Dépouillements

Autistic-relevant behavioral phenotypes of a mouse model of cyclin-dependent kinase-like 5 deficiency disorder / Oceane COIFFARD ; Celeste FERRAGUTO ; Athanasios MANOLIS ; Elisabetta CIANI ; Susanna PIETROPAOLO in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1742-1759 Titre : Autistic-relevant behavioral phenotypes of a mouse model of cyclin-dependent kinase-like 5 deficiency disorder Type de document : Texte imprimé et/ou numérique Auteurs : Oceane COIFFARD, Auteur ; Celeste FERRAGUTO, Auteur ; Athanasios MANOLIS, Auteur ; Elisabetta CIANI, Auteur ; Susanna PIETROPAOLO, Auteur Article en page(s) : p.1742-1759 Langues : Anglais (eng) Mots-clés : acoustic startle  CDD  mouse pups  neurodevelopmental disorders  social behaviors  social interaction  ultrasonic vocalizations Index. décimale : PER Périodiques Résumé : Abstract Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene and characterized by early-onset epilepsy, intellectual disability, and autistic features. To date, the etiological mechanisms underlying CDD are largely unknown and no effective therapies are available. The Cdkl5 knock-out (KO) mouse has been broadly employed in preclinical studies on CDD; Cdkl5-KO mice display neurobehavioral abnormalities recapitulating most CDD symptoms, including alterations in motor, sensory, cognitive, and social abilities. However, most available preclinical studies have been carried out on adult Cdkl5-KO mice, so little is known about the phenotypic characteristics of this model earlier during development. Furthermore, major autistic-relevant phenotypes, for example, social and communication deficits, have been poorly investigated and mostly in male mutants. Here, we assessed the autistic-relevant behavioral phenotypes of Cdkl5-KO mice during the first three post-natal weeks and in adulthood. Males and females were tested, the latter including both heterozygous and homozygous mutants. Cdkl5 mutant pups showed qualitative and quantitative alterations in ultrasonic communication, detected first at 2?weeks of age and confirmed later in adulthood. Increased levels of anxiety-like behaviors were observed in mutants at 3?weeks and in adulthood, when stereotypies, reduced social interaction and memory deficits were also observed. These behavioral effects of the mutation were evident in both sexes, being more marked and varied in homozygous than heterozygous females. These findings provide novel evidence for the autistic-relevant behavioral profile of the Cdkl5 mouse model, thus supporting its use in future preclinical studies investigating CDD pathology and autism spectrum disorders. En ligne : https://doi.org/10.1002/aur.3226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Autistic-relevant behavioral phenotypes of a mouse model of cyclin-dependent kinase-like 5 deficiency disorder [Texte imprimé et/ou numérique] / Oceane COIFFARD, Auteur ; Celeste FERRAGUTO, Auteur ; Athanasios MANOLIS, Auteur ; Elisabetta CIANI, Auteur ; Susanna PIETROPAOLO, Auteur . - p.1742-1759. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1742-1759 Mots-clés : acoustic startle  CDD  mouse pups  neurodevelopmental disorders  social behaviors  social interaction  ultrasonic vocalizations Index. décimale : PER Périodiques Résumé : Abstract Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene and characterized by early-onset epilepsy, intellectual disability, and autistic features. To date, the etiological mechanisms underlying CDD are largely unknown and no effective therapies are available. The Cdkl5 knock-out (KO) mouse has been broadly employed in preclinical studies on CDD; Cdkl5-KO mice display neurobehavioral abnormalities recapitulating most CDD symptoms, including alterations in motor, sensory, cognitive, and social abilities. However, most available preclinical studies have been carried out on adult Cdkl5-KO mice, so little is known about the phenotypic characteristics of this model earlier during development. Furthermore, major autistic-relevant phenotypes, for example, social and communication deficits, have been poorly investigated and mostly in male mutants. Here, we assessed the autistic-relevant behavioral phenotypes of Cdkl5-KO mice during the first three post-natal weeks and in adulthood. Males and females were tested, the latter including both heterozygous and homozygous mutants. Cdkl5 mutant pups showed qualitative and quantitative alterations in ultrasonic communication, detected first at 2?weeks of age and confirmed later in adulthood. Increased levels of anxiety-like behaviors were observed in mutants at 3?weeks and in adulthood, when stereotypies, reduced social interaction and memory deficits were also observed. These behavioral effects of the mutation were evident in both sexes, being more marked and varied in homozygous than heterozygous females. These findings provide novel evidence for the autistic-relevant behavioral profile of the Cdkl5 mouse model, thus supporting its use in future preclinical studies investigating CDD pathology and autism spectrum disorders. En ligne : https://doi.org/10.1002/aur.3226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Somatosensory temporal sensitivity in adults on the autism spectrum: A high-density electrophysiological mapping study using the mismatch negativity (MMN) sensory memory paradigm / Edward G. FREEDMAN ; Sophie MOLHOLM ; John J. FOXE in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1760-1777 Titre : Somatosensory temporal sensitivity in adults on the autism spectrum: A high-density electrophysiological mapping study using the mismatch negativity (MMN) sensory memory paradigm Type de document : Texte imprimé et/ou numérique Auteurs : Edward G. FREEDMAN, Auteur ; Sophie MOLHOLM, Auteur ; John J. FOXE, Auteur Article en page(s) : p.1760-1777 Langues : Anglais (eng) Mots-clés : ASD  autism spectrum disorder  SEP  tactile processing Index. décimale : PER Périodiques Résumé : Abstract Atypical reactivity to somatosensory inputs is common in autism spectrum disorder and carries considerable impact on downstream social communication and quality of life. While behavioral and survey work have established differences in the perception of somatosensory information, little has been done to elucidate the underlying neurophysiological processes that drive these characteristics. Here, we implemented a duration-based somatosensory mismatch negativity (MMN) paradigm to examine the role of temporal sensitivity and sensory memory in the processing of vibrotactile information in autistic (n?=?30) and neurotypical (n?=?30) adults. To capture the variability in responses between groups across a range of duration discrepancies, we compared the electrophysiological responses to frequent standard vibrations (100?ms) and four infrequent deviant vibrations (115, 130, 145, and 160?ms). The same stimuli were used in a follow-up behavioral task to determine active detection of the infrequent vibrations. We found no differences between the two groups with regard to discrimination between standard and deviant vibrations, demonstrating comparable neurologic and behavioral temporal somatosensory perception. However, exploratory analyses yielded subtle differences in amplitude at the N1 and P220 time points. Together, these results indicate that the temporal mechanisms of somatosensory discrimination are conserved in adults on the autism spectrum, though more general somatosensory processing may be affected. We discuss these findings in the broader context of the MMN literature in autism, as well as the potential role of cortical maturity in somatosensory mechanisms. En ligne : https://doi.org/10.1002/aur.3186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Somatosensory temporal sensitivity in adults on the autism spectrum: A high-density electrophysiological mapping study using the mismatch negativity (MMN) sensory memory paradigm [Texte imprimé et/ou numérique] / Edward G. FREEDMAN, Auteur ; Sophie MOLHOLM, Auteur ; John J. FOXE, Auteur . - p.1760-1777. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1760-1777 Mots-clés : ASD  autism spectrum disorder  SEP  tactile processing Index. décimale : PER Périodiques Résumé : Abstract Atypical reactivity to somatosensory inputs is common in autism spectrum disorder and carries considerable impact on downstream social communication and quality of life. While behavioral and survey work have established differences in the perception of somatosensory information, little has been done to elucidate the underlying neurophysiological processes that drive these characteristics. Here, we implemented a duration-based somatosensory mismatch negativity (MMN) paradigm to examine the role of temporal sensitivity and sensory memory in the processing of vibrotactile information in autistic (n?=?30) and neurotypical (n?=?30) adults. To capture the variability in responses between groups across a range of duration discrepancies, we compared the electrophysiological responses to frequent standard vibrations (100?ms) and four infrequent deviant vibrations (115, 130, 145, and 160?ms). The same stimuli were used in a follow-up behavioral task to determine active detection of the infrequent vibrations. We found no differences between the two groups with regard to discrimination between standard and deviant vibrations, demonstrating comparable neurologic and behavioral temporal somatosensory perception. However, exploratory analyses yielded subtle differences in amplitude at the N1 and P220 time points. Together, these results indicate that the temporal mechanisms of somatosensory discrimination are conserved in adults on the autism spectrum, though more general somatosensory processing may be affected. We discuss these findings in the broader context of the MMN literature in autism, as well as the potential role of cortical maturity in somatosensory mechanisms. En ligne : https://doi.org/10.1002/aur.3186 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Reduced spatial frequency differentiation and sex-related specificities in fearful face detection in autism: Insights from EEG and the predictive brain model / Sylvain HARQUEL ; Leonardo S. BARBOSA ; Klara KOVARSKI ; Marta I. GARRIDO ; Laurent VERCUEIL ; Louise KAUFFMANN ; Frédéric DUTHEIL ; Marie GOMOT ; Martial MERMILLOD in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1778-1795 Titre : Reduced spatial frequency differentiation and sex-related specificities in fearful face detection in autism: Insights from EEG and the predictive brain model Type de document : Texte imprimé et/ou numérique Auteurs : Sylvain HARQUEL, Auteur ; Leonardo S. BARBOSA, Auteur ; Klara KOVARSKI, Auteur ; Marta I. GARRIDO, Auteur ; Laurent VERCUEIL, Auteur ; Louise KAUFFMANN, Auteur ; Frédéric DUTHEIL, Auteur ; Marie GOMOT, Auteur ; Martial MERMILLOD, Auteur Article en page(s) : p.1778-1795 Langues : Anglais (eng) Mots-clés : autism  EEG  emotion recognition  fusiform  sex differences  spatial frequencies Index. décimale : PER Périodiques Résumé : Abstract Face processing relies on predictive processes driven by low spatial frequencies (LSF) that convey coarse information prior to fine information conveyed by high spatial frequencies. However, autistic individuals might have atypical predictive processes, contributing to facial processing difficulties. This may be more normalized in autistic females, who often exhibit better socio-communicational abilities than males. We hypothesized that autistic females would display a more typical coarse-to-fine processing for socio-emotional stimuli compared to autistic males. To test this hypothesis, we asked adult participants (44 autistic, 51 non-autistic) to detect fearful faces among neutral faces, filtered in two orders: from coarse-to-fine (CtF) and from fine-to-coarse (FtC). Results show lower d? values and longer reaction times for fearful detection in autism compared to non-autistic (NA) individuals, regardless of the filtering order. Both groups presented shorter P100 latency after CtF compared to FtC, and larger amplitude for N170 after FtC compared to CtF. However, autistic participants presented a reduced difference in source activity between CtF and FtC in the fusiform. There was also a more spatially spread activation pattern in autistic females compared to NA females. Finally, females had faster P100 and N170 latencies, as well as larger occipital activation for FtC sequences than males, irrespective of the group. Overall, the results do not suggest impaired predictive processes from LSF in autism despite behavioral differences in fear detection. However, they do indicate reduced brain modulation by spatial frequency in autism. In addition, the findings highlight sex differences that warrant consideration in understanding autistic females. En ligne : https://doi.org/10.1002/aur.3209 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Reduced spatial frequency differentiation and sex-related specificities in fearful face detection in autism: Insights from EEG and the predictive brain model [Texte imprimé et/ou numérique] / Sylvain HARQUEL, Auteur ; Leonardo S. BARBOSA, Auteur ; Klara KOVARSKI, Auteur ; Marta I. GARRIDO, Auteur ; Laurent VERCUEIL, Auteur ; Louise KAUFFMANN, Auteur ; Frédéric DUTHEIL, Auteur ; Marie GOMOT, Auteur ; Martial MERMILLOD, Auteur . - p.1778-1795. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1778-1795 Mots-clés : autism  EEG  emotion recognition  fusiform  sex differences  spatial frequencies Index. décimale : PER Périodiques Résumé : Abstract Face processing relies on predictive processes driven by low spatial frequencies (LSF) that convey coarse information prior to fine information conveyed by high spatial frequencies. However, autistic individuals might have atypical predictive processes, contributing to facial processing difficulties. This may be more normalized in autistic females, who often exhibit better socio-communicational abilities than males. We hypothesized that autistic females would display a more typical coarse-to-fine processing for socio-emotional stimuli compared to autistic males. To test this hypothesis, we asked adult participants (44 autistic, 51 non-autistic) to detect fearful faces among neutral faces, filtered in two orders: from coarse-to-fine (CtF) and from fine-to-coarse (FtC). Results show lower d? values and longer reaction times for fearful detection in autism compared to non-autistic (NA) individuals, regardless of the filtering order. Both groups presented shorter P100 latency after CtF compared to FtC, and larger amplitude for N170 after FtC compared to CtF. However, autistic participants presented a reduced difference in source activity between CtF and FtC in the fusiform. There was also a more spatially spread activation pattern in autistic females compared to NA females. Finally, females had faster P100 and N170 latencies, as well as larger occipital activation for FtC sequences than males, irrespective of the group. Overall, the results do not suggest impaired predictive processes from LSF in autism despite behavioral differences in fear detection. However, they do indicate reduced brain modulation by spatial frequency in autism. In addition, the findings highlight sex differences that warrant consideration in understanding autistic females. En ligne : https://doi.org/10.1002/aur.3209 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Sex heterogeneity of dynamic brain activity and functional connectivity in autism spectrum disorder / Qi DONG ; Le GAO ; Zaifa XUE ; Xiaoxia NIU ; Rongjuan ZHOU ; Xiaonan GUO in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1796-1809 Titre : Sex heterogeneity of dynamic brain activity and functional connectivity in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Qi DONG, Auteur ; Le GAO, Auteur ; Zaifa XUE, Auteur ; Xiaoxia NIU, Auteur ; Rongjuan ZHOU, Auteur ; Xiaonan GUO, Auteur Article en page(s) : p.1796-1809 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  dynamic amplitude of low-frequency fluctuation  dynamic functional connectivity  resting-state functional magnetic resonance imaging  sex heterogeneity Index. décimale : PER Périodiques Résumé : Abstract Sex heterogeneity has been frequently reported in autism spectrum disorders (ASD) and has been linked to static differences in brain function. However, given the complexity of ASD and diagnosis-by-sex interactions, dynamic characteristics of brain activity and functional connectivity may provide important information for distinguishing ASD phenotypes between females and males. The aim of this study was to explore sex heterogeneity of functional networks in the ASD brain from a dynamic perspective. Resting-state functional magnetic resonance imaging data from the Autism Brain Imaging Data Exchange database were analyzed in 128 ASD subjects (64 males/64 females) and 128 typically developing control (TC) subjects (64 males/64 females). A sliding-window approach was adopted for the estimation of dynamic amplitude of low-frequency fluctuation (dALFF) and dynamic functional connectivity (dFC) to characterize time-varying brain activity and functional connectivity respectively. We then examined the sex-related changes in ASD using two-way analysis of variance. Significant diagnosis-by-sex interaction effects were identified in the left anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC) and left precuneus in the dALFF analysis. Furthermore, there were significant diagnosis-by-sex interaction effects of dFC variance between the left ACC/mPFC and right ACC, left postcentral gyrus, left precuneus, right middle temporal gyrus and left inferior frontal gyrus, triangular part. These findings reveal the sex heterogeneity in brain activity and functional connectivity in ASD from a dynamic perspective, and provide new evidence for further exploring sex heterogeneity in ASD. En ligne : https://doi.org/10.1002/aur.3227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Sex heterogeneity of dynamic brain activity and functional connectivity in autism spectrum disorder [Texte imprimé et/ou numérique] / Qi DONG, Auteur ; Le GAO, Auteur ; Zaifa XUE, Auteur ; Xiaoxia NIU, Auteur ; Rongjuan ZHOU, Auteur ; Xiaonan GUO, Auteur . - p.1796-1809. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1796-1809 Mots-clés : autism spectrum disorder  dynamic amplitude of low-frequency fluctuation  dynamic functional connectivity  resting-state functional magnetic resonance imaging  sex heterogeneity Index. décimale : PER Périodiques Résumé : Abstract Sex heterogeneity has been frequently reported in autism spectrum disorders (ASD) and has been linked to static differences in brain function. However, given the complexity of ASD and diagnosis-by-sex interactions, dynamic characteristics of brain activity and functional connectivity may provide important information for distinguishing ASD phenotypes between females and males. The aim of this study was to explore sex heterogeneity of functional networks in the ASD brain from a dynamic perspective. Resting-state functional magnetic resonance imaging data from the Autism Brain Imaging Data Exchange database were analyzed in 128 ASD subjects (64 males/64 females) and 128 typically developing control (TC) subjects (64 males/64 females). A sliding-window approach was adopted for the estimation of dynamic amplitude of low-frequency fluctuation (dALFF) and dynamic functional connectivity (dFC) to characterize time-varying brain activity and functional connectivity respectively. We then examined the sex-related changes in ASD using two-way analysis of variance. Significant diagnosis-by-sex interaction effects were identified in the left anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC) and left precuneus in the dALFF analysis. Furthermore, there were significant diagnosis-by-sex interaction effects of dFC variance between the left ACC/mPFC and right ACC, left postcentral gyrus, left precuneus, right middle temporal gyrus and left inferior frontal gyrus, triangular part. These findings reveal the sex heterogeneity in brain activity and functional connectivity in ASD from a dynamic perspective, and provide new evidence for further exploring sex heterogeneity in ASD. En ligne : https://doi.org/10.1002/aur.3227 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Characterizing associations between emotion dysregulation, anxiety, and repetitive behaviors in autistic youth with intellectual disability / Emily SPACKMAN ; Ru Ying CAI ; Antonio Y. HARDAN ; Mirko ULJAREVI? in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1810-1817 Titre : Characterizing associations between emotion dysregulation, anxiety, and repetitive behaviors in autistic youth with intellectual disability Type de document : Texte imprimé et/ou numérique Auteurs : Emily SPACKMAN, Auteur ; Ru Ying CAI, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVI?, Auteur Article en page(s) : p.1810-1817 Langues : Anglais (eng) Mots-clés : anxiety  autism Spectrum disorder  emotion dysregulation  intellectual disability  restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Abstract There is a paucity of research that explores associations between emotion dysregulation and the expression and severity of core and co-occurring characteristics of autism spectrum disorder (ASD), especially in autistic youth with co-occurring intellectual disability (ID). This study explored the interplay between developmental characteristics and emotion dysregulation, anxiety, and specific subtypes of RRBs that are elevated in autistic youth with co-occurring ID. Generalized additive models demonstrated that age, sex, language level, dysregulation, and anxiety showed unique patterns of association with subtypes of RRBs in a sample of 150 autistic youth with co-occurring ID who are non-speaking or minimally verbal. More specifically, higher anxiety levels were significantly associated with elevations in repetitive sensory motor behaviors (RSMB), self-injurious behaviors (SIB), insistence on sameness (IS), and unusual interests (UI). While emotion dysregulation was a significant predictor of UI, it demonstrated positive, albeit not significant, associations with the intensity of SIB and RSMB. Language level was a significant predictor of RSMB, such that the intensity of RSMB was higher for individuals who were non-speaking relative to those who spoke in single words. These findings provide preliminary insights into patterns of associations between emotion dysregulation, anxiety, and specific subdomains of RRBs in autistic youth with ID. En ligne : https://doi.org/10.1002/aur.3207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Characterizing associations between emotion dysregulation, anxiety, and repetitive behaviors in autistic youth with intellectual disability [Texte imprimé et/ou numérique] / Emily SPACKMAN, Auteur ; Ru Ying CAI, Auteur ; Antonio Y. HARDAN, Auteur ; Mirko ULJAREVI?, Auteur . - p.1810-1817. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1810-1817 Mots-clés : anxiety  autism Spectrum disorder  emotion dysregulation  intellectual disability  restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Abstract There is a paucity of research that explores associations between emotion dysregulation and the expression and severity of core and co-occurring characteristics of autism spectrum disorder (ASD), especially in autistic youth with co-occurring intellectual disability (ID). This study explored the interplay between developmental characteristics and emotion dysregulation, anxiety, and specific subtypes of RRBs that are elevated in autistic youth with co-occurring ID. Generalized additive models demonstrated that age, sex, language level, dysregulation, and anxiety showed unique patterns of association with subtypes of RRBs in a sample of 150 autistic youth with co-occurring ID who are non-speaking or minimally verbal. More specifically, higher anxiety levels were significantly associated with elevations in repetitive sensory motor behaviors (RSMB), self-injurious behaviors (SIB), insistence on sameness (IS), and unusual interests (UI). While emotion dysregulation was a significant predictor of UI, it demonstrated positive, albeit not significant, associations with the intensity of SIB and RSMB. Language level was a significant predictor of RSMB, such that the intensity of RSMB was higher for individuals who were non-speaking relative to those who spoke in single words. These findings provide preliminary insights into patterns of associations between emotion dysregulation, anxiety, and specific subdomains of RRBs in autistic youth with ID. En ligne : https://doi.org/10.1002/aur.3207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Bilingualism and second-order theory of mind development in autistic children over time: Longitudinal relations with language, executive functions, and intelligence / Margreet VOGELZANG ; Ianthi Maria TSIMPLI ; Stephanie DURRLEMAN in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1818-1829 Titre : Bilingualism and second-order theory of mind development in autistic children over time: Longitudinal relations with language, executive functions, and intelligence Type de document : Texte imprimé et/ou numérique Auteurs : Margreet VOGELZANG, Auteur ; Ianthi Maria TSIMPLI, Auteur ; Stephanie DURRLEMAN, Auteur Article en page(s) : p.1818-1829 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  bilingualism  executive functions  expressive vocabulary  intelligence  longitudinal design  second-order theory of mind Index. décimale : PER Périodiques Résumé : Abstract Theory of Mind has long been studied as a core weakness in autism spectrum disorder due to its relationship with social reciprocity, while bilingualism has been shown to compensate for autistic individuals' mentalizing weaknesses. However, our knowledge of the Theory of Mind developmental trajectories of bilingual and monolingual autistic children, as well as of the factors related to Theory of Mind development in autism spectrum disorder is still limited. The current study has examined first- and second-order Theory of Mind skills in 21 monolingual and 21 bilingual autistic children longitudinally across three time points, specifically at ages 6, 9, and 12, and also investigated associations between Theory of Mind trajectories and trajectories of the children's language, intelligence and executive function skills. The results reveal that bilingual autistic children outperformed their monolingual peers in second-order Theory of Mind at ages 9 and 12, and that intelligence and, especially, expressive vocabulary skills played a pivotal role in advancing bilingual autistic children's second-order Theory of Mind development. On the other hand, monolingual autistic children only managed to capitalize on their language and intelligence resources at age 12. The findings highlight the importance of investigating bilingualism effects on autistic children's advanced cognitive abilities longitudinally. En ligne : https://doi.org/10.1002/aur.3214 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Bilingualism and second-order theory of mind development in autistic children over time: Longitudinal relations with language, executive functions, and intelligence [Texte imprimé et/ou numérique] / Margreet VOGELZANG, Auteur ; Ianthi Maria TSIMPLI, Auteur ; Stephanie DURRLEMAN, Auteur . - p.1818-1829. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1818-1829 Mots-clés : autism spectrum disorder  bilingualism  executive functions  expressive vocabulary  intelligence  longitudinal design  second-order theory of mind Index. décimale : PER Périodiques Résumé : Abstract Theory of Mind has long been studied as a core weakness in autism spectrum disorder due to its relationship with social reciprocity, while bilingualism has been shown to compensate for autistic individuals' mentalizing weaknesses. However, our knowledge of the Theory of Mind developmental trajectories of bilingual and monolingual autistic children, as well as of the factors related to Theory of Mind development in autism spectrum disorder is still limited. The current study has examined first- and second-order Theory of Mind skills in 21 monolingual and 21 bilingual autistic children longitudinally across three time points, specifically at ages 6, 9, and 12, and also investigated associations between Theory of Mind trajectories and trajectories of the children's language, intelligence and executive function skills. The results reveal that bilingual autistic children outperformed their monolingual peers in second-order Theory of Mind at ages 9 and 12, and that intelligence and, especially, expressive vocabulary skills played a pivotal role in advancing bilingual autistic children's second-order Theory of Mind development. On the other hand, monolingual autistic children only managed to capitalize on their language and intelligence resources at age 12. The findings highlight the importance of investigating bilingualism effects on autistic children's advanced cognitive abilities longitudinally. En ligne : https://doi.org/10.1002/aur.3214 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Characterizing social communication among minimally verbal children with autism: An application of item response theory / Connie KASARI in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1830-1843 Titre : Characterizing social communication among minimally verbal children with autism: An application of item response theory Type de document : Texte imprimé et/ou numérique Auteurs : Connie KASARI, Auteur Article en page(s) : p.1830-1843 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  item response theory  minimally verbal  social communication  Index. décimale : PER Périodiques Résumé : Abstract Minimally verbal children constitute a portion of the autism spectrum. The paucity of proper measurement tools that sensitively and accurately assess behaviors has been one limiting factor in the improved knowledge of these children. Short of creating and validating a new measurement tool for this subpopulation, this study took an alternative and more immediate approach: conduct a secondary data analysis and examine an existing social communication measure, the Early Social Communication Scales (ESCS), with item response theory. The final sample consisted of 453 minimally verbal children culled from four different completed studies. The IRT models analyzed the frequency of social communication gestures from the ESCS and returned an objective difficulty hierarchy regarding initiations of joint attention and behavior regulation gestures. The best-fitting and final model was a zero-inflated negative binomial model (ZINBM), which determined that joint attention gestures were, on average, more difficult than behavior regulation gestures. Joint attentional shows and gives were essentially absent in the children's repertoire, and behavior regulation reaches were the easiest gestures for this sample. The ZINBM separately modeled children with some gestures and children who did not present with any gestures and determined that behavior regulation reaches and gives were likely the first gestures a child will eventually exhibit among children with no gestures. Methodological contributions and potential future applications of IRT are discussed. En ligne : https://doi.org/10.1002/aur.3218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Characterizing social communication among minimally verbal children with autism: An application of item response theory [Texte imprimé et/ou numérique] / Connie KASARI, Auteur . - p.1830-1843. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1830-1843 Mots-clés : autism spectrum disorder  item response theory  minimally verbal  social communication  Index. décimale : PER Périodiques Résumé : Abstract Minimally verbal children constitute a portion of the autism spectrum. The paucity of proper measurement tools that sensitively and accurately assess behaviors has been one limiting factor in the improved knowledge of these children. Short of creating and validating a new measurement tool for this subpopulation, this study took an alternative and more immediate approach: conduct a secondary data analysis and examine an existing social communication measure, the Early Social Communication Scales (ESCS), with item response theory. The final sample consisted of 453 minimally verbal children culled from four different completed studies. The IRT models analyzed the frequency of social communication gestures from the ESCS and returned an objective difficulty hierarchy regarding initiations of joint attention and behavior regulation gestures. The best-fitting and final model was a zero-inflated negative binomial model (ZINBM), which determined that joint attention gestures were, on average, more difficult than behavior regulation gestures. Joint attentional shows and gives were essentially absent in the children's repertoire, and behavior regulation reaches were the easiest gestures for this sample. The ZINBM separately modeled children with some gestures and children who did not present with any gestures and determined that behavior regulation reaches and gives were likely the first gestures a child will eventually exhibit among children with no gestures. Methodological contributions and potential future applications of IRT are discussed. En ligne : https://doi.org/10.1002/aur.3218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Enhanced pitch discrimination in autistic children with unexpected bilingualism / Marie BELENGER ; Inge-Marie EIGSTI ; Mikhail KISSINE in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1844-1852 Titre : Enhanced pitch discrimination in autistic children with unexpected bilingualism Type de document : Texte imprimé et/ou numérique Auteurs : Marie BELENGER, Auteur ; Inge-Marie EIGSTI, Auteur ; Mikhail KISSINE, Auteur Article en page(s) : p.1844-1852 Langues : Anglais (eng) Mots-clés : autism  enhanced auditory perception  language acquisition  low-level processing  screen exposure  unexpected bilingualism Index. décimale : PER Périodiques Résumé : Abstract Some autistic children acquire foreign languages from exposure to screens. Such unexpected bilingualism (UB) is therefore not driven by social interaction, rather, language acquisition appears to rely on less socially mediated learning and other cognitive processes. We hypothesize that UB children may rely on other cues, such as acoustic cues, of the linguistic input. Previous research indicates enhanced pitch processing in some autistic children, often associated with language delays and difficulties in forming stable phonological categories due to sensitivity to subtle linguistic variations. We propose that repetitive screen-based input simplifies linguistic complexity, allowing focus on individual cues. This study hypothesizes that autistic UB children exhibit superior pitch discrimination compared with both autistic and non-autistic peers. From a sample of 46 autistic French-speaking children aged 9 to 16, 12 were considered as UB. These children, along with 45 non-autistic children, participated in a two-alternative forced-choice pitch discrimination task. They listened to pairs of pure tones, 50% of which differed by 3% (easy), 2% (medium), or 1% (hard). A stringent comparison of performance revealed that only the autistic UB group performed above chance for tone pairs that differed, across all conditions. This group demonstrated superior pitch discrimination relative to autistic and non-autistic peers. This study establishes the phenomenon of UB in autism and provides evidence for enhanced pitch discrimination in this group. Acute perception of auditory information, combined with repeated language content, may facilitate UB children's focus on phonetic features, and help acquire a language with no communicative support or motivation. En ligne : https://doi.org/10.1002/aur.3221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Enhanced pitch discrimination in autistic children with unexpected bilingualism [Texte imprimé et/ou numérique] / Marie BELENGER, Auteur ; Inge-Marie EIGSTI, Auteur ; Mikhail KISSINE, Auteur . - p.1844-1852. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1844-1852 Mots-clés : autism  enhanced auditory perception  language acquisition  low-level processing  screen exposure  unexpected bilingualism Index. décimale : PER Périodiques Résumé : Abstract Some autistic children acquire foreign languages from exposure to screens. Such unexpected bilingualism (UB) is therefore not driven by social interaction, rather, language acquisition appears to rely on less socially mediated learning and other cognitive processes. We hypothesize that UB children may rely on other cues, such as acoustic cues, of the linguistic input. Previous research indicates enhanced pitch processing in some autistic children, often associated with language delays and difficulties in forming stable phonological categories due to sensitivity to subtle linguistic variations. We propose that repetitive screen-based input simplifies linguistic complexity, allowing focus on individual cues. This study hypothesizes that autistic UB children exhibit superior pitch discrimination compared with both autistic and non-autistic peers. From a sample of 46 autistic French-speaking children aged 9 to 16, 12 were considered as UB. These children, along with 45 non-autistic children, participated in a two-alternative forced-choice pitch discrimination task. They listened to pairs of pure tones, 50% of which differed by 3% (easy), 2% (medium), or 1% (hard). A stringent comparison of performance revealed that only the autistic UB group performed above chance for tone pairs that differed, across all conditions. This group demonstrated superior pitch discrimination relative to autistic and non-autistic peers. This study establishes the phenomenon of UB in autism and provides evidence for enhanced pitch discrimination in this group. Acute perception of auditory information, combined with repeated language content, may facilitate UB children's focus on phonetic features, and help acquire a language with no communicative support or motivation. En ligne : https://doi.org/10.1002/aur.3221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Feasibility and acceptability of a caregiver-mediated early support program, delivered online, for infants at elevated familial likelihood for autism: A feasibility randomized controlled trial / Malavi SRIKAR ; Reny RAJU ; Divya SWAMINATHAN ; Rachel Elizabeth JOHNSON ; Linda R. WATSON ; Deepa Bhat NAIR ; John Vijay Sagar KOMMU ; Jo CHOPRA-MCGOWAN ; Prathyusha P. VASUKI in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1853-1866 Titre : Feasibility and acceptability of a caregiver-mediated early support program, delivered online, for infants at elevated familial likelihood for autism: A feasibility randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Malavi SRIKAR, Auteur ; Reny RAJU, Auteur ; Divya SWAMINATHAN, Auteur ; Rachel Elizabeth JOHNSON, Auteur ; Linda R. WATSON, Auteur ; Deepa Bhat NAIR, Auteur ; John Vijay Sagar KOMMU, Auteur ; Jo CHOPRA-MCGOWAN, Auteur ; Prathyusha P. VASUKI, Auteur Article en page(s) : p.1853-1866 Langues : Anglais (eng) Mots-clés : acceptability  caregiver perspectives  caregiver-mediated intervention  elevated likelihood for autism  feasibility  LiL' STEPS  randomized controlled trial Index. décimale : PER Périodiques Résumé : Abstract Preliminary evidence indicates potential benefit of providing caregiver-mediated intervention, prior to diagnosis, for infants at elevated familial likelihood for autism and related developmental delays including language delay (EL-A). However, delivering such interventions online and in low-resource settings like India has not been reported. This study aimed to evaluate the feasibility and acceptability of delivering a novel manualized caregiver-mediated early support program, the ?LiL' STEPS,? online in India, for EL-A infants. LiL' STEPS stands for Language development & Intervention Lab's (LiL') Supporting Early social-communication and language by Promoting caregiver Sensitive responsiveness (STEPS). The program comprised 14 sessions with a focus on social-communication and language, conducted over 12-weeks using demonstration and video feedback. Families of 36 EL-A infants aged 9 to 15-months participated in this feasibility randomized controlled trial (RCT). Families were randomized in a 2:1 ratio (n?=?24 LiL' STEPS and n?=?12 care as usual groups). Information on feasibility and acceptability was collated following a mixed methods approach from caregiver interviews, fidelity forms, session notes, and study register. Findings indicated the LiL' STEPS study trial as feasible and acceptable with recruitment rate of 4 per month, 100% willingness for randomization, 8.3% attrition, and 3.03% loss of blinding. Interventionist and caregiver fidelity was maintained above 80%. Despite challenges like interruptions during sessions, 100% families found the program acceptable and satisfactory, 86% said they would recommend the program to others, and 71% preferred online modality. Caregivers' perspectives on beneficial components and experience attending the program have been described. Accordingly, recommendations for future definitive RCTs have been presented. En ligne : https://doi.org/10.1002/aur.3217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Feasibility and acceptability of a caregiver-mediated early support program, delivered online, for infants at elevated familial likelihood for autism: A feasibility randomized controlled trial [Texte imprimé et/ou numérique] / Malavi SRIKAR, Auteur ; Reny RAJU, Auteur ; Divya SWAMINATHAN, Auteur ; Rachel Elizabeth JOHNSON, Auteur ; Linda R. WATSON, Auteur ; Deepa Bhat NAIR, Auteur ; John Vijay Sagar KOMMU, Auteur ; Jo CHOPRA-MCGOWAN, Auteur ; Prathyusha P. VASUKI, Auteur . - p.1853-1866. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1853-1866 Mots-clés : acceptability  caregiver perspectives  caregiver-mediated intervention  elevated likelihood for autism  feasibility  LiL' STEPS  randomized controlled trial Index. décimale : PER Périodiques Résumé : Abstract Preliminary evidence indicates potential benefit of providing caregiver-mediated intervention, prior to diagnosis, for infants at elevated familial likelihood for autism and related developmental delays including language delay (EL-A). However, delivering such interventions online and in low-resource settings like India has not been reported. This study aimed to evaluate the feasibility and acceptability of delivering a novel manualized caregiver-mediated early support program, the ?LiL' STEPS,? online in India, for EL-A infants. LiL' STEPS stands for Language development & Intervention Lab's (LiL') Supporting Early social-communication and language by Promoting caregiver Sensitive responsiveness (STEPS). The program comprised 14 sessions with a focus on social-communication and language, conducted over 12-weeks using demonstration and video feedback. Families of 36 EL-A infants aged 9 to 15-months participated in this feasibility randomized controlled trial (RCT). Families were randomized in a 2:1 ratio (n?=?24 LiL' STEPS and n?=?12 care as usual groups). Information on feasibility and acceptability was collated following a mixed methods approach from caregiver interviews, fidelity forms, session notes, and study register. Findings indicated the LiL' STEPS study trial as feasible and acceptable with recruitment rate of 4 per month, 100% willingness for randomization, 8.3% attrition, and 3.03% loss of blinding. Interventionist and caregiver fidelity was maintained above 80%. Despite challenges like interruptions during sessions, 100% families found the program acceptable and satisfactory, 86% said they would recommend the program to others, and 71% preferred online modality. Caregivers' perspectives on beneficial components and experience attending the program have been described. Accordingly, recommendations for future definitive RCTs have been presented. En ligne : https://doi.org/10.1002/aur.3217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Investigating the utility of the AQ-10 in children and adolescents assessed in an outpatient ARFID clinic / Emma WILLMOTT ; Cate KELLY ; Louise BRADBURY ; Pippa HUGO ; Rachel BRYANT-WAUGH in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1867-1875 Titre : Investigating the utility of the AQ-10 in children and adolescents assessed in an outpatient ARFID clinic Type de document : Texte imprimé et/ou numérique Auteurs : Emma WILLMOTT, Auteur ; Cate KELLY, Auteur ; Louise BRADBURY, Auteur ; Pippa HUGO, Auteur ; Rachel BRYANT-WAUGH, Auteur Article en page(s) : p.1867-1875 Langues : Anglais (eng) Mots-clés : AQ-10  ARFID  ASD  autism  autism screening  autism spectrum disorder  avoidant restrictive food intake disorder  eating disorders Index. décimale : PER Périodiques Résumé : Abstract The high co-occurrence of autism and eating disorders is well established, including for those with Avoidant Restrictive Food Intake Disorder (ARFID). It is therefore important to consider autism and identify possible autism when people present to eating disorder services to ascertain whether further assessment is indicated, to support clinical formulation and to make appropriate adaptations during interventions. This paper explores the utility of a validated autism screening measure, the AQ-10, in a population of children and adolescents who presented to an outpatient eating disorders clinic for an assessment of possible ARFID. Over 19?months, 335 young people were assessed and 246 families with children aged between 4 and 17?years completed one of three versions of the AQ-10 (Child, Adolescent, and Adult), as part of a battery of routinely administered pre-assessment questionnaires. Results indicated that 80.2% (n?=?69) of those with an existing autism diagnosis scored above clinical threshold of ?6 (M?=?7.2, SD?=?1.9), 43.9% (n?=?43) of those queried to be autistic scored above clinical threshold (M?=?5.2, SD?=?2.5), and 6.5% (n?=?4) of non-autistic individuals scored above clinical threshold (M?=?2.8, SD?=?1.8). Additionally, the AQ-10 satisfactorily discriminated between those with a known autism diagnosis and those who are not autistic across all age groups and sex. We conclude that the AQ-10, alongside a comprehensive clinical assessment and clinical judgment, is a useful screening tool that can support clinicians to identify appropriate onward referrals for autism assessments, aid clinical formulation, and consider appropriate adaptations and reasonable adjustments during ARFID interventions. En ligne : https://doi.org/10.1002/aur.3220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Investigating the utility of the AQ-10 in children and adolescents assessed in an outpatient ARFID clinic [Texte imprimé et/ou numérique] / Emma WILLMOTT, Auteur ; Cate KELLY, Auteur ; Louise BRADBURY, Auteur ; Pippa HUGO, Auteur ; Rachel BRYANT-WAUGH, Auteur . - p.1867-1875. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1867-1875 Mots-clés : AQ-10  ARFID  ASD  autism  autism screening  autism spectrum disorder  avoidant restrictive food intake disorder  eating disorders Index. décimale : PER Périodiques Résumé : Abstract The high co-occurrence of autism and eating disorders is well established, including for those with Avoidant Restrictive Food Intake Disorder (ARFID). It is therefore important to consider autism and identify possible autism when people present to eating disorder services to ascertain whether further assessment is indicated, to support clinical formulation and to make appropriate adaptations during interventions. This paper explores the utility of a validated autism screening measure, the AQ-10, in a population of children and adolescents who presented to an outpatient eating disorders clinic for an assessment of possible ARFID. Over 19?months, 335 young people were assessed and 246 families with children aged between 4 and 17?years completed one of three versions of the AQ-10 (Child, Adolescent, and Adult), as part of a battery of routinely administered pre-assessment questionnaires. Results indicated that 80.2% (n?=?69) of those with an existing autism diagnosis scored above clinical threshold of ?6 (M?=?7.2, SD?=?1.9), 43.9% (n?=?43) of those queried to be autistic scored above clinical threshold (M?=?5.2, SD?=?2.5), and 6.5% (n?=?4) of non-autistic individuals scored above clinical threshold (M?=?2.8, SD?=?1.8). Additionally, the AQ-10 satisfactorily discriminated between those with a known autism diagnosis and those who are not autistic across all age groups and sex. We conclude that the AQ-10, alongside a comprehensive clinical assessment and clinical judgment, is a useful screening tool that can support clinicians to identify appropriate onward referrals for autism assessments, aid clinical formulation, and consider appropriate adaptations and reasonable adjustments during ARFID interventions. En ligne : https://doi.org/10.1002/aur.3220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Higher or lower? Interpersonal behavioral and neural synchronization of movement imitation in autistic children / Wenjun ZHANG ; Liu CHEN ; Xiaorui DENG ; Kaiyun LI ; Fengxun LIN ; Fanlu JIA ; Shuhua SU ; Wanzhi TANG in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1876-1901 Titre : Higher or lower? Interpersonal behavioral and neural synchronization of movement imitation in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Wenjun ZHANG, Auteur ; Liu CHEN, Auteur ; Xiaorui DENG, Auteur ; Kaiyun LI, Auteur ; Fengxun LIN, Auteur ; Fanlu JIA, Auteur ; Shuhua SU, Auteur ; Wanzhi TANG, Auteur Article en page(s) : p.1876-1901 Langues : Anglais (eng) Mots-clés : Autism  movement imitation  interpersonal neural synchronization  functional near-infrared spectroscopy hyperscanning  an intra- and interindividual imitation mechanism model Index. décimale : PER Périodiques Résumé : Abstract How well autistic children can imitate movements and how their brain activity synchronizes with the person they are imitating have been understudied. The current study adopted functional near-infrared spectroscopy (fNIRS) hyperscanning and employed a task involving real interactions involving meaningful and meaningless movement imitation to explore the fundamental nature of imitation as a dynamic and interactive process. Experiment 1 explored meaningful and meaningless gesture imitation. The results revealed that autistic children exhibited lower imitation accuracy and behavioral synchrony than non-autistic children when imitating both meaningful and meaningless gestures. Specifically, compared to non-autistic children, autistic children displayed significantly higher interpersonal neural synchronization (INS) in the right inferior parietal lobule (r-IPL) (channel 12) when imitating meaningful gestures but lower INS when imitating meaningless gestures. Experiment 2 further investigated the imitation of four types of meaningless movements (orofacial movements, transitive movements, limb movements, and gestures). The results revealed that across all four movement types, autistic children exhibited significantly lower imitation accuracy, behavioral synchrony, and INS in the r-IPL (channel 12) than non-autistic children. This study is the first to identify INS as a biomarker of movement imitation difficulties in autistic individuals. Furthermore, an intra- and interindividual imitation mechanism model was proposed to explain the underlying causes of movement imitation difficulties in autistic individuals. En ligne : https://doi.org/10.1002/aur.3205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Higher or lower? Interpersonal behavioral and neural synchronization of movement imitation in autistic children [Texte imprimé et/ou numérique] / Wenjun ZHANG, Auteur ; Liu CHEN, Auteur ; Xiaorui DENG, Auteur ; Kaiyun LI, Auteur ; Fengxun LIN, Auteur ; Fanlu JIA, Auteur ; Shuhua SU, Auteur ; Wanzhi TANG, Auteur . - p.1876-1901. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1876-1901 Mots-clés : Autism  movement imitation  interpersonal neural synchronization  functional near-infrared spectroscopy hyperscanning  an intra- and interindividual imitation mechanism model Index. décimale : PER Périodiques Résumé : Abstract How well autistic children can imitate movements and how their brain activity synchronizes with the person they are imitating have been understudied. The current study adopted functional near-infrared spectroscopy (fNIRS) hyperscanning and employed a task involving real interactions involving meaningful and meaningless movement imitation to explore the fundamental nature of imitation as a dynamic and interactive process. Experiment 1 explored meaningful and meaningless gesture imitation. The results revealed that autistic children exhibited lower imitation accuracy and behavioral synchrony than non-autistic children when imitating both meaningful and meaningless gestures. Specifically, compared to non-autistic children, autistic children displayed significantly higher interpersonal neural synchronization (INS) in the right inferior parietal lobule (r-IPL) (channel 12) when imitating meaningful gestures but lower INS when imitating meaningless gestures. Experiment 2 further investigated the imitation of four types of meaningless movements (orofacial movements, transitive movements, limb movements, and gestures). The results revealed that across all four movement types, autistic children exhibited significantly lower imitation accuracy, behavioral synchrony, and INS in the r-IPL (channel 12) than non-autistic children. This study is the first to identify INS as a biomarker of movement imitation difficulties in autistic individuals. Furthermore, an intra- and interindividual imitation mechanism model was proposed to explain the underlying causes of movement imitation difficulties in autistic individuals. En ligne : https://doi.org/10.1002/aur.3205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Developmental process of the understanding of linguistic register in children: A comparison of typically developing children, autistic children, and children with Williams syndrome / Yoko HAKUNO ; Kosuke ASADA ; Takahiro IKEDA ; Takanori YAMAGATA ; Masahiro HIRAI in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1902-1915 Titre : Developmental process of the understanding of linguistic register in children: A comparison of typically developing children, autistic children, and children with Williams syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Yoko HAKUNO, Auteur ; Kosuke ASADA, Auteur ; Takahiro IKEDA, Auteur ; Takanori YAMAGATA, Auteur ; Masahiro HIRAI, Auteur Article en page(s) : p.1902-1915 Langues : Anglais (eng) Mots-clés : autism  cross-syndrome comparison  linguistic register  register selection  Williams syndrome Index. décimale : PER Périodiques Résumé : Abstract Although the developmental process of linguistic register?the appropriate manner of speech as determined by the listener and social situation?has been gradually clarified in typically developing (TD) children, research on the mechanism and developmental process of register acquisition in atypically developing children are insufficient. This study compared the developmental process of understanding linguistic register among TD children, autistic children, and those with Williams syndrome (WS), and examined the contributions of social cognition and motivation to the acquisition of linguistic register. Two experiments were designed to assess the recognition of which linguistic register to use when communicating with different listeners and of the listener's feelings according to the speakers' use of register. The results revealed that the process of understanding register-listener associations was nearly identical among all groups of children and their understanding improved with age. Conversely, their understanding of the effect of register selection on the listener's feelings varied. Importantly, as TD children mature, they become aware that adult listeners may feel negatively when spoken to in an inappropriate register, whereas autistic children and those with WS do not exhibit the same awareness. Thus, our results suggest that atypical social cognition and motivation do not disturb the understanding of register-listener associations. However, social cognition and motivation play important roles in understanding the effect of register selection on the listener's feelings. These findings provide a significant contribution to clarifying the mechanism of linguistic register acquisition. En ligne : https://doi.org/10.1002/aur.3219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Developmental process of the understanding of linguistic register in children: A comparison of typically developing children, autistic children, and children with Williams syndrome [Texte imprimé et/ou numérique] / Yoko HAKUNO, Auteur ; Kosuke ASADA, Auteur ; Takahiro IKEDA, Auteur ; Takanori YAMAGATA, Auteur ; Masahiro HIRAI, Auteur . - p.1902-1915. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1902-1915 Mots-clés : autism  cross-syndrome comparison  linguistic register  register selection  Williams syndrome Index. décimale : PER Périodiques Résumé : Abstract Although the developmental process of linguistic register?the appropriate manner of speech as determined by the listener and social situation?has been gradually clarified in typically developing (TD) children, research on the mechanism and developmental process of register acquisition in atypically developing children are insufficient. This study compared the developmental process of understanding linguistic register among TD children, autistic children, and those with Williams syndrome (WS), and examined the contributions of social cognition and motivation to the acquisition of linguistic register. Two experiments were designed to assess the recognition of which linguistic register to use when communicating with different listeners and of the listener's feelings according to the speakers' use of register. The results revealed that the process of understanding register-listener associations was nearly identical among all groups of children and their understanding improved with age. Conversely, their understanding of the effect of register selection on the listener's feelings varied. Importantly, as TD children mature, they become aware that adult listeners may feel negatively when spoken to in an inappropriate register, whereas autistic children and those with WS do not exhibit the same awareness. Thus, our results suggest that atypical social cognition and motivation do not disturb the understanding of register-listener associations. However, social cognition and motivation play important roles in understanding the effect of register selection on the listener's feelings. These findings provide a significant contribution to clarifying the mechanism of linguistic register acquisition. En ligne : https://doi.org/10.1002/aur.3219 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Prevalence and treatment of autism spectrum disorder in the United States, 2016-2022 / Wen-Qiang HE in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1916-1927 Titre : Prevalence and treatment of autism spectrum disorder in the United States, 2016-2022 Type de document : Texte imprimé et/ou numérique Auteurs : Wen-Qiang HE, Auteur Article en page(s) : p.1916-1927 Langues : Anglais (eng) Mots-clés : ASD prevalence  COVID-19 pandemic  geographical region variation  medication treatment Index. décimale : PER Périodiques Résumé : Abstract This study aims to assess the prevalence of Autism Spectrum Disorder (ASD) and its treatment. The study population was children aged 3?17?years with information on current ASD from National Survey of Children's Health, 2016?2022. Analysis of treatment was also conducted within the population of children with a current ASD diagnosis. A multivariate log-binomial regression model was used to assess the change of current ASD prevalence and ASD treatment by two study period (prior to COVID-19 pandemic: 2016?2019; during COVID-19 pandemic: 2020?22) and sociodemographic information. Compared to the current ASD at 2.5% in 2016, it increased to 3.6% in 2022. The treatment has decreased from 70.5% in 2016 to 61.6% in 2022 for any treatment and from 27.2% in 2016 to 20.4% in 2022 for medication treatment. Compared to children from 2016?2019, children from the following group were more likely to have ASD diagnosis during the pandemic (2020?2022), including those aged 3?5?years (aPR?=?1.66, 95%CI 1.29?2.13), non-Hispanic white children, children from family with above national family income, and those with private insurance. However, medication treatment almost halved during the pandemic for non-Hispanic black children (aPR?=?0.49, 95%CI 0.26?0.93) and children born overseas. In conclusion, higher prevalence of ASD might indicate a better awareness of ASD. The reduction in treatment correlates to the health service disruption caused by the pandemic, highlighting the needs of policy efforts to improve treatment for ASD. En ligne : https://doi.org/10.1002/aur.3228 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Prevalence and treatment of autism spectrum disorder in the United States, 2016-2022 [Texte imprimé et/ou numérique] / Wen-Qiang HE, Auteur . - p.1916-1927. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1916-1927 Mots-clés : ASD prevalence  COVID-19 pandemic  geographical region variation  medication treatment Index. décimale : PER Périodiques Résumé : Abstract This study aims to assess the prevalence of Autism Spectrum Disorder (ASD) and its treatment. The study population was children aged 3?17?years with information on current ASD from National Survey of Children's Health, 2016?2022. Analysis of treatment was also conducted within the population of children with a current ASD diagnosis. A multivariate log-binomial regression model was used to assess the change of current ASD prevalence and ASD treatment by two study period (prior to COVID-19 pandemic: 2016?2019; during COVID-19 pandemic: 2020?22) and sociodemographic information. Compared to the current ASD at 2.5% in 2016, it increased to 3.6% in 2022. The treatment has decreased from 70.5% in 2016 to 61.6% in 2022 for any treatment and from 27.2% in 2016 to 20.4% in 2022 for medication treatment. Compared to children from 2016?2019, children from the following group were more likely to have ASD diagnosis during the pandemic (2020?2022), including those aged 3?5?years (aPR?=?1.66, 95%CI 1.29?2.13), non-Hispanic white children, children from family with above national family income, and those with private insurance. However, medication treatment almost halved during the pandemic for non-Hispanic black children (aPR?=?0.49, 95%CI 0.26?0.93) and children born overseas. In conclusion, higher prevalence of ASD might indicate a better awareness of ASD. The reduction in treatment correlates to the health service disruption caused by the pandemic, highlighting the needs of policy efforts to improve treatment for ASD. En ligne : https://doi.org/10.1002/aur.3228 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Specificity of the short-story task for autism diagnosis when controlling for depression / Johannes PFISTERER ; Katrin DÖHNEL ; Lore BLAAS ; Manuela ULLMANN ; Berthold LANGGUTH ; Rainer RUPPRECHT ; Monika SOMMER in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1928-1933 Titre : Specificity of the short-story task for autism diagnosis when controlling for depression Type de document : Texte imprimé et/ou numérique Auteurs : Johannes PFISTERER, Auteur ; Katrin DÖHNEL, Auteur ; Lore BLAAS, Auteur ; Manuela ULLMANN, Auteur ; Berthold LANGGUTH, Auteur ; Rainer RUPPRECHT, Auteur ; Monika SOMMER, Auteur Article en page(s) : p.1928-1933 Langues : Anglais (eng) Mots-clés : fiction-based mentalizing  depression  diagnostics  mentalizing  short-story task Index. décimale : PER Périodiques Résumé : Abstract Securing an accurate autism-spectrum-condition diagnosis, particularly among women, remains challenging for autistic adults. Building upon previous research highlighting the short-story task (SST) as a promising tool for detecting fiction-based mentalizing difficulties in autistic adults, this study expands its scope. We investigated the SST's discriminative capacity across three distinct groups: autistic individuals (n?=?32), nonautistic individuals without mental health problems (n?=?32), and nonautistic individuals with clinical depression (n?=?30). All three groups differed significantly from each other in their SST mentalizing score with the nonautistic group having the highest scores, the nonautistic but depressed group having medium scores and the autistic group showing the lowest scores. Receiver operator curve (ROC) analysis reaffirmed the SST's efficacy as a discriminator. Moreover, a linear regression analysis identified the SST mentalizing score, the SST comprehension score, and the number of books read per month as significant predictors of autism-spectrum-condition diagnosis. These findings bolster the SST's potential as a valuable adjunct in autism diagnostics, highlighting its discriminatory ability across diverse samples. En ligne : https://doi.org/10.1002/aur.3191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Specificity of the short-story task for autism diagnosis when controlling for depression [Texte imprimé et/ou numérique] / Johannes PFISTERER, Auteur ; Katrin DÖHNEL, Auteur ; Lore BLAAS, Auteur ; Manuela ULLMANN, Auteur ; Berthold LANGGUTH, Auteur ; Rainer RUPPRECHT, Auteur ; Monika SOMMER, Auteur . - p.1928-1933. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1928-1933 Mots-clés : fiction-based mentalizing  depression  diagnostics  mentalizing  short-story task Index. décimale : PER Périodiques Résumé : Abstract Securing an accurate autism-spectrum-condition diagnosis, particularly among women, remains challenging for autistic adults. Building upon previous research highlighting the short-story task (SST) as a promising tool for detecting fiction-based mentalizing difficulties in autistic adults, this study expands its scope. We investigated the SST's discriminative capacity across three distinct groups: autistic individuals (n?=?32), nonautistic individuals without mental health problems (n?=?32), and nonautistic individuals with clinical depression (n?=?30). All three groups differed significantly from each other in their SST mentalizing score with the nonautistic group having the highest scores, the nonautistic but depressed group having medium scores and the autistic group showing the lowest scores. Receiver operator curve (ROC) analysis reaffirmed the SST's efficacy as a discriminator. Moreover, a linear regression analysis identified the SST mentalizing score, the SST comprehension score, and the number of books read per month as significant predictors of autism-spectrum-condition diagnosis. These findings bolster the SST's potential as a valuable adjunct in autism diagnostics, highlighting its discriminatory ability across diverse samples. En ligne : https://doi.org/10.1002/aur.3191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Acute effects of exercise on gaze fixation and affective response inhibition in children with autism spectrum disorder: A randomized cross-over study / Fabienne BRUGGISSER ; Rahel LEUENBERGER ; Toru ISHIHARA ; Keita KAMIJO ; Mark BROTZMANN ; Sarah TRESCHER ; Markus FÖRSTER ; Markus GERBER in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1934-1943 Titre : Acute effects of exercise on gaze fixation and affective response inhibition in children with autism spectrum disorder: A randomized cross-over study Type de document : Texte imprimé et/ou numérique Auteurs : Fabienne BRUGGISSER, Auteur ; Rahel LEUENBERGER, Auteur ; Toru ISHIHARA, Auteur ; Keita KAMIJO, Auteur ; Mark BROTZMANN, Auteur ; Sarah TRESCHER, Auteur ; Markus FÖRSTER, Auteur ; Markus GERBER, Auteur Article en page(s) : p.1934-1943 Langues : Anglais (eng) Mots-clés : executive function  eye-tracking  face recognition  physical activity  social cognition Index. décimale : PER Périodiques Résumé : Abstract Children with autism spectrum disorder (ASD) show impairments in response inhibition, especially in socio-emotional contexts. A single aerobic exercise session has the potential to temporarily reduce such impairments as findings from neurotypical children support acute benefits of this exercise type for inhibitory control and emotion recognition. In children with ASD, we therefore aimed to investigate the effects of an aerobic exercise bout on response inhibition in an emotional Go/NoGo task and gaze fixation as possible mechanism underlying changes in performance. Using a cross-over design, 29 patients completed a 20-min aerobic exercise bout at moderate intensity on a cycling ergometer and a control condition in a randomized order. An emotional Go/NoGo task was administered before and after both experimental conditions. Eye-tracking was performed during the cognitive task to assess the duration of gaze fixation of eyes and mouth parts of faces expressing happy or sad emotions. The results support no beneficial effect of exercise on performance on the emotional Go/NoGo task. Instead, patients showed a greater decrease in accuracy on Go trials displaying happy faces in the exercise compared to the control condition. This change was associated with a more pronounced decrease in the fixation duration of the eyes for faces expressing either happy or sad emotions. In conclusion, while a single session of moderately intense aerobic exercise does not affect response inhibition, it temporarily aggravates ASD-specific deficits in the processing of and response to facial emotions. En ligne : https://doi.org/10.1002/aur.3224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Acute effects of exercise on gaze fixation and affective response inhibition in children with autism spectrum disorder: A randomized cross-over study [Texte imprimé et/ou numérique] / Fabienne BRUGGISSER, Auteur ; Rahel LEUENBERGER, Auteur ; Toru ISHIHARA, Auteur ; Keita KAMIJO, Auteur ; Mark BROTZMANN, Auteur ; Sarah TRESCHER, Auteur ; Markus FÖRSTER, Auteur ; Markus GERBER, Auteur . - p.1934-1943. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1934-1943 Mots-clés : executive function  eye-tracking  face recognition  physical activity  social cognition Index. décimale : PER Périodiques Résumé : Abstract Children with autism spectrum disorder (ASD) show impairments in response inhibition, especially in socio-emotional contexts. A single aerobic exercise session has the potential to temporarily reduce such impairments as findings from neurotypical children support acute benefits of this exercise type for inhibitory control and emotion recognition. In children with ASD, we therefore aimed to investigate the effects of an aerobic exercise bout on response inhibition in an emotional Go/NoGo task and gaze fixation as possible mechanism underlying changes in performance. Using a cross-over design, 29 patients completed a 20-min aerobic exercise bout at moderate intensity on a cycling ergometer and a control condition in a randomized order. An emotional Go/NoGo task was administered before and after both experimental conditions. Eye-tracking was performed during the cognitive task to assess the duration of gaze fixation of eyes and mouth parts of faces expressing happy or sad emotions. The results support no beneficial effect of exercise on performance on the emotional Go/NoGo task. Instead, patients showed a greater decrease in accuracy on Go trials displaying happy faces in the exercise compared to the control condition. This change was associated with a more pronounced decrease in the fixation duration of the eyes for faces expressing either happy or sad emotions. In conclusion, while a single session of moderately intense aerobic exercise does not affect response inhibition, it temporarily aggravates ASD-specific deficits in the processing of and response to facial emotions. En ligne : https://doi.org/10.1002/aur.3224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

Neurophysiological effects of a combined treatment of lovastatin and minocycline in patients with fragile X syndrome: Ancillary results of the LOVAMIX randomized clinical trial / Camille CHAMPIGNY ; Samantha CÔTÉ ; Teddy MOHAMAD ; Seyede Anis HASANI ; Artuela ÇAKU ; François CORBIN ; Jean-François LEPAGE in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1944-1956 Titre : Neurophysiological effects of a combined treatment of lovastatin and minocycline in patients with fragile X syndrome: Ancillary results of the LOVAMIX randomized clinical trial Type de document : Texte imprimé et/ou numérique Auteurs : Camille CHAMPIGNY, Auteur ; Samantha CÔTÉ, Auteur ; Teddy MOHAMAD, Auteur ; Seyede Anis HASANI, Auteur ; Artuela ÇAKU, Auteur ; François CORBIN, Auteur ; Jean-François LEPAGE, Auteur Article en page(s) : p.1944-1956 Langues : Anglais (eng) Mots-clés : dual therapy  fragile X syndrome  lovastatin  minocycline  transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : Abstract Fragile X syndrome (FXS) is the primary hereditary cause of intellectual disability and autism spectrum disorder. It is characterized by exacerbated neuronal excitability, and its correction is considered an objective measure of treatment response in animal models, a marker albeit rarely used in clinical trials. Here, we used an extensive transcranial magnetic stimulation (TMS) battery to assess the neurophysiological effects of a therapy combining two disease-modifying drugs, lovastatin (40?mg) and minocycline (100?mg), administered alone for 8?weeks and in combination for 12?weeks, in 19 patients (mean age of 23.58?+?1.51) with FXS taking part in the LOVAmix trial. The TMS battery, which included the resting motor threshold, short-interval intracortical inhibition, long-interval intracortical inhibition, corticospinal silent period, and intracortical facilitation, was completed at baseline after 8?weeks of monotherapy (visit 2 of the clinical trial) and after 12?weeks of dual therapy (visit 4 of the clinical trial). Repeated measure ANOVAs were performed between baseline and visit 2 (monotherapy) and visit 3 (dual therapy) with interactions for which monotherapy the participants received when they began the clinical trial. Results showed that dual therapy was associated with reduced cortical excitability after 20?weeks. This was reflected by a significant increase in the resting-motor threshold after dual therapy compared to baseline. There was a tendency for enhanced short-intracortical inhibition, a marker of GABAa-mediated inhibition after 8?weeks of monotherapy compared to baseline. Together, these results suggest that a combined therapy of minocycline and lovastatin might act on the core neurophysiopathology of FXS. This trial was registered at clinicaltrials.gov (NCT02680379). En ligne : https://doi.org/10.1002/aur.3222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Neurophysiological effects of a combined treatment of lovastatin and minocycline in patients with fragile X syndrome: Ancillary results of the LOVAMIX randomized clinical trial [Texte imprimé et/ou numérique] / Camille CHAMPIGNY, Auteur ; Samantha CÔTÉ, Auteur ; Teddy MOHAMAD, Auteur ; Seyede Anis HASANI, Auteur ; Artuela ÇAKU, Auteur ; François CORBIN, Auteur ; Jean-François LEPAGE, Auteur . - p.1944-1956. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1944-1956 Mots-clés : dual therapy  fragile X syndrome  lovastatin  minocycline  transcranial magnetic stimulation Index. décimale : PER Périodiques Résumé : Abstract Fragile X syndrome (FXS) is the primary hereditary cause of intellectual disability and autism spectrum disorder. It is characterized by exacerbated neuronal excitability, and its correction is considered an objective measure of treatment response in animal models, a marker albeit rarely used in clinical trials. Here, we used an extensive transcranial magnetic stimulation (TMS) battery to assess the neurophysiological effects of a therapy combining two disease-modifying drugs, lovastatin (40?mg) and minocycline (100?mg), administered alone for 8?weeks and in combination for 12?weeks, in 19 patients (mean age of 23.58?+?1.51) with FXS taking part in the LOVAmix trial. The TMS battery, which included the resting motor threshold, short-interval intracortical inhibition, long-interval intracortical inhibition, corticospinal silent period, and intracortical facilitation, was completed at baseline after 8?weeks of monotherapy (visit 2 of the clinical trial) and after 12?weeks of dual therapy (visit 4 of the clinical trial). Repeated measure ANOVAs were performed between baseline and visit 2 (monotherapy) and visit 3 (dual therapy) with interactions for which monotherapy the participants received when they began the clinical trial. Results showed that dual therapy was associated with reduced cortical excitability after 20?weeks. This was reflected by a significant increase in the resting-motor threshold after dual therapy compared to baseline. There was a tendency for enhanced short-intracortical inhibition, a marker of GABAa-mediated inhibition after 8?weeks of monotherapy compared to baseline. Together, these results suggest that a combined therapy of minocycline and lovastatin might act on the core neurophysiopathology of FXS. This trial was registered at clinicaltrials.gov (NCT02680379). En ligne : https://doi.org/10.1002/aur.3222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535