[article]
| Titre : |
Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Jeremy R. PARR, Auteur ; Ann LE COUTEUR, Auteur ; Gillian BAIRD, Auteur ; Michael RUTTER, Auteur ; Andrew PICKLES, Auteur ; Eric FOMBONNE, Auteur ; Anthony J. BAILEY, Auteur ; INTERNATIONAL MOLECULAR GENETIC STUDY OF AUTISM CONSORTIUM (IMGSAC), Auteur |
| Année de publication : |
2011 |
| Article en page(s) : |
p.332-340 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
ASD Regression Genetics Language Development Concordance |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-010-1055-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 |
in Journal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.332-340
[article] Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample [Texte imprimé et/ou numérique] / Jeremy R. PARR, Auteur ; Ann LE COUTEUR, Auteur ; Gillian BAIRD, Auteur ; Michael RUTTER, Auteur ; Andrew PICKLES, Auteur ; Eric FOMBONNE, Auteur ; Anthony J. BAILEY, Auteur ; INTERNATIONAL MOLECULAR GENETIC STUDY OF AUTISM CONSORTIUM (IMGSAC), Auteur . - 2011 . - p.332-340. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.332-340
| Mots-clés : |
ASD Regression Genetics Language Development Concordance |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-010-1055-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 |
|
Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample in Journal of Autism and Developmental Disorders, 41-3 (March 2011)
