Brief Report: Biological Sound Processing in Children with Autistic Spectrum Disorder / Melissa LORTIE in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1904-1909 Titre : Brief Report: Biological Sound Processing in Children with Autistic Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Melissa LORTIE, Auteur ; Léa PROULX-BEGIN, Auteur ; Dave SAINT-AMOUR, Auteur ; Dominique COUSINEAU, Auteur ; Hugo THEORET, Auteur ; Jean-François LEPAGE, Auteur Article en page(s) : p.1904-1909 Langues : Anglais (eng) Mots-clés : Social impairments  Event related potentials  EEG  Biological actions  Auditory  Attention  Novelty detection  MMN  P3 Index. décimale : PER Périodiques Résumé : There is debate whether social impairments in autism spectrum disorder (ASD) are truly domain-specific, or if they reflect generalized deficits in lower-level cognitive processes. To solve this issue, we used auditory-evoked EEG responses to assess novelty detection (MMN component) and involuntary attentional orientation (P3 component) induced by socially-relevant, human-produced, biological sounds and acoustically-matched control stimuli in children with ASD and controls. Results show that early sensory and novelty processing of biological stimuli are preserved in ASD, but that automatic attentional orientation for biological sounds is markedly altered. These results support the notion that at least some cognitive processes of ASD are specifically altered when it comes to processing social stimuli. En ligne : http://dx.doi.org/10.1007/s10803-017-3093-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Brief Report: Biological Sound Processing in Children with Autistic Spectrum Disorder [Texte imprimé et/ou numérique] / Melissa LORTIE, Auteur ; Léa PROULX-BEGIN, Auteur ; Dave SAINT-AMOUR, Auteur ; Dominique COUSINEAU, Auteur ; Hugo THEORET, Auteur ; Jean-François LEPAGE, Auteur . - p.1904-1909. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1904-1909 Mots-clés : Social impairments  Event related potentials  EEG  Biological actions  Auditory  Attention  Novelty detection  MMN  P3 Index. décimale : PER Périodiques Résumé : There is debate whether social impairments in autism spectrum disorder (ASD) are truly domain-specific, or if they reflect generalized deficits in lower-level cognitive processes. To solve this issue, we used auditory-evoked EEG responses to assess novelty detection (MMN component) and involuntary attentional orientation (P3 component) induced by socially-relevant, human-produced, biological sounds and acoustically-matched control stimuli in children with ASD and controls. Results show that early sensory and novelty processing of biological stimuli are preserved in ASD, but that automatic attentional orientation for biological sounds is markedly altered. These results support the notion that at least some cognitive processes of ASD are specifically altered when it comes to processing social stimuli. En ligne : http://dx.doi.org/10.1007/s10803-017-3093-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Cerebellar Transcranial Direct Current Stimulation in Children with Developmental Coordination Disorder: A Randomized, Double-Blind, Sham-Controlled Pilot Study / Haifa AKREMI in Journal of Autism and Developmental Disorders, 52-7 (July 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3202-3213 Titre : Cerebellar Transcranial Direct Current Stimulation in Children with Developmental Coordination Disorder: A Randomized, Double-Blind, Sham-Controlled Pilot Study Type de document : Texte imprimé et/ou numérique Auteurs : Haifa AKREMI, Auteur ; Raphaël HAMEL, Auteur ; Anne DUMAS, Auteur ; Chantal CAMDEN, Auteur ; Hélène CORRIVEAU, Auteur ; Jean-François LEPAGE, Auteur Article en page(s) : p.3202-3213 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Cerebellum  Child  Double-Blind Method  Humans  Motor Skills Disorders/therapy  Pilot Projects  Transcranial Direct Current Stimulation/methods  Motor learning  Neurodevelopmental disorders  Neurostimulation  Transcranial direct current stimulation (tDCS) Index. décimale : PER Périodiques Résumé : Evidence-based therapeutic options for children with developmental coordination disorder (DCD) are scarce. This work explored the effects of cerebellar anodal transcranial direct current stimulation (atDCS) on three 48 h-apart motor sequence learning and upper limb coordination sessions in children with DCD. The results revealed that, as compared to a Sham intervention (n=10), cerebellar atDCS (n=10) did not meaningfully improve execution speed but tended to reduce the number of execution errors during motor sequence learning. However, cerebellar atDCS did neither meaningfully influence offline learning nor upper limb coordination, suggesting that atDCS' effects are circumscribed to its application duration. These results suggest that cerebellar atDCS could have beneficial effects as a complementary therapeutic tool for children with DCD. En ligne : http://dx.doi.org/10.1007/s10803-021-05202-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Cerebellar Transcranial Direct Current Stimulation in Children with Developmental Coordination Disorder: A Randomized, Double-Blind, Sham-Controlled Pilot Study [Texte imprimé et/ou numérique] / Haifa AKREMI, Auteur ; Raphaël HAMEL, Auteur ; Anne DUMAS, Auteur ; Chantal CAMDEN, Auteur ; Hélène CORRIVEAU, Auteur ; Jean-François LEPAGE, Auteur . - p.3202-3213. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3202-3213 Mots-clés : Autism Spectrum Disorder  Cerebellum  Child  Double-Blind Method  Humans  Motor Skills Disorders/therapy  Pilot Projects  Transcranial Direct Current Stimulation/methods  Motor learning  Neurodevelopmental disorders  Neurostimulation  Transcranial direct current stimulation (tDCS) Index. décimale : PER Périodiques Résumé : Evidence-based therapeutic options for children with developmental coordination disorder (DCD) are scarce. This work explored the effects of cerebellar anodal transcranial direct current stimulation (atDCS) on three 48 h-apart motor sequence learning and upper limb coordination sessions in children with DCD. The results revealed that, as compared to a Sham intervention (n=10), cerebellar atDCS (n=10) did not meaningfully improve execution speed but tended to reduce the number of execution errors during motor sequence learning. However, cerebellar atDCS did neither meaningfully influence offline learning nor upper limb coordination, suggesting that atDCS' effects are circumscribed to its application duration. These results suggest that cerebellar atDCS could have beneficial effects as a complementary therapeutic tool for children with DCD. En ligne : http://dx.doi.org/10.1007/s10803-021-05202-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Neurophysiological effects of a combined treatment of lovastatin and minocycline in patients with fragile X syndrome: Ancillary results of the LOVAMIX randomized clinical trial / Camille CHAMPIGNY ; Samantha CÔTÉ ; Teddy MOHAMAD ; Seyede Anis HASANI ; Artuela ÇAKU ; François CORBIN ; Jean-François LEPAGE in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1944-1956 Titre : Neurophysiological effects of a combined treatment of lovastatin and minocycline in patients with fragile X syndrome: Ancillary results of the LOVAMIX randomized clinical trial Type de document : Texte imprimé et/ou numérique Auteurs : Camille CHAMPIGNY, Auteur ; Samantha CÔTÉ, Auteur ; Teddy MOHAMAD, Auteur ; Seyede Anis HASANI, Auteur ; Artuela ÇAKU, Auteur ; François CORBIN, Auteur ; Jean-François LEPAGE, Auteur Article en page(s) : p.1944-1956 Langues : Anglais (eng) Mots-clés : dual therapy  fragile X syndrome  lovastatin  minocycline  transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : Abstract Fragile X syndrome (FXS) is the primary hereditary cause of intellectual disability and autism spectrum disorder. It is characterized by exacerbated neuronal excitability, and its correction is considered an objective measure of treatment response in animal models, a marker albeit rarely used in clinical trials. Here, we used an extensive transcranial magnetic stimulation (TMS) battery to assess the neurophysiological effects of a therapy combining two disease-modifying drugs, lovastatin (40?mg) and minocycline (100?mg), administered alone for 8?weeks and in combination for 12?weeks, in 19 patients (mean age of 23.58?+?1.51) with FXS taking part in the LOVAmix trial. The TMS battery, which included the resting motor threshold, short-interval intracortical inhibition, long-interval intracortical inhibition, corticospinal silent period, and intracortical facilitation, was completed at baseline after 8?weeks of monotherapy (visit 2 of the clinical trial) and after 12?weeks of dual therapy (visit 4 of the clinical trial). Repeated measure ANOVAs were performed between baseline and visit 2 (monotherapy) and visit 3 (dual therapy) with interactions for which monotherapy the participants received when they began the clinical trial. Results showed that dual therapy was associated with reduced cortical excitability after 20?weeks. This was reflected by a significant increase in the resting-motor threshold after dual therapy compared to baseline. There was a tendency for enhanced short-intracortical inhibition, a marker of GABAa-mediated inhibition after 8?weeks of monotherapy compared to baseline. Together, these results suggest that a combined therapy of minocycline and lovastatin might act on the core neurophysiopathology of FXS. This trial was registered at clinicaltrials.gov (NCT02680379). En ligne : https://doi.org/10.1002/aur.3222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Neurophysiological effects of a combined treatment of lovastatin and minocycline in patients with fragile X syndrome: Ancillary results of the LOVAMIX randomized clinical trial [Texte imprimé et/ou numérique] / Camille CHAMPIGNY, Auteur ; Samantha CÔTÉ, Auteur ; Teddy MOHAMAD, Auteur ; Seyede Anis HASANI, Auteur ; Artuela ÇAKU, Auteur ; François CORBIN, Auteur ; Jean-François LEPAGE, Auteur . - p.1944-1956. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1944-1956 Mots-clés : dual therapy  fragile X syndrome  lovastatin  minocycline  transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : Abstract Fragile X syndrome (FXS) is the primary hereditary cause of intellectual disability and autism spectrum disorder. It is characterized by exacerbated neuronal excitability, and its correction is considered an objective measure of treatment response in animal models, a marker albeit rarely used in clinical trials. Here, we used an extensive transcranial magnetic stimulation (TMS) battery to assess the neurophysiological effects of a therapy combining two disease-modifying drugs, lovastatin (40?mg) and minocycline (100?mg), administered alone for 8?weeks and in combination for 12?weeks, in 19 patients (mean age of 23.58?+?1.51) with FXS taking part in the LOVAmix trial. The TMS battery, which included the resting motor threshold, short-interval intracortical inhibition, long-interval intracortical inhibition, corticospinal silent period, and intracortical facilitation, was completed at baseline after 8?weeks of monotherapy (visit 2 of the clinical trial) and after 12?weeks of dual therapy (visit 4 of the clinical trial). Repeated measure ANOVAs were performed between baseline and visit 2 (monotherapy) and visit 3 (dual therapy) with interactions for which monotherapy the participants received when they began the clinical trial. Results showed that dual therapy was associated with reduced cortical excitability after 20?weeks. This was reflected by a significant increase in the resting-motor threshold after dual therapy compared to baseline. There was a tendency for enhanced short-intracortical inhibition, a marker of GABAa-mediated inhibition after 8?weeks of monotherapy compared to baseline. Together, these results suggest that a combined therapy of minocycline and lovastatin might act on the core neurophysiopathology of FXS. This trial was registered at clinicaltrials.gov (NCT02680379). En ligne : https://doi.org/10.1002/aur.3222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

The Neurophysiology of Early Motor Resonance / François CHAMPOUX

Public ISBD contenu dans Mirror Neuron Systems / Jaime A. PINEDA Titre : The Neurophysiology of Early Motor Resonance Type de document : Texte imprimé et/ou numérique Auteurs : François CHAMPOUX, Auteur ; Jean-François LEPAGE, Auteur ; Christine DESY, Auteur ; Mélissa LORTI, Auteur ; Hugo THEORET, Auteur Année de publication : 2009 Importance : p.63-76 Langues : Anglais (eng) Index. décimale : PAR-G PAR-G - Imitation Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=995 contenu dans Mirror Neuron Systems / Jaime A. PINEDA The Neurophysiology of Early Motor Resonance [Texte imprimé et/ou numérique] / François CHAMPOUX, Auteur ; Jean-François LEPAGE, Auteur ; Christine DESY, Auteur ; Mélissa LORTI, Auteur ; Hugo THEORET, Auteur . - 2009 . - p.63-76. Langues : Anglais (eng) Index. décimale : PAR-G PAR-G - Imitation Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=995

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