI, Auteur ; Maurizio FAVA, Auteur ; Stephen R. WISNIEWSKI, Auteur ; Jonathan E. ALPERT, Auteur ; Susan G. KORNSTEIN, Auteur ; Gabrielle CERDA, Auteur ; Erin MALLOY, Auteur ; Judy GARBER, Auteur ; Carroll W. HUGHES, Auteur ; A. John RUSH, Auteur ; Ardesheer TALATI, Auteur ; Priya J. WICKRAMARATNE, Auteur ; Daniel J. PILOWSKY, Auteur ; Melissa C. WEBSTER, Auteur ; Myrna WEISSMAN, Auteur ; Cheryl A. KING, Auteur Année de publication : 2008 Article en page(s) : p.714-724 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Family functioning and parenting were hypothesized to mediate the relation between remission of maternal depression and children's psychosocial adjustment. Participants were 114 mother-child dyads participating in the Sequenced Treatment Alternatives to Relieve Depression Child 3-month follow-up. All mothers had been diagnosed with major depressive disorder and were treated initially with citalopram; 33% of mothers experienced remission of depressive symptoms. Youth ranged in age from 7 to 17. Remission of maternal depression was associated with changes in children's reports of their mothers' warmth/acceptance, which in turn partially mediated the relation between maternal depression remission and youth internalizing symptoms, accounting for 22.9% of the variance. En ligne : http://dx.doi.org/10.1080/15374410802359726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=645 [article] Remission of Maternal Depression: Relations to Family Functioning and Youth Internalizing and Externalizing Symptoms [texte imprimé] / Cynthia EWELL FOSTER, Auteur ; Madhukar H. TRIVEDI, Auteur ; Maurizio FAVA, Auteur ; Stephen R. WISNIEWSKI, Auteur ; Jonathan E. ALPERT, Auteur ; Susan G. KORNSTEIN, Auteur ; Gabrielle CERDA, Auteur ; Erin MALLOY, Auteur ; Judy GARBER, Auteur ; Carroll W. HUGHES, Auteur ; A. John RUSH, Auteur ; Ardesheer TALATI, Auteur ; Priya J. WICKRAMARATNE, Auteur ; Daniel J. PILOWSKY, Auteur ; Melissa C. WEBSTER, Auteur ; Myrna WEISSMAN, Auteur ; Cheryl A. KING, Auteur . - 2008 . - p.714-724. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 37-4 (October-December 2008) . - p.714-724 Index. décimale : PER Périodiques Résumé : Family functioning and parenting were hypothesized to mediate the relation between remission of maternal depression and children's psychosocial adjustment. Participants were 114 mother-child dyads participating in the Sequenced Treatment Alternatives to Relieve Depression Child 3-month follow-up. All mothers had been diagnosed with major depressive disorder and were treated initially with citalopram; 33% of mothers experienced remission of depressive symptoms. Youth ranged in age from 7 to 17. Remission of maternal depression was associated with changes in children's reports of their mothers' warmth/acceptance, which in turn partially mediated the relation between maternal depression remission and youth internalizing symptoms, accounting for 22.9% of the variance. En ligne : http://dx.doi.org/10.1080/15374410802359726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=645

Response to vestibular sensory events in autism / Janet K. KERN in Research in Autism Spectrum Disorders, 1-1 (January/March 2007)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 1-1 (January/March 2007) . - p.67-74 Titre : Response to vestibular sensory events in autism Type de document : texte imprimé Auteurs : Janet K. KERN, Auteur ; Madhukar H. TRIVEDI, Auteur ; Bruce D. GRANNEMANN, Auteur ; Carolyn R. GARVER, Auteur ; Alonzo A. ANDREWS, Auteur ; Jyutika A. MEHTA, Auteur ; Thomas CARMODY, Auteur Année de publication : 2007 Article en page(s) : p.67-74 Langues : Anglais (eng) Mots-clés : Autism Sensory-processing Vestibular Thresholds Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine the response to vestibular sensory events in persons with autism. The data for this study was collected as part of a cross-sectional study that examined sensory processing (using the Sensory Profile) in 103 persons with autism, 3–43 years of age, compared to age- and gender-matched community controls. The Vestibular Processing section of the Sensory Profile was used. The results showed that Vestibular Processing (both high and low threshold processing) on the Sensory Profile was significantly different in persons with autism as compared to community controls, with persons with autism engaging in the behaviors more frequently than the controls. Vestibular processing differences could explain certain problems in autism. It is important to try to understand sensory problems in autism because it can enable us to better understand the needs of persons with autism, and in turn, influence treatment protocols. En ligne : http://dx.doi.org/10.1016/j.rasd.2006.07.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Response to vestibular sensory events in autism [texte imprimé] / Janet K. KERN, Auteur ; Madhukar H. TRIVEDI, Auteur ; Bruce D. GRANNEMANN, Auteur ; Carolyn R. GARVER, Auteur ; Alonzo A. ANDREWS, Auteur ; Jyutika A. MEHTA, Auteur ; Thomas CARMODY, Auteur . - 2007 . - p.67-74. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 1-1 (January/March 2007) . - p.67-74 Mots-clés : Autism Sensory-processing Vestibular Thresholds Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine the response to vestibular sensory events in persons with autism. The data for this study was collected as part of a cross-sectional study that examined sensory processing (using the Sensory Profile) in 103 persons with autism, 3–43 years of age, compared to age- and gender-matched community controls. The Vestibular Processing section of the Sensory Profile was used. The results showed that Vestibular Processing (both high and low threshold processing) on the Sensory Profile was significantly different in persons with autism as compared to community controls, with persons with autism engaging in the behaviors more frequently than the controls. Vestibular processing differences could explain certain problems in autism. It is important to try to understand sensory problems in autism because it can enable us to better understand the needs of persons with autism, and in turn, influence treatment protocols. En ligne : http://dx.doi.org/10.1016/j.rasd.2006.07.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

Sensory correlations in autism / Janet K. KERN in Autism, 11-2 (March 2007)  

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