Childhood trauma and cognitive functioning in individuals at clinical high risk (CHR) for psychosis / T. VELIKONJA in Development and Psychopathology, 33-1 (February 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-1 (February 2021) . - p.53-64 Titre : Childhood trauma and cognitive functioning in individuals at clinical high risk (CHR) for psychosis Type de document : Texte imprimé et/ou numérique Auteurs : T. VELIKONJA, Auteur ; E. VELTHORST, Auteur ; J. ZINBERG, Auteur ; Tyrone D. CANNON, Auteur ; Barbara A. CORNBLATT, Auteur ; Diana O. PERKINS, Auteur ; Kristin S. CADENHEAD, Auteur ; M. T. TSUANG, Auteur ; Jean ADDINGTON, Auteur ; S. W. WOODS, Auteur ; T. MCGLASHAN, Auteur ; D. H. MATHALON, Auteur ; W. STONE, Auteur ; M. KESHAVAN, Auteur ; L. SEIDMAN, Auteur ; Carrie E. BEARDEN, Auteur Article en page(s) : p.53-64 Langues : Anglais (eng) Mots-clés : childhood trauma  clinical high risk  nonsocial cognition  psychosis  social cognition Index. décimale : PER Périodiques Résumé : Evidence suggests that early trauma may have a negative effect on cognitive functioning in individuals with psychosis, yet the relationship between childhood trauma and cognition among those at clinical high risk (CHR) for psychosis remains unexplored. Our sample consisted of 626 CHR children and 279 healthy controls who were recruited as part of the North American Prodrome Longitudinal Study 2. Childhood trauma up to the age of 16 (psychological, physical, and sexual abuse, emotional neglect, and bullying) was assessed by using the Childhood Trauma and Abuse Scale. Multiple domains of cognition were measured at baseline and at the time of psychosis conversion, using standardized assessments. In the CHR group, there was a trend for better performance in individuals who reported a history of multiple types of childhood trauma compared with those with no/one type of trauma (Cohen d = 0.16). A history of multiple trauma types was not associated with greater cognitive change in CHR converters over time. Our findings tentatively suggest there may be different mechanisms that lead to CHR states. Individuals who are at clinical high risk who have experienced multiple types of childhood trauma may have more typically developing premorbid cognitive functioning than those who reported minimal trauma do. Further research is needed to unravel the complexity of factors underlying the development of at-risk states. En ligne : http://dx.doi.org/10.1017/s095457941900155x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 [article] Childhood trauma and cognitive functioning in individuals at clinical high risk (CHR) for psychosis [Texte imprimé et/ou numérique] / T. VELIKONJA, Auteur ; E. VELTHORST, Auteur ; J. ZINBERG, Auteur ; Tyrone D. CANNON, Auteur ; Barbara A. CORNBLATT, Auteur ; Diana O. PERKINS, Auteur ; Kristin S. CADENHEAD, Auteur ; M. T. TSUANG, Auteur ; Jean ADDINGTON, Auteur ; S. W. WOODS, Auteur ; T. MCGLASHAN, Auteur ; D. H. MATHALON, Auteur ; W. STONE, Auteur ; M. KESHAVAN, Auteur ; L. SEIDMAN, Auteur ; Carrie E. BEARDEN, Auteur . - p.53-64. Langues : Anglais (eng) in Development and Psychopathology > 33-1 (February 2021) . - p.53-64 Mots-clés : childhood trauma  clinical high risk  nonsocial cognition  psychosis  social cognition Index. décimale : PER Périodiques Résumé : Evidence suggests that early trauma may have a negative effect on cognitive functioning in individuals with psychosis, yet the relationship between childhood trauma and cognition among those at clinical high risk (CHR) for psychosis remains unexplored. Our sample consisted of 626 CHR children and 279 healthy controls who were recruited as part of the North American Prodrome Longitudinal Study 2. Childhood trauma up to the age of 16 (psychological, physical, and sexual abuse, emotional neglect, and bullying) was assessed by using the Childhood Trauma and Abuse Scale. Multiple domains of cognition were measured at baseline and at the time of psychosis conversion, using standardized assessments. In the CHR group, there was a trend for better performance in individuals who reported a history of multiple types of childhood trauma compared with those with no/one type of trauma (Cohen d = 0.16). A history of multiple trauma types was not associated with greater cognitive change in CHR converters over time. Our findings tentatively suggest there may be different mechanisms that lead to CHR states. Individuals who are at clinical high risk who have experienced multiple types of childhood trauma may have more typically developing premorbid cognitive functioning than those who reported minimal trauma do. Further research is needed to unravel the complexity of factors underlying the development of at-risk states. En ligne : http://dx.doi.org/10.1017/s095457941900155x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442

Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia / Katherine H. KARLSGODT in Development and Psychopathology, 20-4 (Fall 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-4 (Fall 2008) . - p.1297-1327 Titre : Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Katherine H. KARLSGODT, Auteur ; Tyrone D. CANNON, Auteur ; Daqiang SUN, Auteur ; Amy M. JIMENEZ, Auteur ; Evan S. LUTKENHOFF, Auteur ; Rachael WILLHITE, Auteur ; Theo G. M. VAN ERP, Auteur Année de publication : 2008 Article en page(s) : p.1297-1327 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Schizophrenia has been thought of as a disorder of reduced functional and structural connectivity. Recent advances in neuroimaging techniques such as functional magnetic resonance imaging, structural magnetic resonance imaging, diffusion tensor imaging, and small animal imaging have advanced our ability to investigate this hypothesis. Moreover, the power of longitudinal designs possible with these noninvasive techniques enable the study of not just how connectivity is disrupted in schizophrenia, but when this disruption emerges during development. This article reviews genetic and neurodevelopmental influences on structural and functional connectivity in human populations with or at risk for schizophrenia and in animal models of the disorder. We conclude that the weight of evidence across these diverse lines of inquiry points to a developmental disruption of neural connectivity in schizophrenia and that this disrupted connectivity likely involves susceptibility genes that affect processes involved in establishing intra- and interregional connectivity. En ligne : http://dx.doi.org/10.1017/s095457940800062x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=603 [article] Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia [Texte imprimé et/ou numérique] / Katherine H. KARLSGODT, Auteur ; Tyrone D. CANNON, Auteur ; Daqiang SUN, Auteur ; Amy M. JIMENEZ, Auteur ; Evan S. LUTKENHOFF, Auteur ; Rachael WILLHITE, Auteur ; Theo G. M. VAN ERP, Auteur . - 2008 . - p.1297-1327. Langues : Anglais (eng) in Development and Psychopathology > 20-4 (Fall 2008) . - p.1297-1327 Index. décimale : PER Périodiques Résumé : Schizophrenia has been thought of as a disorder of reduced functional and structural connectivity. Recent advances in neuroimaging techniques such as functional magnetic resonance imaging, structural magnetic resonance imaging, diffusion tensor imaging, and small animal imaging have advanced our ability to investigate this hypothesis. Moreover, the power of longitudinal designs possible with these noninvasive techniques enable the study of not just how connectivity is disrupted in schizophrenia, but when this disruption emerges during development. This article reviews genetic and neurodevelopmental influences on structural and functional connectivity in human populations with or at risk for schizophrenia and in animal models of the disorder. We conclude that the weight of evidence across these diverse lines of inquiry points to a developmental disruption of neural connectivity in schizophrenia and that this disrupted connectivity likely involves susceptibility genes that affect processes involved in establishing intra- and interregional connectivity. En ligne : http://dx.doi.org/10.1017/s095457940800062x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=603

Infant motor development is associated with adult cognitive categorisation in a longitudinal birth cohort study / Graham K. MURRAY in Journal of Child Psychology and Psychiatry, 47-1 (January 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-1 (January 2006) . - p.25–29 Titre : Infant motor development is associated with adult cognitive categorisation in a longitudinal birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Graham K. MURRAY, Auteur ; Juha VEIJOLA, Auteur ; Jouko MIETTUNEN, Auteur ; David C. GLAHN, Auteur ; Tyrone D. CANNON, Auteur ; Peter B. JONES, Auteur ; Matti ISOHANNI, Auteur Année de publication : 2006 Article en page(s) : p.25–29 Langues : Anglais (eng) Mots-clés : Development executive-function longitudinal-studies motor-skills neuropsychology infancy Index. décimale : PER Périodiques Résumé : Background: The relationship between the age of reaching infant developmental milestones and later intellectual function within the normal population remains unresolved. We hypothesised that the age of learning to stand in infancy would be associated with adult executive function and that the association would be apparent throughout the range of abilities, rather than confined to extremes. Methods: The Northern Finland 1966 Birth Cohort is based upon 12,058 live-born children in a geographic and temporally defined population. Information on age at learning to stand without support was obtained at one year. At age 33–35 a random sample of 104 subjects underwent a neuropsychological test battery including tests of executive function (cognitive categorisation), visuo-spatial memory, verbal learning and visual object learning. We investigated associations between developmental data and adult neuropsychological test scores. Results: There was a significant linear relationship between age of learning to stand and adult categorisation: the earlier the attainment of the milestone, the better was the categorisation. No such relationships were observed between infant neurodevelopment and adult cognition in other neuropsychological domains. Conclusion: Even within the normal range of development, early development in the gross motor domain is associated with better adult executive function (in tests of categorisation). Investigation of the determinants and sequelae of normal neural development will facilitate research into a variety of neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01450.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=699 [article] Infant motor development is associated with adult cognitive categorisation in a longitudinal birth cohort study [Texte imprimé et/ou numérique] / Graham K. MURRAY, Auteur ; Juha VEIJOLA, Auteur ; Jouko MIETTUNEN, Auteur ; David C. GLAHN, Auteur ; Tyrone D. CANNON, Auteur ; Peter B. JONES, Auteur ; Matti ISOHANNI, Auteur . - 2006 . - p.25–29. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-1 (January 2006) . - p.25–29 Mots-clés : Development executive-function longitudinal-studies motor-skills neuropsychology infancy Index. décimale : PER Périodiques Résumé : Background: The relationship between the age of reaching infant developmental milestones and later intellectual function within the normal population remains unresolved. We hypothesised that the age of learning to stand in infancy would be associated with adult executive function and that the association would be apparent throughout the range of abilities, rather than confined to extremes. Methods: The Northern Finland 1966 Birth Cohort is based upon 12,058 live-born children in a geographic and temporally defined population. Information on age at learning to stand without support was obtained at one year. At age 33–35 a random sample of 104 subjects underwent a neuropsychological test battery including tests of executive function (cognitive categorisation), visuo-spatial memory, verbal learning and visual object learning. We investigated associations between developmental data and adult neuropsychological test scores. Results: There was a significant linear relationship between age of learning to stand and adult categorisation: the earlier the attainment of the milestone, the better was the categorisation. No such relationships were observed between infant neurodevelopment and adult cognition in other neuropsychological domains. Conclusion: Even within the normal range of development, early development in the gross motor domain is associated with better adult executive function (in tests of categorisation). Investigation of the determinants and sequelae of normal neural development will facilitate research into a variety of neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01450.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=699

Potentially important periods of change in the development of social and role functioning in youth at clinical high risk for psychosis / Eva VELTHORST in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.39-47 Titre : Potentially important periods of change in the development of social and role functioning in youth at clinical high risk for psychosis Type de document : Texte imprimé et/ou numérique Auteurs : Eva VELTHORST, Auteur ; Jamie ZINBERG, Auteur ; Jean ADDINGTON, Auteur ; Kristin S. CADENHEAD, Auteur ; Tyrone D. CANNON, Auteur ; Ricardo E. CARRIÓN, Auteur ; Andrea M. AUTHER, Auteur ; Barbara A. CORNBLATT, Auteur ; Thomas H. MCGLASHAN, Auteur ; Daniel H. MATHALON, Auteur ; Diana O. PERKINS, Auteur ; Larry J. SEIDMAN, Auteur ; Ming T. TSUANG, Auteur ; Elaine F. WALKER, Auteur ; Scott W. WOODS, Auteur ; Abraham REICHENBERG, Auteur ; Carrie E. BEARDEN, Auteur Article en page(s) : p.39-47 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The developmental course of daily functioning prior to first psychosis-onset remains poorly understood. This study explored age-related periods of change in social and role functioning. The longitudinal study included youth (aged 12–23, mean follow-up years = 1.19) at clinical high risk (CHR) for psychosis (converters [CHR-C], n = 83; nonconverters [CHR-NC], n = 275) and a healthy control group (n = 164). Mixed-model analyses were performed to determine age-related differences in social and role functioning. We limited our analyses to functioning before psychosis conversion; thus, data of CHR-C participants gathered after psychosis onset were excluded. In controls, social and role functioning improved over time. From at least age 12, functioning in CHR was poorer than in controls, and this lag persisted over time. Between ages 15 and 18, social functioning in CHR-C stagnated and diverged from that of CHR-NC, who continued to improve (p = .001). Subsequently, CHR-C lagged behind in improvement between ages 21 and 23, further distinguishing them from CHR-NC (p < .001). A similar period of stagnation was apparent for role functioning, but to a lesser extent (p = .007). The results remained consistent when we accounted for the time to conversion. Our findings suggest that CHR-C start lagging behind CHR-NC in social and role functioning in adolescence, followed by a period of further stagnation in adulthood. En ligne : https://doi.org/10.1017/S0954579417000451 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335 [article] Potentially important periods of change in the development of social and role functioning in youth at clinical high risk for psychosis [Texte imprimé et/ou numérique] / Eva VELTHORST, Auteur ; Jamie ZINBERG, Auteur ; Jean ADDINGTON, Auteur ; Kristin S. CADENHEAD, Auteur ; Tyrone D. CANNON, Auteur ; Ricardo E. CARRIÓN, Auteur ; Andrea M. AUTHER, Auteur ; Barbara A. CORNBLATT, Auteur ; Thomas H. MCGLASHAN, Auteur ; Daniel H. MATHALON, Auteur ; Diana O. PERKINS, Auteur ; Larry J. SEIDMAN, Auteur ; Ming T. TSUANG, Auteur ; Elaine F. WALKER, Auteur ; Scott W. WOODS, Auteur ; Abraham REICHENBERG, Auteur ; Carrie E. BEARDEN, Auteur . - p.39-47. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.39-47 Index. décimale : PER Périodiques Résumé : The developmental course of daily functioning prior to first psychosis-onset remains poorly understood. This study explored age-related periods of change in social and role functioning. The longitudinal study included youth (aged 12–23, mean follow-up years = 1.19) at clinical high risk (CHR) for psychosis (converters [CHR-C], n = 83; nonconverters [CHR-NC], n = 275) and a healthy control group (n = 164). Mixed-model analyses were performed to determine age-related differences in social and role functioning. We limited our analyses to functioning before psychosis conversion; thus, data of CHR-C participants gathered after psychosis onset were excluded. In controls, social and role functioning improved over time. From at least age 12, functioning in CHR was poorer than in controls, and this lag persisted over time. Between ages 15 and 18, social functioning in CHR-C stagnated and diverged from that of CHR-NC, who continued to improve (p = .001). Subsequently, CHR-C lagged behind in improvement between ages 21 and 23, further distinguishing them from CHR-NC (p < .001). A similar period of stagnation was apparent for role functioning, but to a lesser extent (p = .007). The results remained consistent when we accounted for the time to conversion. Our findings suggest that CHR-C start lagging behind CHR-NC in social and role functioning in adolescence, followed by a period of further stagnation in adulthood. En ligne : https://doi.org/10.1017/S0954579417000451 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=335

Premorbid functional development and conversion to psychosis in clinical high-risk youths / Sarah I. TARBOX in Development and Psychopathology, 25-4 (November 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-4 (November 2013) . - p.1171-1186 Titre : Premorbid functional development and conversion to psychosis in clinical high-risk youths Type de document : Texte imprimé et/ou numérique Auteurs : Sarah I. TARBOX, Auteur ; Jean ADDINGTON, Auteur ; Kristin S. CADENHEAD, Auteur ; Tyrone D. CANNON, Auteur ; Barbara A. CORNBLATT, Auteur ; Diana O. PERKINS, Auteur ; Larry J. SEIDMAN, Auteur ; Ming T. TSUANG, Auteur ; Elaine F. WALKER, Auteur ; Robert HEINSSEN, Auteur ; Thomas H. MCGLASHAN, Auteur ; Scott W. WOODS, Auteur Article en page(s) : p.1171-1186 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Deterioration in premorbid functioning is a common feature of schizophrenia, but sensitivity to psychosis conversion among clinical high-risk samples has not been examined. This study evaluates premorbid functioning as a predictor of psychosis conversion among a clinical high-risk sample, controlling for effects of prior developmental periods. Participants were 270 clinical high-risk individuals in the North American Prodrome Longitudinal Study—I, 78 of whom converted to psychosis over the next 2.5 years. Social, academic, and total maladjustment in childhood, early adolescence, and late adolescence were rated using the Cannon–Spoor Premorbid Adjustment Scale. Early adolescent social dysfunction significantly predicted conversion to psychosis (hazard ratio = 1.30, p = .014), independently of childhood social maladjustment and independently of severity of most baseline positive and negative prodromal symptoms. Baseline prodromal symptoms of disorganized communication, social anhedonia, suspiciousness, and diminished ideational richness mediated this association. Early adolescent social maladjustment and baseline suspiciousness together demonstrated moderate positive predictive power (59%) and high specificity (92.1%) in predicting conversion. Deterioration of academic and total functioning, although observed, did not predict conversion to psychosis. Results indicate early adolescent social dysfunction to be an important early predictor of conversion. As such, it may be a good candidate for inclusion in prediction algorithms and could represent an advantageous target for early intervention. En ligne : http://dx.doi.org/10.1017/S0954579413000448 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] Premorbid functional development and conversion to psychosis in clinical high-risk youths [Texte imprimé et/ou numérique] / Sarah I. TARBOX, Auteur ; Jean ADDINGTON, Auteur ; Kristin S. CADENHEAD, Auteur ; Tyrone D. CANNON, Auteur ; Barbara A. CORNBLATT, Auteur ; Diana O. PERKINS, Auteur ; Larry J. SEIDMAN, Auteur ; Ming T. TSUANG, Auteur ; Elaine F. WALKER, Auteur ; Robert HEINSSEN, Auteur ; Thomas H. MCGLASHAN, Auteur ; Scott W. WOODS, Auteur . - p.1171-1186. Langues : Anglais (eng) in Development and Psychopathology > 25-4 (November 2013) . - p.1171-1186 Index. décimale : PER Périodiques Résumé : Deterioration in premorbid functioning is a common feature of schizophrenia, but sensitivity to psychosis conversion among clinical high-risk samples has not been examined. This study evaluates premorbid functioning as a predictor of psychosis conversion among a clinical high-risk sample, controlling for effects of prior developmental periods. Participants were 270 clinical high-risk individuals in the North American Prodrome Longitudinal Study—I, 78 of whom converted to psychosis over the next 2.5 years. Social, academic, and total maladjustment in childhood, early adolescence, and late adolescence were rated using the Cannon–Spoor Premorbid Adjustment Scale. Early adolescent social dysfunction significantly predicted conversion to psychosis (hazard ratio = 1.30, p = .014), independently of childhood social maladjustment and independently of severity of most baseline positive and negative prodromal symptoms. Baseline prodromal symptoms of disorganized communication, social anhedonia, suspiciousness, and diminished ideational richness mediated this association. Early adolescent social maladjustment and baseline suspiciousness together demonstrated moderate positive predictive power (59%) and high specificity (92.1%) in predicting conversion. Deterioration of academic and total functioning, although observed, did not predict conversion to psychosis. Results indicate early adolescent social dysfunction to be an important early predictor of conversion. As such, it may be a good candidate for inclusion in prediction algorithms and could represent an advantageous target for early intervention. En ligne : http://dx.doi.org/10.1017/S0954579413000448 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

Prenatal inflammation and risk for schizophrenia: A role for immune proteins in neurodevelopment / D. M. ALLSWEDE in Development and Psychopathology, 30-3 (August 2018)  

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Reciprocal social behavior in youths with psychotic illness and those at clinical high risk / Maria JALBRZIKOWSKI in Development and Psychopathology, 25-4 (November 2013)  

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Stress perception following childhood adversity: Unique associations with adversity type and sex / Allison M. LOPILATO in Development and Psychopathology, 32-1 (February 2020)  

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