Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders / Benjamin E. YERYS in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.322-333 Titre : Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders Type de document : texte imprimé Auteurs : Benjamin E. YERYS, Auteur ; Gregory L. WALLACE, Auteur ; Lauren KENWORTHY, Auteur ; Jennifer L. SOKOLOFF, Auteur ; Devon A. SHOOK, Auteur ; Joette D. JAMES, Auteur Année de publication : 2009 Article en page(s) : p.322-333 Langues : Anglais (eng) Mots-clés : clinical-psychology neuropsychology school-age Index. décimale : PER Périodiques Résumé : Recent estimates suggest that 31% of children with autism spectrum disorders (ASD) meet diagnostic criteria for attention deficit/hyperactivity disorder (ADHD), and another 24% of children with ASD exhibit subthreshold clinical ADHD symptoms. Presence of ADHD symptoms in the context of ASD could have a variety of effects on cognition, autistic traits, and adaptive/maladaptive behaviors including: exacerbating core ASD impairments; adding unique impairments specific to ADHD; producing new problems unreported in ASD or ADHD; having no clear impact; or producing some combination of these scenarios. Children with ASD and co-morbid ADHD symptoms (ASD+ADHD; n=21), children with ASD without ADHD (ASD; n=28), and a typically developing control group (n=21) were included in the study; all groups were matched on age, gender-ratio, IQ, and socioeconomic status. Data were collected on verbal and spatial working memory, response inhibition, global executive control (EC), autistic traits, adaptive functioning, and maladaptive behavior problems. In this sample, the presence of ADHD symptoms in ASD exacerbated impairments in EC and adaptive behavior and resulted in higher autistic trait, and externalizing behavior ratings. ADHD symptoms were also associated with greater impairments on a lab measure of verbal working memory. These findings suggest that children with ASD+ADHD symptoms present with exacerbated impairments in some but not all domains of functioning relative to children with ASD, most notably in adaptive behavior and working memory. Therefore, ADHD may moderate the expression of components of the ASD cognitive and behavioral phenotype, but ASD+ADHD may not represent an etiologically distinct phenotype from ASD alone. En ligne : http://dx.doi.org/10.1002/aur.103 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968 [article] Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders [texte imprimé] / Benjamin E. YERYS, Auteur ; Gregory L. WALLACE, Auteur ; Lauren KENWORTHY, Auteur ; Jennifer L. SOKOLOFF, Auteur ; Devon A. SHOOK, Auteur ; Joette D. JAMES, Auteur . - 2009 . - p.322-333. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.322-333 Mots-clés : clinical-psychology neuropsychology school-age Index. décimale : PER Périodiques Résumé : Recent estimates suggest that 31% of children with autism spectrum disorders (ASD) meet diagnostic criteria for attention deficit/hyperactivity disorder (ADHD), and another 24% of children with ASD exhibit subthreshold clinical ADHD symptoms. Presence of ADHD symptoms in the context of ASD could have a variety of effects on cognition, autistic traits, and adaptive/maladaptive behaviors including: exacerbating core ASD impairments; adding unique impairments specific to ADHD; producing new problems unreported in ASD or ADHD; having no clear impact; or producing some combination of these scenarios. Children with ASD and co-morbid ADHD symptoms (ASD+ADHD; n=21), children with ASD without ADHD (ASD; n=28), and a typically developing control group (n=21) were included in the study; all groups were matched on age, gender-ratio, IQ, and socioeconomic status. Data were collected on verbal and spatial working memory, response inhibition, global executive control (EC), autistic traits, adaptive functioning, and maladaptive behavior problems. In this sample, the presence of ADHD symptoms in ASD exacerbated impairments in EC and adaptive behavior and resulted in higher autistic trait, and externalizing behavior ratings. ADHD symptoms were also associated with greater impairments on a lab measure of verbal working memory. These findings suggest that children with ASD+ADHD symptoms present with exacerbated impairments in some but not all domains of functioning relative to children with ASD, most notably in adaptive behavior and working memory. Therefore, ADHD may moderate the expression of components of the ASD cognitive and behavioral phenotype, but ASD+ADHD may not represent an etiologically distinct phenotype from ASD alone. En ligne : http://dx.doi.org/10.1002/aur.103 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968

A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder / Philip SHAW in Journal of Child Psychology and Psychiatry, 59-10 (October 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-10 (October 2018) . - p.1114-1123 Titre : A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder Type de document : texte imprimé Auteurs : Philip SHAW, Auteur ; Ayaka ISHII-TAKAHASHI, Auteur ; Min Tae PARK, Auteur ; Gabriel A. DEVENYI, Auteur ; Chava ZIBMAN, Auteur ; Steven W. KASPAREK, Auteur ; Gustavo SUDRE, Auteur ; Aman MANGALMURTI, Auteur ; Martine HOOGMAN, Auteur ; Henning TIEMEIER, Auteur ; Georg G. VON POLIER, Auteur ; Devon SHOOK, Auteur ; Ryan L. MUETZEL, Auteur ; M. Mallar CHAKRAVARTY, Auteur ; Kerstin KONRAD, Auteur ; Sarah DURSTON, Auteur ; Tiffany C. WHITE, Auteur Article en page(s) : p.1114-1123 Langues : Anglais (eng) Mots-clés : Cerebellum attention deficit hyperactivity disorder growth meta-analysis neuroanatomy white matter Index. décimale : PER Périodiques Résumé : BACKGROUND: The cerebellum supports many cognitive functions disrupted in attention deficit hyperactivity disorder (ADHD). Prior neuroanatomic studies have been often limited by small sample sizes, inconsistent findings, and a reliance on cross-sectional data, limiting inferences about cerebellar development. Here, we conduct a multicohort study using longitudinal data, to characterize cerebellar development. METHODS: Growth trajectories of the cerebellar vermis, hemispheres and white matter were estimated using piecewise linear regression from 1,656 youth; of whom 63% had longitudinal data, totaling 2,914 scans. Four cohorts participated, all contained childhood data (age 4-12 years); two had adolescent data (12-25 years). Growth parameters were combined using random-effects meta-analysis. RESULTS: Diagnostic differences in growth were confined to the corpus medullare (cerebellar white matter). Here, the ADHD group showed slower growth in early childhood compared to the typically developing group (left corpus medullare z = 2.49, p = .01; right z = 2.03, p = .04). This reversed in late childhood, with faster growth in ADHD in the left corpus medullare (z = 2.06, p = .04). Findings held when gender, intelligence, comorbidity, and psychostimulant medication were considered. DISCUSSION: Across four independent cohorts, containing predominately longitudinal data, we found diagnostic differences in the growth of cerebellar white matter. In ADHD, slower white matter growth in early childhood was followed by faster growth in late childhood. The findings are consistent with the concept of ADHD as a disorder of the brain's structural connections, formed partly by developing cortico-cerebellar white matter tracts. En ligne : http://dx.doi.org/10.1111/jcpp.12920 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder [texte imprimé] / Philip SHAW, Auteur ; Ayaka ISHII-TAKAHASHI, Auteur ; Min Tae PARK, Auteur ; Gabriel A. DEVENYI, Auteur ; Chava ZIBMAN, Auteur ; Steven W. KASPAREK, Auteur ; Gustavo SUDRE, Auteur ; Aman MANGALMURTI, Auteur ; Martine HOOGMAN, Auteur ; Henning TIEMEIER, Auteur ; Georg G. VON POLIER, Auteur ; Devon SHOOK, Auteur ; Ryan L. MUETZEL, Auteur ; M. Mallar CHAKRAVARTY, Auteur ; Kerstin KONRAD, Auteur ; Sarah DURSTON, Auteur ; Tiffany C. WHITE, Auteur . - p.1114-1123. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-10 (October 2018) . - p.1114-1123 Mots-clés : Cerebellum attention deficit hyperactivity disorder growth meta-analysis neuroanatomy white matter Index. décimale : PER Périodiques Résumé : BACKGROUND: The cerebellum supports many cognitive functions disrupted in attention deficit hyperactivity disorder (ADHD). Prior neuroanatomic studies have been often limited by small sample sizes, inconsistent findings, and a reliance on cross-sectional data, limiting inferences about cerebellar development. Here, we conduct a multicohort study using longitudinal data, to characterize cerebellar development. METHODS: Growth trajectories of the cerebellar vermis, hemispheres and white matter were estimated using piecewise linear regression from 1,656 youth; of whom 63% had longitudinal data, totaling 2,914 scans. Four cohorts participated, all contained childhood data (age 4-12 years); two had adolescent data (12-25 years). Growth parameters were combined using random-effects meta-analysis. RESULTS: Diagnostic differences in growth were confined to the corpus medullare (cerebellar white matter). Here, the ADHD group showed slower growth in early childhood compared to the typically developing group (left corpus medullare z = 2.49, p = .01; right z = 2.03, p = .04). This reversed in late childhood, with faster growth in ADHD in the left corpus medullare (z = 2.06, p = .04). Findings held when gender, intelligence, comorbidity, and psychostimulant medication were considered. DISCUSSION: Across four independent cohorts, containing predominately longitudinal data, we found diagnostic differences in the growth of cerebellar white matter. In ADHD, slower white matter growth in early childhood was followed by faster growth in late childhood. The findings are consistent with the concept of ADHD as a disorder of the brain's structural connections, formed partly by developing cortico-cerebellar white matter tracts. En ligne : http://dx.doi.org/10.1111/jcpp.12920 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

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