Dépouillements

Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics / Suma JACOB in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.293-311 Titre : Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics Type de document : Texte imprimé et/ou numérique Auteurs : Suma JACOB, Auteur ; James F. LECKMAN, Auteur ; Angeli LANDEROS-WEISENBERGER, Auteur Année de publication : 2009 Article en page(s) : p.293-311 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are a phenotypically and etiologically heterogeneous set of disorders that include obsessive-compulsive behaviors (OCB) that partially overlap with symptoms associated with obsessive-compulsive disorder (OCD). The OCB seen in ASD vary depending on the individual's mental and chronological age as well as the etiology of their ASD. Although progress has been made in the measurement of the OCB associated with ASD, more work is needed including the potential identification of heritable endophenotypes. Likewise, important progress toward the understanding of genetic influences in ASD has been made by greater refinement of relevant phenotypes using a broad range of study designs, including twin and family-genetic studies, parametric and nonparametric linkage analyses, as well as candidate gene studies and the study of rare genetic variants. These genetic analyses could lead to the refinement of the OCB phenotypes as larger samples are studied and specific associations are replicated. Like ASD, OCB are likely to prove to be multidimensional and polygenic. Some of the vulnerability genes may prove to be generalist genes influencing the phenotypic expression of both ASD and OCD while others will be specific to subcomponents of the ASD phenotype. In order to discover molecular and genetic mechanisms, collaborative approaches need to generate shared samples, resources, novel genomic technologies, as well as more refined phenotypes and innovative statistical approaches. There is a growing need to identify the range of molecular pathways involved in OCB related to ASD in order to develop novel treatment interventions. En ligne : http://dx.doi.org/10.1002/aur.108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968 [article] Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics [Texte imprimé et/ou numérique] / Suma JACOB, Auteur ; James F. LECKMAN, Auteur ; Angeli LANDEROS-WEISENBERGER, Auteur . - 2009 . - p.293-311. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.293-311 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are a phenotypically and etiologically heterogeneous set of disorders that include obsessive-compulsive behaviors (OCB) that partially overlap with symptoms associated with obsessive-compulsive disorder (OCD). The OCB seen in ASD vary depending on the individual's mental and chronological age as well as the etiology of their ASD. Although progress has been made in the measurement of the OCB associated with ASD, more work is needed including the potential identification of heritable endophenotypes. Likewise, important progress toward the understanding of genetic influences in ASD has been made by greater refinement of relevant phenotypes using a broad range of study designs, including twin and family-genetic studies, parametric and nonparametric linkage analyses, as well as candidate gene studies and the study of rare genetic variants. These genetic analyses could lead to the refinement of the OCB phenotypes as larger samples are studied and specific associations are replicated. Like ASD, OCB are likely to prove to be multidimensional and polygenic. Some of the vulnerability genes may prove to be generalist genes influencing the phenotypic expression of both ASD and OCD while others will be specific to subcomponents of the ASD phenotype. In order to discover molecular and genetic mechanisms, collaborative approaches need to generate shared samples, resources, novel genomic technologies, as well as more refined phenotypes and innovative statistical approaches. There is a growing need to identify the range of molecular pathways involved in OCB related to ASD in order to develop novel treatment interventions. En ligne : http://dx.doi.org/10.1002/aur.108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968

Relative clinical utility of three child symptom inventory-4 scoring algorithms for differentiating children with autism spectrum disorder vs. attention-deficit hyperactivity disorder / Carla DEVINCENT in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.312-321 Titre : Relative clinical utility of three child symptom inventory-4 scoring algorithms for differentiating children with autism spectrum disorder vs. attention-deficit hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Carla DEVINCENT, Auteur ; Kenneth D. GADOW, Auteur Année de publication : 2009 Article en page(s) : p.312-321 Langues : Anglais (eng) Mots-clés : autism-spectrum-disorder Child-Symptom-Inventory-4 autism Asperger's-syndrome PDD-NOS pervasive-developmental-disorder Index. décimale : PER Périodiques Résumé : Objective: The present study compared three separate Child Symptom Inventory-4 (CSI-4) scoring algorithms for differentiating children with autism spectrum disorder (ASD) from youngsters with attention-deficit/hyperactivity disorder (ADHD). Method: Parents/teachers completed the CSI-4, a DSM-IV-referenced rating scale, for 6 to 12-year-old clinical referrals with ASD (N=186) and ADHD (N=251). Algorithms were based on either all CSI-4 items (forward logistic regressions) or the 12 DSM-IV symptoms of pervasive developmental disorder (PDD) included in the CSI-4. Results: ROC analyses indicated generally good to excellent values for area under the curve, sensitivity, specificity, and positive predictive power. Algorithms for parent ratings were superior to teacher ratings. The algorithm based solely on PDD symptoms evidenced the greatest generalizability. Conclusion: Although algorithms generated from regression analyses produced greater clinical utility for specific samples, the PDD-based algorithm resulted in greater stability across samples. En ligne : http://dx.doi.org/10.1002/aur.106 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968 [article] Relative clinical utility of three child symptom inventory-4 scoring algorithms for differentiating children with autism spectrum disorder vs. attention-deficit hyperactivity disorder [Texte imprimé et/ou numérique] / Carla DEVINCENT, Auteur ; Kenneth D. GADOW, Auteur . - 2009 . - p.312-321. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.312-321 Mots-clés : autism-spectrum-disorder Child-Symptom-Inventory-4 autism Asperger's-syndrome PDD-NOS pervasive-developmental-disorder Index. décimale : PER Périodiques Résumé : Objective: The present study compared three separate Child Symptom Inventory-4 (CSI-4) scoring algorithms for differentiating children with autism spectrum disorder (ASD) from youngsters with attention-deficit/hyperactivity disorder (ADHD). Method: Parents/teachers completed the CSI-4, a DSM-IV-referenced rating scale, for 6 to 12-year-old clinical referrals with ASD (N=186) and ADHD (N=251). Algorithms were based on either all CSI-4 items (forward logistic regressions) or the 12 DSM-IV symptoms of pervasive developmental disorder (PDD) included in the CSI-4. Results: ROC analyses indicated generally good to excellent values for area under the curve, sensitivity, specificity, and positive predictive power. Algorithms for parent ratings were superior to teacher ratings. The algorithm based solely on PDD symptoms evidenced the greatest generalizability. Conclusion: Although algorithms generated from regression analyses produced greater clinical utility for specific samples, the PDD-based algorithm resulted in greater stability across samples. En ligne : http://dx.doi.org/10.1002/aur.106 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968

Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders / Benjamin E. YERYS in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.322-333 Titre : Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin E. YERYS, Auteur ; Gregory L. WALLACE, Auteur ; Lauren E. KENWORTHY, Auteur ; Jennifer L. SOKOLOFF, Auteur ; Devon A. SHOOK, Auteur ; Joette D. JAMES, Auteur Année de publication : 2009 Article en page(s) : p.322-333 Langues : Anglais (eng) Mots-clés : clinical-psychology neuropsychology school-age Index. décimale : PER Périodiques Résumé : Recent estimates suggest that 31% of children with autism spectrum disorders (ASD) meet diagnostic criteria for attention deficit/hyperactivity disorder (ADHD), and another 24% of children with ASD exhibit subthreshold clinical ADHD symptoms. Presence of ADHD symptoms in the context of ASD could have a variety of effects on cognition, autistic traits, and adaptive/maladaptive behaviors including: exacerbating core ASD impairments; adding unique impairments specific to ADHD; producing new problems unreported in ASD or ADHD; having no clear impact; or producing some combination of these scenarios. Children with ASD and co-morbid ADHD symptoms (ASD+ADHD; n=21), children with ASD without ADHD (ASD; n=28), and a typically developing control group (n=21) were included in the study; all groups were matched on age, gender-ratio, IQ, and socioeconomic status. Data were collected on verbal and spatial working memory, response inhibition, global executive control (EC), autistic traits, adaptive functioning, and maladaptive behavior problems. In this sample, the presence of ADHD symptoms in ASD exacerbated impairments in EC and adaptive behavior and resulted in higher autistic trait, and externalizing behavior ratings. ADHD symptoms were also associated with greater impairments on a lab measure of verbal working memory. These findings suggest that children with ASD+ADHD symptoms present with exacerbated impairments in some but not all domains of functioning relative to children with ASD, most notably in adaptive behavior and working memory. Therefore, ADHD may moderate the expression of components of the ASD cognitive and behavioral phenotype, but ASD+ADHD may not represent an etiologically distinct phenotype from ASD alone. En ligne : http://dx.doi.org/10.1002/aur.103 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968 [article] Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Benjamin E. YERYS, Auteur ; Gregory L. WALLACE, Auteur ; Lauren E. KENWORTHY, Auteur ; Jennifer L. SOKOLOFF, Auteur ; Devon A. SHOOK, Auteur ; Joette D. JAMES, Auteur . - 2009 . - p.322-333. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.322-333 Mots-clés : clinical-psychology neuropsychology school-age Index. décimale : PER Périodiques Résumé : Recent estimates suggest that 31% of children with autism spectrum disorders (ASD) meet diagnostic criteria for attention deficit/hyperactivity disorder (ADHD), and another 24% of children with ASD exhibit subthreshold clinical ADHD symptoms. Presence of ADHD symptoms in the context of ASD could have a variety of effects on cognition, autistic traits, and adaptive/maladaptive behaviors including: exacerbating core ASD impairments; adding unique impairments specific to ADHD; producing new problems unreported in ASD or ADHD; having no clear impact; or producing some combination of these scenarios. Children with ASD and co-morbid ADHD symptoms (ASD+ADHD; n=21), children with ASD without ADHD (ASD; n=28), and a typically developing control group (n=21) were included in the study; all groups were matched on age, gender-ratio, IQ, and socioeconomic status. Data were collected on verbal and spatial working memory, response inhibition, global executive control (EC), autistic traits, adaptive functioning, and maladaptive behavior problems. In this sample, the presence of ADHD symptoms in ASD exacerbated impairments in EC and adaptive behavior and resulted in higher autistic trait, and externalizing behavior ratings. ADHD symptoms were also associated with greater impairments on a lab measure of verbal working memory. These findings suggest that children with ASD+ADHD symptoms present with exacerbated impairments in some but not all domains of functioning relative to children with ASD, most notably in adaptive behavior and working memory. Therefore, ADHD may moderate the expression of components of the ASD cognitive and behavioral phenotype, but ASD+ADHD may not represent an etiologically distinct phenotype from ASD alone. En ligne : http://dx.doi.org/10.1002/aur.103 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968

Adaptation of object descriptions to a partner under increasing communicative demands: a comparison of children with and without autism / Aparna NADIG in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.334-347 Titre : Adaptation of object descriptions to a partner under increasing communicative demands: a comparison of children with and without autism Type de document : Texte imprimé et/ou numérique Auteurs : Aparna NADIG, Auteur ; Giacomo VIVANTI, Auteur ; Sally OZONOFF, Auteur Année de publication : 2009 Article en page(s) : p.334-347 Langues : Anglais (eng) Mots-clés : social-cognition developmental-psychology Index. décimale : PER Périodiques Résumé : This study compared the object descriptions of school-age children with high-functioning autism (HFA) with those of a matched group of typically developing children. Descriptions were elicited in a referential communication task where shared information was manipulated, and in a guessing game where clues had to be provided about the identity of an object that was hidden from the addressee. Across these tasks, increasingly complex levels of audience design were assessed: (1) the ability to give adequate descriptions from one's own perspective, (2) the ability to adjust descriptions to an addressee's perspective when this differs from one's own, and (3) the ability to provide indirect yet identifying descriptions in a situation where explicit labeling is inappropriate. Results showed that there were group differences in all three cases, with the HFA group giving less efficient descriptions with respect to the relevant context than the comparison group. More revealing was the identification of distinct adaptation profiles among the HFA participants: those who had difficulty with all three levels, those who displayed Level 1 audience design but poor Level 2 and Level 3 design, and those demonstrated all three levels of audience design, like the majority of the comparison group. Higher structural language ability, rather than symptom severity or social skills, differentiated those HFA participants with typical adaptation profiles from those who displayed deficient audience design, consistent with previous reports of language use in autism. En ligne : http://dx.doi.org/10.1002/aur.102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968 [article] Adaptation of object descriptions to a partner under increasing communicative demands: a comparison of children with and without autism [Texte imprimé et/ou numérique] / Aparna NADIG, Auteur ; Giacomo VIVANTI, Auteur ; Sally OZONOFF, Auteur . - 2009 . - p.334-347. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.334-347 Mots-clés : social-cognition developmental-psychology Index. décimale : PER Périodiques Résumé : This study compared the object descriptions of school-age children with high-functioning autism (HFA) with those of a matched group of typically developing children. Descriptions were elicited in a referential communication task where shared information was manipulated, and in a guessing game where clues had to be provided about the identity of an object that was hidden from the addressee. Across these tasks, increasingly complex levels of audience design were assessed: (1) the ability to give adequate descriptions from one's own perspective, (2) the ability to adjust descriptions to an addressee's perspective when this differs from one's own, and (3) the ability to provide indirect yet identifying descriptions in a situation where explicit labeling is inappropriate. Results showed that there were group differences in all three cases, with the HFA group giving less efficient descriptions with respect to the relevant context than the comparison group. More revealing was the identification of distinct adaptation profiles among the HFA participants: those who had difficulty with all three levels, those who displayed Level 1 audience design but poor Level 2 and Level 3 design, and those demonstrated all three levels of audience design, like the majority of the comparison group. Higher structural language ability, rather than symptom severity or social skills, differentiated those HFA participants with typical adaptation profiles from those who displayed deficient audience design, consistent with previous reports of language use in autism. En ligne : http://dx.doi.org/10.1002/aur.102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968

Local vs. global approaches to reproducing the Rey Osterrieth complex figure by children, adolescents, and adults with high-functioning autism / Emily S. KUSCHNER in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.348-358 Titre : Local vs. global approaches to reproducing the Rey Osterrieth complex figure by children, adolescents, and adults with high-functioning autism Type de document : Texte imprimé et/ou numérique Auteurs : Emily S. KUSCHNER, Auteur ; Nancy J. MINSHEW, Auteur ; Kimberly E. BODNER, Auteur Année de publication : 2009 Article en page(s) : p.348-358 Langues : Anglais (eng) Mots-clés : autism visual-processing visuo-spatial-abilities local-processing global-processing strategic-planning problem-solving neural-connectivity Index. décimale : PER Périodiques Résumé : Individuals with autism have an atypical pattern of visual processing. Various studies have provided evidence that individuals with autism perceive the details of stimuli before the gestalt, the reverse of the typical pattern of visual processing. This study used the Rey Osterreith Complex Figure (ROCF) task and an objective scoring system to examine local/global processing approaches to its reproduction in 37 individuals diagnosed with high-functioning autism (HFA) compared to 49 age-, IQ-, and gender-matched typically developing controls (TD). The sample was divided into children (aged 8-14 years) and adolescents/adults (aged 15-47 years) to assess age effects. Results showed no difference in overall performance on the ROCF between HFA and TD children. TD participants displayed improved organizational and planning skills with age and a shift to global processing approaches, but there were no differences in performance between children and adolescents/adults with HFA. There was no evidence of enhanced local processing in either HFA group. These findings suggest that HFA individuals with average IQ scores do not have the clinically demonstrable evidence of the enhanced local processing thought to reflect increased local brain connectivity in more severely autistic individuals. The deficient global processing of the HFA adults reflects dependence of performance on impaired strategic problem-solving abilities, which has been demonstrated to result from under development of neural connectivity between visuo-spatial and frontal brain regions in HFA adults. En ligne : http://dx.doi.org/10.1002/aur.101 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968 [article] Local vs. global approaches to reproducing the Rey Osterrieth complex figure by children, adolescents, and adults with high-functioning autism [Texte imprimé et/ou numérique] / Emily S. KUSCHNER, Auteur ; Nancy J. MINSHEW, Auteur ; Kimberly E. BODNER, Auteur . - 2009 . - p.348-358. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.348-358 Mots-clés : autism visual-processing visuo-spatial-abilities local-processing global-processing strategic-planning problem-solving neural-connectivity Index. décimale : PER Périodiques Résumé : Individuals with autism have an atypical pattern of visual processing. Various studies have provided evidence that individuals with autism perceive the details of stimuli before the gestalt, the reverse of the typical pattern of visual processing. This study used the Rey Osterreith Complex Figure (ROCF) task and an objective scoring system to examine local/global processing approaches to its reproduction in 37 individuals diagnosed with high-functioning autism (HFA) compared to 49 age-, IQ-, and gender-matched typically developing controls (TD). The sample was divided into children (aged 8-14 years) and adolescents/adults (aged 15-47 years) to assess age effects. Results showed no difference in overall performance on the ROCF between HFA and TD children. TD participants displayed improved organizational and planning skills with age and a shift to global processing approaches, but there were no differences in performance between children and adolescents/adults with HFA. There was no evidence of enhanced local processing in either HFA group. These findings suggest that HFA individuals with average IQ scores do not have the clinically demonstrable evidence of the enhanced local processing thought to reflect increased local brain connectivity in more severely autistic individuals. The deficient global processing of the HFA adults reflects dependence of performance on impaired strategic problem-solving abilities, which has been demonstrated to result from under development of neural connectivity between visuo-spatial and frontal brain regions in HFA adults. En ligne : http://dx.doi.org/10.1002/aur.101 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968

Copy number and sequence variants implicate APBA2 as an autism candidate gene / Timothy D. BABATZ in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.359-364 Titre : Copy number and sequence variants implicate APBA2 as an autism candidate gene Type de document : Texte imprimé et/ou numérique Auteurs : Timothy D. BABATZ, Auteur ; Ravinesh A. KUMAR, Auteur ; Jyotsna SUDI, Auteur ; William B. DOBYNS, Auteur ; Susan L. CHRISTIAN, Auteur Année de publication : 2009 Article en page(s) : p.359-364 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We recently reported an autistic proband and affected sibling with maternally inherited microduplications within the 15q13.1 and 15q13.3 regions that contain a total of 4 genes. The amyloid precursor protein-binding protein A2 (APBA2) gene is located within the 15q13.1 duplication and encodes a neuronal adaptor protein essential to synaptic transmission that interacts directly with NRXN1 at the presynaptic membrane. We interpreted this as evidence for a putative role of APBA2 in autism as larger maternal duplications of 15q11-q13 are the most common known cause of autism. We therefore resequenced 512 subjects with autism spectrum disorder (ASD) and 463 controls, and identified 7 novel nonsynonymous coding variants in ASD subjects compared with 4 in controls. Five of the seven variants in the ASD group were predicted to affect protein function, alter residues conserved across 18 species, or both. All of the variants for which parental DNA was available were inherited. We also found two different nonsynonymous variants in two siblings with autism: (1) a paternally inherited heterozygous 6 bp deletion and (2) a maternally inherited heterozygous missense mutation, the latter also found in a single control. These results indicate compound heterozygous mutations of APBA2 in this autism sibship. The co-occurrence of two nonsynonymous mutations in both affected siblings in a single family, each transmitted from a different unaffected parent, suggest a role for APBA2 mutations in rare individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968 [article] Copy number and sequence variants implicate APBA2 as an autism candidate gene [Texte imprimé et/ou numérique] / Timothy D. BABATZ, Auteur ; Ravinesh A. KUMAR, Auteur ; Jyotsna SUDI, Auteur ; William B. DOBYNS, Auteur ; Susan L. CHRISTIAN, Auteur . - 2009 . - p.359-364. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.359-364 Index. décimale : PER Périodiques Résumé : We recently reported an autistic proband and affected sibling with maternally inherited microduplications within the 15q13.1 and 15q13.3 regions that contain a total of 4 genes. The amyloid precursor protein-binding protein A2 (APBA2) gene is located within the 15q13.1 duplication and encodes a neuronal adaptor protein essential to synaptic transmission that interacts directly with NRXN1 at the presynaptic membrane. We interpreted this as evidence for a putative role of APBA2 in autism as larger maternal duplications of 15q11-q13 are the most common known cause of autism. We therefore resequenced 512 subjects with autism spectrum disorder (ASD) and 463 controls, and identified 7 novel nonsynonymous coding variants in ASD subjects compared with 4 in controls. Five of the seven variants in the ASD group were predicted to affect protein function, alter residues conserved across 18 species, or both. All of the variants for which parental DNA was available were inherited. We also found two different nonsynonymous variants in two siblings with autism: (1) a paternally inherited heterozygous 6 bp deletion and (2) a maternally inherited heterozygous missense mutation, the latter also found in a single control. These results indicate compound heterozygous mutations of APBA2 in this autism sibship. The co-occurrence of two nonsynonymous mutations in both affected siblings in a single family, each transmitted from a different unaffected parent, suggest a role for APBA2 mutations in rare individuals with ASD. En ligne : http://dx.doi.org/10.1002/aur.107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968

Literature review: Similar prevalence of ASD across the life span; amygdala enlargement in young children / Edwin H. Jr COOK in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.365-366 Titre : Literature review: Similar prevalence of ASD across the life span; amygdala enlargement in young children Type de document : Texte imprimé et/ou numérique Auteurs : Edwin H. Jr COOK, Auteur Année de publication : 2009 Article en page(s) : p.365-366 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.112 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968 [article] Literature review: Similar prevalence of ASD across the life span; amygdala enlargement in young children [Texte imprimé et/ou numérique] / Edwin H. Jr COOK, Auteur . - 2009 . - p.365-366. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.365-366 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.112 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968

Lay abstracts in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.367-369 Titre : Lay abstracts Type de document : Texte imprimé et/ou numérique Année de publication : 2009 Article en page(s) : p.367-369 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=969 [article] Lay abstracts [Texte imprimé et/ou numérique] . - 2009 . - p.367-369. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.367-369 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=969

The International Meeting for Autism Research in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.370-371 Titre : The International Meeting for Autism Research Type de document : Texte imprimé et/ou numérique Année de publication : 2009 Article en page(s) : p.370-371 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.114 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=969 [article] The International Meeting for Autism Research [Texte imprimé et/ou numérique] . - 2009 . - p.370-371. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.370-371 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.114 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=969

International Society for Autism Research News in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.372 Titre : International Society for Autism Research News Type de document : Texte imprimé et/ou numérique Année de publication : 2009 Article en page(s) : p.372 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=969 [article] International Society for Autism Research News [Texte imprimé et/ou numérique] . - 2009 . - p.372. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.372 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=969