Clinical Presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic Spectrum Disorder and Chronic Gastrointestinal Symptoms / Arthur KRIGSMAN in Autism Insights, 2 ([01/01/2010])  

Public ISBD [article]  inAutism Insights > 2 [01/01/2010] . - p.1-11 Titre : Clinical Presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic Spectrum Disorder and Chronic Gastrointestinal Symptoms Type de document : Application, site Internet Auteurs : Arthur KRIGSMAN, Auteur ; Marvin BORIS, Auteur ; Alan GOLDBLATT, Auteur ; Carol STOTT, Auteur Année de publication : 2010 Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background: Children with developmental disorders experience chronic gastrointestinal symptoms. Aims: To examine the nature of these gastrointestinal symptoms and histologic findings in children with autism spectrum/developmental disorders and ileocolonic disease. Methods: Chart review. 143 autism spectrum/developmental disorder patients, with chronic gastrointestinal symptoms, undergoing diagnostic ileocolonoscopy. Results: Diarrhea was present in 78%, abdominal pain in 59% and constipation in 36%. Ileal and/or colonic lymphonodular hyperplasia (LNH), defined as the presence of an increased number of enlarged lymphoid follicles, often with hyperactive germinal centers, was present in 73.2%. Terminal ileum LNH presented visually in 67% and histologically in 73%. Colonic LNH was multifocal and presented histologically in 32%. Ileal and/or colonic inflammation presented in 74%, consisting primarily of active or chronic colitis (69%). Ileal inflammation presented in 35%. Presence of LNH significantly predicted mucosal inflammation. Patients with ileal and/or colonic LNH had lower mean/median age than those without; patients with ileal and/or colonic inflammation had lower mean/median age than those without. There was a significant association between ileo and/or colonic inflammation or LNH, and onset of developmental disorder; plateaued or regressive onset conferred greater risk than early onset. Conclusions: Patients with autism or related disorders exhibiting chronic gastrointestinal symptoms demonstrate ileal or colonic inflammation upon light microscopic examination of biopsy tissue. Further work is needed to determine whether resolution of histopathology with appropriate therapy is accompanied by GI symptomatic and cognitive/behavioral improvement. En ligne : http://dx.doi.org/10.4137/AUI.S3252 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Clinical Presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic Spectrum Disorder and Chronic Gastrointestinal Symptoms [Application, site Internet] / Arthur KRIGSMAN, Auteur ; Marvin BORIS, Auteur ; Alan GOLDBLATT, Auteur ; Carol STOTT, Auteur . - 2010 . - p.1-11. Langues : Anglais (eng) in Autism Insights > 2 [01/01/2010] . - p.1-11 Index. décimale : PER Périodiques Résumé : Background: Children with developmental disorders experience chronic gastrointestinal symptoms. Aims: To examine the nature of these gastrointestinal symptoms and histologic findings in children with autism spectrum/developmental disorders and ileocolonic disease. Methods: Chart review. 143 autism spectrum/developmental disorder patients, with chronic gastrointestinal symptoms, undergoing diagnostic ileocolonoscopy. Results: Diarrhea was present in 78%, abdominal pain in 59% and constipation in 36%. Ileal and/or colonic lymphonodular hyperplasia (LNH), defined as the presence of an increased number of enlarged lymphoid follicles, often with hyperactive germinal centers, was present in 73.2%. Terminal ileum LNH presented visually in 67% and histologically in 73%. Colonic LNH was multifocal and presented histologically in 32%. Ileal and/or colonic inflammation presented in 74%, consisting primarily of active or chronic colitis (69%). Ileal inflammation presented in 35%. Presence of LNH significantly predicted mucosal inflammation. Patients with ileal and/or colonic LNH had lower mean/median age than those without; patients with ileal and/or colonic inflammation had lower mean/median age than those without. There was a significant association between ileo and/or colonic inflammation or LNH, and onset of developmental disorder; plateaued or regressive onset conferred greater risk than early onset. Conclusions: Patients with autism or related disorders exhibiting chronic gastrointestinal symptoms demonstrate ileal or colonic inflammation upon light microscopic examination of biopsy tissue. Further work is needed to determine whether resolution of histopathology with appropriate therapy is accompanied by GI symptomatic and cognitive/behavioral improvement. En ligne : http://dx.doi.org/10.4137/AUI.S3252 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders / Bryan JEPSON in Journal of Autism and Developmental Disorders, 41-5 (May 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-5 (May 2011) . - p.575-588 Titre : Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Bryan JEPSON, Auteur ; Doreen GRANPEESHEH, Auteur ; Jonathan TARBOX, Auteur ; Melissa L. OLIVE, Auteur ; Carol STOTT, Auteur ; Scott BRAUD, Auteur ; J. Helen YOO, Auteur ; Andrew WAKEFIELD, Auteur ; Michael S. ALLEN, Auteur Année de publication : 2011 Article en page(s) : p.575-588 Langues : Anglais (eng) Mots-clés : Hyperbaric oxygen therapy  Autism  Behavioral pharmacology Index. décimale : PER Périodiques Résumé : Hyperbaric oxygen therapy (HBOT) has been used to treat individuals with autism. However, few studies of its effectiveness have been completed. The current study examined the effects of 40 HBOT sessions at 24% oxygen at 1.3 ATA on 11 topographies of directly observed behavior. Five replications of multiple baselines were completed across a total of 16 participants with autism spectrum disorders. No consistent effects were observed across any group or within any individual participant, demonstrating that HBOT was not an effective treatment for the participants in this study. This study represents the first relatively large-scale controlled study evaluating the effects of HBOT at the level of the individual participant, on a wide array of behaviors. En ligne : http://dx.doi.org/10.1007/s10803-010-1075-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 [article] Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Bryan JEPSON, Auteur ; Doreen GRANPEESHEH, Auteur ; Jonathan TARBOX, Auteur ; Melissa L. OLIVE, Auteur ; Carol STOTT, Auteur ; Scott BRAUD, Auteur ; J. Helen YOO, Auteur ; Andrew WAKEFIELD, Auteur ; Michael S. ALLEN, Auteur . - 2011 . - p.575-588. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-5 (May 2011) . - p.575-588 Mots-clés : Hyperbaric oxygen therapy  Autism  Behavioral pharmacology Index. décimale : PER Périodiques Résumé : Hyperbaric oxygen therapy (HBOT) has been used to treat individuals with autism. However, few studies of its effectiveness have been completed. The current study examined the effects of 40 HBOT sessions at 24% oxygen at 1.3 ATA on 11 topographies of directly observed behavior. Five replications of multiple baselines were completed across a total of 16 participants with autism spectrum disorders. No consistent effects were observed across any group or within any individual participant, demonstrating that HBOT was not an effective treatment for the participants in this study. This study represents the first relatively large-scale controlled study evaluating the effects of HBOT at the level of the individual participant, on a wide array of behaviors. En ligne : http://dx.doi.org/10.1007/s10803-010-1075-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121

Engineering and Autism: Exploring the Link Further: Reply to Wolff, Braunsberg and Islam / Simon BARON-COHEN in Autism, 2-1 (March 1998)  

Public ISBD [article]  inAutism > 2-1 (March 1998) . - p.98-104 Titre : Engineering and Autism: Exploring the Link Further: Reply to Wolff, Braunsberg and Islam Type de document : Texte imprimé et/ou numérique Auteurs : Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur ; Carol STOTT, Auteur ; Patrick BOLTON, Auteur ; Ian M. GOODYER, Auteur Article en page(s) : p.98-104 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361398021016 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=207 [article] Engineering and Autism: Exploring the Link Further: Reply to Wolff, Braunsberg and Islam [Texte imprimé et/ou numérique] / Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur ; Carol STOTT, Auteur ; Patrick BOLTON, Auteur ; Ian M. GOODYER, Auteur . - p.98-104. Langues : Anglais (eng) in Autism > 2-1 (March 1998) . - p.98-104 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1177/1362361398021016 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=207

Is There a Link between Engineering and Autism? / Simon BARON-COHEN in Autism, 1-1 (July 1997)  

Public ISBD [article]  inAutism > 1-1 (July 1997) . - p.101-109 Titre : Is There a Link between Engineering and Autism? Type de document : Texte imprimé et/ou numérique Auteurs : Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur ; Carol STOTT, Auteur ; Patrick BOLTON, Auteur ; Ian M. GOODYER, Auteur Article en page(s) : p.101-109 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism is a severe childhood neuropsychiatric condition with a substantial genetic component. At the cognitive level children with autism are impaired in the development of their folk psychology, seict while they are normal or even superior in the development of their folk physics. We predicted that if their parent shared this cognitive phenotype, then they should be over-represented in engineering as an occupation. This prediction was confirmed. Both fathers and grand-fathers of children with autism were found more than twice as often in the field of engineering, compared with fathers and grandfathers of other children. This link between autism and engineering may throw light not only on autism itself, but ultimately on the genetic basis of two essential human abilities: folk psychology and folk physics. En ligne : http://dx.doi.org/10.1177/1362361397011010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=206 [article] Is There a Link between Engineering and Autism? [Texte imprimé et/ou numérique] / Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur ; Carol STOTT, Auteur ; Patrick BOLTON, Auteur ; Ian M. GOODYER, Auteur . - p.101-109. Langues : Anglais (eng) in Autism > 1-1 (July 1997) . - p.101-109 Index. décimale : PER Périodiques Résumé : Autism is a severe childhood neuropsychiatric condition with a substantial genetic component. At the cognitive level children with autism are impaired in the development of their folk psychology, seict while they are normal or even superior in the development of their folk physics. We predicted that if their parent shared this cognitive phenotype, then they should be over-represented in engineering as an occupation. This prediction was confirmed. Both fathers and grand-fathers of children with autism were found more than twice as often in the field of engineering, compared with fathers and grandfathers of other children. This link between autism and engineering may throw light not only on autism itself, but ultimately on the genetic basis of two essential human abilities: folk psychology and folk physics. En ligne : http://dx.doi.org/10.1177/1362361397011010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=206

The Childhood Asperger Syndrome Test (CAST): Test–retest reliability in a high scoring sample / Carrie ALLISON in Autism, 11-2 (March 2007)  

Public ISBD [article]  inAutism > 11-2 (March 2007) . - p.173-185 Titre : The Childhood Asperger Syndrome Test (CAST): Test–retest reliability in a high scoring sample Type de document : Texte imprimé et/ou numérique Auteurs : Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; Jo WILLIAMS, Auteur ; Fiona J. SCOTT, Auteur ; Carol STOTT, Auteur ; Patrick BOLTON, Auteur ; Carol BRAYNE, Auteur Année de publication : 2007 Article en page(s) : p.173-185 Langues : Anglais (eng) Mots-clés : Asperger-syndrome Autism Childhood-screening Pervasive-developmental-disorder Reliability Index. décimale : PER Périodiques Résumé : The Childhood Asperger Syndrome Test (CAST) is a 37-item parental self-completion questionnaire designed to screen for high-functioning autism spectrum conditions in epidemiological research. The CAST has previously demonstrated good accuracy for use as a screening test, with high sensitivity in studies with primary school aged children in mainstream schools. This study aimed to investigate test–retest reliability of the CAST in a high scoring sample. To this end, 73 parents filled in the second CAST (CAST-2) within approximately 2 months of the first administration of the CAST (CAST-1). Agreement above and below the cut-point of 15 was investigated. The kappa statistic for agreement (<15 versus 15) was 0.41. It was found that 70 percent (95% CI: 58, 80) of children did not move across the cut-point of 15. The correlation between the two test scores was 0.67 (Spearman's rho). The CAST shows moderate test–retest reliability in a high scoring sample, further evidence that it is a relatively robust screening tool for epidemiological research. En ligne : http://dx.doi.org/10.1177/1362361307075710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=669 [article] The Childhood Asperger Syndrome Test (CAST): Test–retest reliability in a high scoring sample [Texte imprimé et/ou numérique] / Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; Jo WILLIAMS, Auteur ; Fiona J. SCOTT, Auteur ; Carol STOTT, Auteur ; Patrick BOLTON, Auteur ; Carol BRAYNE, Auteur . - 2007 . - p.173-185. Langues : Anglais (eng) in Autism > 11-2 (March 2007) . - p.173-185 Mots-clés : Asperger-syndrome Autism Childhood-screening Pervasive-developmental-disorder Reliability Index. décimale : PER Périodiques Résumé : The Childhood Asperger Syndrome Test (CAST) is a 37-item parental self-completion questionnaire designed to screen for high-functioning autism spectrum conditions in epidemiological research. The CAST has previously demonstrated good accuracy for use as a screening test, with high sensitivity in studies with primary school aged children in mainstream schools. This study aimed to investigate test–retest reliability of the CAST in a high scoring sample. To this end, 73 parents filled in the second CAST (CAST-2) within approximately 2 months of the first administration of the CAST (CAST-1). Agreement above and below the cut-point of 15 was investigated. The kappa statistic for agreement (<15 versus 15) was 0.41. It was found that 70 percent (95% CI: 58, 80) of children did not move across the cut-point of 15. The correlation between the two test scores was 0.67 (Spearman's rho). The CAST shows moderate test–retest reliability in a high scoring sample, further evidence that it is a relatively robust screening tool for epidemiological research. En ligne : http://dx.doi.org/10.1177/1362361307075710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=669

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